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At least 361 records · Page 20Linked to original sources

PubMed2001

Addressing and imaging high optical index dielectric ridges in the optical near field.

Experimental observation of light coupling between TiO(2) integrated waveguides of subwavelength cross section and pure three-dimensional evanescent light fields is reported. This near-field optical phenomenon is produced by controlling the location of the focusing of a laser beam totally reflected at the surface of the sample. The phenomenon is observed in direct space with a photon scanning tunneling microscope. Dielectric ridges several tens of micrometers long have been efficiently excited with this technique. Upon excitation, the extremities of the linear dielectric wires display intense light spots localized both inside and around the ridge. For ridge lengths up to 30 microm, the observed phenomenon has been reproduced numerically with a parallel implementation based on the three-dimensional Green dyadic method.

Journal Article↗

PubMed2004

Triangular to square flux lattice phase transition in YBa2Cu3O7.

We have used the technique of small-angle neutron scattering to observe magnetic flux lines directly in a YBa2Cu3O7 single crystal at fields higher than previously reported. For field directions close to perpendicular to the CuO2 planes, we find that the flux lattice structure changes smoothly from a distorted triangular coordination to nearly perfectly square as the magnetic induction approaches 11 T. The orientation of the square flux lattice is as expected from recent d-wave theories but is 45 degrees from that recently observed in La(1.83)Sr(0.17)CuO(4+delta).

Journal Article↗

PubMed2006

Non-steady state effects in diurnal 180 discrimination by Picea sitchensis branches in the field.

We report diurnal variations in 18O discrimination (18 delta) during photosynthesis (18 delta A) and respiration (18 delta R) of Picea sitchensis branches measured in branch chambers in the field. These observations were compared with predicted 18 delta (18 delta pred) based on concurrent measurements of branch gas exchange to evaluate steady state and non-steady state (NSS) models of foliage water 18O enrichment for predicting the impact of this ecosystem on the Delta 18O of atmospheric CO2. The non-steady state approach substantially improved the agreement between 18 delta pred and observed 18 delta (18 delta obs) compared with the assumption of isotopic steady state (ISS) for the Delta 18O signature of foliage water. In addition, we found direct observational evidence for NSS effects: extremely high apparent 18 delta values at dusk, dawn and during nocturnal respiration. Our experiments also show the importance of bidirectional foliage gas exchange at night (isotopic equilibration in addition to the net flux). Taken together, neglecting these effects leads to an underestimation of daily net canopy isofluxes from this forest by up to 30%. We expect NSS effects to be most pronounced in species with high specific leaf water content such as conifers and when stomata are open at night or when there is high relative humidity, and we suggest modifications to ecosystem and global models of delta 18O of CO2.

Circadian Rhythm↗

PubMed1998

Low-field electron emission from undoped nanostructured diamond

Strong and sustained electron emission at low electric fields was observed in undoped, nanostructured diamond. Electron emission of 10 milliamperes per square centimeter was observed at applied fields of 3 to 5 volts per micrometer. These are the lowest fields ever reported for any field-emitting material at technologically useful current densities. The emitter consists of a layer of nanometer-size diamond particulates, which is heat-treated in a hydrogen plasma. These emission characteristics are attributed to the particles' high defect density and the low electron affinity of the diamond surface. Such emitters are technologically useful, because they can be easily and economically fabricated on large substrates.

Journal Article↗

PubMed2006

Indirect detection of nuclear magnetic resonance via geometrically induced long-range dipolar fields.

We report the indirect detection of the magnetization of one spin species via the NMR signal of a second species. Our method relies on the control of long-range dipolar fields between two separate objects, in this case, a water droplet (sensor) immersed in a tube containing mineral oil (sample). Unlike prior experiments, no gradient pulses are used; rather, the setup geometry is exploited to select the part of the sample to be probed and modulate the spin alignment in the sensor. Our results are discussed in the context of Dipolar Field Microscopy, a proposed strategy in which the detector is a hyperpolarized tip.

Magnetic Resonance Spectroscopy↗

PubMed1997

The late blink reflex response abnormality due to lesion of the lateral tegmental field.

