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At least 361 records · Page 20Linked to original sources
PubMed2001

Good diagnoses require good diagnosticians: collecting and integrating the data.

The use of sets of diagnostic criteria and excellent structured clinical interviews will not result in data that is adequate for valid diagnoses or for dimensional measures if the rater collecting the data does not have adequate clinical skills. In the absence of biological measures or tests we are dependent on the rater's diagnostic and interviewing skills-both with subjects about themselves and with family informants asked to provide information about others. Best estimate diagnosticians (who usually have more experience and training) cannot compensate for inadequate or incorrect information and may even be misled by the information provided to them. In reviewing videotaped interviews sent by "trained" and "experienced" raters who were seeking "certification," approximately 40% of the raters were judged to have failed to conduct an adequate diagnostic evaluation. Principal Investigators should make every effort to assure that their diagnostic data is being collected by experienced and well-trained professional raters and that the raters' ongoing work is subjected to close supervision and review.

Clinical Competence↗
PubMed2003

Integration of data and methods for genome analysis.

The development of genomic and post-genomic technologies has created an explosion in the quantity, diversity and availability of both biological data and methods of analysis. Biologists are currently facing the problem of using all these resources to convert raw data into new valuable knowledge. This review presents software platforms designed to handle data and/or methods in the context of genome analysis.

Animals↗
PubMed1990

[Noninvasive hemodynamic monitoring via the integration of data obtained by ECG, aortic flow by Doppler esophageal probe and by finger plethysmography].

The aims of this work are to describe the general and technical characteristics of a new device for the noninvasive monitoring of patients in intensive care and during general anaesthesia, and the results concerning the reliability of this method. An ultrasonic esophageal probe and an echo-Doppler device have been used to obtain continuous data of the aortic diameter and of blood velocity. Aortic output is calculated automatically. This method, together with other non-invasive monitoring techniques (blood pressure, heart rate, rhythm and cardiac conduction), gives on the one hand the data of aortic output, systemic peripheral resistance and stroke volume; on the other, through a computerized elaboration, the systolic time intervals (PEP pre-ejection period, LVET left ventricular ejection time, QS2 electromechanical systole, PEP/LVET ratio of PEP to LVET). The validation of STI data, has been obtained through 125 comparative measurements for each of the three parameters. The data obtained through the aortic velocity waveform in descending aorta (pulsed Doppler) have been compared with those obtained through the aortic pressure waveform (intra aortic catheter). The correlation was: PEP 0.92, LVET 0.95, QS2 0.93. The clinical application of this method supplies data concerning cardiac load, after-load and indirectly cardiac pre-load. This non-invasive procedure gives us a continuous measurement of hemo-dynamic situation, which allows the physician to plan and evaluate the therapeutical efficacy. Finally new pathologic events may be opportunely faced.

Anesthesia, General↗