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PubMedDate not supplied

Composite tissue transplantation in rats: fusion of donor muscle to the recipient site.

UNLABELLED: Little information currently exists on the repair of muscular tissue at the site of an amputation stump. This study examined the healing process of muscular tissue following composite limb transplantation using transgenic rat models. METHODS: Green fluorescent protein (GFP) transgenic rats were used to study the process of connection of donor muscle with the recipient. A DsRed2/GFP double-reporter transgenic rat and an NCre transgenic rat were used to study cell fusion. These rats have the unique characteristic of changing red fluorescence to green fluorescence by Cre/LoxP recombination when cell-to-cell fusion occurs between the two transgenic strains. Orthotopic hind limb transplantation was performed in two combinations: GFP transgenic rat to Wild Wistar rat and DsRed2/GFP transgenic rat to NCre transgenic rat. RESULTS: We observed extension of donor-derived GFP(+) myofibers into recipient site a few weeks after limb transplantation. A histologic study of the DsRed2/GFP transgenic rat to the NCre transgenic rat combination showed that red myofibers of the DsRed2/GFP rat were partly replaced by green myofibers as a result of Cre-mediated recombination. PCR analysis detected both the recombined transgene (330 bp) and the nonrecombined gene (1420 bp) in muscle around the junction. These findings indicate that the muscles sutured between the amputation stumps fused with each other and that donor-recipient hybrid cells were formed at the muscle junction following limb transplantation. CONCLUSIONS: This basic information shows muscle fusion between donor and recipient at the site of composite tissue transplant using newly established transgenic rats.

Animals↗
PubMed2002

Flow-through use of the osteomusculocutaneous free fibular flap.

A case of a forearm defect resulting from a high-velocity firearm injury was reconstructed by flow-through free transfer of the osteomusculocutaneous fibular flap harvested from the remaining stump of the patient's left leg that was amputated below the knee. The dimensions of the bone defect and damage to anatomic structures of more than one type (including ulnar artery, ulnar bone, and overlying soft tissue) were the reasons for the treatment approach with a composite tissue transfer including vascularized bone. Preoperative radiographic and angiographic examination revealed that the amputation stump offered a fibular shaft with adequate length and a peroneal artery patent up to the most distal point of the bone. Instead of the usual osteocutaneous fibular harvest, flap harvest was performed in an osteomusculocutaneous manner with incorporation of a segment of soleus muscle with an overlying skin paddle. In addition to the replacement of the bone defect, transfer of the flap in a flow-through manner reestablished the dual blood supply of the hand by replacing the ulnar artery gap, whereas the muscle and skin of the flap allowed three-dimensional reconstruction of the complex defect. In severe injuries of the upper extremity, flow-through free transfer of the fibular flap provides not only replacement of the resulting composite defect but also may offer salvage, or at least revascularization, of the extremity when complicated by arterial damage.

Adult↗
PubMed1998

Incidence and characteristics of patients with hand ischemia after a hemodialysis access procedure.

The purpose of this study was to determine the clinical characteristics of chronic renal failure patients who developed hand ischemia in the limb carrying the dialysis angioaccess. A retrospective review of the charts of 352 patients who underwent 409 upper extremity arteriovenous access, and who were subsequently diagnosed as steal syndrome, was performed at the Emory University Hospital between February 1992 and January 1997. Hand ischemia occurred after 13 of 299 arteriovenous grafts (4.3%) and after 2 of 110 direct forearm arteriovenous fistulas (1.8%). Six patients developed ischemic manifestations immediately postoperatively, 2 in the first week, 4 after 1 month, and 1 after 1 year. Thirteen occurred in association with the primary access procedure. Two cases occurred following graft thrombectomy and outflow dilatation. Seven patients were mildly symptomatic with dialysis-induced pain, coldness, or numbness; 8 patients developed severe ischemic manifestations in the form of sensory loss in 3, severe intolerable pain with impalpable pulse in 3, and digital gangrene and amputation in 2, one of whom developed an unhealed amputation stump and required a higher amputation level with satisfactory healing of the revised stump. Three patients were treated conservatively, 6 by banding, 4 by ligation, 1 by embolization, and 1 by distal ligation and bypass operation. Clinical characteristics of patients with hand ischemia included long-standing insulin-dependent diabetes (10), chronic hypertension (12), peripheral arterial disease (14; 93.3%), coronary artery disease (8), and systemic lupus erythematosis (1). Severe peripheral arterial diseases are commonly found and may be markers for risk of hand ischemia after access surgery.

