PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “ERYTHEMA INFECTIOSUM”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 361 records · Page 20Linked to original sources
PubMed1989

[Parvovirus infections in dermatology].

Human parvovirus B19 is the causative agent of erythema infectiosum and other atypical (rubelliform) exanthemas. On account of the relatively high prevalence of B19, these infections are rather frequent. They usually occur during childhood, but also up to the age of 30, and there are various clinical manifestations. During pregnancy, B19 infection may cause hydrops of the fetus with ensuing fetal death. Anti-B19 IgM and IgG can be detected by means of ELISA or RIA; B19-DNA is identified by hybridization of nucleic acid.

Humans↗
PubMed1989

[Vascular purpura and other cardiovascular alterations in children with acute parvovirus B19 infection. Report of 3 personal cases].

Most frequent skin manifestation of parvovirus B19 infection is the erythema infectiosum (fifth disease; Sticker's disease). Vascular purpura (some cases of Henoch-Schönlein purpura) has been reported in virus infections such as infectious mononucleosis (Epstein-Barr virus), hepatitis B, cytomegalovirus etc., and human parvovirus B19 could be another cause. Clinical course, procedure of diagnostics and therapy in 3 own serologically established cases of vascular purpura or severe alterations of the blood circulation due to parvovirus B19 infection are presented. Parvovirus B19 (or other viruses) as a trigger for vascular purpura and alteration of the blood vessel wall and blood circulation could explain the childhood predominance and seasonal clustering of that disease. Furthermore an individual disposion (in form of special HLA type?) for the development of vascular purpura can be suggested.

Cardiovascular Diseases↗
PubMed1989

[Parvovirus infections in humans].

The Human Parvovirus (HPV) like other Parvovirus is a single strand DNA virus with autonomous replication which measures 23mm. Infection with this virus is followed by a non-specific viral syndrome during the prodrome, leading to viremia, which may be followed by arthropathy and/or different kind of rash including the syndrome called erythema infectiosum. It has also been related to an increase in the number of spontaneous abortion in pregnant women with acute infection; and it is the etiology of the aplastic crisis in patients with hemolytic anemias. Many other Parvovirus serologically different from HPV are present in stools and are responsible for acute infectious non bacterial gastroenteritis in people more than 5 years old.

Female↗
PubMed1989

[Parvovirus infections in children with hemolytic anemia].

Acute episodes of erythroblastopenia in children with chronic hemolytic anemias have been recognized for a considerable length of time. In 1981, a small virus with a single strand of DNA, parvovirus B 19, was identified as the causative agent in most such episodes. Other diseases have been ascribed to parvovirus B 19, including erythema infectiosum or fifth disease, polyarthralgia, fetal death. Schonlein-Henoch disease, and bone marrow aplasia. In acute attacks of erythroblastopenia, anemia is the most prominent manifestation, but coexistence of neutropenia and thrombopenia has been reported. Hematologic disorders last for approximately ten days. The diagnosis of recent parvovirus B 19 infection rests on detection of specific IgM antibodies, or direct visualisation of the virus by electron microscopy. More recently, detection of the viral genome using molecular hybridization techniques has been achieved. In vitro studies have confirmed the inhibiting effect of parvovirus B 19 on red cell line progenitors, particularly CFU-E, but the exact mechanism of the inhibition remains uncertain. Other diseases due to parvovirus B 19 or other parvoviruses probably remain to be discovered.

Anemia, Hemolytic↗
PubMed1989

[Aplastic crisis due to human parvovirus B19 infection in glucose-6-phosphate dehydrogenase deficiency].

