Proceedings: Pharmacological studies on centrally-acting drugs belonging to enaminone mannich bases. II. Pharmacology of MK l-203 and l-907, new potent analgesics.
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Comparison of the action of TURISYNCHRON and its zinc complex SUISYNCHRON in mice, rats and dogs showed that neither compound interfered with the implantation process in rats. After oral administration, blood concentrations were lower with SUISYNCHRON than with TURISYNCHRON. The zinc complex was broken down in the acid medium of the stomach, and absorbed in the duodinum or in distal segments of the intestine. Metallibure did not affect on phagocytosis not the course of infections with Escherichia coli or Erysipelothrix insidosa. Both compounds had a thymolytic action, which did not mimic the effect of cofticosteriods.
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