Amputation, Surgical↗
PubMed1991

A clinical evaluation of stumps in lower limb amputees.

A study was carried out on 93 consecutive unilateral below-knee (BK) and 62 above-knee (AK) amputees. The dimensions of the amputation stumps were measured and the general condition and contralateral limb assessed at the time of prosthetic fitting. After one postoperative year, follow-up information for 124 (89%) of the surviving patients was obtained by personal contact. The observations were based on the standard formula for stump classification constructed by the International Society for Prosthetics and Orthotics. The 93 BK stumps had a mean length of 16.0 cm and the 62 AK stumps a mean length of 28.0 cm. The scar on the stump was adherent in 13% of BK and 2% of AK stumps. The scar was deeply wrinkled in 7% of BK stumps and 10% of AK stumps. The scar on the stump was most frequently adherent or deeply wrinkled in trauma patients (33%). The skin was undamaged in 93% of all the patients at the first visit and in 94% at the time of follow-up. The mobility of the stump in the proximal joint was limited at the time of prosthetic fitting in 15% of cases. Phantom pain was reported by 59% and stump pain by 5% of patients at this time. Although the phantom pain was mild in most cases, it was usually still present after one year, and 53% of the surviving patients suffered from phantom pain. At the first visit, 20% of patients had problems in their contralateral leg. During the first postoperative year, 6 contralateral BK amputations were performed in the BK group and one contralateral AK amputation in the AK group. Thus, along with examination of the stump, attention must be paid to the contralateral limb with a view to preserving it. The study supports the usefulness of the standard form and classification of amputation stumps.

Adolescent↗
PubMed1991

The autologous stump plasty. Treatment for bony overgrowth in juvenile amputees.

Autologous stump capping is a procedure designed to prevent bony overgrowth in skeletally immature amputation stumps. All 19 capping procedures in the lower extremities were successful after an average follow-up of 7.3 years. All patients use their prostheses, and no secondary operations have been needed for stump problems. Of the 31 cap-plasties of the humerus, six required re-operation. The overall failure rate of 12% is low compared with the failure rate of re-amputation.

Adolescent↗
PubMed1994

Revision of failed below knee amputations. Local debridement with gentamicin collagen.

OBJECTIVE: To describe our results with a new technique of revision of failed below knee amputation stumps using gentamicin impregnated collagen sponge. DESIGN: Open study. SETTING: District hospital. SUBJECTS: 31 patients who underwent below knee amputations between 1988 and 1992, compared with 31 historical controls who were operated on between 1984 and 1988. INTERVENTIONS: Two thirds of the stumps that failed to heal underwent excision of necrotic and devitalised tissue; half had shortening of tibia and fibula and a gentamicin impregnated collagen sponge was left in the wound, which was then closed. MAIN OUTCOME MEASURES: Successful wound healing and rehabilitation. RESULTS: 12 Stumps failed to heal, 8 of which were suitable for local treatment with the gentamicin sponge. All 8 healed satisfactorily, though one required revision of the scar 6 months later. Of the remainder, the stumps were converted to above knee amputations (n = 3) and one was disarticulated at the knee. In the control group 5 of the 7 stumps in which healing failed, were converted to above knee amputations and the other two healed after split skin grafting. CONCLUSION: We think that local treatment with the collagen sponge with gentamicin offers a viable alternative to conversion to above knee amputation for below knee amputation stumps that fail to heal. The treatment should now be subjected to a randomised controlled trial.

Adult↗
PubMed1979

Preservation of the functional above knee stump following hip disarticulation by means of an Austin-Moore prosthesis.

Patients can be provided with a functional above-knee amputation stump when the tumor is not resectable. In order to do this and still remove the entire upper end of the femur a small Austin-Moore prosthesis with drill holes is inserted and enclosed in long anterior and posterior flaps. Muscle attachments are sutured into the distal stem to obtain the balance between abduction and extension of a functional stump.

Adolescent↗
PubMedDate not supplied

The use of bone bridges in transtibial amputations.

