PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “MENIERE'S DISEASE”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 379 records · Page 21Linked to original sources
PubMed2002

Can electrocochleography in Meniere's disease be noninvasive?

OBJECTIVES: To evaluate and compare the results of extratympanic and transtympanic electrocochleography (ECochg) in clinically diagnosed cases of Meniere's disease and controls. DESIGN: Prospective study on 20 clinically diagnosed cases of Meniere's disease and 20 age- and sex-matched controls. SETTING: Department of Otolaryngology, Head and Neck Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India. METHODS: Electrocochleography was performed by a transtympanic method using a stainless steel needle electrode kept on the promontory and by an extratympanic method whereby the needle electrode was inserted into bony canal skin. MAIN OUTCOME MEASURES: The various parameters compared were summation potential latency and amplitude, action potential latency and amplitude, and ratio of summation to action potential amplitude (SP/AP). RESULTS: A significant difference in summation to action potential amplitude ratio (SP/AP) between cases and controls was obtained by both methods. Using 0.29 as a cutoff for SP/AP, the transtympanic method yielded a sensitivity of 100% and a specificity of 90%, whereas the extratympanic method showed corresponding values of 90% and 80%, respectively. CONCLUSION: Contrary to previous studies, extratympanic ECochg is shown to be an efficacious and a less invasive test as compared with the transtympanic method and can be easily performed in clinical practice.

Action Potentials↗
PubMed1999

[Multi-frequency impedance measurement and Meniere's disease. Analysis of the results of TEFLAG].

We present today our preliminary results of the TEFLAG test performed on 58 patients suffering from Meniere's disease. This test completed in 1993 has already led to a 4-stage classification of noise induced hearing losses. On the one hand, it is based on the morphological study of susceptance B curves, and on the other hand, on the study of the resonant frequency (RF) of the annular ligament of the stapes, provided by a multifrequential impedancemeter. The endolymphatic hydrops coming with the Meniere's disease practically always cohabits in the intercritical period with the decrease of the perilymphatic pressure of the scala vestibuli, which is shown in the morphology of Stage IV curves especially, and the decrease of the annular ligament rigidity. Inversely, during the vertigo or around, we mainly have stage I curves, and an increase of the stapes annular ligament resonant frequency (RF), testifying the labyrinthic hydrops, which is the physiopathological essence of the Meniere's disease.

Acoustic Impedance Tests↗
PubMed1982

Revision endolymphatic sac and duct surgery for recurrent Meniere's disease and hydrops: failure analysis and technical aspects.

Endolymphatic system surgery for Meniere's disease has been shown to be effective in selected cases; however, some patients do not achieve substantial long-term relief from their symptoms in spite of early success and may require revision surgery. Revision endolymphatic system surgery has been reported in the literature in 9.7% to 16.3% of patients. As part of an ongoing prospective analysis of endolymphatic valve implant surgery, the first 400 procedures performed over 6 years were analyzed to determine the rate and cause for revision surgery. Fifty-four of 386 (13.9%) of endolymphatic valve implants performed by the authors required revision. Fourteen cases initially operated on elsewhere are also analyzed. The most frequent causes of failure was outflow tract obstruction caused by temporalis fascia, previously used to anchor the valve. Since that technique has been abandoned, the revision rate of primary valve implants is 6.7%.

Ear, Inner↗
PubMed1985

Treatment of Meniere's disease by intratympanic injection with lidocaine.

Intratympanic injection of lidocaine hydrochloride was used to alleviate distressing symptoms of tinnitus and vertigo in 28 patients with Meniere's disease. Of the 28 patients, 82% found an immediate improvement in vertigo, and there was an improvement in tinnitus in 67.8%. There was no change in complaints of tinnitus or vertigo in five patients with Meniere's disease who were each injected with a similar amount of saline into the middle ear, and who acted as a control group. An intratympanic injection of lidocaine alleviated the disabling symptoms of tinnitus and vertigo in some of the patients with Meniere's disease who had not reacted well to medical treatment. The procedure is without the hazards of the intravenous injection of lidocaine, and can be done by every otologist, even in clinic practice.

Adult↗
PubMed1975

The contralateral ear in Méniére disease.

