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PubMed1990

Two rare cutaneous neoplasms in horses: apocrine gland adenocarcinoma and carcinosarcoma.

Two rare equine cutaneous neoplasms, an apocrine gland adenocarcinoma and a carcinosarcoma were diagnosed in a 17-year-old pony and a 14-year-old mare, respectively. The apocrine gland adenocarcinoma was present on the prepuce. Histologically, papillary projections of low cuboidal to columnar epithelial cells were generally well differentiated, and surrounded dilated acini. Stromal invasion was present, but vascular and lymphatic invasion was not seen. The carcinosarcoma was present in the right flank of the mare. Two discrete cell populations were characterized histologically. One portion of the mass was composed of elongated, loosely arranged mesenchymatous cells; the second population consisted of dense sheets of pleomorphic, basophilic cells forming irregular acini.

Adenocarcinoma↗

PubMed1985

Carcinosarcoma of the floor of mouth.

Carcinosarcomas are rare tumors of the upper aerodigestive tract, consisting of both carcinomatous and sarcomatous tissue. The larynx and oral cavity are most frequently involved. There has been much controversy regarding the histological nature and clinical course of these tumors. We report a case of carcinosarcoma of the floor of mouth in a 76 year old man who presented with a large pedunculated sublingual mass. There was no evidence of regional or systemic metastatic disease. After local excision, he was followed for one year without evidence of recurrence or metastasis. A review of the literature is presented, with an attempt to clarify clinically relevant aspects of nomenclature, pathogenesis, and clinical course.

Aged↗

PubMedDate not supplied

Changes in tumor morphology in one human endometrial carcinosarcoma heterotransplanted into nude mice.

Tissue material from one human endometrial carcinosarcoma was transplanted into nude mice. In the third passage two independent tumor lines developed, which continued to grow independently. After the fifth passage one line could be diagnosed histopathologically as a poorly differentiated adenocarcinoma without sarcoma components, while the other line was still a carcinosarcoma. It was assumed that the development of two histologically different tumor lines could be due to clonal selection induced by the new host.

Adenocarcinoma↗

PubMed1989

[Carcinosarcoma of the lung: a report of 3 cases and a review of the literature].

Three cases of lung carcinosarcoma are reported. This kind of tumour accounts for 0.1 percent in lung tumours. 53 cases in the literatures were reviewed. Authors analysed the histology, morphology, diagnosis, treatment and diagnosis. The carcinosarcoma is single or multiple symptoms of the carcinoma in the bronchi appear early, but it is difficult to diagnose it early. Final diagnosis depends on the biopsies.

Adult↗

PubMed1988

[Carcinosarcomas of the bladder. Immunohistochemical study in 3 cases].

We present 3 cases of carcinosarcoma of the bladder. We discuss the value of histochemistry on their diagnosis. We compare them to similar tumors reported in the medical literature. Like fusocellular carcinoma, carcinosarcoma finally appear as a morphological variant of high grade urothelial carcinoma, often difficult to diagnose. With our present knowledge, it is not possible to propose for these tumors other therapeutic measures than those already in use for high grade urothelial malignancies, based on the level of infiltration in the bladder wall. The classic pejorative prognosis of these tumors is contradicted by the favorable evolution in some cases reported in medical literature.

Carcinosarcoma↗

PubMed1987

[Immunohistological demonstration of the intermediate filaments in a laryngeal carcinosarcoma: considerations on its histogenesis].

A carcinosarcoma of the larynx was analysed by means of a light microscope and by immunohistological staining technique using antibodies against various intermediate filament proteins. Whereas tumour areas of an epithelial character reacted with antibodies against keratin, the spindle cells demonstrated a positive immunofluorescence with vimentin antibodies. Inside some tumour cells a coexpression of keratin and vimentin (intermediate filaments of mesenchymal cells) could be demonstrated. It is likely that these double stained cells represent the primitive stem cell of the carcinosarcoma, differentiating during further development either into epithelial or mesenchymal tumour cells.

Carcinosarcoma↗

PubMed1988

Carcinosarcoma of the gallbladder: a case report and review of the literature.

A case of pedunculated carcinosarcoma of the gallbladder, presenting with common duct obstruction is reported; radiological, operative and pathological findings are described. The patient was treated with cholecystectomy, common bile duct exploration and postoperative radiotherapy applied through a t-tube. Only 20 cases of carcinosarcoma of the gallbladder have been described. The current state of knowledge regarding the natural history of these tumors are reviewed.

Aged↗

PubMed1986

[Carcinosarcoma of the gallbladder. Echographic and anatomopathological diagnosis. Apropos of a case with review of the literature].

