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PubMed1988

Comparison between radioimmunoassay and direct and indirect enzyme-linked immunosorbent assays for determination of antibodies against Haemophilus influenzae type b capsular polysaccharide.

Levels of antibodies against Haemophilus influenzae type b capsular polysaccharide were determined in acute-phase and convalescent-phase serum samples obtained from 21 children with invasive H. influenzae type b infections and from 44 children vaccinated with two H. influenzae type b vaccines. Amounts of immunoglobulin G (IgG), IgM, and IgA antibodies were measured by direct and indirect enzyme-linked immunosorbent assay (ELISA), and the total amount of antibodies was measured by radioimmunoassay (RIA). Results obtained by ELISA were calculated by multiple-point parallel-line comparison and by endpoint analysis. A very good correlation was obtained between direct and indirect ELISA values. In the lower range of antibody concentrations, the correlation between ELISA values obtained by endpoint analysis and those obtained by multiple-point parallel-line comparison was poor, since the latter method of calculation yielded values of up to 1 microgram/ml in sera that were negative according to endpoint analysis. These sera with negative endpoint titers also had undetectable or very low antibody concentrations as measured by RIA. Consistent with this finding, in acute-phase and prevaccination sera with undetectable or low antibody concentrations as measured by RIA, ELISA values calculated by multiple-point parallel-line comparison were much higher. In sera with higher antibody concentrations, however, parallel-line comparisons showed good correlation between RIA and ELISA values. Although no reference method for measuring true antibody concentrations is available, ELISA values as calculated by multiple-point parallel-line comparison appear to overestimate antibody concentrations in sera containing low antibody concentrations, whereas ELISA values obtained by endpoint analysis are less well correlated with RIA values at higher concentrations.

Antibodies, Bacterial↗

PubMed2006

Pigtail catheters used for percutaneous fluid drainage: comparison of performance characteristics.

PURPOSE: To compare the performance characteristics of various single-lumen all-purpose pigtail drainage catheters. MATERIALS AND METHODS: The following parameters were compared: flow rates between catheters of the same size, whether changing the fluid viscosity has any effect on catheter comparisons, the effect on flow of leaving an open three-way stopcock in the drainage pathway, the tendency of the catheters to kink, and catheter patency after kinking, as measured according to flow. All-purpose 8.0-, 8.3-, and 8.5-F (collectively referred to as 8-F); 10.0-, 10.2-, and 10.3-F (collectively referred to as 10-F); and 12.0-F pigtail drainage catheters from three manufacturers were evaluated. Data were compared by using two-tailed t tests after normal distributions were confirmed. P < .05 was considered to represent a significant difference. RESULTS: At comparison of the 8-F catheters, the C.R. Bard catheters demonstrated better flow rates than the Cook and Boston Scientific devices. Among the 10-F catheters, there were no significant differences in the flow rates of fluid with viscosity equivalent to that of water between the C.R. Bard and Boston Scientific catheters; however, both these catheter types demonstrated significantly (P < .05) better flow rates than the Cook devices. Among the 12-F catheters, the C.R. Bard catheters demonstrated significantly (P < .05) better flow rates than the other two catheter types. Changing the fluid viscosity caused no changes in comparison results. In all catheter groups, the presence of a stopcock significantly (P < .05) impaired flow. None of the evaluated catheters demonstrated a clear advantage in terms of patency or susceptibility to kinking. CONCLUSION: At comparison of the in vitro performances of catheters from different manufacturers, the C.R. Bard 8.0-F and Cook 10.2-F catheters had comparable flow rates, and flow rates through the C.R. Bard and Boston Scientific 10.0-F catheters were comparable to flow rates through the Cook and Boston Scientific 12.0-F catheters. Varying viscosity had no effect on comparisons of catheter flow rates; however, a stopcock between the vacuum source and the catheter was noted to impair flow rates in all brands and sizes of evaluated catheters.

Catheterization↗

PubMed2000

Multiple comparisons: philosophies and illustrations.

