Clinical and laboratory diagnosis.
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OBJECTIVE: Quality improvement of laboratory diagnostics by general practitioners (GPs) through introduction of a simplified, problem-oriented application form, supported by information and feedback. DESIGN: Prospective descriptive study. SETTING: Laboratory of Clinical Chemistry and Haematology of St. Maartens Gasthuis, Venlo, the Netherlands and the GPs in the region. METHODS: The effects of the intervention were measured by counting the analyses requested by all GPs in the region in 1992, 1993 and 1994. Furthermore requests by every GP for fifteen selected analyses in the first 6 months of 1992, 1993 and 1994 were counted and reported together with the anonymous data of all colleagues. RESULTS: After the intervention a 23% reduction of the total number of analyses request by GPs was noticed. Blood sampling increased by 8% and the mean number of laboratory test requests per patient decreased from 5.9 to 4.2. The largest request reductions were noticed for analyses not listed on the application form. Measurements in the first 6 months of 1992, 1993 and 1994 showed continuation of the trend and a fadeaway of 'redundant' analyses. CONCLUSION: The introduction of a simplified problem-oriented application form for GPs supported by feedback caused a marked decrease of the number of (redundant) laboratory requests.
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Improved laboratory investigative techniques now foster an increased clinical interest in and awareness of the rheumatologic disease. This review is a discussion of the relevance of laboratory tests used in the more common rheumatologic disorders and of their role in both the diagnosis and assessment of these diseases from the standpoint of the practising clinician.
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The office laboratory can be a tremendous resource for the physician. This is particularly true in the evaluation of STD, where many simple procedures may provide at least a preliminary diagnosis. Instead of waiting for more expensive culture results, the physician can make the diagnosis of Candida, Trichomonas or Gardnerella in the female and N. gonorrhoeae in the male, while the patient is in the office. Cultures for N. gonorrhoeae can be, with the use of the Phadebact or newer enzymatic sugar tests, completed in the office. This, however, is not recommended for an office which performs this test infrequently, because quality control procedures and known positives and negatives which should be incorporated into these procedures are often neither practical nor readily available. The wrong diagnosis in the area of STD leads not only to medical mismanagement but also to tremendous emotional and personal trauma. A good working relationship with a referral laboratory will augment the care and services you and your office laboratory can offer to the patient.
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The accuracy of our clinical vascualr laboratory was evaluated. Sixty-nine limbs (55 patients) were examined clinically for thrombophlebitis. All of these patients were then evaluated using segmental plethysmography and Doppler ultrasound techniques. Each limb was then studied with venography. In 57 of the 69 (82.6%) limbs evaluated, measurement of the maximum venous outflow accurately reflected the venographic findings. Doppler augmented venous sounds were correct when compared to venography in 77.6% of limbs. In the 59 limbs that exhibited clinical signs of deep venous thrombosis, only 35.6% had venographic confirmation of the diagnosis. The clinical vascular laboratory provides an accuracy of diagnosis of deep venous thrombosis not achieved by clinical examination. If both segmental plethysmography and Doppler ultrasound were negative, it was very unlikely that deep venous thrombosis had occurred.