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Results for “LYMPHOSARCOMA”

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PubMed1994

Diagnostic and prognostic importance of chromosomal aberrations identified in 61 dogs with lymphosarcoma.

To determine the diagnostic and/or prognostic importance of chromosomal aberrations identified in dogs with malignant (non-Hodgkin's) lymphoma, clinical stages for 61 dogs with lymphosarcoma were determined, the lymph node(s) were histopathologically graded, and the malignant tissue lymphocytes were karyotyped. The results from life table survival curve analysis demonstrated that first remission length and survival time were significantly longer in 15 of 61 (25%) dogs that had a trisomy of chromosome 13 as the primary chromosomal aberration than in those dogs (46/61, 75%) with other primary chromosomal aberrations (P < 0.05). Sex, age, weight, histopathologic subtype and grade, World Health Organization (WHO) clinical stage, WHO and modified Karnofsky performance status, chromosomal modal number, and treatment protocol were of no prognostic importance in predicting first remission length or survival time (P > 0.05). Multivariate analysis did not identify a significant correlation between the prognostic groups or within the various prognostic subsets (P > 0.05). The pathogenesis of canine and human non-Hodgkin's lymphoma, as observed cytogenetically, differs.

Animals↗

PubMed1988

Biochemical and molecular characterization of the glucocorticoid receptor of lymphosarcoma P1798 variants.

Three phenotypically distinct isolates from lymphosarcoma P1798 have been compared with respect to properties of the glucocorticoid receptor. Wild type P1798 cells express functional receptors and glucocorticoid treatment of such cells causes cytolysis in vivo. Wild type cells do not undergo cytolysis in culture. Rather, such cells exhibit reversible inhibition of proliferation in the presence of dexamethasone. Two variant populations were selected from this background. One was selected for the ability to form tumors in mice receiving pharmacological doses of glucocorticoids. Cells from such tumors are resistant to the cytolytic effects of glucocorticoids in vivo, but are sensitive to the antiproliferative effects of the hormone in culture. Variants were also selected based upon their ability to proliferate in the presence of dexamethasone in culture. These variants were resistant to glucocorticoid-mediated cytolysis in vivo. Wild type P1798 cells express approximately 20,000 high affinity dexamethasone-binding sites per cell. Dexamethasone-mesylate labeling and immunoblotting experiments indicate that hormone binding is due to a polypeptide of Mr 90-100 K. This polypeptide is encoded in an mRNA species that resolved as a single entity of approximately 7000 nucleotides. Variants selected for resistance to cytolysis in vivo are indistinguishable in any of these respects from wild type cells. The receptors are fully functional, as evidenced by their ability to precipitate growth arrest of dexamethasone-treated cultures. Variants selected for resistance in culture harbor a receptor mutation. They express fewer than 500 dexamethasone-binding sites per cell. Such variants contain neither detectable dexamethasone-mesylate-binding protein nor any protein that is recognized by a receptor antibody.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed1979

Total-body irradiation in advanced lymphosarcoma.

Thirty patients with stage III and IV non-Hodgkin's lymphoma were treated by total-body irradiation (TBI). Eleven patients had previously received local radiotherapy or chemotherapy. Toxicity was confined to haematological depression. Complete remission of disease was achieved in 14 patients. Non-leukaemic patients who had received no previous treatment reacted best to TBI (ten complete remissions in 13 patients). We consider TBI a helpful treatment in non-leukaemic patients with advanced lymphosarcoma.

Adult↗

PubMed1993

Bilateral renal lymphosarcoma in a dog.

A lymphosarcoma originating from kidneys, which metastasized to the ovaries, oviducts, heart and pancreas, was pathologically diagnosed in a 3-year-old female Japanese dog (Shiba dog). Clinically, the dog exhibited vomiting, diarrhea, oliguria and abdominal enlargement, associated with hypoglycemia. Grossly, the kidneys were enlarged and neoplastic masses were also seen in the ovaries and heart. Histologically, a majority of glomeruli and renal tubules were obliterated due to diffuse invasion by tumor cells. There were no metastatic lesions in the mesenteric and tracheobronchial lymph nodes, spleen and bone marrow. Most of the tumor cells were small- to medium-sized lymphoid cells with a large nucleus and scanty cytoplasm.