Statistical procedures underpin the process of scientific discovery. As researchers, one way we use these procedures is to test the validity of a null hypothesis. Often, we test the validity of more than one null hypothesis. If we fail to use an appropriate procedure to account for this multiplicity, then we are more likely to reach a wrong scientific conclusion-we are more likely to make a mistake. In physiology, experiments that involve multiple comparisons are common: of the original articles published in 1997 by the American Physiological Society, approximately 40% cite a multiple comparison procedure. In this review, I demonstrate the statistical issue embedded in multiple comparisons, and I summarize the philosophies of handling this issue. I also illustrate the three procedures-Newman-Keuls, Bonferroni, least significant difference-cited most often in my literature review; each of these procedures is of limited practical value. Last, I demonstrate the false discovery rate procedure, a promising development in multiple comparisons. The false discovery rate procedure may be the best practical solution to the problems of multiple comparisons that exist within physiology and other scientific disciplines.

Animals↗

PubMed2005

Culture and social comparison seeking: the role of self-motives.

Three studies examined the relation between cultural background and social comparison seeking. Compared to European Canadians, Asian Canadians sought more social comparisons, particularly those that were upward (Study 1), more social comparisons after failure (Study 2), and more social comparisons after failure when the opportunity for self-improvement was made salient (Study 3). Taken together, these data spotlight Asian Canadians' interest in social comparisons that allow for self-improvement.

Adult↗

PubMed2004

Identification of polymorphic tandem repeats by direct comparison of genome sequence from different bacterial strains: a web-based resource.

BACKGROUND: Polymorphic tandem repeat typing is a new generic technology which has been proved to be very efficient for bacterial pathogens such as B. anthracis, M. tuberculosis, P. aeruginosa, L. pneumophila, Y. pestis. The previously developed tandem repeats database takes advantage of the release of genome sequence data for a growing number of bacteria to facilitate the identification of tandem repeats. The development of an assay then requires the evaluation of tandem repeat polymorphism on well-selected sets of isolates. In the case of major human pathogens, such as S. aureus, more than one strain is being sequenced, so that tandem repeats most likely to be polymorphic can now be selected in silico based on genome sequence comparison. RESULTS: In addition to the previously described general Tandem Repeats Database, we have developed a tool to automatically identify tandem repeats of a different length in the genome sequence of two (or more) closely related bacterial strains. Genome comparisons are pre-computed. The results of the comparisons are parsed in a database, which can be conveniently queried over the internet according to criteria of practical value, including repeat unit length, predicted size difference, etc. Comparisons are available for 16 bacterial species, and the orthopox viruses, including the variola virus and three of its close neighbors. CONCLUSIONS: We are presenting an internet-based resource to help develop and perform tandem repeats based bacterial strain typing. The tools accessible at http://minisatellites.u-psud.fr now comprise four parts. The Tandem Repeats Database enables the identification of tandem repeats across entire genomes. The Strain Comparison Page identifies tandem repeats differing between different genome sequences from the same species. The "Blast in the Tandem Repeats Database" facilitates the search for a known tandem repeat and the prediction of amplification product sizes. The "Bacterial Genotyping Page" is a service for strain identification at the subspecies level.

Bacteria↗

PubMed2005

Transformation and other factors of the peptide mass spectrometry pairwise peak-list comparison process.

BACKGROUND: Biological Mass Spectrometry is used to analyse peptides and proteins. A mass spectrum generates a list of measured mass to charge ratios and intensities of ionised peptides, which is called a peak-list. In order to classify the underlying amino acid sequence, the acquired spectra are usually compared with synthetic ones. Development of suitable methods of direct peak-list comparison may be advantageous for many applications. RESULTS: The pairwise peak-list comparison is a multistage process composed of matching of peaks embedded in two peak-lists, normalisation, scaling of peak intensities and dissimilarity measures. In our analysis, we focused on binary and intensity based measures. We have modified the measures in order to comprise the mass spectrometry specific properties of mass measurement accuracy and non-matching peaks. We compared the labelling of peak-list pairs, obtained using different factors of the pairwise peak-list comparison, as being the same or different to those determined by sequence database searches. In order to elucidate how these factors influence the peak-list comparison we adopted an analysis of variance type method with the partial area under the ROC curve as a dependent variable. CONCLUSION: The analysis of variance provides insight into the relevance of various factors influencing the outcome of the pairwise peak-list comparison. For large MS/MS and PMF data sets the outcome of ANOVA analysis was consistent, providing a strong indication that the results presented here might be valid for many various types of peptide mass measurements.

