Studies on direct compression of tablets. III. The effect on tablet strength of changes in particle shape and texture obtained by milling.
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Drug Compounding↗
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Studies on the physical properties of tablets and tablet excipients. IV. A program for accelerated light stability testing.
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Drug Stability↗
Studies on the physical properties of tablets and tablet excipients. VI. The application of accelerating test conditions to the study of water sorption and change in hardness.
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Adsorption↗
[Comparative studies on release of a therapeutic substance from tablets in vitro, and its biological availability. I. Effect of the conditions of the study on the results of sodium salicylate release in vitro from the tablets of different formulations].
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Alginates↗
Studies on direct compression of tablets. IV. The effect of particle size on the mechanical strength of tablets.
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Drug Compounding↗
[Importance of tablet geometry to tablet strength].
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Chemistry, Pharmaceutical↗
[Computer optimization of the dimensions of tablet cores for sugar-coated tablets].
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Computers↗
[Clinical evaluation of amoxicillin tablets (Widecillin tablets) in pediatric field (author's transl)].
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Age Factors↗
[Clinical results with amoxicillin tablets (Widecillin tablets 'Meiji') in urological infections (author's transl)].
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Adolescent↗
[Clinical results with amoxicillin tablets (Widecillin tablet 'Meiji') in gynecological field (author's transl)].
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Adult↗
[Direct compression of tablets. I. Preparation and evaluation of tablets with phenobarbital].
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Phenobarbital↗
Content uniformity of tablets--a comparison of data from automated analysis of tablets performed by two different laboratories.
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Autoanalysis↗
[Influence of formulation of enteric coated tablets on the bioavailability of the drug. 4th Part: Influence of the enteric polymer dissolution pH on the "in vivo" absorption of aspirin from coated tablets (author's transl)].
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Aspirin↗
[Study on tablets. XXVII. Study on the deformative tension in the compression of aminophenazone tablets].
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Aminopyrine↗
[Tablets. XVII. Effect of pressure on the liberation in vitro of sodium salicylate from prolonged-action tablets].
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Delayed-Action Preparations↗
[Influence of formulation of enteric coated tablets on the bioavailability of the drug. 5th Part: Bioavailability of Riboflavin enteric coated tablets (author's transl)].
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Biological Availability↗
Development of computerised procedures for the characterization of the tableting properties with eccentric machines. High precision displacement instrumentation for eccentric tablet machines.
The paper deals with the instrumentation of displacement on an eccentric machine. Two instrumentation variants are evaluated. A displacement instrumentation consisting of two transducers attached to the frame was corrected for a slight non-linear calibration curve and corrected for machine deformation. A powder height signal was calculated from both signals. Upon dynamic punch to punch compression the powder height signal showed an oscillation of +/- 17 microns in amplitude due to tilting of the upper punch holder. A newly developed direct powder height instrumentation consisting of a set of special punches and a special die was also corrected for nonlinearities and punch deformation. The signal was free from any tilting effects and its accuracy is in the order of magnitude of the surface roughness of the punches. The machine deformation is discussed in detail. The instrumentation of the frame of the eccentric press in terms of force is possible but less sensitive by a factor of 5.4 than the use of the force sensors. The total machine deformation reaches nearly 0.5 mm under maximum load which is more than is often expected. The deformation was found to be non-linear for about 2% of the total deformation, the remaining 98% are linear deformation.
Chemistry, Pharmaceutical↗
The effect of ethinyl estradiol 20 mcg and levonorgestrel 250 mcg on the pituitary-ovarian function during normal tablet-taking and when tablets are missed.
A new combined pill containing 20 micrograms of ethinyl estradiol and 250 micrograms of levonorgestrel has been developed. The safety margin of this type of low-dose preparation needed to be assessed and this was done by evaluating daily levels of LH, FSH, estradiol, progesterone, 1-NG and EE2 as well as cervical mucus characteristics in six patients when one and then two consecutive pills were deliberately omitted mid-way through the cycle. Results demonstrated that there was no evidence of breakthrough ovulation, although there was some continued ovarian steroidogenesis, a feature consistent with previous studies using combined preparations. Existing instructions to patients regarding missed pills should continue in order to ensure maximal contraceptive safety.
Adolescent↗