PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “experience sampling methodology”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 361 records · Page 20Linked to original sources

Response surface methodology in the development of a stacking-sensitive capillary electrophoresis method by field-amplified injection for the analysis of tricyclic antidepressants in the presence of salts.

The work presented here explores the possibilities of the electrokinetic injection (EK) to achieve sensitive methods for the determination of tricyclic antidepressants in biological samples (serum). The addition of ACN to the sample, with high content in salts, causes stacking at the tip of the capillary, in a similar way as for hydrodynamic injection. An experimental design with the response surface methodology has been used to find the optimum composition of the matrix of the sample (sodium chloride and ACN percentages) and the conditions for the EK (water-plug length, time, and voltage of injection) in few experiments. The composition of the separation buffer was the same as utilized in a previous paper. The use of a bubble capillary to reach lower detection limits implies a loss of the resolution and requires a new optimization. Finally, a comparison between electrokinetic and hydrodynamic injections is made.

Antidepressive Agents, Tricyclic↗

The strengths and weaknesses of quantitative and qualitative research: what method for nursing?

The overall purpose of research for any profession is to discover the truth of the discipline. This paper examines the controversy over the methods by which truth is obtained, by examining the differences and similarities between quantitative and qualitative research. The historically negative bias against qualitative research is discussed, as well as the strengths and weaknesses of both approaches, with issues highlighted by reference to nursing research. Consideration is given to issues of sampling; the relationship between the researcher and subject; methodologies and collated data; validity; reliability, and ethical dilemmas. The author identifies that neither approach is superior to the other; qualitative research appears invaluable for the exploration of subjective experiences of patients and nurses, and quantitative methods facilitate the discovery of quantifiable information. Combining the strengths of both approaches in triangulation, if time and money permit, is also proposed as a valuable means of discovering the truth about nursing. It is argued that if nursing scholars limit themselves to one method of enquiry, restrictions will be placed on the development of nursing knowledge.

Bias↗

Neuroprotection and traumatic brain injury: theoretical option or realistic proposition.

PURPOSE OF REVIEW: Preclinical studies have shown that treatment to limit secondary cell damage can significantly improve outcome after traumatic brain injury. In contrast, neuroprotection trials in human traumatic brain injury have failed to convincingly demonstrate therapeutic benefit. Recent literature has begun to address this discrepancy between preclinical and clinical trials. RECENT FINDINGS: Perhaps the most important recent observations relate to the potential role of apoptosis in secondary brain injury. Because apoptosis peaks more than 24 h after injury, concepts about the therapeutic window for traumatic brain injury treatment have changed. Apoptosis and necrosis are in delicate balance and inhibition of one cell death pathway may enhance the other. This raises questions about the ultimate effectiveness of treatment strategies directed toward a single injury mechanism. In contrast to clinical head injury, which reflects a complex multi-factorial disorder, animal models are generally designed to address only a single injury component and are performed in genetically inbred animals of a single sex. Moreover, animal studies usually employ pretreatment or early posttreatment administration, examine moderate rather than severe injury, fail to examine brain drug levels or treatment optimization, and do not use an intent-to-treat methodology. SUMMARY: Recognition of these methodological differences between animal and human studies has led to new trial design proposals. For clinical studies, there should be better stratification of patients, a focus on moderate injury and earlier treatment, and larger sample sizes. Animal experiments should better parallel clinical studies and address therapeutic window and treatment optimization. Recognition of multiple cell death pathways should lead to new treatment strategies--including both combination drug treatment and drugs that affect multiple components of the secondary injury cascade.

Animals↗

[Experience in nausea and vomiting of pregnancy(NVP) in woman: grounded theory approach].

PURPOSE: The purpose of this study was to explore NVP process in woman. METHOD: This study is based on grounded theory methodology by Strauss & Corbin. The participant were 12 women selected by theoretical sampling. The data were collected by in-depth interviews using audiotape recording over a period of five months. The data were analyzed simultaneously by a constant comparative method in which new data were continuously coded in categories and properties according to Strauss and Corbin' methodology. RESULT: NVP is caused by having an empty stomach and irritation of smell. NVP occur in connection with environmental change and overworking. The central incident about NVP in Woman were aggravation of physical condition and irritability of emotional state. Intervening condition that conclude action/interational strategies of NVP -Coping behavior is related to family support. Action/interational strategies to NVP-Coping in woman were dependence on medical treatment, change in food intake, rest, removal of smell, conversion in attention. NVP in woman result in ambivalence. CONCLUSION: It is suggested that the result of this study may contributed to the development NVP-coping strategy for woman. There is need to develop family support system and individualized care plan respect to food favorite.

