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Interception of potential adverse drug events in long-term psychiatric care units.

The interception of medication errors is required for patient safety. The aim of the present study was to clarify factors associated with the interception of potential adverse drug events in long-term psychiatric care units. A survey was conducted of medication-related errors in 132 Japanese long-term psychiatric care units for 2 months using an incident reporting system. The relationship was analyzed between the reported potential adverse drug events and the characteristics of the units and the staff, as well as those of the patients involved. A multivariate logistic regression analysis was performed with environmental, organizational, and human factors as independent variables to predict the interception of potential adverse drug events. Of the 221 reported incidents, 55 (24.9%) were intercepted before reaching patients. The following patient groups were significantly associated with the failure to intercept potential adverse drug events: patients receiving a relatively large number of tablets, patients with relatively frequent admissions, and patients exposed to a relatively high patient-staff ratio in the evening. In contrast, patients with a diagnosis of schizophrenia were significantly associated with an increased possibility of interception. To intercept more potential adverse drug events, simpler prescriptions are crucial. To improve the current situation, organizational efforts, such as increasing staff in the evening, and educating the staff about medications, will be required, as well as improvements in the medications themselves.

Adult↗

Applicability of interceptive orthodontics in the community.

The term interceptive orthodontics used in this paper is defined as the prompt treatment of unfavourable features of a developing occlusion categorized as local factors, crowding and displacements of the mandible in closing from the rest position. The aims of the study were to determine the best age or ages for interceptive orthodontics, to establish diagnostic cut-off points for self-correcting features of the developing occlusion which can be quantified, to investigate the reproducibility of treatment decisions and to make an initial estimate of the percentage of children suitable for interception. Based on material in the Belfast Growth Study, maximum or minimum measurements associated with spontaneous correction of quantifiable features were determined and incorporated into a disposable plastic gauge. Using the gauge, the available records of 278 Growth Study subjects at age 9 years and 272 at age 11 years were assessed for suitability for interception. Most of the conditions for interceptive treatments were present at age 9 years, but others were not present until 11 years. The majority of treatment decisions were highly reproducible. Approximately 50 per cent of the children in the Growth Study would have benefitted from interceptive orthodontics. A follow-up community study seems justified.

Age Factors↗

Manual interception of moving targets. I. Performance and movement initiation.

We investigated the capacities of human subjects to intercept moving targets in a two-dimensional (2D) space. Subjects were instructed to intercept moving targets on a computer screen using a cursor controlled by an articulated 2D manipulandum. A target was presented in 1 of 18 combinations of three acceleration types (constant acceleration, constant deceleration, and constant velocity) and six target motion times, from 0.5 to 2.0 s. First, subjects held the cursor in a start zone located at the bottom of the screen along the vertical meridian. After a pseudorandom hold period, the target appeared in the lower left or right corner of the screen and traveled at 45 degrees toward an interception zone located on the vertical meridian 12.5 cm above the start zone. For a trial to be considered successful, the subject's cursor had to enter the interception zone within 100 ms of the target's arrival at the center of the interception zone and stay inside a slightly larger hold zone. Trials in which the cursor arrived more than 100 ms before the target were classified as "early errors," whereas trials in which the cursor arrived more than 100 ms after the target were classified as "late errors." Given the criteria above, the task proved to be difficult for the subjects. Only 41.3% (1080 out of 2614) of the movements were successful, whereas the remaining 58.7% were temporal (i.e., early or late) errors. A large majority of the early errors occurred in trials with decelerating targets, and their percentage tended to increase with longer target motion times. In contrast, late errors occurred in relation to all three target acceleration types, and their percentage tended to decrease with longer target motion times. Three models of movement initiation were investigated. First, the threshold-distance model, originally proposed for optokinetic eye movements to constant-velocity visual stimuli, maintains that response time is composed of two parts, a constant processing time and the time required for the stimulus to travel a threshold distance. This model only partially fit our data. Second, the threshold-tau model, originally proposed as a strategy for movement initiation, assumes that the subject uses the first-order estimate of time-to-contact (tau) to determine when to initiate the interception movement. Similar to the threshold distance model, the threshold-tau model only partially fit the data. Finally, a dual-strategy model was developed which allowed for the adoption of either of the two strategies for movement initiation; namely, a strategy based on the threshold-distance model ("reactive" strategy) and another based on the threshold-tau model ("predictive" strategy). This model provided a good fit to the data. In fact, individual subjects preferred to use one or the other strategy. This preference was allowed to be manifested at long target motion times, whereas shorter target motion times (i.e., 0.5 s and 0.8 s) forced the subjects to use only the reactive strategy.

