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[Effect of occupational environment on the occurrence of chronic nonspecific respiratory tract diseases among workers engaged in the production of superphosphates].

The paper was aimed at establishment of the contribution of work conditions to etiology of chronic bronchitis, asthmatic symptoms and lung ventilation disturbances. The investigation involved 354 men producing superphosphate in the Sulphur Processing Plant in Machów near Tarnborzeg and the control group of 276 workers from the same plant but little exposed to industrial dusts. The analysis of mean FEV1 indices with different smoking habits, respiratory tract symptoms and work environment, was based on so called corrected i.e. standardized mean values, with regard to age and increase based on multiple regression equations. In the workers producing superphosphate much more frequent chronic bronchitis (PNO), asthmatic syndrome (ZA) and lung ventilation disturbances were found. Corrected FEV1 arithmetic means in those with PNO and ZA symptoms were significantly lower in those from superphosphate division than in the control group. In addition, in the superphosphate division a significant linear trend of the proportion of lung ventilation disturbances cases, depending on symptoms category, was found. These results reveal harmful effect of air pollution in work environment upon health status of the exposed workers.

Air Pollutants↗

A new animal model for human respiratory tract disease due to adenovirus.

Cotton rats (Sigmodon hispidus) were tested as a model for human respiratory tract infection due to adenovirus. After intranasal instillation of 10(6.1) 50% tissue culture infectious doses (TCID50) of adenovirus type 5 into one-month-old cotton rats, groups were killed at intervals for nasal and lung titration of virus and lung histopathology. In lung, eclipse occurred at 8 hr followed by peak viral titer (10(7.5) TCID50/g of lung) on day 5. Titers fell to 10(3.2) TCID50/g by day 10 and persisted at that level through the remainder of the study (day 28) despite appearance of serum neutralizing antibody after day 6. Interstitial pneumonia paralleled viral growth, and peribronchial mononuclear infiltration followed one to two days later. Titers in nasal mucosa peaked on day 3 but were undetectable beyond day 21. Pulmonary histopathology and viral replicative patterns paralleled findings in natural human disease.

Adenoviridae Infections↗

Four year incidence of respiratory syncytial virus infection in infants and young children referred to emergency departments for lower respiratory tract diseases in Italy: the "Osservatorio VRS" Study (2000-2004).

Respiratory Syncytial Virus (RSV) is a frequent cause of hospital admission in young children and high risk babies such as premature newborns, or babies with underlying cardiac or pulmonary disease, or immunodeficiency. Outbreaks occur most frequently in the cold season in areas with temperate and Mediterranean climates. Aim of the "Osservatorio VRS" Study was to describe the time-related pattern of RSV epidemics in Italy, across four consecutive epidemics, from 2000 to 2004. Nasal specimens for RSV detection were obtained and tested by an immunoenzymatic test. A total of 2110 children were tested for RSV determination, the rate of children with RSV infection was 21%, and that of children hospitalized for RSV disease was 49%. Considering the whole study period, the RSV epidemics started in October-November and ended in May, showing a peak incidence in February, with a median of 28.1% and a maximum of 48.9%. Analysis of monthly distribution of each year of the study showed a biennial trend for an earlier appearance. A different epidemiological pattern of the infection was observed among the three national areas. In conclusion, even though the mechanism governing RSV infection periodicity remains unknown, its awareness in the absence of an RSV surveillance system as in Italy, may be useful for scheduling RSV prophylaxis and for hospital resource management.

Disease Outbreaks↗