Animals↗

PubMed1996

Primary extranodal lymphosarcoma of the trachea in a cat.

A primary extranodal lymphosarcoma causing recurrent-episodes of dyspnea and exercise intolerance is described in a 13-year-old cat. The affected segment of the tracheal wall was markedly thickened due to transmural infiltration of monomorphic neoplastic lymphoid cells and the lumen was severely compressed. The diagnosis was based on light microscopic studies, positive immunostaining for feline IgA, and special stains.

Animals↗

PubMed2000

Epitheliotropic T-cell gastrointestinal tract lymphosarcoma with metastases to lung and skeletal muscle in a cat.

An Abyssinian cat examined because of hypoproteinemia and weight loss was found to have epitheliotropic T-cell lymphosarcoma of the gastrointestinal tract. Neoplastic lymphocytes infiltrated the epithelium and lamina propria of the stomach, small intestine, and large intestine. Metastatic foci were found in the lungs and the musculature of the right hind limb. Chemotherapy resulted in transient shrinkage of the lung and limb masses; however, these masses grew to approximately their original size within 2 weeks after initiation of treatment, and the cat was euthanatized.

Animals↗

PubMed1983

Non-effectivity of roentgen irradiation in an in vivo rapidly growing murine lymphosarcoma.

The survival time of mice bearing a rapidly growing murine lymphosarcoma (cell doubling time 9.6 h) is hardly influenced by roentgen irradiation with fractions of 2 Gy, not even if delivered according to superfractionated schedules. Growth kinetic measurements reveal an almost complete mitotic block 6 h after exposure, followed by a large overshoot in cell proliferative activity. The dose-response curve for in vivo irradiated cells has a D0 of 1.9 and lacks a shoulder. Hence, repair of sublethal damage must be of restricted significance. The extremely strong proliferative capability appears to lead to rapid repopulation of the tumour. Typically, surviving cells show a high content of RNA and protein.

Animals↗

PubMed1998

A case of ovine lymphosarcoma in Kenya.

Ovine lymphosarcoma was diagnosed clinically in a 5-year-old Blackhead sheep in Kenya, and confirmed on blood smear, leukocyte count and macroscopic pathology. Four progeny of the ewe were examined. They were normal haematologically but 2 revealed bilaterally enlarged lymph nodes.

Animals↗

PubMedDate not supplied

Primary intratracheal lymphosarcoma in four cats.

Four cats presented with clinical signs suggestive of respiratory disease, including dyspnea, wheezing, cyanosis, inspiratory stridor, coughing, and gagging. Radiographs revealed intratracheal masses. Bronchoscopy allowed for lesion localization and collection of samples for cytopathological and histopathological evaluation, which confirmed a diagnosis of lymphosarcoma. Cats treated with systemic chemotherapy or radiation were able to achieve complete remission and long-term resolution of clinical signs.

Animals↗

PubMed1976

Lymphosarcoma of bowel in childhood.

A report of nine cases of lymphosarcoma of the bowel in childhood is presented, together with a review of the literature. Until recently, the prognosis of this condition has been poor,but it is hoped that modern treatment with surgery, radiotherapy and multiple cytotoxic drugs given in high dosage over a two-year period will result in improved results.

Child↗

PubMed1977

Comparative study of bowel lymphosarcoma in childhood.

Five cases of lymphosarcoma of the bowel in Nigerian Igbo children are presented. They were found to be similar to an Australian series in the following respects: boys were more commonly affected than girls; affected children were all aged over two years; and the two main modes of presentation were intussusception and a localized abdominal mass. Unlike Australian children, Nigerian Igbos did not present with features suggestive of acute appendicitis.

Australia↗

PubMed1977

Lymphosarcoma in an infant northern fur seal (Callorhinus ursinus).