Adult↗

External timing constraints facilitate performance of everyday interceptive actions in children with Spastic Hemiparetic Cerebral Palsy.

We examined how children with Spastic Hemiparetic Cerebral Palsy (SHCP) perform interceptive actions they experience in daily life. Children were required to walk towards and intercept a stationary ball or a moving ball, with either their impaired or non-impaired arm. In the stationary ball condition the child was free to determine the speed of their response (internal timing), whereas in the moving ball condition there was a restricted time available (external timing). It was found that the reach movements of the non-impaired arm were different to the impaired arm, and were characterized by some of the typical movement limitations imposed by SHCP. However, there was no evidence of increased contribution from trunk motion or a lengthening of reach movement time or deceleration time. Instead, there was a coordinated change with the walking kinematics, whereby the children spent proportionately more time slowing down as they approached the point of interception when reaching with the impaired arm. There were also several differences in the response when intercepting a moving ball compared to a stationary ball. When the timing constraints were imposed externally (moving ball) rather than internally (stationary ball), children reached with a reduced movement time and deceleration time, and an increased peak wrist velocity and elbow excursion. These adaptations to behaviour were necessary to deal with the restricted time available to make the interception in the moving ball condition compared to when the ball was stationary, and reveal how children with SHCP coordinate walking and reaching when performing natural interceptive actions.

Activities of Daily Living↗

Shoot structure, light interception, and distribution of nitrogen in an Abies amabilis canopy.

We studied the effects of variation in shoot structure and needle morphology on the distributions of light and nitrogen within a Pacific silver fir (Abies amabilis (Dougl.) Forbes) canopy. Specifically, we investigated the role of morphological shade acclimation in the determination of resource use efficiency, which is claimed to be optimal when the distribution of nitrogen within the canopy is directly proportional to the distribution of intercepted photosynthetically active radiation (PAR). Shoots were collected from different heights in the crowns of trees representing four different size classes. A new method was developed to estimate seasonal light interceptance (SLI, intercepted PAR per unit needle area) of the shoots using a model for the directional distribution of above-canopy PAR, measurements of shoot silhouette area and canopy gap fraction in different directions. The ratio SLI/SLI(o), where the reference value SLI(o) represents the seasonal light interceptance of a spherical surface at the shoot location, was used to quantify the efficiency of light capture by a shoot. The ratio SLI/SLI(o) doubled from the top to the bottom of the canopy, mainly as a result of smaller internal shading in shade shoots than in sun shoots. Increased light-capturing efficiency of shade shoots implies that the difference in intercepted light by sun shoots versus shade shoots is much less than the decrease in available light from the upper to the lower canopy. For example, SLI of the five most sunlit shoots was only about 20 times greater than the SLI of the five most shaded shoots, whereas SLI(o) was 40 times greater for sun shoots than for shade shoots. Nitrogen content per unit needle area was about three times higher in sun needles than in shade needles. This variation, however, was not enough to produce proportionality between the amounts of nitrogen and intercepted PAR throughout the canopy.

Journal Article↗

Comparing light interception with stand basal area for predicting tree growth.

