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Results for “Environment Design”

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At least 361 records · Page 20Linked to original sources
PubMed2004

Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study.

INTRODUCTION: Deficiencies in cellular responses to DNA damage can predispose to cancer. Ionizing radiation can cause cluster damage and double-strand breaks (DSBs) that pose problems for cellular repair processes. Three genes (ATM, BRCA1, and BRCA2) encode products that are essential for the normal cellular response to DSBs, but predispose to breast cancer when mutated. DESIGN: To examine the joint roles of radiation exposure and genetic susceptibility in the etiology of breast cancer, we designed a case-control study nested within five population-based cancer registries. We hypothesized that a woman carrying a mutant allele in one of these genes is more susceptible to radiation-induced breast cancer than is a non-carrier. In our study, 700 women with asynchronous bilateral breast cancer were individually matched to 1400 controls with unilateral breast cancer on date and age at diagnosis of the first breast cancer, race, and registry region, and counter-matched on radiation therapy. Each triplet comprised two women who received radiation therapy and one woman who did not. Radiation absorbed dose to the contralateral breast after initial treatment was estimated with a comprehensive dose reconstruction approach that included experimental measurements in anthropomorphic and water phantoms applying patient treatment parameters. Blood samples were collected from all participants for genetic analyses. CONCLUSIONS: Our study design improves the potential for detecting gene-environment interactions for diseases when both gene mutations and the environmental exposures of interest are rare in the general population. This is particularly applicable to the study of bilateral breast cancer because both radiation dose and genetic susceptibility have important etiologic roles, possibly by interactive mechanisms. By using counter-matching, we optimized the informativeness of the collected dosimetry data by increasing the variability of radiation dose within the case-control sets and enhanced our ability to detect radiation-genotype interactions.

Adult↗
PubMed2004

Design and implementation of haptic virtual environments for the training of the visually impaired.

This paper presents a haptic virtual reality (VR) tool developed for the training of the visually impaired. The proposed approach focuses on the development of a highly interactive and extensible haptic VR training system (the ENORASI VR training system) that allows visually impaired, to study and interact with various virtual objects in specially designed virtual environments, while allowing designers to produce and customize these configurations. Based on the system prototype and the use of the CyberGrasp haptic device, a number of custom applications have been developed. An efficient collision detection algorithm is also introduced, by extending the proximity query package (PQP) algorithm to handle five points of contact (a case studied with the use of CyberGrasp). Two test categories were identified and corresponding tests were developed for each category. The training scenarios include: object recognition and manipulation and cane simulation, used for performing realistic navigation tasks. Twenty-six blind persons conducted the tests and the evaluation results have shown the degree of acceptance of the technology and the feasibility of the proposed approach.

Adult↗
PubMedDate not supplied

Microbiological validation of a new manufacturing complex for an injectable biological product.

The Raritan Biological Production Facility (RBPF) at Ortho Pharmaceutical Corporation, Raritan, NJ, is a unique facility designed and built exclusively for the production of a sterile, injectable biological product of murine monoclonal origin. This product is the first injectable monoclonal antibody product to be licensed by FDA's Center for Biologics-Evaluation and Research (CBER). Thus, Ortho's Biotechnology Division had a unique opportunity to work very closely with CBER throughout all aspects of facility design, construction and validation, including microbiological validation of the facility and its equipment. This paper will address how existing guidelines for pharmaceutical and sterile products were used to develop initial validation protocols for the different areas and applications within the facility, and how the data gathered were used, with the assistance of CBER, to develop operating specifications and monitoring programs, for the operations within the complex.

Animal Welfare↗
PubMed2001

Imaging of conformational changes of proteins with a new environment-sensitive fluorescent probe designed for site-specific labeling of recombinant proteins in live cells.

We demonstrate herein a new method for imaging conformational changes of proteins in live cells using a new synthetic environment-sensitive fluorescent probe, 9-amino-6,8-bis(1,3,2-dithioarsolan-2-yl)-5H-benzo[a]phenoxazin-5-one. This fluorescent probe can be attached to recombinant proteins containing four cysteine residues at the i, i + 1, i + 4, and i + 5 positions of an alpha-helix. The specific binding of the fluorescent probe to this 4Cys motif enables fluorescent labeling inside cells by its extracellular administration. The high sensitivity of the fluorophore to its environment enables monitoring of the conformational changes of the proteins in live cells as changes in its fluorescence intensity. The present method was applied to calmodulin (CaM), a Ca2+-binding protein that was well-known to expose hydrophobic domains, depending on the Ca2+ concentration. A recombinant CaM fused at its C-terminal with a helical peptide containing a 4Cys motif was labeled with the fluorescent probe inside live cells. The fluorescence intensity changed reversibly depending on the intracellular Ca2+ concentration, which reflected the conformational change of the recombinant CaM in the live cells.