Human parvovirus B19 is known to cause aplastic crisis in patients with hemolytic anemias due to cytotoxic effect of the infection to erythroid progenitor cells. We report here the first case of aplastic crisis by B19 in a patient with glucose-6-phosphate dehydrogenase deficiency. A five-year-old boy was admitted to the hospital because of severe anemia, fever and jaundice. Four weeks after admission, he developed erythema infectiosum. B19 infection was confirmed using countercurrent immunoelectrophoresis, Southern blotting and hybridization method, and radioimmunoassay for B19 specific IgM. B19 virus antigen was detected by an indirect immunofluorescent method in both the cytoplasm and nucleus of large mononuclear cells that had no granules in bone marrow. On admission, the hemoglobin was 3.1 g/dl and no reticulocytes were detected in the peripheral blood smear. Bone marrow examination revealed a normocellular marrow with erythroid hypoplasia and M/E ratio of 7.38. Large basophilic erythroblasts containing vacuoles were also noticed. Elevation of indirect bilirubin and hemoglobinuria suggested intravascular hemolysis. Transient mild thrombocytopenia associated with increased PAIgG was observed. It is likely that B19 virus infection caused hemolysis which contributed to severe anemia.

Anemia, Aplastic↗
PubMed1989

[Exogenous causes of disordered embryonal morphogenesis].

Recent advances in exogenous factors known to cause embryopathies are reviewed. Among the non-infectious agents alcohol is the most important, followed by a combination of anticonvulsant drugs, valproic acid, retinoic acid, lithium, coumarin derivates, methyl mercury, aminopterin and methotrexate, cocaine and amniogenic bands. Rubella embryopathy is well known. Varicella zoster and herpes simplex type II viruses are now also known to be teratogenic in some cases. Erythema infectiosum has recently been detected as a cause of embryonic death. Diabetic women and women with phenylketonuria must be carefully examined before and during pregnancy. There does not seem to be a world trend towards increased frequency of genetically and non genetically conditioned malformations.

Abnormalities, Drug-Induced↗
PubMed1988

Human parvovirus B19 and pregnancy.

Although B19 infection during pregnancy usually has no adverse effect on the fetus, it can cause fetal death. Recent studies make it possible to estimate risk of infection following different types of exposure and the risk of fetal death after infection. The most common clinical manifestations of B19 infection are erythema infectiosum and aplastic crisis in patients with chronic hemolytic anemias.

Female↗
PubMed1988

[Aplastic crises in hereditary spherocytosis].

Parvovirus B19-infections are diagnosed with increasing frequency. In addition to erythema infectiosum they cause a temporary red cell aplasia of 5-10 days duration, in patients with hemolytic anemia an aplastic crisis as demonstrated in 5 patients with hereditary spherocytosis. In every case an acute infection by parvovirus B19 could be diagnosed. Hemoglobin concentrations dropped to 4.0-6.2 g/dl, reticulocytes were diminished to 0-25,000/microliters. In every case there followed a complete recovery of erythropoiesis after 2-3 days.

Acute Disease↗
PubMed1988

Epidemic patterns of infectious diseases from the results of the surveillance of infectious diseases in Japan.

Epidemic patterns of 12 infectious diseases based on the data derived from the surveillance system of infectious diseases in Japan are analyzed. Weekly numbers of patients per one monitor station (general clinics and hospitals) are calculated by prefecture. Based on these data, the patterns of epidemic are classified into five categories: Category 1, nationwide outbreak of short duration (rotavirus enteritis, hand-foot-mouth disease and herpangina); Category 2, nationwide outbreak of long duration (varicella); Category 3, concurrent outbreaks in several districts (rubella and erythema infectiosum); Category 4, epidemic of long duration in several prefectures at different times (measles, mumps, pertussis, streptococcal infection and atypical pneumonia); Category 5, unclear epidemic pattern (exanthema subitum).

Child↗
PubMed1994

Clinical virology in children.

