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PubMed2006

Autoimmunity: basic mechanisms and implications in endocrine diseases. Part II.

Regulation of the immune response to self-antigens is a complex process that involves maintaining self-tolerance while preserving the capacity to exert an effective immune response. The primary mechanism that leads to self-tolerance is central tolerance. However, potential pathogenic autoreactive lymphocytes are normally present in the periphery of all individuals. This suggests the existence of mechanisms of peripheral tolerance that prevent the initiation of autoimmune diseases by limiting the activation of autoreactive lymphocytes. If these mechanisms of peripheral tolerance are impaired, the autoreactive lymphocytes may be activated and autoimmune diseases can develop. Several processes are involved in the maintenance of peripheral tolerance: the active suppression mediated by regulatory T cell populations, the different maturation state of antigen-presenting cells presenting the autoantigen to autoreactive lymphocytes, inducing tolerance instead of cell activation, the characteristics of B cell populations. A deeper comprehension of these mechanisms may lead to important therapeutic applications, such as the development of cellular vaccines for organ-specific autoimmune diseases. In addition, autoimmunity does not always have pathological consequences, but may exert a protective function, as suggested by several observations on the beneficial role of autoreactive T cells in central nervous system injury.

Animals↗
PubMedDate not supplied

[Hypothalamo-mesencephalic crises in endocrine diseases].

Altogether 261 patients with different vegetative crises were investigated by clinico-neurologic, electro-, rheo-, echoencephalographic methods. The most frequent causes of crises (in 140 patients) were disorders of the hypothalamic and hypothalamo-mesencephalic sections of the brain. In the rest of the patients crises were caused by neuroses, disorders of the caudal zones of the brain stem and temporal region, pheochromocytoma, insulinoma, primary hyperaldosteronism, hypoparathyroidism and other diseases. Criteria of differential diagnosis of hypothalamic crises and crises in neuroses, disorders of the distal sections of the brain stem and temporal lobe epilepsy were specified. Some new, quite informative clinico-neurological and rheo- and electroencephalographic criteria were proposed for the differentiation of hypothalamic crises and crises in pheochromocytoma, insulinoma and primary hyperaldosteronism.

Acute Disease↗