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Results for “Stereotyped Behavior”

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PubMed1982

Altered behavioral responsivity to morphine during the periadolescent period in rats.

The results of previous studies have suggested that periadolescent rats are differentially affected by catecholaminergic agents, when compared with younger or adult animals. Since dopamine-opiate interactions have been demonstrated in rats, the present study was conducted to evaluate the behavioral responsivity of periadolescent and adult rats following doses of morphine ranging from 1 to 10 mg/kg i.p. The responses measured included matrix crossings, rearing, grooming, auto-directed stereotyped behavior and gnawing, and were recorded continuously from 30 to 90 min post-injection. When indicated, scores on each measure were transformed to control for differences observed in the baseline (saline) groups. Analyses of all measures revealed a significant effect of morphine dose, although the shape of the dose-response curve differed for individual responses. In addition, those measures which might be considered locomotor responses (matrix crossing, rearing), as well as grooming, revealed significant main or interactive effects of age. In contrast, those measures characterized as stereotyped behaviors (auto-directed stereotyped behavior and gnawing) revealed no differential effect in periadolescent animals relative to adults. Since locomotor responses and stereotyped behavior have been suggested by previous research to be mediated by the mesolimbic and extrapyramidal dopamine systems, respectively, these results further support the previously suggested hypothesis of the delayed ontogeny of mesolimbic relative to extrapyramidal dopamine pathways.

Animals↗

PubMed1985

Time course of the development of the enhanced behavioral and biochemical responses to amphetamine after pretreatment with amphetamine.

These experiments were designed to examine the time course of development of the enhanced stereotyped behavioral response to amphetamine after withdrawal from chronic pretreatment with amphetamine and to determine whether this time course correlates with that of the enhancement in the amphetamine-induced stimulation of the release of dopamine (DA) from striatal slices. Rats were pretreated with amphetamine (5 mg/kg, i.p.) or saline, twice daily for 5 consecutive days. At 3, 15 and 30 days after withdrawal of the drug the stereotyped behavioral response and the release of endogenous DA from slices of striatum in response to a challenge dose of amphetamine were measured. At all 3 times tested, the stereotyped behavioral response to the challenge dose of amphetamine was enhanced in the rats pretreated with amphetamine, with the greatest degree of enhancement seen at 15 and 30 days after withdrawal of the drug. At these times, the responses were associated with a significant attenuation in the stimulation of locomotor activity produced by the challenge dose of amphetamine, which was probably related to the enhanced stereotyped behavioral response. Amphetamine stimulated the release of endogenous DA from slices of striatum in rats pretreated with saline and amphetamine. However, the release of endogenous DA from slices of rats pretreated with amphetamine was significantly greater than that of saline-pretreated rats at 15 and 30 days after withdrawal of the drug, but not at 3 days after withdrawal. Thus, pretreatment with amphetamine resulted in enhanced behavioral and biochemical responses to amphetamine which increased over time after withdrawal of the drug.(ABSTRACT TRUNCATED AT 250 WORDS)

Amphetamine↗

PubMed2006

Effect of MK-801 and ketamine on hydroxyl radical generation in the posterior cingulate and retrosplenial cortex of free-moving mice, as determined by in vivo microdialysis.

This study investigated the effect of MK-801 and ketamine, N-methyl-D-aspartate (NMDA) receptor antagonists which can induce schizophrenic symptoms and have neurotoxicity in human and animals, on hydroxyl radical (*OH) generation in the posterior cingulate and retrosplenial (PC/RS) cortex of free-moving mice using the salicylic acid trapping technique. MK-801 (0.6 mg/kg) or ketamine (50 mg/kg) acute administration significantly increased *OH levels in mouse PC/RS cortex. The basal *OH levels after MK-801 and ketamine administrations for 7 consecutive days were significantly increased compared with the naive basal levels. MK-801 (0.6 mg/kg) or ketamine (50 mg/kg) challenge after chronic administration further significantly increased dialysate levels of *OH. Our study also found that the release of *OH was secondary to stereotyped behavior, and the intensity of stereotyped behavior induced by MK-801 was more than that induced by ketamine. The results suggested that NMDA receptor antagonists participate in the generation of *OH in the PC/RS cortex of mouse, and oxidative stress, derived from the formation of free radicals, might play an important role in the pathophysiology of these two models of schizophrenia.