Algorithms↗

PubMed2006

PROMPT: a protein mapping and comparison tool.

BACKGROUND: Comparison of large protein datasets has become a standard task in bioinformatics. Typically researchers wish to know whether one group of proteins is significantly enriched in certain annotation attributes or sequence properties compared to another group, and whether this enrichment is statistically significant. In order to conduct such comparisons it is often required to integrate molecular sequence data and experimental information from disparate incompatible sources. While many specialized programs exist for comparisons of this kind in individual problem domains, such as expression data analysis, no generic software solution capable of addressing a wide spectrum of routine tasks in comparative proteomics is currently available. RESULTS: PROMPT is a comprehensive bioinformatics software environment which enables the user to compare arbitrary protein sequence sets, revealing statistically significant differences in their annotation features. It allows automatic retrieval and integration of data from a multitude of molecular biological databases as well as from a custom XML format. Similarity-based mapping of sequence IDs makes it possible to link experimental information obtained from different sources despite discrepancies in gene identifiers and minor sequence variation. PROMPT provides a full set of statistical procedures to address the following four use cases: i) comparison of the frequencies of categorical annotations between two sets, ii) enrichment of nominal features in one set with respect to another one, iii) comparison of numeric distributions, and iv) correlation of numeric variables. Analysis results can be visualized in the form of plots and spreadsheets and exported in various formats, including Microsoft Excel. CONCLUSION: PROMPT is a versatile, platform-independent, easily expandable, stand-alone application designed to be a practical workhorse in analysing and mining protein sequences and associated annotation. The availability of the Java Application Programming Interface and scripting capabilities on one hand, and the intuitive Graphical User Interface with context-sensitive help system on the other, make it equally accessible to professional bioinformaticians and biologically-oriented users. PROMPT is freely available for academic users from http://webclu.bio.wzw.tum.de/prompt/.

Computational Biology↗

PubMed2006

M-GCAT: interactively and efficiently constructing large-scale multiple genome comparison frameworks in closely related species.

BACKGROUND: Due to recent advances in whole genome shotgun sequencing and assembly technologies, the financial cost of decoding an organism's DNA has been drastically reduced, resulting in a recent explosion of genomic sequencing projects. This increase in related genomic data will allow for in depth studies of evolution in closely related species through multiple whole genome comparisons. RESULTS: To facilitate such comparisons, we present an interactive multiple genome comparison and alignment tool, M-GCAT, that can efficiently construct multiple genome comparison frameworks in closely related species. M-GCAT is able to compare and identify highly conserved regions in up to 20 closely related bacterial species in minutes on a standard computer, and as many as 90 (containing 75 cloned genomes from a set of 15 published enterobacterial genomes) in an hour. M-GCAT also incorporates a novel comparative genomics data visualization interface allowing the user to globally and locally examine and inspect the conserved regions and gene annotations. CONCLUSION: M-GCAT is an interactive comparative genomics tool well suited for quickly generating multiple genome comparisons frameworks and alignments among closely related species. M-GCAT is freely available for download for academic and non-commercial use at: http://alggen.lsi.upc.es/recerca/align/mgcat/intro-mgcat.html.

Algorithms↗

PubMed2003

Hydroxyethyl starch (HES) 130/0.4 provides larger and faster increases in tissue oxygen tension in comparison with prehemodilution values than HES 70/0.5 or HES 200/0.5 in volunteers undergoing acute normovolemic hemodilution.

