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PubMed1957

The effect of cortisone on the multiplication of M. tuberculosis in normal and immune mice.

The multiplication of M. tuberculosis, var. bovis inoculated into the cornea of mice was studied by staining the whole cornea at various stages after inoculation. Four groups of animals were studied: untreated animals, animals treated with cortisone, animals previously immunized with the same bovine strain, and immunized animals treated with cortisone.In the untreated immunized group little or no multiplication occurred. In the other three groups multiplication did occur and was about the same for the first week after inoculation. After this stage, cortisone-treated animals, whether previously immunized or not, showed increased multiplication and massive cord formation, as compared with untreated animals in which little further multiplication was seen. The cortisone treatment had thus completely suppressed immunity. The significance of these results is discussed.

Animals↗
PubMed1958

Comparative effects of chlortetracycline and cortisone on a local monilial lesion in the mouse.

The course of a local, closed monilial lesion in the thigh of the mouse is described. Treatment of animals suffering from this lesion with subcutaneous chlortetracycline in near-toxic doses leads to a persistent suppression of the lesion indistinguishable from a curative effect. Treatment with subcutaneous cortisone produces suppression of the lesion during treatment with subsequent "rebound".Super-injection of the lesions with chlortetracycline produces a very large and persistent swelling. Treatment of these lesions with subcutaneous chlortetracycline in near-toxic doses produces suppression and "rebound" resembling that seen in lesions super-injected and treated with cortisone. Aspirin, chosen for its insolubility and acidity, and turpentine, chosen for its irritant effect, did not reproduce the effects of chlortetracycline or cortisone.While it is possible that the suppressive effect of chlortetracycline and cortisone is in certain circumstances related, the local irritant effect of chlortetracycline plays an important part in the enhancement of these lesions.

Animals↗
PubMed1958

The influence of cortisone and hydrocortisone acetates on the course of Mycobacterium lepraemurium infection in rats.

Prolonged administration of cortisone acetate or hydrocortisone acetate produces a decrease in the rate of growth of treated rats. In this respect the effect of the latter steroid is the more pronounced. Lepromata in the steroid treated animals are significantly smaller than those in the control rats. This difference is more pronounced with the cortisone acetate treatment. However, whilst there is no appreciable difference in the distribution of organisms in the lepromata, the spread of infection is not increased by the steroid treatment, as the number of animals showing acid fast organisms in the spleen is no greater in the treated groups than in the controls.

Animals↗