We conducted a survey of 292 patients who had Meniere disease to determine whether there was either some subjective complaint like tinnitus or hearing impairment or an objective symptom like hearing loss or recruitment of the contralateral ear. In 212 (73%) patients, signs of disturbed hearing in the second ear were present. If only the combination of sensorineural hearing loss, recruitment, and tinnitus is accepted as a definite proof of the diagnosis of Meniere disease, at least 10% of the patients we studied suffer from bilateral Meniere disease. Usually, there is an interval between the onset of the impairment in the first and in the second ear; an involvement of both ears from the first onset of the disease has been found in only six patients. We believe that involvement of the second ear in so many of the patients suggest that a conservative method of treatment should always be considered.

Adolescent↗
PubMed1999

Measuring the effects of Meniere's disease: results of the Patient-Oriented Severity Index (MD POSI) version 1.

We describe the development and initial psychometric testing of a new self-report instrument for quantifying the impact of Meniere's disease (MD) on patients' lives: the Meniere's Disease Patient-Oriented Severity Index (MD POSI). Eighty-five volunteers with chronic MD took a self-administered MD POSI. The internal consistency form of reliability was determined by calculating Cronbach's alpha. The relationship between total MD POSI problem severity scores and responses to a global question concerning the degree to which his or her MD had changed the patient's life assessed construct-related validity. The total problem severity score yielded excellent reliability (Cronbach's alpha = .928). No significant age or gender effects were seen. A highly statistically significant association was noted between total problem severity scores and the degree to which the patient's life had been changed by his or her MD (Spearman rank correlation = .526, p < .0001), indicating excellent construct-related validity. The material included in the initial questionnaire provides important information that can be used clinically to quantify the impact of MD on patients' health status. A beta version of the instrument is in the process of validation and determination of its sensitivity to change in health status.

Adult↗
PubMed2000

Role of the new imaging modalities in the investigation of Meniere's disease.

The incidence of nonvisualization of the vestibular aqueduct and the endolymphatic duct-endolymphatic sac (ED-ES) complex as well as the type of periaqueductal pneumatization were evaluated in 23 patients with definite Meniere's disease (MD) by high-resolution CT and by MRI. Fifty subjects with no previous history of any ear disease were used as a control group. High-resolution CT results disclosed that in the control group the percentage of nonvisualized vestibular aqueduct (3.4%) was statistically significantly lower than in the MD group, when either the diseased ear (27.8%) or the nondiseased ear of the same group (22.2%) was examined. In addition, no differences were observed between the diseased and nondiseased ears of the patients with MD. The periaqueductal pneumatization was also found to be statistically significantly lower in the MD group. As regards the MRI examination, the results of the analysis showed that the ED-ES complex was visualized more frequently in the ears of the control subjects (64.1%) than in the diseased ears of the patients with Meniere's disease (39.1%). This difference had a marginal statistical significance (P approximately 0.05). We discussed the results in relation to possible underlying pathophysiologic mechanisms involving the flow of endolymph toward the ES during the different stages of the disease.

Adult↗
PubMed1990

Vestibular recruitment in Meniere's disease.

The aim of this study was to search for vestibular recruitment in a sample of patients with Meniere's disease. Recruitment was defined as an abnormal growth of response with increasing stimulus intensity. Twenty-nine patients were tested with sinusoidal rotation of three different magnitudes at four different frequencies. We also searched for auditory recruitment in each patient via tests of auditory brain stem responses, acoustic reflexes, and loudness balance and discomfort level. Analysis of vestibular responses indicated, on average, a linear relationship between stimulus magnitude and response magnitude, ie, doubling the stimulus magnitude resulted in twice the response magnitude. Meniere's patients did not yield results significantly different (although they were more variable) from those of the normal subjects. The vestibular responses of patients with auditory recruitment did not differ systematically from those of patients without auditory recruitment. We conclude that vestibular recruitment, if it exists in patients with Meniere's disease, is not demonstrated by sinusoidal rotational testing.

Adult↗
PubMed1984

Meniere's disease: a 30-year epidemiologic and clinical study in Rochester, Mn, 1951-1980.

One hundred eighty cases of Meniere's disease were identified in the Rochester, MN population during the 30-year period, 1951 through 1980. The annual age-adjusted incidence rate per 100,000 population was 15.3; the preponderance for females (16.3) over males (13.3) was not statistically significant. There was no change in annual incidence rate from 1951 through 1970, and a slight decrease in the period, 1971 through 1980. The prevalence rate on January 1, 1980, was 218.2 per 100,000 population. Clinical aspects of Meniere's disease noted during the course of this study are reported.

