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Evaluation of patients' preference of two potassium chloride supplements: Slow-K and K-Dur.

Eighteen patients (mean age, 66 years) who were receiving oral potassium supplements while being treated with diuretics were enrolled in this study. The patients were randomly assigned to receive Slow-K, a wax-matrix tablet, or K-Dur, a microencapsulated tablet, for two weeks and then the other drug for an additional two weeks; the daily dose was two to four tablets, equivalent to 20 to 40 mEq of potassium. Patients were asked to complete a survey about their compliance and preference ratings of both products. Of the 17 patients who completed the study, 14 stated that they preferred Slow-K to K-Dur and one preferred K-Dur to Slow-K; 14 patients made positive comments about Slow-K and seven made positive comments about K-Dur. The most common positive comment about Slow-K was its small size and ease in swallowing. Adverse reactions (mostly gastrointestinal) were reported by five patients during treatment with Slow-K and by six during treatment with K-Dur; three patients treated with K-Dur and none treated with Slow-K discontinued treatment because of adverse reactions.

Administration, Oral↗
PubMed1990

Effect of various chloride salts on the utilization of phosphorus, calcium, and magnesium.

Only part of the effect of dietary protein on urinary calcium excretion can be ascribed to sulfur amino acids. We hypothesized that chloride, another factor often associated with isolated proteins, and another amino acid, lysine, affect utilization of calcium. The effects of supplemental dietary chloride, inorganic or organic, on calcium, phosphorus, and magnesium utilization were studied in two rat studies. Weanling Sprague-Dawley rats were fed semi-purified diets that contained moderate (1.8 mg Cl/g diet) or supplemental (15.5 mg Cl/g diet) chloride as sodium chloride, potassium chloride, or lysine monohydrochloride with or without calcium carbonate for 56 or 119 days. Rats fed supplemental sodium chloride or potassium chloride had higher urinary phosphorus excretion, more efficient phosphorus absorption, but unchanged tissue phosphorus levels after 7 and 16 weeks of dietary treatment as compared to rats fed moderate chloride. Rats fed supplemental sodium chloride or potassium chloride excreted more calcium in urine at 7 weeks and absorbed calcium less efficiently at 16 weeks. Tissue calcium concentrations were unaffected, but total tibia magnesium and plasma magnesium concentrations were lower in rats fed supplemental sodium chloride or potassium chloride than those fed moderate chloride. Lysine chloride with or without additional calcium elevated urinary calcium excretion even more than sodium chloride and potassium chloride ingestion. Rats fed lysine chloride with supplemental calcium had smaller apparent absorption and urinary losses of phosphorus and magnesium after 16 weeks and lower tibia and plasma magnesium concentrations than rats fed lysine chloride.

Journal Article↗