Empirical and process-based tree growth models have been developedconcurrently; however, their growth predictions have rarely been compared directly. A major difference between the model types is the explicit quantification of foliage biomass as a key variable in process-based models. The aim of this work was to test if this difference has a significant impact on model behavior, especially when simulating silvicultural practices such as intensive thinning. A method was developed to evaluate leaf area and light interception of the mean tree of an even-aged stand from yield table data for Norway spruce (Picea abies (L.) Karst.) in the northern French Alps. Two scenarios were analyzed: (1) a closed stand where leaf area was limited by a maximum leaf area index-represented by young, dense stands, and (2) an open stand where leaf area was limited by the height of the crown base-represented by old, sparse stands. Light interception was calculated based on interpolation between a closed stand (Beer-Lambert law) and an isolated tree (light interception proportional to leaf area). This approach was then used to build a growth model in which competition was described by the ratio of light intercepted by a mean tree of the stand to light intercepted by an isolated tree of the same size. This process-based model was compared with a simpler empirical model in which competition was described by stand basal area. Both models fit well to yield table diameter increment data, the simpler model being slightly better. Simulation of long-term growth, interspersed with thinning, revealed differences between the models. The empirical model was sensitive to thinning and simulated a discontinuous growth pattern, whereas the model based on light calculation showed a smoother growth response to thinning. Simulations of heavy thinning in a dense stand highlighted these differences. The empirical model simulated heavy thinning in a dense stand unrealistically: after thinning, trees immediately grew as fast as trees of similar diameter in an unthinned stand at the same density. In contrast, leaf area played a regulatory role in the model based on light interception: trees with short crowns, as a result of a previous period of growth at high density, benefited little from an increase in light following thinning. It is concluded that models based on physiological or ecological processes have qualitative behaviors different from those of classical empirical models. This is especially important when models are used to make extrapolations far from reference data, for example, to forecast the long-term effect of a new silvicultural strategy.

Journal Article↗

The interrelationships among plant biomass, plant surface area and the interception of particulate deposition by grasses.

The interrelationships among plant biomass, plant surface area and interception fraction were determined for the interception by corn of 238Pu-bearing particles released to the atmosphere from the H-Area nuclear fuels chemical separations facility on the U.S. Department of Energy's Savannah River Plant in Barnwell County, South Carolina. The relationship between interception fraction and corn biomass was accurately approximated by a filtration model with an absorption coefficient of 3.60 m2 kg-1. A filtration model with an absorption coefficient of 2.91 m2 kg-1 accurately approximated the relationship between biomass and interception fraction for data compiled from the literature for a variety of grass species. A linear regression model accurately approximated the relationship between interception fraction and surface area, but was not a better predictor of interception fraction than the filtration model for biomass.

Air Pollutants↗

Exotic mosquitoes in New Zealand: a review of species intercepted, their pathways and ports of entry.

A review was carried out to identify the exotic mosquito species intercepted in New Zealand to 2004, together with their origins, pathways and ports of entry into the country. A total of 171 interceptions have been recorded since 1929. There was little or no taxonomic information available for many, but at least 27 exotic species not yet established in New Zealand have been intercepted, including important disease vectors such as Aedes albopictus, Aedes aegypti and Culex annulirostris. Of 152 interception records with a described origin, 100 (66%) have originated from the South Pacific, 42 (28%) from Australia alone, while Japan was the likely source for 22 (15%) interceptions and has become the main source of exotic mosquitoes since the 1990s. Aircraft have clearly been the main vessel for invading mosquitoes with 94 (62%) of 151 cases with a described entrance pathway, but that pattern has changed greatly in the past 15 years, with 51 (82%) of 62 interceptions occurring on ships. Auckland, New Zealand's largest city, has been the main port of entry for invaders (75/93; 81%). The data indicate that it is somewhat fortunate that New Zealand has only four exotic mosquito species established. It is necessary, therefore, to adopt comprehensive exotic species monitoring and border surveillance, with particular emphasis on incoming ships and their cargo, in order to stop further mosquito invasions that could potentially lead to future outbreaks of mosquito-borne diseases.

Animals↗

Two zero-flow pressure intercepts exist in autoregulating isolated skeletal muscle.

The autoregulating vascular bed of the isolated canine extensor digitorum longus muscle was investigated for the possible existence of two positive zero-flow pressure axis intercepts, a tone-dependent one and a tone-independent one. An isolated preparation, perfused with autologous blood, was used to exclude effects of collateral flow and nervous and humoral regulation while autoregulation was left intact [mean autoregulatory gain 0.50 +/- 0.24 (SD)]. In a first series of experiments, the steady-state (zero flow) pressure axis intercept [mean 8.9 +/- 2.6 (SD) mmHg, tone independent] and the instantaneous (zero flow) pressure axis intercept [mean 28.5 +/- 9.9 (SD) mmHg, tone dependent] were determined as a function of venous pressure (range: 0-45 mmHg) and were independent of venous pressure until the venous pressure exceeded their respective values. Beyond this point the relations between the venous pressure and the steady-state and instantaneous pressure axis intercept followed the line of identity. The findings agree with the predictions of the vascular waterfall model. In a second series it was shown by means of administration of vasoactive drugs that the instantaneous pressure axis intercept is tone dependent, whereas the steady-state pressure axis intercept is not. It is concluded that there is a (proximal) tone-dependent zero-flow pressure at the arteriolar level and a (distal) tone-independent zero-flow pressure at the venous level.

