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At least 361 records · Page 20Linked to original sources
PubMed1994

Quaternary ammonium compounds in milk: detection by reverse-phase high performance liquid chromatography and their effect on starter growth.

A reverse-phase HPLC method is described that permits detection of quaternary ammonium sanitizers in milk. The commercial mixture of quaternary ammonium sanitizer used, n-alkyl (50% C14, 40% C12, and 10% C16) dimethyl benzyl ammonium chloride, was extracted from raw and homogenized milks by the Mojonnier milk fat extraction protocol, selectively eluted from the reverse-phase column in the presence of organic solvent and ion-pairing agent, and then analyzed by diode array detection at 217 and 280 nm. Quaternary ammonium sanitizer concentrations in augmented milk samples in the range of 1.0 to 60 micrograms/ml were analyzed with high precision as indicated by a small variance around the mean. Starter culture strains currently in use for manufacture of various fermented milk products available in the Department of Microbiology Culture Collection were examined for their sensitivity to quaternary ammonium sanitizer. All strains were greatly inhibited by as little as 20 micrograms/ml in milk; some were inhibited by only 10 micrograms/ml.

Animals↗
PubMed2004

Marine lipids as building blocks for soft quaternary ammonium compounds and their antibacterial activity.

Environmental friendly antibacterial agents have to degrade relatively rapid to non-toxic and inactive products after they have had their desired effect. Environmental friendly quaternary ammonium agents were designed according to Bodor's soft drug approach and evaluated in vitro. Structure-activity relationship (SAR) studies showed that the antibacterial activity of a given soft agent will only be acceptable if its chemical stability is adequate to allow the agent to express its activity for sufficient duration of time. However, the studies also showed that increasing the lipophilicity of a chemically labile antibacterial agent could increase its potency. Two of the lipophilic quaternary ammonium antibacterial agents evaluated had minimum inhibitory concentration (MIC) against Staphylococcus aureus as low as 2 microg/ml and estimated degradation half-life less than 4 to 6 days at room temperature. Decreased MIC could only be obtained by increasing the degradation half-life of the agents.

Administration, Cutaneous↗
PubMed1990

[Antimicrobial activity of quaternary ammonium compounds].

The antimicrobial properties of two new imidazolium and pyridinium chlorides in comparison with three currently in disinfection compounds applied are described. The following research was performed: resistance of organisms to disinfectants and disinfection of hands. The new 3-methyl-n-dodecylthiomethylpyridinium chlorid was the most active compound.

Anti-Bacterial Agents↗