English Abstract↗

Psychosocial aspects of Taiwanese postpartum depression phenomenological approach: a preliminary report.

To understand how Taiwanese women experience postpartum depression, a phenomenological study was conducted. A purposive sample of six mothers participated in the present study. All the subjects' interviews were tape recorded and then transcribed. The transcription of each subject's oral description of postpartum depression experience was analyzed using Colaizzi's phenomenological methodology. Three categories, with ten themes, were derived from the analysis. The first category is unbalanced role-enacting. It includes these four themes: (1) the discrepancies in the husband-wife relationship; (2) the shadowy position of a daughter-in-law; (3) the incompetence as a mother; and (4) the dilemma of a woman's identity. The second category is fragmented time-space representation. The themes included are: (5) cultural bondage; (6) loss of ideals; and (7) reinterpretation of family history. The third category is the uneasy self. It contains the themes of: (8) psychological disability; (9) sense of self-dissatisfaction; and (10) the notion or behavior of destruction.

Adult↗

Prevalence of selected maternal behaviors and experiences, Pregnancy Risk Assessment Monitoring System (PRAMS), 1999.

PROBLEM/CONDITION: Various maternal behaviors and experiences before, during, and after pregnancy (e.g., unintended pregnancy, late entry into prenatal care, cigarette smoking, not breast-feeding) are associated with adverse health outcomes for both the mother and the infant. Information regarding maternal behaviors and experiences is needed to monitor trends, to enhance the understanding of the relations between behaviors and health outcomes, to plan and evaluate programs, to direct policy decisions, and to monitor progress toward Healthy People 2000 and 2010 objectives. REPORTING PERIOD COVERED: This report covers data from 1993 through 1999. DESCRIPTION OF SYSTEM: The Pregnancy Risk Assessment Monitoring System (PRAMS) is an ongoing, state- and population-based surveillance system designed to monitor selected self-reported maternal behaviors and experiences that occur before, during, and after pregnancy among women who deliver a live-born infant. PRAMS employs a mixed-mode data collection methodology; up to three self-administered surveys are mailed to a sample of mothers, and nonresponders are followed up with a telephone interview. Self-reported survey data are linked to selected birth certificate data and weighted for sample design, nonresponse, and noncoverage to create annual PRAMS analysis data sets. PRAMS generates statewide estimates of various perinatal health topics among women delivering a live infant. Data for 1999 from 17 states are examined. In addition, trend data are examined for 12 states that had at least 3 years of data during 1993-1999. RESULTS: In 1999, the prevalence of unintended pregnancy resulting in a live birth ranged from 33.7% to 52% across the 17 states. During 1993-1999, only one state reported a decreasing trend in the prevalence of unintended pregnancy. Women aged <20 years, black women, women with less than or equal to a high school education, and women receiving Medicaid were more likely to report unintended pregnancy. The prevalence of late or no entry into prenatal care ranged from 16.1% to 29.9%. The prevalence of late or no entry into prenatal care significantly decreased over time in seven of the 12 states with trend data. In general, women aged <20 years, black women, women with less than a high school education, and women receiving Medicaid were more likely to report late or no entry into prenatal care. The prevalence of smoking during the last 3 months of pregnancy ranged from 6.2% to 27.2%, and the prevalence decreased in five states from 1993 to 1999. Overall, smoking during the last 3 months of pregnancy was associated with younger age (<25 years), non-Hispanic ethnicity, having less than or equal to a high school education, receiving Medicaid, and delivering a low birthweight infant. The prevalence of physical abuse by a husband or partner during pregnancy ranged from 2.1% to 6.3%. No trends were observed for physical abuse from 1996 to 1999, the only years for which these data were available. Across the 17 states, only Medicaid status was consistently associated with experiencing physical abuse during pregnancy. The prevalence of breast-feeding initiation ranged from 48% to 89%. Ten of 12 states with trend data reported increases in the prevalence of breast-feeding initiation. Overall, women aged <20 years, women with less than or equal to a high school education, and women receiving Medicaid were less likely to breast-feed. The prevalence of breast-feeding duration for at least 4 weeks ranged from 34.9% to 78.1%. From 1993 to 1999, increases in levels of breast-feeding for at least 4 weeks were observed in eight states. Women aged <25 years, black women, women with less than or equal to a high school education, and women receiving Medicaid were generally less likely to breast-feed for at least 4 weeks. The prevalence of back sleep position for infants ranged from 35.1% to 74.6%. Increases in the use of the back sleep position were observed in all 12 states with trend data from 1996 to 1999. Black race and having less than or equal to a high school education were consistently associated with not using the back sleep position. INTERPRETATION: For surveillance during 1993-1999, the majority or all states observed increases in breast-feeding initiation, breast-feeding for at least 4 weeks, and back sleep position. Approximately one half of the states observed decreases for late or no entry into prenatal care and smoking during the last 3 months of pregnancy. Little or no progress was observed in the prevalence of unintended pregnancy or physical abuse during pregnancy. With few exceptions, the 17 states failed to meet the Healthy People 2000 objectives for the seven reported behaviors in 1999. Certain de