Amino Acid Sequence↗
PubMed2000

Ergonomics, gerontechnology, and design for the home-environment.

An ergonomic approach could improve the quality of life and activities in daily living. Gerontechnology reduces the effects of age-related impairments with technological devices and particular design for the home-environment. Physiological decline with increasing age renders the daily activities at home more difficult. This paper highlights some "common sense" and specific design suggestions in the entrance and kitchen, aimed to increase the self-sufficiency of elderly people. We suggest that gerontechnology may have a particular role in the improvement of comfort and safety for aged people.

Activities of Daily Living↗
PubMed1989

Human dimensions in space development.

Space exploration is now moving beyond the stage when technical development dominated research. As thinking shifts towards the problems of long-term colonization of the Solar System, the biological and behavioural sciences must make major contributions. This article outlines some of the issues which must be addressed, such as group behaviour and dynamics in space flight, the environment created at space stations and other outposts, recruitment and training of suitable spacefarers, and the planning and governing of space settlements. Ten dimensions of the human aspect of space habitation are described and an indication given of how they may form the basis for a new taxonomy of space planning, operations and management.

Communication↗
PubMed2006

An automatic variational level set segmentation framework for computer aided dental X-rays analysis in clinical environments.

An automatic variational level set segmentation framework for Computer Aided Dental X-rays Analysis (CADXA) in clinical environments is proposed. Designed for clinical environments, the segmentation contains two stages: a training stage and a segmentation stage. During the training stage, first, manually chosen representative images are segmented using hierarchical level set region detection. Then the window based feature extraction followed by principal component analysis (PCA) is applied and results are used to train a support vector machine (SVM) classifier. During the segmentation stage, dental X-rays are classified first by the trained SVM. The classifier provides initial contours which are close to correct boundaries for three coupled level sets driven by a proposed pathologically variational modeling which greatly accelerates the level set segmentation. Based on the segmentation results and uncertainty maps that are built based on a proposed uncertainty measurement, a computer aided analysis scheme is applied. The experimental results show that the proposed method is able to provide an automatic pathological segmentation which naturally segments those problem areas. Based on the segmentation results, the analysis scheme is able to provide indications of possible problem areas of bone loss and decay to the dentists. As well, the experimental results show that the proposed segmentation framework is able to speed up the level set segmentation in clinical environments.

Algorithms↗
PubMed1999

Counseling model: creating a healing environment in hospitals.

There are ways in which more holistic approaches to medicine can be achieved through the establishment of alternative hospitals and health-care centers, as has happened in the United States, and changes in midwifery and care for the dying through a more compassionate approach and the use of prescriptive music. Transformations of medical care in The Netherlands are also taking place, with existing hospitals gradually developing more patient-centered approaches and organizations like the Helen Dowling Institute providing tailor-made forms of psycho-social counseling for those with cancer and life-threatening illness.

Counseling↗
PubMed2004

Interrelations of psychiatric patient experiences of boredom and mental health.

A review of literature related to psychiatric patients' interrelated experiences of boredom and mental health demonstrated that developing a better understanding of the relationship between boredom and health would provide important implications for development of the therapeutic environment of psychiatric units. The literature suggested that experiences of meaningful roles and relationships contribute substantially to experiences of control essential for mental health. Boredom is an indicator of a lack of experience of meaning. Many psychiatric patients experience boredom and lack opportunities to experience meaning, indicating a lack in the therapeutic potential of the hospital environment and a requisite for change and further research.

Adaptation, Psychological↗
PubMed2000

Case-based support in a cooperative medical diagnosis environment.

Many medical services are often not available to people living in remote areas because of the lack of medical specialists. This problem would be alleviated if a suitable environment was designed to allow physicians to collaborate and exchange ideas with centrally located medical specialists. This article describes an ongoing research project to design and implement a collaborative multimedia environment to allow medical specialists to cooperate in diagnosis. The environment will support remote database access for medical images, the retrieval of relevant medical cases to support diagnosis, and communication among participants through telepointers and image annotation by free-hand drawing.

Cervical Vertebrae↗
PubMed2005

Healing landscapes: patients, relationships, and creating optimal healing places.