UNLABELLED: Stable hemodynamics and improved rheology are important effects of hemodilution with hydroxyethyl starch (HES) infusions. One clinical indicator of improved rheology is increased tissue oxygen tension (tpO(2)). In this prospective, randomized, double-blinded, crossover study, we examined the effects of acute normovolemic hemodilution with HES 130/0.4 on hemodynamics and skeletal muscle tpO(2) in comparison with conventional HES solutions. Twelve healthy volunteers were randomly enrolled in each group. At an interval of >8 days, volunteers donated 18% of their calculated blood volume within 30 min and randomly received 6% HES 130/0.4, 6% HES 70/0.5, or 6% HES 200/0.5 (crossover design) in a 1:1.2 ratio to their blood loss. Hemodynamic variables, tpO(2) in the quadriceps muscle, hematocrit, plasmatic HES concentrations, plasma viscosity, colloid osmotic pressures, and platelet aggregation were measured until 6 h after the infusion of HES. No differences were found among groups with respect to changes of hemodynamics, hematocrit, or platelet aggregation. With HES 200, colloid osmotic pressures and plasma viscosities were larger than after HES 70 (P < 0.05). HES 130 in comparison with HES 70 and 200 caused the fastest (30 min versus 90 min and 150 min after hemodilution; P < 0.05) and largest increase of tpO(2) in comparison to baseline (+93% versus +33% and 40%; P < 0.05). In healthy volunteers undergoing acute normovolemic hemodilution, the newly designed HES 130/0.4 showed a more pronounced and earlier increase of skeletal muscle tpO(2) in comparison with prehemodilution values than HES 70/0.5 or 200/0.5. IMPLICATIONS: The effects of three different hydroxyethyl starch (HES) solutions on hemodynamics, rheology, and skeletal muscle tissue tension after acute normovolemic hemodilution were examined in awake volunteers. With HES 130/0.4, increases of tissue oxygen tension in comparison to baseline were larger and more rapid than with HES 70/0.5 or HES 200/0.5.

Adult↗

PubMed2003

Feeling bad, but satisfied: the effects of upward and downward comparison upon mood and marital satisfaction.

This study in a sample of 135 women from rural areas examined the effects of social comparison with the marriage of another woman upon mood, identification and relationship evaluation. The comparison target constituted either an upward or a downward comparison, characterized by either high or low effort. Upward targets evoked a more positive mood, and a less negative mood than downward targets, while, in contrast, the evaluation of one's own relationship was more positive after being exposed to a downward target than after being exposed to an upward target. Upward targets and high-effort targets instilled more identification than downward and low-effort targets. A higher level of marital quality led to less identification with the downward targets and to more identification with the upward targets, particularly with targets who put a high degree of effort in the relationship. Identification mediated the association between marital quality and positive mood following upward comparison. The present study suggests that upward and downward comparison may have effects upon mood that are opposite to those upon self-evaluation, and demonstrates that happily married individuals may through identification with upward targets derive positive affective consequences from exposure to such targets.

Adult↗

PubMed1992

Adventitious control by the location of comparison stimuli in conditional discriminations.

In a conditional discrimination procedure, samples appeared in a center key, and comparisons appeared in two of four outer keys. The location of comparison keys varied from trial to trial. Separate learning curves for each of the six possible pairs of comparison keys were plotted in a signal-detection space, revealing different patterns of progress on each pair. Also, when learned conditional discriminations were disrupted, pairs of keys differed in their patterns of disruption. Varying the location of comparison stimuli among six different pairs of keys had not eliminated key position as a controlling aspect of the stimuli. The variations simply increased the number of stimulus compounds--key position and experimental stimuli--that the subject learned. Plotting conditional-discrimination learning curves in a signal-detection space reveals relations among hits, false alarms, accuracy, and comparison preference that help to define a subject's progress.

Animals↗

PubMed1996

The effects of race, living standards, and exercise on the degree of motor development: comparison between schoolchildren in the Republic of Honduras and Japan.

To investigate the development of motor ability according to age and physique, a comparison was made among races and/or living standards of schoolchildren in Republic of Honduras, and between Honduran and Japanese schoolchildren. Based on the results of these comparisons, the extent to which exercise contributes to the development of motor ability was examined. Subjects were schoolchildren of typical three races in Honduras: Negroid, Mongoloid (native Indio), and mixed race (Mongoloid, Caucasoid, and Negroid), who attended public elementary schools. For a further comparison, schoolchildren of mixed race attending private schools, whose living standards are thought to be different from children attending public schools, were also selected. Comparing physique among races from the measurement values in the test battery, Negroid group ranked highest followed by the mixed race group and Mongoloid group. The results for the comparison of motor ability were also in the same order. From the viewpoint of living standards, the physique and motor ability of the private school children, who were from wealthy families, was better than that of the public school children. However, when the degrees of motor development were compared using revised values based on age and physique, the differences among groups became smaller, and there was no significant difference between groups in the 50-meter dash or in the standing long jump. However, a comparison with Japanese schoolchildren showed that, even if there was no difference in physique, Japanese schoolchildren were still superior in motor ability. These results suggest that differences in the degree of motor development are mainly due to differences in exercise experience.