Adolescent↗

Left ventricular ejection time. multiple relation to physiological and biometrical data; prediction of reference standards.

The relationship between left ventricular ejection time, and physiological or biometrical data, is submitted to multivariate statistical analysis. Methodology is intended to attain three objectives: 1) to simulate a controlled-condition experiment in clinical research, by using the statistical method of multiple regression; 2) to get a wide inference of conclusions, by selecting a sample of two hundred subjects whose biological data cover a wide field; 3) to check the really prospective value of results, by applying the formula worked out in a group of a hundred subjects to another independent group of a hundred subjects. The prediction formula of ejection time takes into account: stroke volume, cardiac cycle duration, body height, sex, age, pulse pressure, blood capacity in oxygen, presence or absence of digitalis treatment or atrial fibrillation. The first aim of the formula is to better evaluate the normal relationship between considered variables. Secondarily it leads to a proposal for estimating mechanical performance of the left ventricle.

Adolescent↗

Effect of acute portal hypertension on gut mucosa.

BACKGROUND/AIMS: Patients with cirrhosis are predisposed to develop spontaneous bacteremias and peritonitis, mainly by enteric bacteria. Portal hypertension, by producing congestion and edema of the bowel wall, could increase the passage of bacteria from the intestinal lumen to regional lymph nodes to the systemic circulation or to both, a process termed bacterial translocation. The aim of this study was to investigate bacterial translocation, brush border enzyme activity and intestinal permeability of experimental acute portal hypertension. METHODOLOGY: Twenty-six male Wistar rats were used for all experiments. Rats were studied two days after the induction of portal hypertension (n = 13). Control animals were also studied two days after sham operation (n = 13). Samples of mesenteric lymph nodes for standard bacteriological cultures and a fragment of ileum for histological examination and mucosal contents of protein, Alp were obtained. Moreover, we evaluated the intestinal permeability by using the phenolsulfonphthalein test. RESULTS: Two days after surgery, a significantly greater properties of rats with acute portal hypertension (12 of 13, 92%) had positive mesenteric lymph node cultures compared with control group: sham operated (2 of 13, 15%). A significant increase in disappearance of phenol red from the luminal solution was observed in rats with acute portal hypertension. Brush border enzyme of Alp was also significantly decreased in acute portal hypertension, compared with in sham operated controls. CONCLUSIONS: The results of our study suggested that acute portal hypertension may be a major factor in the development of spontaneous infections in cirrhosis.

Alkaline Phosphatase↗

Maternal-fetal attachment: searching for a new definition.

Maternal-fetal attachment is the purest source of the powerful attachment relationship, the gradual internalisation of the life within unspoilt by the realities and complexities of early parenting. This qualitative study searches for a definition of attachment utilising a phenomenological framework. An opportunity sample of 10 women in the final trimester of pregnancy was interviewed. Interviews were transcribed and analysed using Glaser & Strauss's (1967) constant comparative methodology. Thirteen key themes were identified, of these 4 were specific to parenting experience. A novel finding contrary to earlier studies was that women reported their overwhelming emotion was not love but an innate desire to protect. Protection, the developmental nature of attachment and importance of the emotional and physical support of a partner or parent form the kernel of an evolving paradigm.

Empathy↗

[Nucleic acid molecular hybridization as a method for the laboratory diagnosis of influenza: its potentials and prospects].

