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At least 361 records · Page 20Linked to original sources
PubMed2004

[Effect of kidney-warming and astringent therapy on plasma endothelin and interleukin-2 receptor in patients with nephrotic syndrome].

OBJECTIVE: To explore the effect and mechanism of kidney-warming and astringent therapy in treating nephrotic syndrome patients with deficiency of spleen and kidney yang and overflow of water, and to observe the change of plasma endothelin and interleukin-2 receptor after treatment. METHODS: Forty-four patients were randomly divided into conventional steroid treated group (control group, 20 cases) and conventional steroid plus kidney-warming and astringent therapy treated group (treatment group, 24 cases). The levels of plasma endothelin (ET) and soluble interleukin-2 receptor (sIL-2) were observed. RESULTS: Before treatment, plasma ET and sIL-2 in the patients were significantly higher than those in healthy people (P<0.01). After treatment, the ET and sIL-2 levels were obviously improved in both treated groups (P<0.05) and the improvement in the treatment group was more obvious. The difference between the two treated groups after treatment was significant (P<0.05). CONCLUSION: Conventional treatment plus kidney-warming and astringent therapy can effectively improve the levels of plasma ET and sIL-2 in treating nephrotic syndrome patients with deficiency of spleen and kidney yang and overflow of water, and hence alleviate the damage of renal tissue.

Adrenal Cortex Hormones↗
PubMed1995

Therapeutic effects of the blood-activating and stasis-reducing method in 80 cases of coronary heart disease.

The pathogenesis and treatment of coronary heart disease (CHD) may vary, whereas the author believes that the disease is due to blood stasis on a fundamental basis of deficiency, and the principle of treatment is activation of blood. Since stasis may lead to deficiency and vice versa, CHD cannot be cured without removal of stasis, and stasis cannot be completely removed without proper correction of deficiency. The basic method for the treatment of CHD is therefore activation of blood for reduction of stasis. At the same time, according to the conditions of individual patients, the methods of replenishing Qi, warming Yang, nourishing Yin, reducing phlegm and subduing Yang should be applied simultaneously to resolve the problem of deficiency. The author treated 80 cases of CHD by the above rationale and found the results satisfactory, i.e., 28 cases (35%) showed marked symptomatic relief, 46 (57.5%) showed symptomatic improvement, while 6 cases (7.5%) failed. The total effective rate was 92.5%. ECG examination indicated 9 cases markedly effective, 27 improved, while 44 cases failed, for a total effective rate of 45%. Blood pressure and blood lipids also showed significant drops (P < 0.001).

Adult↗
PubMed2001

The principle and technique of using Chinese drugs in the treatment of hypertension.

Differential use of Chinese and western drugs, and combination of traditional theory of materia medica with the results of modern pharmacological research can be regarded as a general principle in the treatment of a disease, while combination of lowering blood pressure with preventing and treating complications is a specific method in the treatment of hypertension. As to the use of drugs based on differentiation of diseases and/or symptoms, drugs which have the action of relieving symptoms but also reducing blood pressure should be used as the first choice. For those drugs which have the action of relieving symptoms but can not lower blood pressure should not be used or should be used as less as possible. Drugs with action of raising blood pressure are contraindicated. When patients have the symptoms of hyperactivity of yang resulting from yin deficiency, Huang Bo ([symbol: see text] Cortex Phellodendri) and Zhi Mu ([symbol: see text] Rhizoma Anemarrhenae) are used together to enhance the effects of both nourishing yin to reduce pathogenic fire, and reducing blood pressure. This practice conforms to the TCM theory and also to the modern pharmacological research.

Diagnosis, Differential↗
PubMed2006

[Study on the shu-points of five zang (viscera) for treatment of insomnia based on the theory of the five zang (viscera) storing vitality].

According to Prof. DONG Gui-rong's law of syndrome differentiation of "viscera, yin and yang, qi and blood, deficiency and excess" in internal injury diseases and academic thought of syndrome differentiation of regulating five zang vitality for treatment of insomnia, the author consults a great number of ancient and modern literature of TCM, analyzes the controlling functions of five zang storing vitality on whole organism and the relation between heart vitality and brain vitality, and explain the basis of acupuncture at five-zang shu-points of the Gallbladder Channel to regulate vitality of five zang-organs for treatment of insomnia from intension and functions of five zang vitality, whole regulative mechanism of five zang vitality, the cause and pathogenesis of insomnia of over or too less five zang-vitality induced by pathogenic factors, and according to typing and syndrome differentiation of five zang vitality, theory and principle of acupoint selection, so as to establish and put forward the method and theory of acupuncture at five zang shu-points of the Gallbladder Channel for treatment of insomnia.

Acupuncture↗
PubMed1990

[Relation of cytochemistry changes in the peripheral blood ANAE in chronic glomerulonephritis and differentiation-syndromes].