UNLABELLED: We sought to describe the bone bridge technique in adults, and present a variation for use in children, as well as to present its applicability as an option in elective transtibial amputations. This paper presents a prospective study of 15 transtibial amputations performed between 1992 and 1995 in which the bone bridge technique was employed. The patients' ages ranged from 8 to 48 years, with an average of 22.5 years. This technique consisted of the preparation of a cylinder of periosteum extracted from the tibia and with cortical bone fragments attached to it to promote a tibiofibular synostosis on the distal extremity of the amputation stump. We noted that the cortical bone fragments were dispensable when the technique was employed in children, due to the increased osteogenic capacity of the periosteum. This led to a variation of the original technique, a bone bridge without the use of the cortical bone fragments. RESULTS: The average time spent with this procedure, without any significant variation between adults and children, was 171 minutes. The adaptation to the definitive prosthesis was accomplished between 20 and 576 days, with an average of 180 days. Revision of the procedure was necessary in 3 amputations. CONCLUSIONS: This technique may be employed in transtibial amputations in which the final length of the stump lies next to the musculotendinous transition of the gastrocnemius muscle, as well as in the revision of amputation stumps in children, where the procedure has been shown to be effective in the prevention of lesions due to excessive bone growth.

Adolescent↗
PubMed1976

Muscle blood flow after amputation with special reference to the influence of osseous plugging of the medullary cavity. Assessed by 133 xenon and histamine. An animal experiment.

The muscle blood flow (MBF) in rabbits subjected to amputation of the crus was assessed by means of 133 Xenon and Histamine. It was shown that after the operation the flow in the amputation stump was initially reduced. MBF in the stump increased more rapidly and stayed at a higher level after closure by myoplasty than after amputation without myoplasty, and it was still further stimulated after osseous plugging of the medullary cavity.

Amputation Stumps↗
PubMed1991

Pilonidal sinus in an amputee.

A pilonidal sinus developed in the superio-medial aspect of the thigh of an above-knee amputee. This is an unusual site for the condition to develop. We suggest that the same aetiological factors that were responsible for the "Jeep Bottom" of World War II were also responsible for this problem in the amputation stump of a Falklands campaign casualty.

Adult↗
PubMed1987

A new treatment of painful amputation neuroma: a preliminary report.

Two cases of painful amputation neuroma treated by a new method are described. A vascularized island transfer from a less important finger was used, but the accompanying nerve was divided and its distal end sutured to the proximal end of the nerve in the recipient finger, after excision of the neuroma. Four years and two years later, no clinical evidence of neuroma was present at either amputation stump or donor site.

Amputation Stumps↗
PubMed1982

Pneumatic Airleg prosthesis: report of 200 cases.

The pneumatic Airleg is a recently developed prosthetic system for the early mobilization of the patient with lower extremity amputation. It has been used as an alternative for the rigid plaster of paris dressing in immediately postoperative prosthetic fitting and ambulation, and has also been employed as a temporary prosthesis in the total contact weight-bearing ambulation of patients with open or ulcerated amputation stumps. The latter is illustrated by 3 case reports Advantages are ease of application and removal, availability of the amputation site for inspection, and early institution of weight-bearing ambulation with minimal discomfort.

Adult↗
PubMedDate not supplied

[Kinematics of various joint mechanisms for the prosthetic substitution of the knee joint following knee exarticulation].

In the past, long amputation stumps of the thigh after knee disarticulation were difficult to fit with a knee prosthesis. Apart from other difficulties, one essential problem was caused by the fact that in preservation of the femoral length there was little or even no space to assemble a knee prosthesis at the level of the axis of the natural knee joint, that is to say at a position somewhere within the femoral condyles. In the meantime the number of knee disarticulations has increased and thus substituted the conventional above knee amputation. Consequently some new, partly polycentric knee joint mechanisms have been designed for the prosthetic fitting of knee disarticulation stumps as well as for long amputation stumps of the thigh. These mechanisms try to cope with the space problem in different ways and, moreover, some of them can also produce a moving centre of rotation at joint flexion similar to the natural knee joint. The motion pattern in current knee joint mechanisms is investigated by graphical construction of their centrodes and it is compared to the motion pattern of the natural knee joint.

Artificial Limbs↗
PubMed1987

Sequence of development of innately regenerated growth-plate cartilage in the hindlimb of the neonatal rat.

It has long been appreciated that the neonatal rat can regenerate the distal femoral growth-plate. Earlier descriptions of this process pointed to the age of the rodent and level and angle of amputation as significant modifiers of the regeneration process; but none identified the origin of the chondrocytes forming the growth-plate regenerate, nor described the time course and significant milestones of the process. Examination of these issues constitutes the objective of the present report. Fifty-four male, outbred albino rats sustained low femoral (48 rats) or midtibiofibular (six rats) hind-limb amputations when ten to eleven days old. They were killed after 0, 1, 2, 4, 7, 14, 22 or 29 postoperative days; and their amputation stumps were sectioned longitudinally. Twenty-four hr after amputation, the distal femoral periosteum was thickened and metachromatic regions were observed forming within it. Intraperiosteal cartilage was observed by the end of the second postoperative day in four of six limb stumps and, during the following week, expanded considerably in volume. Regenerated growth-plate cell architecture was recognized within the enlarging cartilage mass by the end of the second week; and, by the end of the fourth postoperative week, the regenerating growth-plate region had achieved considerable architectural maturity.