Animals↗

Gender Differences in Intercepting a Moving Target by Using a Throw or Button Press.

Humans are a throwing species just as much as a talking species (Calvin, 1982), but preadaptations for throwing remain largely unexplored. The ability of undergraduate students (N = 165) to intercept a stimulus with a thrown object was determined for 10 stimulus speeds, ranging from 2 to 5 m/s. The inclusion of a condition in which the moving stimulus was intercepted via button press allowed the role of the perceptual aspect of velocity estimation to be evaluated separately from the act of throwing. Gender differences were observed in both the button and the throwing intercept tasks: The men had smaller timing errors and higher accuracy than the women. Contrary to expectations, the male and female patterns of intercept errors as a function of stimulus speed were more similar in the throwing task than in the button intercept task.

gender differences↗

Systematic changes in the duration and precision of interception in response to variation of amplitude and effector size.

The results of two experiments are reported that examined how performance in a simple interceptive action (hitting a moving target) was influenced by the speed of the target, the size of the intercepting effector and the distance moved to make the interception. In Experiment 1, target speed and the width of the intercepting manipulandum (bat) were varied. The hypothesis that people make briefer movements, when the temporal accuracy and precision demands of the task are high, predicts that bat width and target speed will divisively interact in their effect on movement time (MT) and that shorter MTs will be associated with a smaller temporal variable error (VE). An alternative hypothesis that people initiate movement when the rate of expansion (ROE) of the target's image reaches a specific, fixed criterion value predicts that bat width will have no effect on MT. The results supported the first hypothesis: a statistically reliable interaction of the predicted form was obtained and the temporal VE was smaller for briefer movements. In Experiment 2, distance to move and target speed were varied. MT increased in direct proportion to distance and there was a divisive interaction between distance and speed; as in Experiment 1, temporal VE was smaller for briefer movements. The pattern of results could not be explained by the strategy of initiating movement at a fixed value of the ROE or at a fixed value of any other perceptual variable potentially available for initiating movement. It is argued that the results support pre-programming of MT with movement initiated when the target's time to arrival at the interception location reaches a criterion value that is matched to the pre-programmed MT. The data supported completely open-loop control when MT was less than between 200 and 240 ms with corrective sub-movements increasingly frequent for movements of longer duration.

Adolescent↗

Evaporation of intercepted precipitation from fruit litter of Liquidambar styraciflua L. (sweetgum) in a clearing as a function of meteorological conditions.

Interception of precipitation by fruit litter is a poorly understood component of the hydrologic cycle in forested ecosystems. Even less well understood is the effect of meteorological conditions on the evaporation of precipitation intercepted by forest litter. This study sought to examine the influence of meteorological conditions on the evaporation of intercepted precipitation by fruit litter from Liquidambar styraciflua L. (sweetgum) by deriving and calibrating a regression model to estimate evaporation from the fruit litter that may be of potential use to forest and watershed managers. Data on evaporative losses from the fruit litter used to derive and calibrate the statistical model were acquired through a larger field experiment conducted from mid November 2002 through April 2003. Results from the forward stepwise least squares multiple regression model demonstrated that evaporative losses from the fruit litter were estimated with a high degree of accuracy based on the amount of water stored, solar radiation inputs, and vapor pressure deficit (adjusted R(2)=0.836, F=82.28, P<0.00001). The amount of water stored in the fruit litter explained the highest proportion of variance in the regression model. Storm to storm comparisons also highlighted the importance of solar radiation and wind speed in determining evaporation from the fruit litter. The regression model potentially may be used in conjunction with a canopy interception model to predict interception losses from L. styraciflua dominated forests and plantations.

Ecosystem↗

A theoretical analysis of radiation interception in a two-species plant canopy.

