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At least 361 records · Page 20Linked to original sources
PubMed2001

The semitendinosus tendon regenerates after resection: a morphologic and MRI analysis in 6 patients after resection for anterior cruciate ligament reconstruction.

Recently, the surprising observation has been made, supported by clinical and MRI findings, that the semitendinosus tendon can regenerate after being harvested in its whole length and thickness for anterior cruciate ligament reconstruction. We studied 6 patients with previous anterior cruciate ligament reconstruction, using a quadruple semitendinosus tendon autograft. In 5 of these, physical examination and MRI showed that the tendond had regenerated. In all 6 patients, the findings were documented macroscopically by open surgical exploration and in the 5 regenerated tendons, also morphologically by biopsies. Macroscopically, histologically and immunohistochemically the regenerated tendons closely resembled normal ones with focal scar-like areas. Our present findings and earlier studies show that full length and thickness harvesting of the semitendinosus tendon in most cases result in full-length tendon regeneration with tissue closely resembling the normal tendon.

Adolescent↗
PubMed1999

Disparate surgical margin lengths of colorectal resection specimens between in vivo and in vitro measurements. The effects of surgical resection and formalin fixation on organ shrinkage.

We noticed almost routine disparate results in margin lengths when colorectal specimens are measured in vivo by the surgeon and in vitro by the pathologist. We studied 26 sigmoid and rectum specimens to document the amount of organ shrinkage after surgical removal and fixation. Each specimen had a 5.0-cm segment at each end of the specimen marked by serosal sutures before vascular devitalization. The segments were measured after the specimen sat unfixed for 10 to 20 minutes and after 12 to 18 hours of formalin fixation. The segments shrank to a median length of 3.0 cm (40% of the in vivo length) after 10 to 20 minutes and an additional 0.85 cm, to a median length of 2.15 cm, after fixation. Overall after fixation, the segments shrank 57% of the in vivo length. Approximately 70% of the shrinkage occurred during the first 10 to 20 minutes after removal, and the remaining 30% occurred after fixation. For optimal accuracy, margin distance must be obtained immediately after surgical removal. Once the specimen has been removed for several minutes, the difference between unfixed and fixed margin lengths is 30%. A correction factor of approximately 2x should be applied when interpreting the margin length.

Adenocarcinoma↗
PubMed1978

Endorectal mucosal resection without proctectomy as an adjunct to abdominoperineal resection for nonmalignant conditions: clinical experience with five patients.

Five patients with chronic ulcerative colitis underwent endorectal excision of the rectal mucosa without removing the rectal muscle in combination with total colectomy and cutaneous ileostomy. This operative technique will cure the patient of the primary disease and obviates many of the usual unpleasant complications following total proctectomy, such as prolonged perineal drainage and sexual and bladder dysfunction. It has the further advantages of lower operative blood loss and earlier safe ambulation. On the basis of favorable clinical experience with these patients, we believe that the operation warrants further clinical trial in patients who have biopsy-proven ulcerative colitis without severe rectal ulcerations as well as in certain other nonmalignant conditions originating in the rectal mucosa.

Adolescent↗
PubMed2005

Magnetic resonance imaging of remaining physis in partial physeal resection with graft interposition in a rabbit model: a comparison with physeal resection alone.

OBJECTIVE: The purpose of this study was to evaluate the effect of graft interposition into a physeal defect on the remaining physis. MATERIALS AND METHODS: Bilateral partial physeal defects were made in the medial half of the proximal tibiae of 8-week-old New Zealand white rabbits (n=25). Biologic material (autogenous chondrocytes derived from perichondrial cells incorporated into beads) was implanted in the left-sided physeal defect, and right-sided untreated tibial defects were used as controls. Magnetic resonance (MR) imaging was obtained at 2, 4, 8, 12, and 16 weeks after operation using a 1.5-tesla MR unit. T1WI, T2WI, and gradient-recalled echo (GRE) images were obtained in the coronal plane. The MR features of physeal defects and of remaining physes were compared between grafted tibiae and controls, as were histologic results and the heights of the remaining physes. RESULTS: Histologically, cartilage clusters were detected in the 17 cases of grafted tibiae (68%), whereas a bone bridge was observed in all controls. The cartilage clusters showed high signal intensity on both T2WI and GRE and low signal intensity on T1WI at 2 weeks postoperatively, and became low signal intensity on T2WI at 8 weeks. On GRE images, high signal intensities of the remaining physes disappeared earlier in the control tibiae than in the grafted tibiae. The remaining physes of control tibiae showed altered histologic configurations and a progressive decrease in physis height. Quantitative measurements of the height of the remaining growth plates showed a significant difference between grafted tibiae and controls (P <0.001). CONCLUSION: Graft interposition into a partial physeal defect may prevent early closure of the remaining physis and bone bridge formation. MR imaging can depict alterations of remaining physes that lead to early closure of the physis.

Animals↗