Healing can be both an intensely personal and a social and community event that often surprises us when it emerges from the landscape of everyday life. This observation raises at least three questions that serve as the focus for this paper's reflections about creating optimal healing places. Who are patients? What relationships and features of those relationships help patients toward healing? How do we understand and facilitate the emergence of healing over time and place? Using existing literature and our own past and current studies of patients, clinical encounters, and primary care practices, we explore each of these questions. We identify four different aspects or faces of patients: patients as human animals, patients as persons, patients as techno-consumers, and patients as patients. We highlight 10 lessons or observations about patients and their healing experiences. Key features of relational process are described, and nine interdependent relationship characteristics that appear to promote healing are discussed. The idea of healing landscapes as an emergent life space is introduced as a way of conceptualizing and further investigating these observations. A reflective action process for facilitating the emergence of healing landscapes and creating an ecology of hope is presented, and recommendations for future research are briefly shared.

Environment Design↗
PubMed2006

Writing place: a comparison of nursing research and health geography.

The concept of 'place', and general references to 'geographies of ...' are making gradual incursions into nursing literature. Although the idea of place in nursing is not new, this recent spatial turn seems to be influenced by the increasing profile of the discipline of health geography, and the broadening of its scope to incorporate smaller and more intimate spatial scales. A wider emphasis within the social sciences on place from a social and cultural perspective, and a wider turn to 'place' across disciplines are probably equally important factors. This trend is raising some interesting questions for nurses, but at the same time contributes some confusion with regard to imputed meanings of 'place'. While it is clear that most nurse clinicians and researchers certainly understand that place of care matters to their practices and patients, many diverse uses of 'place' are found within nursing literature, and contemporary understandings of the term 'place' within nursing are not immediately clear. It is in this context that this article plans to advance the discussion of place. More specifically, the aims of this paper are threefold: to critique 'place' as it appears in nursing literature, to explore the use of 'place' within health geography, whence notions of place and 'geographies of' have originated and, finally, to compare and contrast the use of 'place' in both disciplines. This critique intends to address a deficit in the literature, in this era of growing spatialization in nursing research. The specific questions of interest here are: 'what is "place" in nursing?' and 'how do concepts of place in nursing compare to concepts of place in health geography?'

Body Image↗
PubMedDate not supplied

Orientation behaviors in residents relocated to a redesigned dementia care unit.

This descriptive study took advantage of a scheduled environmental renovation in a secured dementia care unit. A convenience sample of 19 residents who were relocated to the unit completed a performance-based orientation task involving locating their own room. The study included a brief structured interview and tests of psychological function (cognition, depression, and visual-spatial ability) two months after admission. Intrusions (uninvited entry into another resident's room) were tracked for one week. Eighty-four percent of participants were able to find their own rooms during the orientation task. The majority of participants reported use of color (n = 13) and structure (n = 12) as cues for locating their rooms. Thirty-eight percent of those who could find their own rooms also intruded into others' rooms; these intrusions were most commonly related to seeking social interaction. The results attest to the importance of understanding the multiple factors that determine environmental use in this population.

Aged↗
PubMed2005

Topophilia and the quality of life.

With this research I tested the hypothesis that individual preferences for specific ecosystem components and restorative environments are significantly associated with quality of life (QOL). A total of 379 human subjects responded to a structured 18-item questionnaire on topophilia and to the 26-item World Health Organization's Quality of Life (WHOQOL-Bref) instrument. Confirmatory factor analyses revealed four domains of topophilia (ecodiversity, synesthetic tendency, cognitive challenge, and familiarity) and four domains of QOL (physical, psychological, social, and environmental). Synesthetic tendency was the strongest domain of topophilia, whereas the psychological aspect of QOL was the strongest. Structural equation modeling was used to explore the adequacy of a theoretical model linking topophilia and QOL. The model fit the data extremely well: chi2 = 5.02, p = 0.414; correlation = 0.12 (p = 0.047). All four domains of topophilia were significantly correlated with the level of restoration experienced by respondents at their current domicile [for cognitive challenge: r = 0.19; p < 0.01; familiarity: r = 0.12; p < 0.05; synesthetic tendency: r = 0.18; p < 0.01; ecodiversity (the highest value): r = 0.28; p < 0.01]. Within ecodiversity, preferences for water and flowers were associated with high overall QOL (r = 0.162 and 0.105, respectively; p < 0.01 and 0.05, respectively). Within the familiarity domain, identifiability was associated with the environmental domain of QOL (r = 0.115; p < 0.05), but not with overall QOL. These results provide a new methodologic framework for linking environmental quality and human health and for implementing evidence-based provision of restorative environments through targeted design of built environments to enhance human QOL.

Adolescent↗