Classical radiation interception laws for monospecific canopies cannot be used directly for bispecific canopies. They are always based on the gap frequency concept (i.e., the probability of no interception), which does not provide any information about the sharing of intercepted radiation between species. A theoretical analysis is reported that relates the radiation interception probabilities to the geometrical structure of the crop (i.e., the leaf area density and the leaf angle distribution of each component) and the foliage dispersion. The leaf dispersion globally describes the spatial relations between the leaf elements; it may be regular if the leaves avoid mutual shading, random, or clumped if they tend to overlap. For such two-species canopies, the leaf dispersions within each component (WSLD: within-species leaf dispersion) and between two species (BSLD: between-species leaf dispersion) are distinguished. Using bivariate multinomial distributions, general expressions for the gap frequency and the interception probabilities of a homogeneous vegetation layer were set as exponential functions of the foliage thickness, taking into account a number of dispersion parameters as small as possible. First, one WSLD for each species describes the rate of foliage overlap between the leaves of this species; it is quite similar to the leaf dispersion of single-species canopies. Second, the rate of foliage overlap between species is characterized by one BSLD. As in monospecific canopies, this parameter is positive, zero, or negative, respectively, for regular, random, or clumped BSLD. Third, another BSLD parameter has to be used if the foliage overlap between species is more than random (i.e., in the case of clumped BSLD); the latter shows the direction of overlap between species and may be taken as the probability of finding a leaf element of the first species in the case of marked overlapping. Suggestions for estimating the leaf dispersion parameters and possible uses of such relations are also discussed.

Agriculture↗

Size-exclusion chromatography of tea tannins and intercepting potentials of peptides for the inhibition of trypsin-caseinolytic activity by tea tannins.

Molecular-weight distribution and characterization of tea tannin were investigated by high-performance liquid chromatography and the equivalent preparative exclusion gel chromatography using Sephadex G-25. The characteristics of the fractions were studied regarding the amounts of terminal catechin, sugar, and gallic acid, the color reaction of the Folin-Chiocalteu reagent, the UV absorbance, and the inhibition activity for the trypsin-caseinolytic activity per weight. Furthermore, we investigated the intercepting activities of the inhibition by the amino acids, peptides, their analogues, poly(ethylene glycol)s (PEGs), and histatin 5 using the inhibition of trypsin-caseinolytic activity by tea. Arg, Lys, and their peptides had strong intercepting activities for the inhibition, but only a weak activity was detected in the Pro peptides or gelatin-like peptides of (Pro-Pro-Gly)(n) (n = 5 or 10). The guanidyl group of Arg and the amino methylene group of Lys were important for the intercepting activity, but the activity was weakly dependent upon the peptide bond formation. The intercepting activity of the peptides or PEG exponentially increased with the number of polymerizations. Histatin 5 did not have a remarkably strong intercepting activity considering the peptide length. The activity of the synthetic histatin 5 in which all of the Lys and Arg were substituted by Ala was at the same level as histatin 5.

Arginine↗

Control strategies when intercepting slowly moving targets.

In 3 experiments, the authors investigated and described how individuals control manual interceptive movements to slowly moving targets. Participants (N = 8 in each experiment) used a computer mouse and a graphics tablet assembly to manually intercept targets moving across a computer screen toward a marked target zone. They moved the cursor so that it would arrive in the target zone simultaneously with the target. In Experiment 1, there was a range of target velocities, including some very slow targets. In Experiment 2, there were 2 movement distance conditions. Participants moved the cursor either the same distance as the target or twice as far. For both experiments, hand speed was found to be related to target speed, even for the very slowly moving targets and when the target-to-cursor distance ratios were altered, suggesting that participants may have used a strategy similar to tracking. To test that notion, in Experiment 3, the authors added a tracking task in which the participants tracked the target cursor into the target zone. Longer time was spent planning the interception movements; however, there was a longer time in deceleration for the tracking movements, suggesting that more visually guided trajectory updates were made in that condition. Thus, although participants scaled their interception movements to the cursor speed, they were using a different strategy than they used in tracking. It is proposed that during target interception, anticipatory mechanisms are used rather than the visual feedback mechanism used when tracking and when pointing to stationary targets.

Adult↗

Systematic variation in performance of an interceptive action with changes in the temporal constraints.