The ANAE reaction of the peripheral blood from 24 patients of chronic glomerulonephritis (grouped according to the identification of TCM) and 30 normal individuals were observed by cytochemistry and microspectrophotometry. It was found that the percentages of positive lymphocytes of the deficiency of Kidney-Yin was 47.8 +/- 7.6%, among which the percentages of lymphocytes of spot granular pattern and scattered granular pattern were 42.4 +/- 6.3% and 5.4 +/- 2.2% respectively, the ANAE relative quality of monocytes of the deficiency of Kidney-Yin was 51.26 +/- 2.59. They were 39.7 +/- 7.4%, 31.2 +/- 5.8%, 8.5 +/- 2.7% and 41.84 +/- 2.66 respectively in the deficiency of Kidney-Yang. The results of normal group were 65.5 +/- 6.8%, 53.6 +/- 6.7%, 11.9 +/- 3.4% and 54.78 +/- 3.34 in their given order. The differences in three groups each other were marked significantly. The authors have found the difference between the patients of chronic glomerulonephritis and the normal individuals was significant statistically.

Adult↗
PubMed1998

dATP causes specific release of cytochrome C from mitochondria.

The induction of the Mitochondrial Permeability Transition (MPT) has recently been associated with the release of apoptogenic cytochrome c, which could come about in a swelling-dependent or swelling-independent manner. We observed that canonical inducers of MPT (Ca2+, t-butyl hydroperoxide, atractyloside) induce a swelling-dependent release of cytochrome c, and that osmotic support of mitochondria with PEG-1000 abolishes mitochondrial swelling, protein release, and cytochrome c release by these inducers. By contrast, it was observed that dATP is a potent inducer that caused release of cytochrome c in a swelling independent manner, i.e. even in the presence of osmotic support by PEG-1000; in addition this release of cytochrome c is inhibitable by cyclosporin A. The dATP-dependent and swelling-independent release of cytochrome c from mitochondria is not inhibitable by the protease inhibitor z-VAD, suggesting that it is not mediated by upstream caspases. This is the first report to our knowledge that a chemical compound may directly cause release of cytochrome c from mitochondria, and could explain the toxicity of dATP in the context of the genetic immunodeficiency diseases Adenosine Deaminase deficiency and Purine Nucleotide Phosphorylase deficiency.

Adenosine Triphosphate↗
PubMed2006

[Clinical research on effects of yunpi zhixie granule in children with diarrhea].

OBJECTIVE: To investigate the clinical effect of Yunpi Zhixie Granule (YZG) on children's diarrhea. METHODS: Three hundred diarrhea cases were randomly divided into two groups equally, the treated group treated by YZG orally and the control group by smacta, both for 7 days. The clinical efficacy was observed, routine scatologic analysis, scatologic cultivation, rotavirus antigen and urinary D-xylose content were detected. RESULTS: Clinical results showed the effective rate in treating the chronic or Pi-deficiency diarrhea as well as the negative conversion rate and improvement rate of routine scatologic analysis were all higher in the treated group than those in the control group (P < 0.05); while no significant difference was found in negative conversion rate of scatologic cultivation and rotavirus antigen and urinary D-xylose content after treatment, compared with those before treatment (P > 0.05). CONCLUSION: YZG was effective in treating children' s diarrhea, especially on chronic diarrhea and diarrhea of Pi-deficiency type.

Administration, Oral↗
PubMed2001

[Study on reference laboratory diagnostic index of liver-fire ascending syndrome].

OBJECTIVE: To explore the binding point of Syndrome Differentiation of TCM and disease differentiation by western medicine. METHODS: Selected laboratory diagnostic indexes were tested in 59 cases of Liver-Fire Ascending Syndrome (LFAS). Referring to clinical typing and staging, the data obtained were analysed by same syndrome with different diseases and same disease with different syndrome as well as the values determined in related syndrome-types were compared. RESULTS: The levels of prostaglandin F2 alpha (PGF2 alpha) and arginine vasopressin (AVP) in patients of LFAS were higher than those in patients with Liver-Kidney Yin-Deficiency Syndrome and Liver-Yang Hyperactivity Syndrome. As for linking between Syndrome-type and stage of disease, most cases (70%) of herpes simplex viral keratitis of LFAS were deep matrix layer type; and 100% hypertension patients with LFAS belonged to stage II. CONCLUSION: PGF2 alpha and AVP could be used as the reference laboratory diagnostic indexes of LFAS.

Adult↗
PubMed1994

[Study on relationship between brain function and syndrome differentiation-typing of TCM in non-insulin dependent diabetes mellitus].

