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Results for “Dihydroxytryptamines”

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PubMed1976

Effect of intracerebroventricular 5,6-dihydroxytryptamine on blood pressure of spontaneously hypertensive rats.

The effects of intracerebroventricular injections of 5,6-DHT on the development and maintenance of hypertension in spontaneously hypertensive rats has been investigated. 5,6-DHT, injected into 6 week old rats, retarded the development of hypertension for at least 6 weeks; this effect was not accompanied by inhibition of the pressor response produced by stimulation of the total peripheral sympathetic outflow. 5,6-DHT, injected into 14-15 week old rats with established hypertension, produced a short-lived fall in blood pressure. These findings suggest that central 5-HT neurones are involved in the development of hypertension in spontaneously hypertensive rats.

5,6-Dihydroxytryptamine↗
PubMed1999

Dentate granule cell function after neonatal treatment with parachloroamphetamine or 5,7-dihydroxytryptamine.

In vitro, extracellular electrophysiological recording was used to test granule cell responses in P60 rats after neonatal PCA and 5, 7-DHT. Granule cell population EPSP and spike responses were in the normal range for both PCA and 5,7-DHT groups. However, the degree of paired pulse facilitation was reduced in both of these groups relative to control, reflecting a diminished synaptic drive. Synaptic potentiation in the 5,7-DHT group was not different from control, but was significantly reduced in slices from PCA-treated rats.

5,7-Dihydroxytryptamine↗