Animals↗

PubMed2001

Neurotoxic regimen of methamphetamine produces evidence of behavioral sensitization in the rat.

A neurotoxic regimen of methamphetamine (MA) produces long-term depletions in neostriatal dopamine and serotonin concentrations. In addition to evidence of dopaminergic and serotonergic neurotoxicity, there is evidence of MA-induced behavioral changes. In this regard, stereotypic behavior elicited by MA is greater in rats treated previously with a neurotoxic regimen of MA than in control animals. The present study was designed to determine whether the enhanced stereotypy observed in MA-treated rats is due to the MA-induced loss of dopamine (neurotoxicity) or to the repeated exposure to MA (sensitization). Rats were treated with MA (10 mg/kg every 2 h for four injections) or vehicle at either a normal (24 degrees C) room temperature or a cold (4 degrees C) room temperature, which has been shown to attenuate the MA-induced loss of dopamine. Stereotypy was assessed 7 days after treatment. Rats that had received a neurotoxic regimen of MA at 24 degrees C exhibited 49% and 45% reductions in neostriatal dopamine and serotonin concentrations, respectively, whereas rats treated with MA at 4 degrees C had no significant neurochemical depletions. Stereotypy elicited by MA (5.0 mg/kg) was significantly greater in rats treated with a neurotoxic regimen of MA regardless of the initial treatment temperature. In addition, an injection of apomorphine (0.5 mg/kg) elicited an enhanced stereotypic response in MA-treated rats. These data suggest that the augmented stereotypic behavior observed in rats treated with a neurotoxic regimen of MA is not due to the loss of dopamine, but rather the manifestation of behavioral sensitization, possibly due to an increase in dopamine receptor sensitivity.

Animals↗

PubMed2006

Stereotypy in young children with autism and typically developing children.

Although stereotypy is one of the key diagnostic features of autism, few studies have compared stereotypic behavior in children with autism and typically developing children. The present study employed direct observational measurement methods to assess levels of stereotypic behavior in 2-, 3- and 4-year-old children with autism or pervasive developmental disorder - not otherwise specified (PDD-NOS) and age-matched typically developing peers. Thirty children with autism or PDD-NOS and 30 typically developing children participated. Each child's performance of several early learning and play skills was assessed using a direct observational assessment protocol developed for children with autism who were entering early intensive behavioral treatment. Duration of episodes of vocal and motor stereotypy was recorded from a videotaped 10 min portion of that assessment session. Results indicated that the 2-year-old children with autism or PDD-NOS had somewhat higher levels of stereotypic behavior than the typically developing 2-year-olds, while the 3- and 4-year-old children with autism or PDD-NOS displayed substantially higher levels stereotypic behavior than their same-age peers.

Age Factors↗

PubMed2005

Post-Institutional Autistic Syndrome in Romanian adoptees.

Romanian adoptees have a background of severe neglect. International research has shown that this can give rise to symptoms of autistic behavior. Rutter et al. (1999, Journal of Child Psychology Psychiatry, 40(4), 537-549.) refers to "quasi-autistic patterns", and Federici (1998, Help for the hopelss child: A guide for families. Alexandria: Federici & Assocoates.) to Post-Institutional Autistic Syndrome (PIAS). Eighty Romanian adoptees, averaging 8 years of age, who had resided in the Netherlands for 5 years were studied. Parent interviews and the Auti-R scale showed the extent to which the children exhibited PIAS. In one third of these children we observed (in addition to other behavioral problems) stereotypic behaviors and communication and language disorders. Our findings resembled the Rutter et al. (1999, Journal of Child Psychology Psychiatry, 40(4), 537-549). data. Six of the children were classified within the autistic spectrum pursuant to the Auti-R, and seven within the so-called intermediate group. No difference was found between the girls and the boys. Children who had been in their adoptive families for 5 years or more showed fewer behavior problems than children who had been in their adoptive families for four or less years.

Adoption↗

PubMed1980

Pemoline-induced self-biting in rats and self-mutilation in the deLange syndrome.

Self-mutilation in humans occasionally accompanies physiological disorders such as the deLange syndrome. If pemoline-induced self-biting is behaviorally similar to self-mutilation in the deLange syndrome, similar neurochemical mechanisms may be involved in both. Oral administration of 140 and 220 mg/kg pemoline reliably induced persistent self-biting in rats. This behavior was indistinguishable from stereotyped grooming and its most common target was the medial digits of the foreleg. Pemoline-induced self-biting was accompanied by hyperactivity, stereotyped behavior, abnormal social behavior, abnormal sensorimotor behavior, and unresponsiveness or avoidance of moderate levels of sensory stimuli. Several of these behaviors have also been reported in deLange patients.

