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At least 379 records · Page 21Linked to original sources
PubMed2001

Cranial nerve palsy revealing an occipitovertebral metastasis from carcinoma of the uterine cervix.

A 37-year-old woman had a histologically documented occipitovertebral metastasis from an invasive epidermoid carcinoma of the uterine cervix. The metastasis was found 3 months after the primary and was treated by local radiation therapy followed by systemic chemotherapy. Radiation therapy was highly effective in relieving the pain but was not associated with changes in magnetic resonance imaging findings. Lymph node involvement and local extension occurred. The patient died 1 year after the diagnosis of the metastasis. Involvement of the occipitovertebral junction by uterine cervix carcinoma metastasis is exceedingly rare. The relevant literature is reviewed.

Adult↗
PubMed2005

Incipient chordoma: a report of two cases of early-stage chordoma arising from benign notochordal cell tumors.

Chordomas are rare malignant bone tumors primarily involving both ends of the axial skeleton that present as destructive bone lesions with a large soft tissue mass. Chordomas were previously believed to arise from notochordal remnants. However, recent studies suggest the possibility that chordomas arise from benign notochordal cell tumors. We present two cases of coccygeal incipient chordoma that strengthen the new hypothesis. The first case was an 83-year-old man who died of prostatic adenocarcinoma. The second case was a 79-year-old man who died of hepatocellular carcinoma. The coccygeal tumors were composed of intraosseous and extraosseous infiltrative lesions. The intraosseous lesions consisted of both benign notochordal cell tumor and incipient chordoma. The extraosseous lesions were consistent with incipient chordoma. In addition, two other small benign notochordal cell tumors were found at a different level in case 1. It is conceivable that pre-existing intraosseous benign notochordal cell tumors transform into incipient chordoma and then extend through the cortex into the surrounding soft tissue. The incidence of incipient chordoma appears much higher than expected because chordomas are rare tumors with an incidence of one case per 1 000 000 persons per year. We suspect that unknown factors transform incipient chordoma into classic chordoma.

Aged↗
PubMed1999

Low-grade malignant perineurioma of the paravertebral column, transforming into a high-grade malignancy.

A demarcated 6 x 5 cm right paravertebral tumor at the level of T6 in a 39-year-old male was removed surgically. Histologically, the tumor consisted of monomorphous benign-looking, low-cellular spindle cells embedded in desmoplastic stroma. Ten years later, the tumor recurred locally with metastasis to systemic organs, including the occipital skin. Malignancy was histologically evident by the increased cellularity, cellular atypia and mitotic activity. The patient died of respiratory failure at the age of 49. Retrospectively reviewed, the primary lesion was low-grade fibrosarcoma-like spindle cell tumor, with secondary transformation into a highly malignant form. The differential diagnoses included sclerosing epithelioid fibrosarcoma, low-grade fibromyxoid sarcoma and malignant peripheral nerve sheath tumor. Immunohistochemically, the spindle cells in the primary and recurrent tumors consistently expressed epithelial membrane antigen, vimentin, type 4 collagen and laminin. The tumor cells in the present case showed a differentiation toward perineurial cells, which are normally positive for these immunohistochemical markers. Hence, the appropriate diagnostic term should be 'malignant perineurioma', a subtype of malignant peripheral nerve sheath tumor.

Adult↗
PubMed1990

Contralateral trigeminal dysaesthesias associated with second cervical nerve compression: a case report.

This 70-year-old woman presented with a left C2 solitary metastatic lesion producing ipsilateral occipital pain associated with contralateral fronto-orbital dysaesthesias. Examination revealed analgesia in the left C2 dermatome and hyperaesthesia in the right forehead. These symptoms and findings resolved following a course of radiation therapy to the C2 metastasis. Ipsilateral trigeminal dysaesthesias produced by cervical lesions have been described, however, contralateral cervicogenic trigeminal dysaesthesias have not. Relevant experimental data are analysed; neural pathways are suggested by which a cervical lesion, especially at C2 or C3, may produce trigeminal dysaesthesias referred ipsilaterally or contralaterally.

Aged↗
PubMed2000

Cutaneous metastasis of chordoma.

BACKGROUND: Chordomas are rare neoplasms that arise from the notochord remnant. They develop in the sacrococcygeal (50%) or cervical (15%) region and are generally regarded as a locally aggressive tumor with a slow progressive growth rate and a metastatic incidence ranging from 3 to 48%. Skin involvement by chordoma is rare, but can occur by direct extension, by local recurrence and by metastases. OBJECTIVE: To illustrate by a case report the clinical presentation and management of this disease. METHODS: We present a case of sacral chordoma with metastases over a 10-year period to the lungs, the soft tissue of the chest wall, the triceps tendon, and distant cutaneous metastases to the back and the nose. RESULTS: The cutaneous metastases were treated by excision. CONCLUSION: Chordoma is a slow growing tumor of the notochord remnant that may metastasize to the skin. Physicians and pathologists should be aware of this entity.

