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PubMed1993

General Motors Cancer Research Prizewinners Laureates Lectures. Charles F. Kettering Prize. Clinical trials in testicular cancer.

Testicular cancer has become a model for a curable neoplasm. Our studies with cisplatin combination chemotherapy allow us to conclude that (1) short-duration intensive induction therapy with the most active agents in optimal dosage is more important than maintenance therapy; (2) modest dose escalation increases toxicity without improving therapeutic efficacy; (3) it is possible to develop curative salvage therapy for refractory germ cell tumors; and (4) preclinical models predicting synergism, such as vinblastine+bleomycin or cisplatin+VP-16, have clinical relevance. Finally, testicular cancer also has become a model for new drug development. Cisplatin was approved by the FDA for testis and ovarian cancer and VP-16 and ifosfamide for refractory germ cell tumors. The success of these studies confirms the importance of the continued search for new investigational drugs in all solid tumors.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1993

Charles Darwin and other great men in correspondence with Carl Wilhelm von Naegeli.

The great Swiss-German botanist Carl Wilhelm von Naegeli (1817-1891) was a student of Lorenz Oken, A.P. de Candolle, and Matthias Jacob Schleiden and became a key figure in "genetic" (i.e., evolutionary-developmental) biology in the mid-late 19th century. He was an expert on the hawk-weed, Hieracium and also made important contributions to microbiology. One of his many outstanding students was Carl Correns, one of the 3 rediscoverers of Mendel's work. Naegeli was an early proponent and defender of Darwin. The correspondence preserved in the Naegeli family contains many important letters between Naegeli and his contemporaries. Those from Mendel to Naegeli have passed out of the Naegeli family and were published by Correns earlier in the century. However, exceptionally notable items still in the archives of the Naegeli family include 4 surviving letters from Darwin, 2 letters from Virchow, and 10 from Justus von Liebig. In spite of a lack of appreciation of Mendel's work, we call attention to the importance of those surviving documents from an era in which very few of the greatest naturalists and founders of modern biology--including Goethe, Darwin, Galton, Agassiz, von Humboldt, von Baer--were without "blind spots."

Botany↗