Virology has become an increasingly important field of medicine in the past decade. Many infectious diseases that were once of unknown etiology can now be linked to the specific viral pathogen. New methods for diagnosing and treating viral diseases are being developed. In addition, antiviral therapy or prophylaxis is available for many of these viral illnesses. This article reviews the basic medical aspects of some viral infections. Human parvovirus B19 causes erythema infectiosum, with the classic "slapped-cheek" rash. Human herpesvirus type 6 is thought to be the cause of roseola infantum, characterized by the familiar macular/maculopapular rash on the trunk and arms. Varicella-zoster virus infection results in chickenpox, which in the future may be prevented by a vaccine. Herpes simplex virus-1 causes up to 90 percent of oral and labial herpes infections. Congenital cytomegalovirus infection results in birth defects. Epstein-Barr virus is the primary cause of mononucleosis. Human papillomavirus causes laryngeal and genital warts. Respiratory syncytial virus is the major cause of lower respiratory tract disease in children. Rotavirus is the common agent in childhood diarrhea.

Child↗
PubMed1996

Parvovirus B19 infection and rheumatic diseases.

We reviewed the literature on relationships between human parvovirus B19 infection and rheumatic diseases. Parvovirus B19 causes erythema infectiosum in childhood, transient anemia in immunocompetent individuals, and potentially severe infections in fetuses; laboratory evidence that the virus is directly responsible for these disorders has been obtained. Acute arthropathy meeting American College of Rheumatology criteria for rheumatoid arthritis and disorders meeting some of the classification criteria for systemic lupus erythematosus are the most striking rheumatic manifestations of parvovirus B19 infection. Purpuric lesions have also been reported. Parvovirus B19 infection may be capable of inducing a number of manifestations that have not yet been described in the literature. Although the relationship between human parvovirus B19 infection and rheumatic diseases has been the focus of many studies, compelling evidence that the virus is directly involved in the pathogenesis of rheumatic diseases has not yet been obtained.

Humans↗
PubMed1997

Aplastic crisis associated with parvovirus B19 in an adult with hereditary spherocytosis.

Parvovirus B19 is usually associated with an acute, self-limited disease in children. In patients with a congenital hemolytic anemia, infection with this virus can cause an aplastic crisis. We describe such a crisis in an adult with asymptomatic hereditary spherocytosis. The association between acute red blood cell aplasia and infection with parvovirus B19 is well described in patients with hereditary hemolytic anemia, particularly sickle cell anemia. This association has also been described, although less frequently, in patients with other inherited hemolytic diseases, such as hereditary spherocytosis. In children, human parvovirus B19 causes an acute self-limited illness known as erythema infectiosum (fifth disease). In immunocompromised individuals, chronic infections can occur and cause a severe, persistent anemia. In pregnant women, infection can, but usually does not, lead to fetal infection. An infected fetus can have severe anemia, congestive heart failure, generalized edema (fetal hydrops) and even death. Most cases of aplastic crises associated with parvovirus B19 in patients with hereditary spherocytosis have been reported in children and adolescents. In this paper we describe an aplastic crisis in a 28 year old man with asymptomatic hereditary spherocytosis.

Acute Disease↗
PubMed1997

[Human parvovirus B19 infection mimicking systemic lupus erythematosus: case report].

