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At least 37 records · Page 2Linked to original sources
PubMed1984

Trichinella spiralis: genetics of worm expulsion in inbred and F1 mice infected with different worm doses.

The nematode Trichinella spiralis is rejected from the intestine at a time that is characteristic for each inbred strain of mouse. Previous work (R. G. Bell et al. 1982a) had empirically identified strong, intermediate, and weak phenotypes (NFR, C3H/He, and C57B1/10 mice, respectively) in mice infected with 400 muscle larvae. It is shown that this classification applies to another eight inbred strains: SWR, DBA/2, DBA/1, LP, Bub/Bn--all intermediate, and NZB/BIN, C57L, A, and Mus molossinus--all weak. This phenotypic classification consistently applies with infections of 400-800 muscle larvae. Below doses of 300 muscle larvae, the strain designation of phenotype does not consistently apply. By this it is meant that the relative rejection rate changes for certain strains so that eventually some strains that were strong (NFR) or intermediate (AKR) responders to 400 muscle larvae become weak responders to 50 muscle larvae. Other strains increase their relative rejection time (B10 . BR, B10 . Q) while many do not change (NFS, C3Heb/Fe, DBA/2, DBA/1). The phenomenon is most apparent in inbred parental strains rather than in F1 crosses, and it represents a phenotypic variation in rejection time that is dependent on dose. It is also demonstrated that time of rejection is directly proportional to dose in all inbred and F1 mouse strains that we have examined. Analysis of F1 crosses shows that most have the rejection time of the strongest responding parental line, suggesting simple genetic control of strong, intermediate, and weak responses. Two F1 crosses invalidated this theory. The DBA/1 X C3H/He (intermediate X intermediate) showed a strong response. The additive effects of parental rejection phenotype indicated that these lines could not be genetically identical for intermediate responsiveness. Similarly, the NFR (strong) X B10 . BR (weak) F1 showed intermediate rejection, indicating partial dominance of C57B1/10 genes over the strong responder NFR strain. Neither the primary expulsion time phenotype, phenotypic variation to low doses, or the rejection characteristics of F1 crosses could be ascribed to genes linked to the major histocompatibility complex.

Animals↗
PubMed2005

Morphology of mitochondria during apoptosis: worms-to-beetles in worms.

Although mitochondria are crucial for most pathways of mammalian cell apoptosis, evidence for their role in classic invertebrate models of programmed cell death has been frustratingly scant. New work showing that inhibition of mitochondrial fragmentation during C. elegans development inhibits programmed cell death bridges this gap and should advance a more detailed understanding of the role of mitochondria in caspase activation.

Animals↗
PubMedDate not supplied

[On the morphology of Syphacia callosciuri n. sp., pin-worm parasite of a Malaysian squirrel and on the origin of Rattus pin-worm, Syphacia muris (Yamaguti, 1935) (author's transl)].

Description of a new species of Oxyurid: Syphacia (Syphatineria) callosciuri n. sp. parasite of a Sciurid rodent Callosciuris caniceps in Malaysia. In rodents belonging to the genus Callosciurus in Malaysia two species: S callosciuri n. sp. and S. owyangi Quentin, 1975, show morphological characteristics which are intermediate between the primitive Syphacia and two different lines of species parasite of recent rodents. These observations appear to indicate that the adaptation of Syphacia of Sciurids to the modern rodents has occured in South-East Asia.

Animals↗