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PubMed1982

The serum levels of some trace and bulk elements in cancer patients.

The levels of copper, zinc, calcium, manganese and magnesium have been monitored in the sera of patients suffering from various types of cancer. Only serum copper appeared to be of any diagnostic significance, its levels being above the normal reported range in the breast cancer, leukaemia and Hodgkin's lymphoma patients. In the case of breast cancer, serum copper is progressively elevated according to the stage of the disease. Serum calcium levels were also significantly lower in patients with tumours of the breast, gastrointestinal tract and cervix. The results suggest that serum copper levels could be of prognostic significance in breast cancer patients receiving radiotherapy.

Adolescent↗
PubMed1989

[Cancer incidence in the department of la Manche: heterogeneity and geographic autocorrelation].

In order to demonstrate systematic spatial variations of cancer morbidity in the French "department of la Manche" (1979-1981), heterogeneity and spatial autocorrelation tests are performed. The "canton" (electoral ward of around 10,000 inhabitants) is retained as the statistical unit and the standardized incidence ratio (SIR) in each ward for the most frequent cancer sites, as morbidity rate. For males, three cancers show organized patterns: upper respiratory and digestive tract cancers with a North/South gradient; lung and other respiratory cancers mainly in the urban wards; and cancer of the skin with a high incidence on the West coast and a low incidence in the northern area. For females, cancer of the skin is the only one to show significant spatial variation characterized by a pronounced South/North gradient. The possible etiological factors involved are discussed for each cancer site.

Female↗
PubMed2002

Risk of second cancers in patients with colorectal carcinoids.

INTRODUCTION: It is often stated that patients with colorectal carcinoid tumors have an increased risk of developing other malignancies. However, this risk has not been conclusively documented. A comprehensive evaluation is needed to more thoroughly assess the risk of second cancers in patients with colorectal carcinoids. METHODS: A search of the National Cancer Institute Surveillance, Epidemiology, and End Result database from 1973 to 1996 revealed 2,086 patients with colorectal carcinoids. This subset of patients was examined for occurrence of second cancers. The observed incidence of cancer for each site was compared with the expected incidence based on the gender-adjusted and age-adjusted cancer rates in the remaining Surveillance, Epidemiology, and End Result file. A Poisson distribution probability was used to determine the significance of these comparisons. RESULTS: Patients with colorectal carcinoids had an increased rate of cancer in the colon and rectum (P < 0.001), small bowel (P < 0.001), esophagus/stomach (P = 0.02), lung/bronchus (P < 0.001), urinary tract (P = 0.005), and prostate (P < 0.001), when compared with a control population. Most of the gastrointestinal tract cancers were synchronous cancers, whereas lesions outside the gastrointestinal tract were most commonly metachronous tumors. CONCLUSIONS: A significantly increased risk of synchronous colorectal, small-bowel, gastric, and esophageal cancers and metachronous lung, prostate, and urinary tract neoplasms is clearly demonstrated. After the diagnosis of colorectal carcinoid tumors, patients should undergo appropriate screening and surveillance for cancer at these sites.

Age Distribution↗