Human parvovirus B19 (HPV-B19) has been known as the etiologic agents of erythema infectiosum in normal childhood, and chronic anemia and thrombocytopenia in immuno-compromised patients. Recently, this virus has been reported as the association with rheumatic manifestation such as rheumatoid arthritis and systemic lupus erythematosus (SLE). We described here a patient whose HPV-B19 infection was mimiking atypical symptoms of SLE at diagnosis, and was persistent because of immuno-suppressive therapy for SLE. A 34-year-old female was admitted to our hospital on 22 June 1995, presenting fever episode and cervical lymph node swelling. Before eighteen months, she was received methyl-predonisolone pulse therapy and plasma exchange by fresh frozen plasma for the treatment of Stevens-Johnson syndrome, and after several weeks these therapy she was suffered from viral infection with lymphadenopathies with a transient appearance of atypical lymphocytes in her peripheral blood smear. On laboratory examination at the present admission, her peripheral blood showed anemia, thrombocytopenia with atypical lymphocytes. Throughout her hospitalization, anti-nuclear antibody (ANA) suspected SLE including anti-DNA and anti-Sm antibody were all negative except of transient week positive ANA screening test. Her physical condition presented poor clinical course with fever elevation, increased ascites and renal dysfunction showing the elevation of CRP and circulating immune-complex (Clq binding method). Her serum was positive for IgM and IgG antibody against VP-1 and VP-2 antigen of HPV-B19 by ELISA in April 1996. And then, HPV-B19 DNA by polymerase chain reaction (PCR) was positive in bone marrow sample in March 1996, and also positive in spleen necropsy at death. We confirmed persistent chronic HPV-B19 infection by measurement of HPV-B19 IgM and IgG antibody by ELISA and HPV-B19 DNA by PCR. The plasmapheresis and administration of intravenous immunoglobulin showed the possible efficacy for her symptom throughout this clinical course. Moreover, bone marrow smear showed the finding of virus-associated hemophagocytic syndrome, and finally, she was died of cervical hemorrhage accompanied with disseminated intravascular coagulation syndrome on July 1996. HPV-B19 infection can present an atypical clinical picture that is highly suggestive of SLE. We suggest that the therapy of steroids and immuno-suppressive agents should be cautious, because these may potentially cause persistent chronic HPV-B19 infection and induced life-threatening clinical course.

Adult↗
PubMed1997

[Viral exanthematic childhood diseases].

Exanthem is defined as multiple, inflammatory skin alteration with a hematogenic, lymphogenic or neurogenic origin. Typically, so called exanthematic children's diseases are measles, mumps, rubella, varicella, erythema infectiosum (fifth disease) and in the past small pox. The pathogenesis of the viral-caused diseases primarily occurs in the vascular connective tissue. The cytopathogenetic effects result in inflammatory tissue reactions with activation of defence mechanism and producing of immune complexes. First symptoms are hyperemia, edema and inflammatory infiltrates with itchy swellings. Virological laboratory diagnosis are necessary especially for the progress of atypical infectious diseases, for persons with immunological or chronical illness and under chemotherapeutical or immunosuppressival treatment.

Age Factors↗
PubMed1998

[Diagnosis for human parvovirus B19-polyarthritis: usefulness of empty particle B19.ELISA and B19-DNA.PCR].

OBJECTIVE: To evaluate the usefulness of new ELISA for human parvovirus B19 (B19) antibodies and PCR for the diagnosis of acute onset of B19 polyarthritis. METHODS: We evaluated the reproducibility and sensitivity on the detection of anti-B19 antibody by ELISA using recombinant VP-1 and VP-2 (empty particle), and then studied for the prevalence of IgM and IgG B19 antibody in 125 samples for anti-B19 tests. The random study on anti-B19 antibody assay as well as PCR for B19-DNA was also performed in 130 cases with acute onset of arthritis excluding those with known origins, 224 with rheumatoid arthritis and 149 with other categories. RESULTS: The results by using B19-empty particle ELISA were reproducible and showed the assay was a sensitive way for clinical use. IgM anti-B19 antibodies were positive not only in all samples from erythema infectiosum, but also often in those from hemolytic anemia, pure red cell aplasia, fetal hydrops, hepatic injury, fever of unknown origin. Among 130 with acute onset of arthritis, 21 showed positive tests for IgM anti-B19 antibody and/or B19 DNA. On the other hand, 4 among 224 patients with rheumatoid arthritis were positive for IgM anti-B19 antibody, but all of 149 in control group were negative for IgM anti-B19 antibodies and for B19 DNA. CONCLUSION AND DISCUSSION: Anti-B19 ELISA using B19-empty particle which has been introduced as a routine test system, is a useful tool for the diagnosis of acute onset of B19 arthritis. An additional examination using PCR for B19 DNA may contribute for understanding persistent B19 polyarthritis or reactivation of B19 infection.

Adolescent↗
PubMed1951

[The fifth disease].

Explore the source record for details and available documents.

Erythema Infectiosum↗