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At least 361 records · Page 20Linked to original sources
PubMed1997

[The combined treatment of lichen ruber planus of the mouth mucosa].

The treatment of 53 patients with lichen planus of the buccal mucosa included common methods of detoxication and immunomodulators in order to normalize the immune status and was supplemented with applications of codfish oil enriched with polyunsaturated fatty acids. As a result of such treatment, the duration of exacerbation was shorter and a stable more than one-year remission was attained, associated with normalization of the immunological parameters. In patients with the erosive ulcerative form of lichen local applications of codfish oil and gargling with Potentilla tormentilla tincture were conducive to a sooner control of the process.

Adjuvants, Immunologic↗
PubMed1988

Pattern of oral cytokeratins: I. SDS-electrophoretic analysis of the frequency of cytoskeletal keratins in the normal human mucosa of mouth.

In the SDS-electrophoretic pattern of cytokeratins of the normal human mouth mucosa one has to distinguish between the cytokeratins which occur continually and stamp the organ and site specificity of pattern, from those not always detectable. The cytokeratins no. 5, 6/11, and 14/15 are solidly expressed in the whole oral mucosa, no. 1 only in the regions forming a stratum corneum, no. 3 and 16 in the masticatory mucosa, and no. 8 in gingiva and the lining mucosa. Moreover, no. 16 and 18 in the lining mucosa and no. 2, 4, 17, and 18 in the masticatory mucosa appear as minor components with interindividually varying frequency. The highest variability of the cytokeratin pattern exists in the specialized mucosa.

Cytoskeleton↗
PubMed2004

Comparative permeability of various chemical markers through human vaginal and buccal mucosa as well as porcine buccal and mouth floor mucosa.

A number of drugs undergo extensive first-pass metabolism after oral administration, necessitating large doses for effective therapeutic responses in the body. Buccal administration of drugs is becoming more popular because the drugs diffuse into the systemic circulation directly, circumventing the first-pass metabolism. Lower concentrations thus need to be administered and side effects may be minimized. In this study, one of the classic models for human buccal permeability, i.e. the porcine buccal mucosal model, is compared with the more recent human vaginal model and both these are in turn further compared to porcine mouth floor mucosa. To determine the permeability of the different markers (arecoline, 17beta-estradiol, water and vasopressin), a continuous flow-through perfusion system was used (20 degrees C, 24h). Mean steady state flux values were compared statistically using a t-test at a significance level of 5%. Porcine buccal mucosa showed a consistently lower permeability towards all the markers than the other mucosae tested. Porcine mouth floor mucosa was found to be more permeable than porcine buccal mucosa. From these studies we concluded that human vaginal and porcine mouth floor mucosae were superior models for human buccal mucosa than porcine buccal mucosa, using in vitro permeability studies with various chemical markers.

Administration, Buccal↗
PubMed1989

[Clinical-experimental study on the temperature behaviour of the mucosa of mouth related to the season of the year].

A long-term investigation of 20 juvenile patients indicated a great seasonal and interdiurnal variation of the gingival temperature, which had a trend to a high interindividual correlation. The absolute individual differences was upto 2 degrees C. The lower jaw had a higher temperature than the upper jaw. The temperature of the right and left sides of the jaw differed from each other. The calculation of a standard temperature is only useful, when it is related to the individual sublingual temperature.

Adolescent↗
PubMed1997

[Interstitial radiotherapy for cancers of the tongue and mouth floor mucosa].

The report deals with new procedures of interstitial, complex and combined treatment of cancer of the tongue and mucosa of fundus of the oral cavity with time space-differentiated doses of radiation. If indicated, cervical lymph nodes undergo surgery at the final stage of therapy. Interstitial radiotherapy has proved a highly-effective radical component of said treatment for cancers of the tongue and oral cavity.

Humans↗
PubMed1994

[DNA level in cell nuclei of squamous cell carcinoma of the tongue and mouth floor mucosa as an indicator of the biological behavior of the tumor].

DNA was assayed in cell nuclei of squamous-cell carcinoma of the tongue (35 cases) and mucosa of the oral cavity fundus (15) using flow cytometry. The measurements were made versus size of tumor, cell differentiation stage and presence of metastasis to regional lymph nodes. Aneuploidy incidence was found to be in direct correlation with tumor size, low cell differentiation and ability to disseminate.

Adult↗
PubMedDate not supplied

[Melanoma of the mucosa of the mouth and upper respiratory tract].

