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PubMed1982

Key concepts in geriatric psychopharmacology. Altered pharmacokinetics and polypharmacy.

Certain general principles should be considered whenever psychotropic drugs are prescribed to elderly patients. 1. The aging body usually responds to psychotropic drugs with a prolonged and heightened effect. 2. Before prescribing a psychotropic drug, it is necessary to determine all other medications an older patient is taking, including medications from other physicians as well as self-prescribed, over-the-counter preparations. 3. A careful assessment of the physical health of the patient must be completed before drug treatment begins. 4. The possibility of psychotropic drug toxicity should be considered in any older patient who is taking a psychotropic drug and who appears restless, agitated, confused, forgetful, or depressed. Doses of psychotropic drug should be reduced or the drug discontinued before adding another drug the the regimen. 5. Psychiatric drugs with simple metabolic pathways, particularly tricyclic antidepressants (secondary amines) and short-acting benzodiazepines, are preferred in elderly patients.

Aged↗
PubMed1977

Clinicopathological Conference. Diagnostic difficulties in a case of polypharmacy. Demonstrated at the Royal College of Physicians of London.

The fifteenth quarterly clinicopathological conference was held at the Royal College of Physicians of London on 29 July 1976. The conference was chaired by Professor Sheila Sherlock (1). She began by introducing Professor Jean-Pierre Benhamou (2), professor of gastroenterology at the Beaujon-Clichy Hospital, University of Paris, who was to open the discussion of the case. Professor Sherlock emphasised that this case had no great dénouement but was more a talking point for various aspects of hepatology, a review of the state of the art. Dr James Scott (3) presented the case, and Dr R Dick (4) described the radiological findings.

Acute Kidney Injury↗