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[Effect of 5,6-dihydroxytryptamine and 6-hydroxydopamine on the maze behavior of the snail Helix lucroum].

One-trial Y-maze test in snails did not reveal any predominance of the right or left alley choice. The choice of the right alley (but not of the left one) was accompanied by a slowing down of forward motion. After the administration of 10 mg/kg of 6-hydroxydopamine 24 hr before the test, right alley choice without slowing down became more frequent. Administration of 5,6-dihydroxytrypamine (10 mg/kg) caused a reduction of motion rate along all parts of the maze and an increase in frequency of the orienting head movements towards the alley to be chosen.

5,6-Dihydroxytryptamine↗
PubMed1978

Time course of 5,6-dihydroxytryptamine neurotoxic effects on fowl diencephalon and upper brain stem monoaminergic pathways.

In adult fowls the time-course of the neurotoxic effects of 5,6-DHT on indolaminergic neurons (in comparison with controls and with animals pre-treated with mebanazine, a MAO-inhibitor) was studied. It was shown that 5,6-DHT given into the third cerebral ventricle produced a rather selective degeneration of indolaminergic neurons which was most dramatic 4 and 7 days after the injection. Injured axons characterized by a pile-up of strongly yellow fluorescent material were seen in areas bordering the third ventricle, and in the posterior, medium and anterior hypothalamus, preoptic area, median eminence, n. tuberalis and paleostriatum augmentatum. A decrease in yellow fluorescence in areas distal to the injured axons was only detectable after 19 days. A certain regrowth of some terminal networks was observed 30 days after 5,6-DHT administration. Present data indicate that, in fowls, ascending indolamine neurons mainly originate in tegmental cell bodies and are organized in a large tract which runs along the medial forebrain bundle, sending terminals innervating several diencephalic and other subcortical areas.

5,6-Dihydroxytryptamine↗
PubMed1976

Acute central effects of 5,6-dihydroxytryptamine in fowl.

In adult hens (Gallus domesticus) infusion into the IIIrd cerebral ventricle of 5,6-DHT (50, 75 and 100 mug) produced, after 5-10 min behavioural and electrocortical sedation and sleep lasting about 6-8 hr,and a monophasic or biphasic increase in body temperature for about 8 hr, Two and a half hr after 5,6-DHT administration, the histochemical picture showed a sustained decrease in yellow and green fluorescence in areas adjacent to the IIIrd ventricle, in the anterior hypothalamus and in the preoptic area, whereas no significant changes were detected in fluorescence of the tegmental cell-bodies. The present experiments suggest that behavioural and electrocortical effects evoked by 5,6-DHT seem to be due to a synergistic action of 5-HT and catecholamines displaced and released by this compound, whereas hyperthermic effects seem to be due to a more sustained release of 5-HT and/or to a direct action on 5-HT receptors and/or inhibition of 5-HT reuptake.

5,6-Dihydroxytryptamine↗