The relationship between brain function and syndrome-types of TCM in 51 patients with non-insulin dependent diabetes mellitus (NIDDM) was observed. The syndromes were divided into three types. (1) Yin Deficiency with internal excessive Heat (YDIEH), 15 cases; (2) Qi-Yin Deficiency (QYD), 21 cases; (3) Deficiency of both Yin and Yang (DYY), 15 cases. The control group consisted of 30 healthy subjects matched in age, sex and educational level. The brain function were tested by neurobehavioral and neuroelectrophysiological tests. The former included short-term memory, thinking, eye-hand coordination and emotion tests; the latter consisted of brainstem auditory evoked potentials (BAEP), visual evoked potentials (VEP) and somatosensory evoked potentials (SEP). The results showed that the brain function in YDIEH group approached normal controls, and the brain function in QYD and QYY groups were significantly deteriorated. The results suggested that the brain function were correlated with the syndrome-types of patients with NIDDM. This would be valuable for diagnosis and treatment of NIDDM in TCM.

Adult↗
PubMed2004

RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta.

We have described previously the use of microarray technology to identify novel target genes of TGF-beta (transforming growth factor-beta) signalling in mouse embryo fibroblasts deficient in Smad2 or Smad3 [Yang, Piek, Zavadil, Liang, Xie, Heyer, Pavlidis, Kucherlapati, Roberts and Böttinger (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 10269-10274]. Among the TGF-beta target genes identified, a novel gene with sequence homology to members of the Ras superfamily was identified, which we have designated as RLP (Ras-like protein). RLP is a Smad3-dependent immediate-early TGF-beta target gene, its expression being induced within 45 min. Bone morphogenetic proteins also induce expression of RLP, whereas epidermal growth factor and phorbol ester PMA suppress TGF-beta-induced expression of RLP. Northern-blot analysis revealed that RLP was strongly expressed in heart, brain and kidney, and below the detection level in spleen and skeletal muscles. At the protein level, RLP is approx. 30% homologous with members of the Ras superfamily, particularly in domains characteristic for small GTPases. However, compared with prototypic Ras, RLP contains a modified P-loop, lacks the consensus G2 loop and the C-terminal prenylation site and harbours amino acid substitutions at positions that render prototypic Ras oncogenic. However, RLP does not have transforming activity, does not affect phosphorylation of mitogen-activated protein kinase and is unable to bind GTP or GDP. RLP was found to associate with certain subtypes of the TGF-beta receptor family, raising the possibility that RLP plays a role in TGF-beta signal transduction. Although RLP did not interact with Smads and did not affect TGF-beta receptor-induced Smad2 phosphorylation, it inhibited TGF-beta-induced transcriptional reporter activation, suggesting that it is a novel negative regulator of TGF-beta signalling.

Amino Acid Sequence↗
PubMed2001

An analysis of therapeutic effect of drug acupoint application in 209 cases of allergic asthma.

Both therapies of traditional crude herb moxibustion and drug acupoint application were used in 209 cases of allergic asthma to compare their long-term and short-term therapeutic effects and to analyze the relationship between clinic therapeutic effects of both therapies and differential types of the disease. The results showed that the short-term total effective rate in the group of drug acupoint application was higher than that in the group of traditional crude herb moxibustion, the therapeutic effects of drug acupoint application being closely related to differential types. Analysis also shows the best short-term therapeutic effect was in the type of heat in the lung while the poorest effect in the type of deficiency of the kidney-yang.

Acupuncture Points↗
PubMed1990

[Determination of blood flow of the lower leg in patients with diabetes mellitus and the effects of treatment with the principle of vitalizing blood and solubilizing thrombus].

This paper reports the determination of blood flow of the lower leg in 50 cases of non-insulin dependent diabetes mellitus (NIDDM) using an XLJ-2 Bipolar Rheoencephalometry Impedance Rheogram. In patients with leg pain (but without obvious vascular pathological changes, 85 legs) the blood flow was decreased. In male patients the blood flow of the left leg (9 legs) was 3.28 +/- 0.47 ml/100ml.tissue.min (mean +/- S), while that in the right leg (11 legs) was 3.88 +/- 0.80; in females, the blood flow of the left leg (32 legs) was 2.72 +/- 0.8; while that in the right leg (33 legs) was 2.94 +/- 0.66. These figures were significantly (P less than 0.01-0.001) lower than those obtained from normals. In diabetic feet (15 painful legs) the decrease of blood flow of the lower leg was more apparent: it averaged 1.87 +/- 0.79 for the left leg (7 legs) and 2.66 +/- 0.87 for the right leg (5 legs) in male patients. The values were significantly different when compared with those of normals (P less than 0.001) or with those of the diabetic patients with leg pain (P less than 0.05). These results demonstrated that determination of the blood flow of the lower leg of diabetic patients might aid in early discovery of the abnormal changes of blood supply to the lower legs in diabetes mellitus and judge the degree of ischemia. Of the 50 cases of diabetics 32 were Qi-Yin deficiency with blood stasis while the remaining 18 cases were deficiency of both Yin and Yang with blood stasis.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

[Correlation of syndrome types in traditional Chinese medicine and insulin release curves in pre-aged and aged diabetics--an analysis of 142 cases].