Adolescent↗
PubMed1982

Vestibular function assessment in patients with Meniere's disease: the vestibulospinal system.

The state-of-the-art approach to clinical assessment of vestibular disturbances includes a number of procedures in which it is assumed that the status of major vestibular pathways is quantified independently from converging somatosensory and visual influences. Although it has been known for some time that this approach has limitations in a highly integrative system in which inputs from a number of sensory modalities interact, a practical remedy has been only recently forthcoming. Using an approach to assessment of the vestibulospinal system developed by Nashner, the application of moving platform techniques has been the first to systematically identify the interactions among vestibular, visual, and proprioceptive senses and determine the role of vestibular losses in the process of postural control. A group of Meniere's disease patients were studied in order to determine whether or not such tests could be used as an effective vestibular screening method for Meniere's disease patients in remission, and whether the ability of Meniere's disease patients to use vision and proprioception to compensate for their vestibular disorders, could be assessed. Results indicated that quantitative evaluation of the vestibulospinal system was a very effective vestibular screening test. Furthermore, the adaptive ability of the subject can be estimated by varying the amounts of visual and proprioceptive vestibular information available to the patient for the control of postural sway. Preliminary results indicate that such a technique would be of great value clinically for the initial and on-going evaluation of patients with Meniere's disease and for pre and post-therapeutic evaluation of the Meniere's disease patient.

Adult↗
PubMed1980

Clinical usefulness of electrocochleography in Meniere's disease: an analysis of dehydrating agents.

Both electrocochleography and glycerol dehydration have an important diagnostic and prognostic role in the management of patients with endolymphatic hydrops, whether idiopathic as in Meniere's disease or secondary to certain diseases of the otic capsule. Abnormal electrocochleographic responses in a "normal" ear can be used to predict when Meniere's disease will become bilateral. There is a significant correlation between the effects of glycerol and of endolymphatic sac surgery on the pars inferior, at least over the span of several years. The subject hearing gains, the objective improvements in electrocochleographic responses, and the objective evidence of diminished inner ear impedance, all following proven glycerol dehydration, indicate that even in fairly advanced Meniere's disease, but especially in the earlier stages, reversibility is possible. This is a tantalizing therapeutic challenge.

Action Potentials↗
PubMed2006

[Intratympanic treatment in Meniere's disease: the effect of gentamicin and dexamethasone on vertigo control and hearing].

OBJECTIVES: We investigated the effect of intratympanic gentamicin and dexamethasone treatments on the control of vertigo and hearing loss in patients with Meniere's disease. PATIENTS AND METHODS: Forty-five patients with a diagnosis of Meniere's disease according to the 1995 criteria of American Academy of Otorhinolaryngology Head and Neck Surgery were assigned to receive intratympanic gentamicin (40 mg/ml, 0.7 ml; n=24; 11 males, 13 females; mean age 46 years) or dexamethasone (4 mg/ml, 0.7 ml; n=21; 8 males, 13 females; mean age 50.4 years). The results were evaluated with respect to changes in vertigo and hearing symptoms. RESULTS: In the gentamicin group, vertigo symptoms were controlled in 22 patients (92%), deterioration in hearing was seen in only two patients (8%). In the dexamethasone group, nine patients had complete follow-up. Of these, vertigo control was achieved in six patients (67%), none had worsened hearing, and one patient (5%) had improved hearing. When improvement in hearing was defined as at least a 5 dB change, then five patients (24%) benefited from treatment. CONCLUSION: Intratympanic treatment modalities in Meniere's disease are easy to perform, cheap, and effective. They are expected to have a more extensive use with higher success rates in the future.

Anti-Bacterial Agents↗
PubMed1984

Streptomycin drug fever during treatment of bilateral Meniere's disease.

The use of intramuscular injections of streptomycin sulfate for the ablation of vestibular function in patients with bilateral Meniere's disease is well established. Although hypersensitivity reactions to streptomycin are documented, frank drug fevers are rare. Our patient, with no previous history of drug allergies, was treated with parenteral streptomycin for disabling bilateral Meniere's disease. The patient's hospital course was complicated by severe hypotension and spiking fevers, which were temporally related to the streptomycin injections, and which resolved on cessation of the drug therapy. A challenge dose of a new batch of streptomycin resulted in renewed rigors, fever, and hypotension. The necessity of early recognition of this uncommon, life-threatening drug fever with streptomycin is emphasized by our experience.

Drug Hypersensitivity↗