Amputation, Surgical↗
PubMed1999

Relaxed versus activated stump muscles during casting for trans-tibial prostheses.

In prosthetic practice, the question often arises as to whether the hand cast should be made from a contracted or from a non-contracted amputation stump. To elucidate this question, the authors have performed a study to quantify the volume difference between these 2 conditions, and to relate the differences to prosthetic fitting. Sixteen (16) trans-tibial amputees participated in the study. All of them were fitted with an ICEROSS silicone socket. Electromyographic studies, with electrodes attached to the anterior tibial and medial gastrocnemius muscles, were carried out to determine muscle contraction levels. Volume determinations were made with the CAPOD laser scanning system. Measurements were performed with and without the silicone liner on the stump. Without a silicone liner, the volume of the stump increased by 5.8% (SD=5.3) as the muscles contracted. This increase was statistically significant. With the liner donned the volume increased 3.5% (SD=3.3). This increase was also statistically significant. The volume of the prosthetic socket was also compared with the stump volume with a silicone liner on. For the relaxed stump, the difference was 1.8% (SD=10.1), and for the contracted stump -1.7% (SD=11.3). Neither difference was statistically significant. The importance of these volume changes and how they influence stiffness of the coupling between the stump and the socket are discussed. It is concluded, that the observed difference in volume between a contracted and a non-contracted stump are large enough to be considered by the prosthetist in his decision on how to make a hand cast.

Aged↗
PubMed1991

The selection of amputation level: an approach using decision analysis.

The choice of level for a major amputation of the leg depends upon the careful balancing of the advantages of preserving the knee joint against the risks of failure to heal and subsequent revision of the amputation stump. A study has been carried out to measure the values that health care professionals put upon different levels of disability resulting from amputation. The results show that the reduction of quality of life is thought to be 5-10% and 10-20%, respectively, for ambulation upon a below-knee and above-knee prosthesis and about 50% for failure to mobilise on an artificial limb. These utilities have been incorporated into a decision analysis to determine the optimum strategy for evaluation of amputation level, with other probabilities obtained from published data. The results demonstrate the advantage of attempting to preserve the knee joint, even if the chance of primary healing is as low as 20%. Tests of likely healing are most useful if the sensitivity is high, with specificity being less important, and the advantages may be outweighed by the costs of false negatives if sensitivity is below 90%. Sensitivity analysis shows that these findings remain valid over a wide range of possible values. Further research is required to gain more accurate information on which to base decisions, but on current evidence a policy of below-knee amputation in all cases of clinical doubt may be preferable to the use of currently available tests.

Amputation, Surgical↗
PubMedDate not supplied

Integra Artificial Skin as a useful adjunct in the treatment of purpura fulminans.

Purpura fulminans is a devastating disorder characterized by rapidly progressing hemorrhagic necrosis of the skin, vascular collapse, and disseminated intravascular coagulation. It is most often seen in children, and it is usually preceded by meningococcemia or another infection. Most often, the disorder results in severe skin loss, but it can also result in the need for extremity amputations. In extreme cases, wound coverage after excision may be problematic because of the limited existence of donor sites and the need for amputation revisions. The case of a 21/2-year-old male requiring amputations of all four extremities due to severe purpura fulminans is presented to illustrate the use of Integra Artificial Skin (Integra Lifesciences Corp., Plainsboro, NJ) to obtain immediate wound closure. Integra Artificial Skin is a bilayered skin substitute that engrafts to a viable wound bed. In the case presented here, where the viability of the underlying tissue of the amputated stumps was questionable, the artificial skin acted as an indicator of that viability. It engrafted well onto the upper extremity stumps, which were of excellent viability, but it needed to be replaced on the lower extremity stumps, which required further debridement and amputation revisions. The use of artificial skin spared the patient the immediate use of his limited and valuable autograft sites. In conclusion, Integra Artificial Skin can be a useful adjunct in the treatment of severe purpura fulminans that includes skin and extremity necrosis.

Amputation, Surgical↗