We report on a blink reflex abnormality observed in two patients, which provides additional information on the central pathways mediating this reflex. Autopsy was performed in one patient and MRI in the other. In the first patient there was a small lesion at the dorsal middle third of the lateral tegmental field and in the second patient at the level of the dorsal lower third of the medulla oblongata. In both patients the common finding was the absence of the late response (R2) ipsilateral to the side of the lesion, while the R2 response on the unaffected side was normal regardless of the side of the supraorbital nerve stimulation. The R1 responses were normal. This type of blink reflex abnormality has not been reported before and is referred to by us as 'tegmental type' of R2 abnormality. The results led to the conclusions that: (i) the crossed and uncrossed ascending trigeminofacial connections are mediated through the lateral tegmental field; (ii) the uncrossed trigeminofacial connection originates at the level of at least the lower medulla oblongata; (iii) the contralateral R2 response is established by way of an ascending pathway, which crosses the midline at the level of at least the lower third of the medulla oblongata.

Afferent Pathways↗

PubMed2001

Phase locking in Josephson ladders and the discrete sine-Gordon equation: the effects of boundary conditions and current-induced magnetic fields.

We report on the stability of phase-locked solutions to ladder arrays of underdamped Josephson junctions under both periodic and open boundary conditions and in the presence of current-induced magnetic fields. We calculate the Floquet exponents based on the resistively and capacitively shunted junction (RCSJ) model, as well as on a simplified model of the ladder that leads to a discrete sine-Gordon (DSG) equation for the horizontal, current-biased junctions. In the case of zero induced magnetic fields, we find the DSG equation (commonly applied to parallel arrays) appreciably overestimates the exponents of the full ladder in the overdamped regime (corresponding to the limit of small junction capacitance, beta(c)), and that difference physically results from differing spectra for small-amplitude phase oscillations of the DSG and RCSJ equations. mutual inductance between plaquettes is included we find there are ranges of values for the mutual inductance for which the ladder is in fact unstable. To understand the cause of the observed instabilities, it is crucial to consider the behavior of the vertical junctions.

Journal Article↗

PubMed2003

Trapping and manipulating neutral atoms with electrostatic fields.

We report on experiments with cold thermal (7)Li atoms confined in combined magnetic and electric potentials. A novel type of three-dimensional trap was formed by modulating a magnetic guide using electrostatic fields. We observed atoms trapped in a string of up to six individual such traps, a controlled transport of an atomic cloud over a distance of 400 microm, and a dynamic splitting of a single trap into a double well potential. Applications for quantum information processing are discussed.

Journal Article↗

PubMed2005

In silico folding of a three helix protein and characterization of its free-energy landscape in an all-atom force field.

We report the reproducible first-principles folding of the 40 amino-acid, three-helix headpiece of the HIV accessory protein in a recently developed all-atom free-energy force field. Six of 20 simulations using an adapted basin-hopping method converged to better than 3 A backbone rms deviation to the experimental structure. Using over 60 000 low-energy conformations of this protein, we constructed a decoy tree that completely characterizes its folding funnel.

Amino Acid Sequence↗

PubMed1997

Impact of annual dosing with ivermectin on progression of onchocercal visual field loss.

Reported are the results of a randomized, double-masked, placebo-controlled trial of annual ivermectin dosing in 34 rural communities, Kaduna State, northern Nigeria, where guinea savanna onchocerciasis is mesoendemic. A total of 939 individuals underwent Friedmann field analysis at the first examination and saw at least 19 spots in at least one eye. Of these, 636 (68%) completed a subsequent Friedmann field analysis 2-3 years later. The adjusted incidence rate ratio for the ivermectin group versus the placebo group was 0.64 (95% confidence interval (CI): 0.42-0.98). There was some evidence that the impact of ivermectin was greatest among those who had received one dose of ivermectin. The majority of the deteriorations occurred in eyes that gave evidence of optic atrophy at the first examination. An analysis restricted to individuals with optic atrophy at baseline indicated a reduction of 45% in the incidence of visual field deterioration in the ivermectin group (95% CI: 8-67%). Previous findings have shown that ivermectin has an impact on the incidence of optic atrophy. Our results indicate, for the first time, that ivermectin has a substantial impact on the progression of visual field loss among those with pre-existing optic atrophy.

Adolescent↗

PubMed2003

Isolation and phylogenetic diversity of members of previously uncultivated epsilon-Proteobacteria in deep-sea hydrothermal fields.