Aging↗

PubMed1994

Obtaining previous mammograms for comparison: usefulness and costs.

OBJECTIVE: We undertook a study to evaluate the usefulness and the cost of our policy of obtaining all previous mammograms, whether done at our facility or another, for purposes of comparison with current mammographic examinations. MATERIALS AND METHODS: We reviewed 1432 randomly selected screening mammography examinations from the year 1992. Information collected included whether there were previous mammograms, whether they could be obtained, the clinical impact of the comparisons, and the time and cost of obtaining the earlier mammograms. RESULTS: Of the 1432 cases, 1245 women (87%) had had previous mammograms: 971 (78%) of these were done at our institution (all but 12 were available for comparison) or were brought in by the woman at the time of her scheduled examination; 274 (22%) were done elsewhere and were not available at the time of the examination. Of the latter 274 examinations, 140 (51%) could not be obtained despite vigorous efforts. Clinical management was affected as a result of comparison in 35 of the 1093 cases in which previous mammograms were obtained: seven biopsies were performed (four benign, two malignant, one pending), 10 imaging workups or follow-ups were initiated, two biopsies were avoided, and 16 imaging workups or short-term follow-ups were avoided. The two cancers that were detected as a result of obtaining previous films included one manifested by an increase in calcifications and one by a neodensity that was recognized in retrospect in an otherwise normal mammogram. The average labor and postage cost for each outside mammogram requested and received was $12.52; if the film was requested but not received, the average labor cost was $5.33. CONCLUSION: When interpreting mammograms, a comparison with previous examinations has a positive impact on clinical management and cancer detection in a limited number of cases. The overall costs and time involved in obtaining previous mammograms from other facilities are substantial. The previous mammograms cannot be obtained in all cases, and in our study only 50% of the mammograms done at other facilities could be obtained. These issues need additional consideration before binding policies are established.

Breast Neoplasms↗

PubMed1992

Use and misuse of multiple comparisons in animal experiments.

The objective of many animal experiments is to detect meaningful relationships among treatments and associated responses. Types of comparisons of means include pairwise multiple comparisons, planned orthogonal or nonorthogonal contrasts, and orthogonal polynomials. Some procedures are appropriate only for specific types of treatment designs and specific types of objectives. Pairwise, multiple comparisons are appropriate only for comparing unstructured, qualitative treatments. Planned comparisons partition the overall set of treatment effects into independent or nonindependent subsets, with special application to factorials. Orthogonal polynomial (regression) procedures assess relationships between quantitative treatments and response when a full range of responses or an optimal dose is of interest. Recommendations for appropriate use of each mean comparison procedure are illustrated using data from three Journal of Animal Science articles. Also mentioned are a number of computer graphics packages that provide creative ways to display biological relationships and can be linked to statistical packages for input and to word processors or 35-mm cameras for output.

Analysis of Variance↗

PubMed1989

Semantic congruity effects in perceptual comparisons.

Semantic congruity effects occur when, as in Experiment 1, for example, the time to select the shorter of two relatively short lines is faster than the time to select the longer; conversely, selection of the longer of two relatively long lines is faster than selection of the shorter. Semantic congruity effects are also demonstrated in experiments requiring comparisons of the heaviness of weights (Experiment 2) and horizontal extent (Experiment 3). In Experiment 1, the magnitude of the semantic congruity effect was larger under conditions emphasizing accuracy rather than speed and when the comparison was difficult. In fact, when comparisons were errorless, the effect was minimal (20 msec), thereby replicating previous failures to obtain the effect with supraliminal perceptual comparisons (Banks, Mermelstein, & Yu, 1982; Marschark & Paivio, 1981; Petrusic & Baranski, 1988a). In confirmation of Henmon's (1911) introspective analyses of psychophysical comparisons, Experiments 2 and 3 extend the range of the semantic congruity effect to include judgments of confidence. However, in each of the three experiments, semantic congruity effects were not evident with the response-accuracy measure. Finally, using highly confusable stimuli, in Experiment 3 the magnitude of the semantic congruity effect was shown to be larger for error than for correct response times. The implications of these findings for a decisional locus of the effect and for the semantic coding theory are discussed.