3 cases of extracutaneous melanoma are described: those of the alveolar process of maxilla, nose septum and ethmoidal cavity. Clinical symptoms were nose haemorrhages, difficulties of the nose respiration, pains in the month. Histologically melanomas were of a typical structure being formed of the epithelioid and naevus-like cells with high content of melanine with an extra- and intracellular location.

Adult↗
PubMed1975

[Results of primary and combined radiotherapy of mouth carcinomas (tongue, tonsil, maxilla, mandible, palate, floor of the mouth cheek mucosa)].

Responses to highvoltage radiotherapy of 320 patients with carcinomas of the oral cavity are discussed. Five year survival rate according to the stage of the, disease were the following ones: in carcinoma of the anterior 2/3 of the tongue and floor of the mouth 20-60%, buccal mucosa, upper and lower jaw 30-50%, base of the tongue 26% and tonsil 30-100%. After simultaneous irradiation of the efferent lymphatics in parimary N0 patients, whose primary tumor subsequently was under control, a significantly lower frequency of metastases to the lymph nodes was found than without coirradiation of the lymph flow. Clinically verifiable metastases of the lymph nodes are also controllable to a high percentage by radiotherapy alone: Only in a little more than five per cent of the primary N1-3 patients with the parimary tumor being under control, additional metastases of the lymph nodes developed later on. The complication rate was 6.8 per cent. Most frequently, osteonecrosis was involved, indeed occurring chiefly in cases, where a primary skeletal manifestation of the tumor already was existing.

Bone Neoplasms↗
PubMed1998

[Cytogenetic aberrations in somatic cells of children living in areas with various levels of environmental pollution].

Micronuclear test was used to carry out genetic screening in somatic cells of children from different St. Petersburg districts with varying ecologic conditions. Preschool children from districts with high anthropogenic load (soil, air) revealed significant increase of epitheliocyte number in mouth mucosa. Girls appeared to be more sensitive to unfavourable environmental effects than boys. Mean values of cells with micronuclei in ecologically safe districts were 0.38 and 0.66% in pre- and school children, respectively. The study performed showed a possibility to use micronuclei count in the mouth mucosa investigating genetic effects of environmental pollution.

Adolescent↗
PubMed1986

[Short-term results of radiotherapy of cancer of the tongue and mouth floor mucosa using 60Co and 252Cf].

The authors presented the immediate and 3-year results of interstitial and combined therapy of 90 patients with cancer of the tongue and oral fundus mucosa. 60Co- and 252Cf-sources were employed in interstitial radiotherapy. There were no significant differences in therapeutic efficacy using different radiation sources. Some methodological aspects of administration of interstitial radiotherapy, radiation reactions and complications were covered.

Adult↗
PubMedDate not supplied

[A comparative study of the effects of vegetable oils and cholesterol on enzymes of the mouth and jejunal mucosae].

The influence of sunflower and olive oils and their combination with cholesterol on the activity of lysosomal hydrolases and lipid peroxidation (LPO) in the mucosa of the mouth and jejunum was studied. It was shown that in the presence of cholesterol in the oral mucosa the activity of N-acetylhexosaminidase increased and there was a tendency to decreasing cathepsin D and acetyl esterase activity, and LPO processes were found to be suppressed. Cathepsin D and B activities in the jejunum mucosa increased in response to cholesterol administration. The changes revealed in the activities of N-acetylhexosaminidase, proteinase, acetyl esterase, catalase and glutathione peroxidase in the oral mucosa, as well as cathepsins in the jejunum depend on the character of lipid additives.

Animals↗
PubMed1995

Oral epithelial dysplasia and the development of invasive squamous cell carcinoma.

Oral epithelial dysplasia, the histopathologic marker of a premalignant disorder of the mouth mucosa, may present clinically as leukoplakia, erythroplakia, or leukoerythroplakia. Its presence in lesions of the oral mucosa is predictive by a variable rate (6.6% to 36%) of transformation to invasive squamous cell carcinoma. We studied the clinical features and microscopic slides of 308 case of oral epithelial dysplasia in our biopsy service and retrospectively evaluated 44 of these with follow-up data for transformation to invasive squamous cell carcinoma. Forty-four patients had follow-up of more than 6 months with a mean follow-up time of 18.4 months. Twenty (45%) were clinically free of disease and 15 (34%) had recurrence of the dysplasia. An additional two cases of lower grades of the disease recurred as carcinoma in situ. Invasive squamous cell carcinoma developed in seven (16%) in a mean transformation time of 33.6 months.

Adult↗