This paper deals with the correlation between insulin release curves and syndrome types of TCM in 142 cases of diabetes. The syndromes were divided into 3 types: I, Qi-Yin deficiency, 94 cases; II, Yin deficiency with interior heat overabundance, 36 cases; and III, deficiency of both Yin and Yang, 12 cases. The results showed that fasting for 60 min, the postprandial (M +/- SD) of serum insulin were 18.27 +/- 1.10 mu/L and 45.21 +/- 2.82 mu/L in type I 25.47 +/- 1.88 mu/L and 60.53 +/- 0.25 mu/L in Type II; 8.29 +/- 0.93 mu/L and 19.20 +/- 1.67 mu/L in type III respectively. It was obvious that serum insulin level was Type II greater than Type I greater than Type III. But there was no difference between the aged and the pre-aged with diabetes (P greater than 0.05); even though the former was lower than the latter. According to the analysis of insulin release curve types (insulin secretion level and peak time), there were 39 cases (41.5%) of the low secretion type, 7 cases (7.5%) of the high secretion type among the 94 cases of Type I. Of the 36 cases of Type II, there were 7 cases (19.4%) of high secretion, more than that of Type I, and the highest value reached 155-106 mu/L. The 12 cases of Type III are all of the lower secretion type, with the fasting mean value being 47.5 mu/L and 10.93 mu/L and the postprandial highest value 21.69 mu/L and 20.73 mu/L, much lower than those of Types I and II. The results also showed that correlation between insulin secretion level and blood glucose value was significantly negative. The paper also discussed the mechanism of insulin secretion condition of 3 syndrome types according to the theory of TCM.

Aged↗
PubMed1994

Influence of iron deficiency on serum IgG subclass and pneumococcal polysaccharides specific IgG subclass antibodies.

The serum IgG subclass concentrations in 47 cases and specific IgG subclass antibodies against pneumococcal polysaccharides (PnPs) were measured in 18 cases with iron deficiency. IgG subclass deficiencies were found in 28 (59.6%) cases with the frequency in order as IgG4 (27.7%, 13/47), IgG1 (21.3%, 10/47), IgG3 (14.9%, 7/47), and IgG2 (2.1%, 1/47). Compared with age-matched healthy children, the mean concentration of serum IgG4 and IgG1, and PnPs specific IgG1, IgG2 antibodies were decreased in children with iron deficiency. Decreased CD4+ cells and CD4+/CD8+ ratio in peripheral blood, low interleukin-6 (IL-6) activity, reduced lymphocyte proliferative responsiveness and increased recurrent respiratory tract infections (RRTI) were found in iron deficiency children. These results suggested that serum IgG subclass and PnPs specific IgG subclass antibody deficiencies caused by dysfunction of the regulation of T lymphocyte on B lymphocyte may be related to the susceptibility to RRTI in children with iron deficiency.

Anemia, Iron-Deficiency↗
PubMed1999

[Effect of regulation of kidney-yin and kidney-yang on hypothalamus-pituitary-adrenal-thymus axis in monosodium L-glutamate rats].

OBJECTIVE: To study the interrelationship between hypothalamus-pituitary-adrenal-thymus (HPAT) axis and Kidney-Yang and Kidney-Yin in arcuate nucleus destroyed rats. METHODS: Monosodium glutamate (MSG) 4 mg/g body weight was given subcutaneously to neonatal rats at 2, 4, 6, 8 and 10th day after born to destroy the ARC, and Zuogui pill or Yougui pill (5 g/kg daily) was given respectively by gastrogavage when the model rats entered adulthood. RESULTS: Immunohistochemical staining showed that in the model group the number of corticotropin-releasing hormone (CRH) positive neurons in hypothalamic paraventricular nucleus and anterior pituitary adrenotrophin (ACTH) positive secretory cells, which stained deeply, were more than those in the control group, the adrenal fasciculate zone disturbed with increased cells and obviously dilated sinusoid. The thymus atrophied with lymphocyte proliferation apparently lower, blood corticosterone, ACTH content and hypothalamic CRF level higher in the model than those in the control. Zuogui pill could improve above-mentioned pathophysiologic changes effectively but Yougui pill could not. CONCLUSION: Process of pathophysiology of HPA axis hyperfunction accompanied cell-mediated immunodeficiency may belong to the category of Kidney-Yin Deficiency Syndrome.

Animals↗