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[Efficacy of a preparation based on Lactobacillus acidophilus for protection from myelotoxic effects of ionizing radiation and antineoplastic cytostatics].

The ability of a Lactobacillus acidophilius (LA) based preparation to prevent from a myelotoxic damage was studied on (CBA.C57BL/6)F1 mice upon total gamma-irradiation or single intraperitoneal injection of cyclophosphan. The antitumor and antimetastatic activity of LA-based preparation was studied in experiments with C57BL/6 mice bearing Lewis lung carcinoma or melanoma B16. The preparation obtained from heat-killed Lactobacillus acidophilius species provides protection of hemopoietic stem cells, as evidenced by the amount of endogenous CFUs increased 3.4-6.7 times. The LA-based preparation favored accelerated overcoming the radiation- and cyclophosphan-induced leukopenia. At the same time, the drug did not affect the proliferative activity and apoptosis of tumor cells, their growth rate, and metastatic activity. Nor did it reduce the efficacy of the experimental tumor radiotherapy.

Animals↗
PubMed1961

Utilization of pyrimidines and pyrimidine deoxynucleosides by Thermobacterium acidophilum (Lactobacillus acidophilus).

Løvtrup, Søren (University of Göteborg, Sweden) and David Shugar. Utilization of pyrimidines and pyrimidine deoxynucleosides by Thermobacterium acidophilum (Lactobacillus acid-ophilus). J. Bacteriol. 82:623-631. 1961.-The utilization of pyrimidine deoxynucleosides was investigated by means of deoxyribosides of unnatural pyrimidines, especially by halogen-substituted uracil derivatives. All investigated deoxyribosides could be used, except that of N-methylthymidine. It was concluded that this substance cannot be a substrate for the enzyme trans-N-deoxyribosylase, which has been shown to be active in the utilization of deoxyribosides in this microorganism. With uracil as the only pyrimidine source, the halogen-substituted deoxyuridines had a certain inhibitory effect on growth. Contrary to previous findings, it was observed that normal growth occurs in the presence of thymine as the only pyrimidine source. The utilization of this substance is less efficient than that of uracil; a 1:10 dilution leads to a decrease in the extent of growth with the former, but not with the latter. From these results, complemented with experiments in which halogen-substituted uracil derivatives and the corresponding ribosides or deoxyribosides were used as inhibitors, it has been possible to account for most of the metabolic interconversions of pyrimidines in the investigated microorganism.

Lactobacillus↗