Precise diagnosis of carcinosarcoma of gallbladder, a rare tumor, is based on histopathology since clinical and epidemiologic elements fail to differentiate it from other gallbladder cancers. Ultrasound imaging is the most effective radiodiagnostic technique since it allows visualization of the tumor and suggests the presence of a carcinosarcoma when a polypoid or vegetating mass is detected within the gallbladder.

Aged↗

PubMed1987

[An autopsy case of a so-called carcinosarcoma of the pancreas].

A case of a "so-called carcinosarcoma" of the pancreas that occurred in a 48-year-old female is reported. At autopsy, the pancreatic tumor was seen to have deeply invaded the gastric wall, causing ulceration. The pancreatic tumor consisted of two different histological components: a squamous cell carcinoma and spindle-cell sarcomatous tumor cells. Transitional areas between the two different tumor cells were also present. Since there were transitional areas and a lack of definitive electron microscopic evidence favoring a sarcoma in the sarcomatous tumor cells, the pancreatic tumor was considered to represent a "so-called carcinosarcoma".

Carcinoma, Squamous Cell↗

PubMed1985

Carcinosarcoma of the urinary bladder. Report of a case with electron microscopy and review of the literature.

A case of carcinosarcoma of the urinary bladder in a 33-year-old man is presented. The tumor developed from the left anterolateral wall and protruded into the vesical lumen. The excised tumor revealed that more than 99% was sarcomatous component with the appearance of an osteochondrosarcoma. Small foci of papillo-tubular carcinoma were scattered in the sarcomatous area. The histological features, histogenesis and treatment of carcinosarcoma of the bladder are discussed in relation to the literature.

Adult↗

PubMed1978

[Sarcomalike patterns in laryngeal carcinoma (pseudosarcoma, carcinosarcoma, spindle-cell-carcinoma, pleomorphic carcioma (author's transl)].

Report on 5 cases of so called carcinosarcomas of the larynx and hypopharynx and review of literature. These polypoid tumors have a small epidermoid carcinomatous part and a major part with sarcoma like appearance. The sarcomatoid tissue resembles to fibrosarcomas or some undifferentiated pleomorphic sarcoma. Observations of a gradual transition from the epithelial tumor cells to cells with a mesodermal appearance show that these tumors are varieties of squamous cell carcinomas (spindle cell or pleomorphic variety) and not "combination"--or "collision-tumors", "carcinosarcomas" or "seudosarcomas". These tumors appear in the larynx predominantly in man, at the same sites and in the same ageclasses as common squamous cell cancers and are not less malignant. The sarcomatoid tissue can arise at the beginning of the disease or at a later stage it can appear or disappear after operation or irradiation. The reason for this change of cellular structure is unknown.

Aged↗

PubMed1978

[Carcinosarcoma of the uterus and ovaries].

It was established on the material of 15 observations that carcinosarcomas represented a distinct group of rarely occurring malignancies. Among malignant tumors of the body of the uterus, cervix and ovary they comprise 1.5%, 0.03% and 0.17%, respectively. The details of the structure of two tumor components, epithelial and mesenchymal, are described. A special group of carcinosarcomas of the body of the uterus and ovary consisting of three tumor germs, adenoacanthocarcinosarcoma, is distinguished.

Adenocarcinoma↗

PubMed1982

Heterologous carcinosarcoma of the fallopian tube. A case report.

Carcinosarcomas occur infrequently in the female genital tract. They arise predominantly in the uterus and much less frequently in the vagina, cervix and ovary. They rarely occur in the fallopian tube; only 25 such cases have been reported in the literature to date. The rarity of carcinosarcoma of the fallopian tube prompted this case report.

Aged↗

PubMed1981

[Carcinosarcomas of the lung].

The authors analysed the literature on pulmonary carcinosarcomas and described two own observations of this rare pathology. The predominant occurrence of this tumor in men of 40-65 years, rapid development of the process, frequent asymptomatic course and late surgical help are noted. Clinico-anatomical manifestations of pulmonary carcinosarcomas are nonspecific. Their histological structure is variable and depends on the nature of tissue components involved in the neoplastic process. The authors emphasize a great diagnostic value of prophylactic fluorographic examinations of the population.

Aged↗

PubMed1994

p53 gene mutation in female genital tract carcinosarcomas (malignant mixed müllerian tumors): a clinicopathologic study of 74 cases.