Experiments carried out by the present moment in a number of laboratories indicate that the method of molecular hybridization (MH) has great diagnostic potential. Sufficient methodological mastery of the reaction of radioactively labeled DNA probes with RNA samples applied into a polymer membrane and good supply of commercially available materials make it possible to recommend this method for use in reference laboratories at specialized diagnostic centers. Hybridization should be used in combination with traditional virological and serological tests; the combined use of MH and the enzyme immunoassay for the determination of viral antigens permits the documentation of 90-98% of all cases of influenza A with sufficient rapidity. In the near future DNA probes for the diagnosis of influenza B and C are likely to appear. MH has rather good prospects for the analysis of experimental infection in laboratory animals, as well as for the study of the replication of influenza virus in all cultures. The prospects of the study of the processes of expression of individual genes seem to be particularly attractive. MH may play an important role as a tool for documenting vaccinal reaction, as well as for the study of the action of different chemical preparations in volunteers. And finally, the greatest expectations are linked with the use of MH for the search of inapparent (persistent, latent, etc.) forms of influenza virus infection both in experimental systems and in humans. Optimistic prospects of the studies in this field are based on high sensitivity of this method combined with its equally high specificity. An additional reserve for enhancing sensitivity is also present here due to the amplification of target molecules.

DNA Probes↗

Tentacle regeneration in Hydra: a quantitative methodological approach.

A quantitative method is proposed for the evaluation of distal regeneration in Hydra attenuata; it is based on estimates of tentacle elongation during 10 days of regeneration, determination of a Tentacle Regeneration Index, and a statistical analysis of profiles obtained from various samples in different experiments. The results show that: polyps under normal conditions have similar regeneration patterns, regardless of individual variability; and ATxII, a neurotoxin of cnidarian origin, produces a statistically significant increase in the Tentacle Regeneration Index. The results are discussed in relation to pattern formation and growth in Hydra.

Animals↗

Making a difference: nursing assistants' perspectives of restorative care nursing.

This article explores the experiences of nursing assistants who participated in the Res-Care Pilot Intervention. A qualitative study used a focus group methodology. An interview guide was used and data from focus groups were audiotaped and transcribed verbatim. A purposive sample of 13 nursing assistants participated in the focus groups. A total of 35 different codes were identified, and these were reduced to the following four themes: resident barriers to restorative care, facility or system barriers to restorative care, nursing assistant strategies, and system facilitators of restorative care. The study supports and adds to previous work that suggests that in order to successfully implement changes in care in nursing home settings the following issues should be addressed: real or perceived workload issues, poor communication with nursing, insufficient knowledge or education, lack of appropriate supplies, and insufficient administrative support. The findings may be used to revise the Res-Care Pilot Intervention and direct future implementation of programs in nursing home settings.

Attitude of Health Personnel↗

Teaching development in undergraduate and graduate medical education.

Faculty members from three different institutions, each with long-standing experience teaching development, present strategies for teaching normal development in undergraduate and graduate medical education. This article provides an overview of licensing body requirements, teaching methodology, audiovisual and textbook resources, goals and objectives (knowledge, skills, and attitudes), and sample curricula for teaching human development to medical students, general psychiatry residents, and child and adolescent psychiatry residents. The challenges of teaching development to various groups of trainees with different required course lengths and expected levels of competency, using lifespan and topical approaches, are reviewed.

Accreditation↗

Prevalence of childhood sexual abuse among incarcerated males in county jail.

OBJECTIVE: The current study examined the prevalence and characteristics of childhood sexual abuse in a jailed-based population. METHODOLOGY: A retrospective, self-reported survey was administered over an 8-week period to a random sample of 100 men who were incarcerated in a county jail in Southeastern Texas. The survey included questions about childhood sexual experiences before and after puberty, drug history and use, and sexual risk-taking behaviors. RESULTS: Of the 100 male inmates who participated in this study, 59% reported experiencing some form of sexual abuse before puberty, and all such instances occurred before or at the age of 13 years. The first episode of childhood sexual abuse began at an average age of 9.6 years (SD = 2.4), and ended at an average age of 13.0 years (SD = 2.3). Kissing and touching without intercourse (64%) was the common pattern of sexual abuse experience reported. The total number of perpetrators was 165, with 10% male and 90% female. Friends (n = 72) and family (n = 56) were the most frequent perpetrators. CONCLUSION: Childhood sexual abuse may be more prevalent among inmates than among males in the general population. These results show a high percentage of inmates who report a history of childhood sexual abuse; this rate is higher than those reported by other studies for incarcerated males. The findings support the belief held by professionals in the criminal justice field that a significant number of incarcerated males may have been victims of sexual abuse.