Attention↗

PubMed1997

[The effect of self-enhancement expectation on selection of comparisons as a self-assessment strategy].

Selection of others for comparison influences the outcome of self-assessment. The present study attempted to examine the effect of expectation for self-enhancement on strategic selection of comparisons. A questionnaire study was conducted with 169 undergraduates, who responded to four sets of questions. First, they listed ten abilities each for three areas that desired to acquire in high-level, in average-level, and undesired to acquire. Then, they evaluated themselves in comparison with others on the thirty abilities, and indicated whom they chose as comparisons. Finally, perceived probabilities were assessed of acquiring each ability. Results showed that selection of superior others was more when evaluated abilities were desired to acquire in high-level and perceived probability high than otherwise. This suggested that comparison with superior others was made if expectation for self-enhancement was high. The expectation therefore affects the likelihood of self-assessment behavior, and self-assessment is a necessary component of future self-enhancement.

Adult↗

PubMed2004

[Paired comparison analysis by using structural equation modeling: Scheffe's method and its improvements].

The purpose of this study is to propose a way to express and implement paired comparison analysis in a framework of structural equation modeling (SEM). By this method, one can perform paired comparison using widely available SEM programs and can develop a variety of models for specific purposes. Here, three models are shown. One is a model for performing basic paired comparison by using SEM. Another is an expanded model which makes it possible to apply analysis of variance (ANOVA) or regression analysis to the result of paired comparison. A third model is for paired comparison of latent factors. All models are illustrated with actual numerical examples.

Adult↗

PubMedDate not supplied

[Quality of data or quality of care? Comparison of diverse standarization methods by clinical severity, based on the discharge form, in the analysis of hospital mortality].

Using discharge abstract data, we analysed hospital mortality comparing four different methods of risk adjustment. All patients discharged from the S. Giovanni Battista (Molinette) hospital in Turin (Italy) between January 1996 and June 1999 (n = 169,746) were classified with All Patient Refined--Diagnosis Related Groups (APR-DRG). A first analysis evaluated the time trend of hospital mortality by semester. A second analysis compared hospital mortality during the last 12 months among eight units of internal medicine (n = 5592). All comparisons were made through logistic regression models. As the quality of discharge abstracts increased during time and showed variation among units with similar patients, all comparisons were repeated using four models, characterised by increasing predictivity and sensitivity to quality of data. In addition to crude comparisons (A), the other models included as risk factors: B) age and emergency admission; C) same as 'B' plus expected mortality by APR-DRG; D) same as 'B' plus expected mortality by APR-DRG and risk of death subclass. If no risk factors were considered (A), hospital mortality showed an increasing trend, with an odds ratio (OR) of 1.02 by semester, with a 95% confidence interval (CI) between 1.01 and 1.03. The association was weakened when age and mode of admission were taken into account (B) and disappeared when the APR-DRG expected mortality was also considered (C) (OR = 1.00; CI = 0.98-1.01). Finally, if the comparisons were adjusted also for the expected mortality by APR-DRG and risk of death subclass (D) a reversed trend appeared (OR = 0.95; CI = 0.94-0.97). The comparison among the units of internal medicine gave discordant results according to the method used to adjust for confounders. The most striking variations were detected for those units with the best and the worst clinical data. The unit with the poorer clinical data (average number of diagnoses per patient = 2.9) showed a crude OR of 1.38 (CI = 0.99-1.93) and an adjusted OR (D) of 1.71 (CI = 1.10-2.66); the unit with the best quality of data (average number of diagnoses per patient = 4.4) changed the OR from 1.55 (CI = 1.06-2.26) (A) to 0.66 (CI = 0.37-1.17) (D). In conclusion, these results confirm the high sensitivity of the APR-DRG classification to the quality of data and, more in general, suggest to be prudent when using powerful instruments like this to assess quality of care, especially if the quality of data among the units compared is less than optimal or not homogeneous.

Hospital Mortality↗