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PubMed1989

[Syndrome of chronic overdose of insulin and hypoglycemic sulfanilamide drugs].

Clinical features, pathogenesis and treatment of the syndrome of chronic overdosage of insulin and hypoglycemic sulpha drugs are discussed. The typical features of this syndrome were found not only in type I and II diabetes mellitus patients who were treated with insulin but also in those who were given large dosages of hypoglycemic sulpha drugs. Treatment of this syndrome has been recommended.

Diabetes Mellitus, Type 1↗
PubMed1977

[Pyrazole sulfanilamides. XV. Nitroderivatives of 1-phenyl-4-sulfanilamidopyrazole].

The research on the change of antibacterial activity due to the introduction of a nitro group in the benzene nucleus linked at the heterocyclic nitrogen of N-phenylsulfanilamidopyrazoles is continued with the preparation of 1-(2'-nitrophenyl)-4-sulfanilamidopyrazole (IIa: -NO2 in 2'; R=-H), 1-(3'-nitrophenyl)-4-sulfanilamidopyrazole (IIb: -NO2 in 3'; R=-H) and 1-(4'-nitrophenyl)-4-sulfanilamidopyrazole (IIc: -NO2 in 4'; R=-H). By analogy with the results obtained for the derivatives of 4-sulfanilamidopyrazole (I) previously prepared, enhancement of the bacteriostatic activity in vitro against S. aureus and E. coli, have been observed in almost all the cases, especially with 1-(3-nitrophenyl)-4-sulfanilamidopyrazole (IIb).

Escherichia coli↗
PubMed1988

[Sulfanilamides].

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Administration, Oral↗
PubMed1987

[Fluorometric determination of sulfanilamide and sulfaguanidine residues in animal tissues with high-performance-liquid chromatography].

A high-performance liquid chromatographic method is presented for the selective analysis of sulphanilamide (SA) and sulphaguanidine (SG) residues in animal tissues (muscle, liver), egg and milk at the 0.01-0.1 mg/kg level. A 25-g amount of the samples was extracted with 90 ml acetonitrile at pH 8.5 to which 2 ml saturated sodium carbonate had been added. After centrifugation, co-extracted water was separated by saturating the extract with sodium chloride and adding 50 ml dichloromethane. The residue of the dried and evaporated organic layer was partitioned between methanol, n-hexane and mobile phase (1 ml each). A 20-microliter volume of the aqueous layer was injected onto a Nucleosil 5 SA column [mobile phase 0.05 M sodium dihydrogenphosphate (adjusted to pH 2.0 with 85% orthophosphoric acid)-methanol, 85:15, v/v]. SA and SG were detected by their native fluorescence (excitation 275 nm, emission 340 nm) at retention times of 7 and 13 min, respectively, without interference of co-extractives. Parallel detection by ultraviolet absorption (275 nm) allowed on-line confirmation of the results. Recovery of spiked samples (0.1 mg/kg) was 80% (coefficient of variation, C.V. = 5%) for SA and 62% (C.V. = 6%) for SG. Concentrations of 0.27 mg/kg for SA and 0.05 mg/kg for SG were analyzed in muscle meat of a swine which received a single intramuscular injection of 2.1 g SA and 0.6 g SG and was slaughtered 24 h later.

Animals↗