We report the successful cultivation and partial characterization of novel members of epsilon-Proteobacteria, which have long been recognized solely as genetic signatures of small subunit ribosomal RNA genes (rDNA) from a variety of habitats occurring in deep-sea hydrothermal fields. A newly designed microhabitat designated 'in situ colonization system' was used for enrichment. Based on phylogenetic analysis of the rDNA of the isolates, most of these represent the first cultivated members harboring previously uncultivated phylotypes classified into the Uncultivated epsilon-Proteobacteria Groups A, B, F and G, as well as some novel members of Group D. Preliminary characterization of the isolates indicates that all are mesophilic or thermophilic chemolithoautotrophs using H(2) or reduced sulfur compounds (elemental sulfur or thiosulfate) as an electron donor and O(2), nitrate or elemental sulfur as an electron acceptor. The successful cultivation will enable the subsequent characterization of physiological properties and ecological impacts of a diversity of epsilon-Proteobacteria in the deep-sea hydrothermal environments.

DNA, Bacterial↗

PubMed2002

YbRh2Si2: spin fluctuations in the vicinity of a quantum critical point at low magnetic field.

We report a 29Si NMR study on aligned single crystals of YbRh2Si2 which shows behavior characteristic of a quantum critical point (QCP: T(N)-->0). The Knight shift K and the nuclear spin-lattice relaxation rate 1/T(1) of Si show a strong dependence on the external field H, especially below 5 kOe. At the lowest H used in this measurement (H approximately 1.5 kOe), it was found that 1/T(1)T continues to increase down to 50 mK, whereas K stays constant with a large magnitude below 200 mK. This result strongly suggests the development of antiferromagnetic fluctuations with finite q vectors that compete with q=0 spin fluctuations in the vicinity of the QCP near H=0.5 kOe.

Journal Article↗

PubMed2002

Intrinsic behavior of flux lines in pure niobium near the upper critical field.

We report small-angle neutron-scattering (SANS) measurements of flux line properties near H(c2) in an ultrapure sample of niobium with weak pinning of flux in the bulk. These confirm in detail the Abrikosov picture of the flux line lattice to within 20 mK of the upper critical field line. However, it has recently been claimed [X. S. Ling et al., Phys. Rev. Lett. 86, 712 (2001)], on the basis of SANS observations of a disordering of flux lines in niobium, that the flux lattice melts at temperatures clearly separated from the upper critical field line. This discrepancy may possibly arise from differences in sample purity and pinning.

Journal Article↗

PubMed2005

Visually perceived vertical (VPV): induced changes in orientation by 1-line and 2-line roll-tilted and pitched visual fields.

We report a series of nine experiments which show that a single roll-tilted line in darkness induces changes of the orientation perceived as vertical (VPV) that are similar in magnitude and direction to those measured by Witkin and Asch (1948a) [Studies in space orientation. I. Perception of the upright with displaced visual fields. Journal of Experimental Psychology, 38, 762-782] with the classical square 4-sided frame, and we describe the configuration-independent mass-action rules by which the influences of the individual lines influences are combined. Clockwise (cw) and counterclockwise (ccw) orientations of a line produce cw and ccw displacements of the VPV setting, respectively, with effect magnitude increasing approximately linearly with line orientation (e.g., a 66.25 degrees - long line at 25 degrees horizontal eccentricity that varies in roll-tilt through +/-13.2 degrees around vertical generates a systematic variation in VPV over +/-7 degrees). The slope of the VPV-vs-roll-tilt function increases with line length along a negatively accelerated exponential function (length constant = 17.1 degrees). The influences of two bilaterally symmetric lines combine linearly and algebraically and the combined influence is linearly related to the sum of the VPVs for the 1-line components with a slope equal to 0.91 for short lines and 0.66 for long lines; thus, VPV for short lines manifests nearly complete additive summation, but for long lines, the 2-line VPV is nearer to the average of the VPV values for the two components measured separately. The effectiveness of the conjunction of two line segments within a visual scene does not depend on their separate orientations, only on their sum. Individual lines from pitched-only planes or from combinations of such planes generate identical influences to those generated from lines in frontoparallel planes with the same image orientations at the eye of the observer (their "retinal orientations"). Retinal orientation is the key to the induction of VPV change independently of the line's plane of origin.

Adult↗

PubMed2006

Preliminary outcome and toxicity report of extended-field, intensity-modulated radiation therapy for gynecologic malignancies.

