Recalcitrant ulcers in necrobiosis lipoidica diabeticorum healed by topical granulocyte-macrophage colony-stimulating factor.
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Administration, Cutaneous↗
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Results for “NECROBIOSIS LIPOIDICA”
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Necrobiosis lipoidica diabeticorum. A clinical and pathological investigation of 171 cases.
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Adolescent↗
Aggressive ulcerative necrobiosis lipoidica associated with venous insufficiency, giant-cell phlebitis and arteritis.
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Arteritis↗
[Diabetic necrobiosis lipoidica with an aspect of erythema elevatum diutinum].
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Blood Protein Disorders↗
Necrobiosis lipoidica presenting on the face and scalp. An account of 29 patients and a detailed consideration of recent histochemical findings.
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Adult↗
Increased factor VIII-related antigen in necrobiosis lipoidica and widespread granuloma annulare without associated diabetes.
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Adult↗
Atypical (annular) necrobiosis lipoidica of the face and scalp. A report of the clinical and histological features of 7 cases.
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Adult↗
Ultrastructure of necrobiosis lipoidica diabeticorum.
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Adolescent↗
[Diabetic necrobiosis lipoidica. Histochemical and ultrastructural study of a case].
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Aged↗
[Perforating necrobiosis lipoidica].
This is the case history of a woman with a 6 year history of insulin-dependent diabetes mellitus and a 5 year history of tuberous lesions on the dorsal aspect of the metacarpophalangeal joints. Histological examination revealed multiple necrobiotic foci throughout the dermis and subcutaneous tissue, with varying degrees of degeneration, alternating with fibrotic areas. This picture is compatible with lipoid necrobiosis. The existence of various foci of epithelial perforation, manifested clinically by a point hyperkeratosis similar in appearance to blackheads, suggests transfollicular elimination. This would explain the total absence of a pilosebaceous follicles in the lesion.
Adult↗
Generalized necrobiosis lipoidica treated with a combination of split-thickness autografting and immunomodulatory therapy.
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Adolescent↗
Necrobiosis lipoidica diabeticorum in a juvenile diabetic: treatment by excision and skin grafting.
A fifteen year old female juvenile diabetic had severe ulceration of NLD lesions, which were treated by skin grafting. Twenty-four months postoperatively, she has an excellent cosmetic result.
Adolescent↗
Necrobiosis lipoidica diabeticorum.
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Adolescent↗
Necrobiosis lipoidica diabeticorum.
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Diabetes Complications↗
Necrobiosis lipoidica diabeticorum.
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Diabetes Complications↗
On the Patho- and Histogenesis of the Necrobiosis Lipoidica Diabeticorum.
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Diabetes Complications↗
[Acnitis Berthélemy (papulonecrotic tuberculid), dermatitis caused by insects, terebrating basalioma, lupus erythematosus chronicus discoides periocularis, necrobiosis lipoidica diabeticorum, multiple giant chancre].
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Adult↗
Superficial ulcerating necrobiosis in rheumatoid arthritis. A variant of the necrobiosis lipoidica-rheumatoid nodule spectrum?
Although necrobiosis is not a precise term, it primarily refers to collagen changes found in association with the palisading granulomas seen in granuloma annulare, necrobiosis lipoidica diabeticorum (NLD), and rheumatoid nodules. While the pathogenesis of each of these conditions remains unknown, immune complex vasculitis and delayed hypersensitivity mechanisms have been postulated. Two patients are described, having "classic" rheumatoid arthritis with chronic, superficial, ulcerating, discrete lesions on their lower legs that histologically were interpreted as NLD. While the argument for a chance association of NLD and rheumatoid arthritis could be advanced, the occurrence of identical lesions in two patients with high-titer rheumatoid factor, rheumatoid nodules, and some clinical and microscopic evidence of a low-grade rheumatoid vasculitis suggests a new subset of patients with necrobiotic palisading granulomas.
Aged↗