Chordoma↗
PubMed2003

Paget's disease of the spine: unusual features and complications.

Paget's disease of bone is a common disorder, with the spine being involved in over 50% of cases. This pictorial review illustrates unusual features and complications of the disease as related to the spine. Unusual features include location in the atlanto-axial region, lytic vertebral Paget's disease and Pagetic ankylosis. Complications related to the spine are mainly neurological due to spinal stenosis, compression fractures and sarcomatous degeneration

Humans↗
PubMedDate not supplied

Disseminated metastatic intramedullary melanoma in an aged grey horse.

A 12-year-old grey Warmblood stallion presented with fever of unknown origin, and anaemia. Five days later it had developed ataxia and become recumbent, and was humanely killed. At necropsy, malignant melanomas were identified in the perineal subcutis, spleen, and thoracic vertebral canal (T10-11). Populations of malignant melanoma cells were scattered throughout medullary cavities of the axial and appendicular skeleton, and were identified grossly as irregular areas of black to grey discoloration. To the authors' knowledge, this is the first report of disseminated intramedullary melanoma in a domestic species.

Animals↗
PubMed2003

Metastatic hepatocellular carcinoma of the maxillary sinus: a rare autopsy case without lung metastasis and a review.

A rare case of metastatic hepatocellular carcinoma (HCC) of the maxillary sinus in a 67-year-old man is reported along with the findings at autopsy. A fine needle aspiration biopsy specimen revealed a characteristic tumour structure resembling primary HCC. At autopsy, metastatic lesions were recognized in the bilateral adrenals, spleen, sternum, vertebrae and lymph node at the lesser curvature of the stomach, but not in the lung, suggesting that the HCC had metastasized to the maxillary sinus via the plexus venous vertebralis and/or the azygos vein, or lymph duct. In our reviewed 29 cases of metastatic HCC in the oro-maxillofacial region, most patients were men in the 50- to 70-year age range. At least 11 cases did not have lung metastasis, and in 18, metastasis to the oro-maxillofacial region was the first sign of HCC. One should be aware of the possibility to encounter the oral lesion as first sign of metastatic HCC.

Adrenal Gland Neoplasms↗
PubMed2002

Intratumoral hemorrhage due to hemangioblastoma arising from a cervical nerve root--a case report.

We describe a case of a 70 year old man suffering from sudden weakness of the left foot. Preoperative neuroimaging examinations showed an oval mass 2 cm in maximal diameter with intratumoral hemorrhage at the seventh cervical vertebra. The mass was supplied by the right lateral thoracocervical artery and was drained to the anterior spinal vein. The intraoperative findings showed the hard reddish tumor was not attached to the pia and the posterior root of the fifth cervical nerve was totally encased by the tumor. A histopathological examination revealed that hemangioblastoma encasing the posterior nerve root totally, so that the tumor was thought to arise from it. Unusual presentation of the neuroimaging examinations is described.

Aged↗
PubMed1975

[A comparison of radiology and scanning with 99mTc-pyrophosphate in 125 patients with tumours (author's transl)].

Various portions of the skeleton were examined in 125 patients both radiologically and by scanning, using 99mTc-pyrophosphate. The results are compared, particular attention being paid to errors in diagnosis. The figures show that scans represent a valuable additional form of examination for detecting tumours which have not been found radiologically. The importance of serial observations is discussed.

Bone Neoplasms↗
PubMed1976

[Radiological aspects of cervical chordomas (author's transl)].

The radiological findings in two patients with histologically verified cervical chordomas are described and compared with 40 others described in the literature. There is no typical radiographic picture. Our cases showed benign-looking, extensive bone erosions of vertebral bodies and neural arches. In addition, there was destruction of the related discs and a soft tissue mass at the level of the bony lesions.

Cervical Vertebrae↗
PubMed1977

[Special indications for using the whole body scanner (author's transl)].

In addition to the role of the body scanner in the diagnosis of diseases of the body cavity and parenchymal organs, the authors review the scope and indications for using whole body computer tomography in special situations. Examples are given of its use in the diagnosis of tumours in the vicinity of the skull base, in the orbits, the facial skeleton, soft tissue tumours, bone diseases and CT-controlled biopsies.

Adult↗