People are highly skilled at intercepting moving objects and are capable of remarkably accurate timing. The timing accuracy required depends upon the period of time for which contact with a moving target is possible--the "time window" for successful interception. Studies of performance in an experimental interception task that allows this time window to be manipulated suggest that people change aspects of their performance (movement time, MT, and movement speed) in response to changes in the time window. However, this research did not establish whether the observed changes in performance were the results of a response to the time window per se or of independent responses to the quantities defining the time window (the size and speed of a moving target). Experiment 1 was designed to resolve this issue. The speed and size of the target were both varied, resulting in variations in the time window; MT was the primary dependent measure. Predictions of the hypothesis that people respond directly to changes in the time window were verified. Predictions of the alternative hypothesis that responses to changes in target speed and size are independent of one another were not supported. Experiment 2 examined how the type of performance change observed in Experiment 1 was affected by changing the time available for executing the interception. The time available and the target speed were varied, and MT was again the primary dependent measure. MT was smaller when there was less time available, and the effect of target speed (and hence the time window) on MT was also smaller, becoming undetectable at the shortest available time (0.4 s). The results of the two experiments are interpreted as providing information about the "rule" used to preprogramme movement parameters in anticipatory interceptive actions.

Adult↗

Simulations of the effects of shoot structure and orientation on vertical gradients in intercepted light by conifer canopies.

Coniferous tree canopies typically carry more leaf area than is necessary to intercept most of the incoming light. I postulated that an excessively large leaf area will reduce net productivity at tree level, unless the net photosynthetic production of the most shaded shoots in the canopy remains positive. The hypothesis tested was that a coniferous tree canopy maintains a large productive leaf area by increasing the efficiency of light capture as the available light decreases. The light interception efficiency of a shoot was quantified by the ratio of shoot silhouette area to total needle surface area (STAR). The STAR depends on shoot geometry and varies with shoot orientation relative to the direction of light. Shade shoots have a larger STAR and, in particular, higher values of STAR(max) than sun shoots. In addition, shade shoots tend to be horizontally inclined, which may increase the advantage of a large STAR(max) in the lower canopy, where radiation is incident from angles closer to the zenith. Adaptation to shade (changes in STAR and shoot orientation) was described on the basis of empirical data for several coniferous species, and the vertical gradient of seasonal light interception by shoots was simulated assuming different adaptive strategies. Simulations were performed at two latitudes, to account for differences in the amount and directional distribution of light during the growing season. Results support the hypothesis that increases in STAR, shoot zenith angle and shoot asymmetry (flatness) with shading increase the efficiency of light interception by deeply shaded shoots. However, because competition for light among shoots increases progressively as soon as shade acclimation occurs, there cannot exist a deep layer of shade shoots, such that the net productivity of each shoot remains positive (i.e., irradiance is above the compensation point). Therefore, if maximization of productive leaf area is the goal, the optimal strategy is to maintain an inefficient deep canopy and to increase light interception efficiency only when shading becomes severe.

Journal Article↗

Leaf orientation, light interception and stomatal conductance of Eucalyptus globulus ssp. globulus leaves.

Juvenile and adult leaves of the heteroblastic species Eucalyptus globulus Labill. ssp. globulus did not show active diurnal orientation toward or away from incident radiation. Juvenile leaves of a late-maturing sapling of a Tasmanian provenance were evenly distributed in all azimuth sectors. In contrast, an early-maturing sapling of the same age from Wilsons Promontory, Victoria had a predominance of adult leaf blades facing east and west. Mid-vein and blade angles of juvenile and adult leaves were non-random with an overall vertical declination of the leaves. Both leaf types intercepted a greater irradiance during the morning than at midday. Sub-horizontal juvenile leaves intercepted 22% more irradiance than vertical adult leaves during the middle of the day. The amphistomatal and isobilateral adult leaves intercepted sunlight equally on both leaf surfaces. Stomatal conductance was variable during the period of measurement but was similar for the Tasmanian juvenile (0.4 to 0.9 cm s(-1)) leaves and Wilsons Promontory adult (0.5 to 1.2 cm s(-1)) leaves. Greater light interception by the sub-horizontal juvenile leaves would confer a growth advantage to saplings and regenerating canopies. Reduced light interception and leaf temperature of vertical adult E. globulus leaves would assist in water conservation, particularly at high solar angles.

Journal Article↗