PURPOSE: The aim of this article is to report a preliminary analysis of our initial clinical experience with extended-field intensity-modulated radiotherapy for gynecologic malignancies. METHODS AND MATERIALS: Between November 2002 and May 2005, 13 women with gynecologic malignancies were treated with extended-field radiation therapy. Of the women, 7 had endometrial cancer, 4 cervical cancer, 1 recurrent endometrial cancer, and 1 suspected cervical cancer. All women underwent computed tomography planning, with the upper vagina, parametria, and uterus (if present) contoured within the CTV. In addition, the clinical target volume contained the pelvic and presacral lymph nodes as well as the para-aortic lymph nodes. All acute toxicity was scored according to the Common Terminology Criteria for Adverse Events (CTCAE v 3.0). All late toxicity was scored using the Radiation Therapy Oncology Group late toxicity score. RESULTS: The median follow-up was 11 months. Extended-field intensity-modulated radiation therapy (IMRT) for gynecologic malignancies was well tolerated. Two patients experienced Grade 3 or higher toxicity. Both patients were treated with concurrent cisplatin based chemotherapy. Neither patient was planned with bone marrow sparing. Eleven patients had no evidence of late toxicity. One patient with multiple previous surgeries experienced a bowel obstruction. One patient with bilateral grossly involved and unresectable common iliac nodes experienced bilateral lymphedema. Extended-field-IMRT achieved good local control with only 1 patient, who was metastatic at presentation, and 1 patient not able to complete treatment, experiencing in-field failure. CONCLUSIONS: Extended-field IMRT is safe and effective with a low incidence of acute toxicity. Longer follow-up is needed to assess chronic toxicity, although early results are promising.

Aged↗

PubMed2000

Diver's mouth syndrome: a field study.

Reports of clinical presentations of diver's mouth syndrome and prevalence of at least one of its symptoms in many successive Joint Service (JS) diving expeditions prompted the author (who is an advanced diving instructor and an Armed Forces dental surgeon and has been present on, or organized, at least six JS diving expeditions in regions from cold temperate to tropical) to construct customized diving mouthpieces and investigate their effectiveness during intensive use in the field.

Adult↗

PubMed2002

New type of vortex pinning structure effective at very high magnetic fields.

We report on a new type of correlated nanometer-scale pinning structure observed in a melt-processed (Nd0.33Eu0.38Gd0.28)Ba(2)Cu(3)O(y) (NEG-123). It consists of NEG/Ba-rich clusters in the stoichiometric NEG-123 matrix forming a lamellar array with a period of a few nanometers. These lamellas appear within regular twins, thus representing their fine substructure-sometimes straight, sometimes wavy. This new material structure correlates well with the significant enhancement of pinning at high fields, represented by irreversibility field above 14 T at 77 K (B parallel c). We believe that the new pinning medium enables one to significantly broaden the limits for high-field applications.

Journal Article↗

PubMed2005

Dynamics of field-induced droplet ionization: time-resolved studies of distortion, jetting, and progeny formation from charged and neutral methanol droplets exposed to strong electric fields.

We recently reported that strong electric fields may be employed to directly extract positive and negative ions for mass analysis, including intact proteins, from neutral droplets. The present study investigates the dynamics of this process using switched high electric fields to enable time-resolved studies of droplet distortion, Taylor cone formation, and charged progeny droplet extraction from neutral and charged 225 microm methanol droplets. After a specific time in the field, a flashlamp is triggered to record droplet distortions using shadow photography. At a critical field strength E(c)0 corresponding to the Taylor limit, neutral droplets exhibit a prolate elongation along the field axis forming symmetric cone-jets of positive and negatively charged progeny droplets, approximately 10 microm in diameter. This process is termed field-induced droplet ionization (FIDI). Because the time scale of FIDI is related to the frequency of shape oscillations that occur below the Taylor limit, models of field-dependent oscillation become an important predictor of the time scale for progeny jet formation. Droplets with a net charge q distort into asymmetric tear shapes and emit a single charged jet of progeny at a critical field E(c)(q) that is less than E(c)0. The measured decrease in droplet stream charge indicates that total charge loss can be greater than the original charge on the droplet, resulting in oppositely charged droplets. Interestingly, above E(c)0, charged droplets sequentially emit a jet of the same polarity as the net charge followed by a jet of reverse polarity emitted in the opposite direction. For both neutral and charged droplets, increasing the electric field decreases the time to form jets and the combination of net charge and higher-than-critical fields has a compound effect in accelerating progeny formation. The implications of our results for using switched fields in FIDI-mass spectrometry for on-demand ion sampling from neutral and charged droplets are discussed.

Electric Conductivity↗