PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “VERATRUM ALKALOIDS”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 37 records · Page 2Linked to original sources
PubMed1980

Stimulation of cardiac receptors with veratrum alkaloids inhibits ADH secretion.

The purpose of this study was to determine whether cardiac receptors that are stimulated by veratrum alkaloids exert an inhibitory influence on the secretion of vasopressin (ADH). In six chloralose-anesthetized dogs, injection of cryptenamine (2 microgram/kg) into the circumflex coronary artery resulted in a significant (P < 0.05) fall in arterial pressure (-45 +/- 5 mmHg). Despite this hypotension and the presence of intact arterial baroreflexes, there was no change in plasma ADH (measured in the superior vena cava). In eight dogs with sinoaortic baroreceptor denervation, hemorrhage of 10 ml/kg decreased arterial pressure 20 +/- 5 mmHg (P < 0.05) and increased plasma ADH from 14 +/- 5 to 38 +/- 13 microU/ml (P < 0.05). Intracoronary injection of cryptenamine (1 microgram/kg) decreased plasma ADH to 23 +/- 7 microU/ml during the 5 min immediately after cryptenamine injection and to 16 +/- 4 microU/ml 20 min after injection. In eight dogs with sinoaortic denervation, hemorrhage and injection of vehicle resulted in a progressive increase in plasma ADH over the same time period. Vagotomy abolished the inhibitory response to cryptenamine injection. These data show that stimulation of cardiac receptors with vagal afferents by intracoronary injection of a veratrum alkaloid inhibits ADH secretion. Activation of these receptors can prevent arterial baroreflex-induced increases in ADH.

Afferent Pathways↗
PubMed1981

New substances with cytotoxic and antitumor effects. IV. In vitro effect of some veratrum alkaloids and their derivatives on leukemia P388 cells.

Some Veratrum alkaloids and their derivatives exhibited an in vitro cytotoxic effect on leukemia P388 cells, depending on the structure of the skeleton of the molecule, particularly on the type of the heterocycle attached to C-20. Veracintine and 20-(2-methyl-1-pyrrolin-5-yl)-4-pregnen-3-one, which proved to be the most effective, inhibited incorporation of uridine, and to a lesser extent that of L-valine into P388 cells fractions. After a brief reaction (15 min), these substances became irreversibly bound in the P388 cells and stopped their further in vitro proliferation. The cytotoxic effect of veracintine became enhanced by sublethal doses of tubercidine (phase of maximum lethality of G1).

Animals↗
PubMed1994

[Veratrum alkaloids. I].

Alkaloids represent an important group of therapeutically significant secondary metabolites. The plants of the genus Veratrum contain alkaloids with an antihypertensive effect. Also the genera Schoenocaulon and Zygadenus are sources of veratrum alkaloids. The present paper presents a survey of isolated alkaloids from the underground and aerial parts of 17 species of the genus Veratrum. The alkaloids occur as glycosides, aglycones or in the form of esters with various acids. In conformity with the IUPAC regulations for the nomenclature of steroids, Veratrum alkaloids were divided into 7 groups. The present paper lists the compounds of the first two groups, i.e. (1) alkaloids of the jervanine and veratranine types (I-XXIII), and (2) alkaloids with the cevanine skeleton (XXIV-XXXV). The individual compounds are characterized by their physico-chemical constants (melting point, optical rotation).

Veratrum Alkaloids↗
PubMed2000

Blood-pressure lowering, positive chronotropy and inotropy by the Veratrum alkaloids germidine and germerine but negative chronotropy by veratridine in mice.

Germidine and germerine, the Veratrum alkaloids lowered blood pressure accompanied with positive chronotropy and inotropy in mice. Germerine was more potent than germidine in both blood-pressure lowering and positive inotropy, whereas veratridine produced negative chronotropy and positive inotropy. An acyl group (an acetyl or a 2-methylbutyroyl group) at 3-O-R1 position and a 2-methylbutyroyl group at 15-O-R2 position in germine were important to produce the positive inotropy and chronotropy. The presence of a veratroyl group at 3-O-R1 position and a free hydroxyl group at 15-O-R2 position may be essential to produce the negative chronotropy by veratridine. The positive inotropy by germidine and veratridine may be due to TTX-resistant Na+ channel activation.

Animals↗
PubMed1976

Myocardial responses to acetylstrophanthidin during veratrum alkaloid refractoriness.

Studies were undertaken in the isolated blood perfused dog heart to determine the nature of the myocardial refractoriness induced by veratrum alkaloids. The initial intracoronary injection of cryptenamine acetates (Unitensin) was always associated with an increase in myocardial contractility and a loss of myocardial potassium. Subsequent doses produced refractoriness with respect to both the contractile and potassium responses. Acetylstrophanthidin still produced an inotropic and potassium losing effect duct of the glycoside was potentiated whereas the contractile response was not.

Animals↗
PubMed1960

Interactions of veratrum alkaloids, procaine, and calcium with monolayers of stearic acid and their implications for pharmacological action.

The interactions of veratridine, cevadine, veracevine, and veratramine with monolayers of stearic acid show marked differences. Veratridine and cevadine, at concentrations that are known from potential, ionic flux, and other measurements to affect living membranes, react strongly with the film and appear to cause an "interfacial dissolution" whereby both the alkaloid and the stearate leave the surface. Veracevine at the same concentration does not interact with the film. The veratramine reaction is weak, much like that of the local anesthetic procaine. The veratridine and cevadine effects are antagonized by 10(-3)M Ca(++), low pH, and 3.7 and 7.4 x 10(-3)M procaine. These differences among the veratrum alkaloids and the antagonisms parallel effects observed in living systems. Such parallelism suggests that similar physical interactions are involved in the stearate film and in natural membranes.

Anesthetics, Local↗