An infant northern fur seal (Callhorinus ursinus) died in a rookery on St. Paul Island, Pribilof Islands, Alaska. Grossly, slight enlargement of the mesenteric lymph nodes was seen. Microscopically, a lymphosarcoma composed of sheets of monomorphic lymphoid cells in sections of lymph node and tonsil was seen. Electron microscopy of formalin-fixed tissues revealed several structures that were possible of viral origin in the cytoplasm of the neoplastic cells.

Animals↗

PubMed1980

Lymphosarcoma in a harbor seal (Phoca vitulina richardii).

Lymphosarcoma is described in a wild juvenile harbor seal (Phoca vitulina richardii). Gross lesions included hepatomegaly, splenomegaly and lymphadenopathy. Neoplastic lymphoid cells were observed histologically in lung, kidney, liver, spleen, adrenals, bone marrow and visceral and peripheral lymph nodes.

Animals↗

PubMed1987

A lymphosarcoma in an Atlantic salmon (Salmo salar).

A lymphosarcoma that appeared to be of thymic origin and of lymphoblastic type was found in a 3.5-yr-old Atlantic salmon (Salmo salar). The fish was from a population of 60 broodfish maintained at a research fish laboratory. A large tumor mass was found under the left operculum. Small tumor nodules were found on the swim bladder and in the abdominal adipose tissue. The location of this neoplasm differed from those of previously described tumors in this fish species.

Animals↗

PubMed1976

Effect of pre- and post-surgical active BCG immunotherapies on murien EAkR lymphosarcoma.

A combined treatment modality incorporating surgery plus BCG immunotherapy was administered to (DBA/2 X C57B/6) F1 mice grafted with EAkR lymphosarcoma. 30% of mice survived free of disease when BCG was injected intravenously two days after operation consisting of tumorectomy plus excision of the regional lymph node performed on the 8th day after tumor inoculation. Similar results were obtained when BCG was injected subcutaneously 6 days before surgery. Pre-operative intravenous and post-operative subcutanous BCG administration failed to cure the animals just as BCG or surgery alone.

Animals↗

PubMed1975

Chronic lymphocytic leukemia and lymphosarcoma associated with multiple myeloma: report of three cases.

Three patients had the rare occurrence of multiple myeloma coexisting with chronic lymphocytic leukemia or lymphosarcoma. It is not possible at present to resolve the question as to whether these two diseases represent part of the spectrum of a single B-cell disease or wether multiple myeloma and lymphoproliferative disorders are two separate entities, which may rarely occur by coincidence in the same patient.

Aged↗

PubMed1999

[The effect of dexamethasone on the functional features in rats with Pliss lymphosarcoma transplant].

A computer-assisted method of video imaging the adhesive, permeability and thrombogenic properties of microvessels was used to study the effect of dexamethasone on the functional activity of the mesenteric microvascular endothelium in rats with Pliss' lymphosarcoma. Dexamethasone-21 Na-phosphate (0.1 mg/ml) was supplied to the desired mesenteric area and the necessary measurements were carried out. The latter showed that tumor growth was associated with microcirculation disturbances, namely, raised leukocyte adhesion to the mesenteric microvascular endothelium, microvascular permeability and thrombogenicity. Enhanced microvascular sensitivity to dexamethasone pointed to the important role played by changes in the adhesive properties of the endothelium among general paraneoplastic disorders of microcirculation.

Animals↗

PubMed1999

Microvascular endothelium dysfunction during growth of transplanted lymphosarcoma and glioma in rats.

The changes of endothelium functional parameters (adhesivity, permeability, thrombogenity and thromboresistance) in mesenteric microvasculature in rats with two transplanted tumors: fast-growing Pliss' lymphosarcoma (PLS) and slow-growing glioma-35 (G-35) were studied, using a complex method, based upon a computer-assisted microscopic video image processing. The endothelial dysfunction in mesenteric microvessels is characterized by the increase of leukocyte adhesion to the endothelial cells, microvessels permeability and their thromboresistance properties decrease in tumor-bearing rats. The observed changes are shown to be the nonspecific manifestation of the tumor process development. They are determined by the duration of the process development and are not dependent on the tumor node size.

Animals↗