Mutations of the p53 suppressor gene are involved in carcinogenesis by inactivating p53 protein (p53P), which is involved in normal cell growth control. Mutant p53P, detectable by immunohistochemistry due to longer half-life as compared to wild-type, is a marker for p53 gene mutation. Seventy-four female genital tract carcinosarcomas (FGTCSs) (41 of the heterologous type exhibiting 33 rhabdomyosarcomatous, 13 chondrosarcomatous, one osteosarcomatous, and one liposarcomatous component) were stained using two commercially available monoclonal antibodies: p53P, clone DO7 (p53P-DO7) and p53P, Ab-6 (p53P-P6). p53P-DO7 and p53P-P6 stained 33 and 36, respectively, of 56 endometrial, 8 of 11 ovarian, 2 of 5 cervical, and 2 of 2 fallopian tube carcinosarcomas. Considering all 74 FGTCSs, p53P-DO7 and p53P-P6 stained both the carcinomatous component (CC) and the sarcomatous component (SC) in 46% and 54%, the CC only in 9.5% and 8.1%, and the SC only in 5.4 and 2.7%, respectively. The two antibodies for p53P showed the following concordance for staining of FGTCSs (either CC or SC or both) (p53P-DO7/p53P-P6): +/+, 58%; +/-, 1.3%; -/+, 6.7%; -/-, 34%. p53P immunoreactivity was not associated with histological features or grade of the CC or SC. Clinical follow-up was available in 72 cases, which showed 48.5% and 70.8% of patients recurred or died of disease by 12 and 80 months, respectively. 20.8% of patients were disease-free after 19 to 307 months of follow-up (median, 62; mean, 92). The remaining 8.4% of patients were disease-free but had insufficient follow-up (< 1 year).(ABSTRACT TRUNCATED AT 250 WORDS)

Antibodies, Monoclonal↗

PubMed1994

Carcinosarcoma of the ureter with unusual histologic features.

We report a rare case of carcinosarcoma of the ureter presented as a retroperitoneal tumor. The tumor originated in the ureter as a polypoid protrusion and spread around peri-ureteral, retroperitoneal tissues. The polypoid ureteral tumor was composed of an intra-epithelial carcinoma and a submucosal mesenchymal tumor; the histology of the retroperitoneal tumor in the original site was that of a carcinosarcoma. The bulk of the tumor in the retroperitoneum was composed of blastematous, epithelial and sarcomatous neoplastic cells with foci resembling an incomplete glomeruloid formation, thus mimicking a Wilms' tumor. The lesion appeared to originate from multipotential cells in the mucosal layer of the ureter. Whether or not this tumor has a true nephrogenic property is currently unknown. When a retroperitoneal tumor of the adult resembling a Wilms' tumor is found, one should suspect a possible carcinosarcomatous origin in the ureter.

Aged↗

PubMed1994

[Carcinosarcoma arising in eccrine spiradenoma. A morphologic and immunohistochemical study].

Malignant change in a benign eccrine spiradenoma is a rare but definite phenomenon. Since it was first reported by Dabska, 23 cases have been reported. All cases present recent changes in a long standing cutaneous nodule which, when excised and examined microscopically, disclosed carcinoma associated and arising from benign eccrine spiradenoma. Eight patients died of disseminated tumours. Histologic features, in three fatal cases, showed carcinosarcoma and particularly osteosarcoma in one case. A further fatal case of carcinosarcoma arising in spiradenoma, is reported in a Melanesian man aged 38, who died after 8 months. Histologic examination showed squamous cell carcinoma associated with osteosarcoma in the recurrence.

Adenoma, Sweat Gland↗

PubMed1994

Malignant mixed tumor (carcinosarcoma) of the pancreas: a case report supporting organ-induced differentiation of malignancy.

BACKGROUND: We present an unusual case of a malignant mixed tumor (carcinosarcoma) of the head of the pancreas that was surgically resected and whose tissue pathologic condition supported the concept of organ-induced differentiation of malignancy. METHODS: After a pancreaticoduodenectomy, tissue sections from various anatomic regions of the tumor were studied by routine histologic examination and immunocytochemistry. Genomic DNA from various regions of the tumor was extracted and digested with Hpa II, and a 511 bp region of the hypoxanthine phosphoribosyltransferase gene was amplified with the polymerase chain reaction to assess clonality. RESULTS: The pathologic findings revealed areas of both adenocarcinoma and leiomyosarcoma, but these disparate areas were not randomly distributed but rather were polar in nature. The adenocarcinomatous areas localized to the tumor within the head of the pancreas, an area of normal ontogenetic glandular development, whereas the leiomyosarcomatous areas localized to regions of the tumor infiltrating the duodenal wall, an area of normal ontogenetic smooth muscle development. Both the adenocarcinomatous and the leiomyosarcomatous areas showed evidence of monoclonality and clonal identity. CONCLUSIONS: This interesting polar distribution of histologic patterns illustrated by this malignant mixed tumor (carcinosarcoma) supports the hypothesis of organ-induced differentiation of malignancy.

Adenocarcinoma↗