Adolescent↗

The formation of rhythmic categories and metric priming.

Two experiments on categorical rhythm perception are reported, the object of which was to investigate how listeners perceive discrete rhythmic categories while listening to rhythms performed on a continuous time scale. This is studied by considering the space of all temporal patterns (all possible rhythms made up of three intervals) and how they, in perception, are partitioned into categories, ie where the boundaries of these categories are located. This process of categorisation is formalised as the mapping from the continuous space of a series of time intervals to a discrete, symbolic domain of integer-ratio sequences. The methodological framework uses concepts from mathematics and psychology (eg convexity and entropy) that allow precise characterisations of the empirical results. In the first experiment, twenty-nine participants performed an identification task with 66 rhythmic stimuli (a systematic sampling of the performance space). The results show that listeners do not just perceive the time intervals between onsets of sounds as placed in a homogeneous continuum. Instead, they can reliably identify rhythmic categories, as a chronotopic time clumping map reveals. In a second experiment, the effect of metric priming was studied by presenting the same stimuli but preceded with a duple or triple metre subdivision. It is shown that presenting patterns in the context of a metre has a large effect on rhythmic categorisation: the presence of a specific musical metre primes the perception of specific rhythmic patterns.

Auditory Perception↗

Population aspects of human working capacity.

Population measurements of human physical working capacity are reviewed. Problems of technique include an appropriate sample size, allowance of sampling bias, selection of an appropriate criterion of working capacity, and standardization of test methodology. The impact of constitution has been studied in terms of overall variance of data, frequencies of genetic markers, and twin sibling studies. Environmental experiments have compared similar races in different environments and vice versa. Athletes have been examined as examples of a combined genotypic and phenotypic response. Adaptations to the environment include adverse climate (extremes of heat, cold, rain and drought), hilly terrain and extreme high altitudes; an enhanced working capacity in hilly districts and circumpolar regions probably reflects vigorous daily activity. Socio-economic determinants of working capacity include nutrition, family size, chronic disease, and daily activity. Population differences in the course of growth and ageing seem to reflect differences of nutrition and daily activity. Population scientists have yet to define clearly the relative importance of phenotypic and genotypic adaptation in the development of working capacity; however, studies arising from the International Biological Programme have made valuable contributions to both test methodology and the understanding of interactions between man and his environment.

Adaptation, Physiological↗

Phenomenological lived experience of patients with rheumatoid arthritis.

This phenomenological study explored (a) the lived experience of rheumatoid arthritis (RA), (b) the patient's view of the nurse's role, and (c) the patient as comanager of RA. The purposive sample consisted of 6 Caucasian women living in West Virginia. Using Colaizzi's methodology, a rich, exhaustive description of living with RA emerged. Recommendations for nursing care quality focus on providing personalized, holistic, and humanistic care, which may ultimately improve the patient's quality of life.

Activities of Daily Living↗

Evaluating health-care: the perspectives of sufferers with upper limb pain.

BACKGROUND AND AIMS: There is considerable uncertainty over the diagnosis, treatment and management of upper limb pain, which has implications for patient care. Research into patient experiences and evaluation of health-care has been neglected and the study presented here aims to fill this gap. METHODS: A two-staged, mixed methodology was adopted. Phase 1 involved a postal survey of a random sample (n = 2781) of the working age population (25-64) of an area in south-west England. Phase 2 consisted of follow-up, informal face-to-face interviews with a purposive sample of 47 informants identified, according to pre-defined criteria, from the survey sample. RESULTS: Our data showed that concerns about the effectiveness of treatments for alleviating pain were fundamental to users' evaluations of both orthodox and non-orthodox health-care. This took priority over the need for a diagnosis and other information. There was a general recognition that the treatments available were, at least, only partially effective and the pragmatic approach led some to eventually withdraw from both orthodox care and complementary and alternative medicines (CAM). CONCLUSION: Patients' priorities for health-care, in this context, were perceived to involve the provision of treatments which alleviated pain and were safe and painless. Orthodox and non-orthodox care needed to be more closely integrated into primary care services.

Adult↗