Animals↗

PubMed2000

The children's Social Behavior Questionnaire for milder variants of PDD problems: evaluation of the psychometric characteristics.

The Children's Social Behavior Questionnaire (CSBQ) contains items referring to behavior problems seen in children with milder variants of PDD. Data of large samples of children diagnosed as having high-functioning autism, PDDNOS, ADHD, and other child-psychiatric disorders were gathered. Besides the CSBQ, parents completed the Autism Behavior Checklist (ABC) and the Child Behavior Checklist (CBCL). The data provided the basis for scale construction of the CSBQ, a comparison of the CSBQ scales with other instruments and a comparison of groups on scores on the CSBQ. The 5 scales obtained referred to Acting-out behaviors, Social Contact problems, Social Insight problems, Anxious/Rigid behaviors and Stereotypical behaviors. Results show that the CSBQ has good psychometric qualities with respect to both reliability and validity. A comparison of the different groups showed that significant group differences were found on all scales. In general, the autism group received the highest scores, followed by the PDDNOS group and the ADHD group. Exceptions were on the Acting-out scale, where the ADHD group scored highest and on the Social Insight scale, where no significant difference was found between the PDDNOS group and the ADHD group. Implications of the results and suggestions for further research are discussed.

Adolescent↗

PubMed1992

The amygdala is essential for the expression of conditional hypoalgesia.

Two experiments were conducted to determine whether the amygdala is involved in the performance of hypoalgesia as a Pavlovian conditional response. Rats were trained by pairing a distinctive observation chamber with a series of 3 footshocks. Rats were returned to the chamber 24 hr later, and the time spent engaged in freezing behavior and stereotyped behavioral reactions to a subcutaneous injection of dilute formalin was recorded. Sham-operated subjects spent large amounts of time freezing and were hypoalgesic on the formalin test in relation to nonshocked controls. Small electrolytic lesions of the amygdala eliminated both defensive freezing behavior and hypoalgesia without altering baseline reactions to formalin. Larger lesions made with ibotenic acid produced a similar pattern of results implicating neurons intrinsic to the amygdala. These results indicate that the amygdala may represent a forebrain site critical for the activation of descending antinociceptive systems in response to certain classes of environmental stressors.

Amygdala↗

PubMed1996

Functional changes in neuronal systems induced by phencyclidine administration.

To analyze the mechanisms of PCP abuse, we investigated the changes in PCP-induced motivational properties and neuronal functions in animals. First, we determined that PCP-induced withdrawal syndrome may, in part, be produced by 5-HTergic neuronal systems. Second, using rats treated with subacute PCP, we established that subacute PCP may produce behavioral changes (stereotyped behaviors and hyperlocomotion), mediated by both dopaminergic, 5-HTergic neuronal, and NO systems. Third, using the place conditioning paradigm, we confirmed that (1) both dopamine-D1 and 5-HT2A receptors, but not sigma receptors, may be involved in PCP-induced place aversion, and (2) subacute PCP produces place preference. Finally, we demonstrated that subacute PCP may produce neurochemical changes (the number of 5-HT2A receptors, dopamine turnover, NO synthesis, and immediate early gene expression). These results suggested that several neuronal changes may be related to behavioral changes induced by subacute PCP. Furthermore, it is hypothesized that the alternations of several neuronal systems may establish PCP abuse via the changes of the immediate early gene expression and NO activity induced by subacute PCP treatment. Further studies using receptor selective ligands and sensitive probes that could associate with the pharmacological actions of PCP may elucidate the mechanisms of PCP abuse.

Animals↗

PubMed2000

Studies of amphetamine or methamphetamine psychosis in Japan: relation of methamphetamine psychosis to schizophrenia.

There exist clinical characteristics of methamphetamine (MAP) psychosis in the Japanese population. MAP psychosis involves paranoid-hallucinatory states indistinguishable from paranoid schizophrenia, with residual volitional disturbances (e.g., loss of spontaneity and idleness). Paranoid-hallucinatory states persist after the pharmacological effects of MAP have worn off and readily reappear upon a reinjection of MAP. Individuals with a history of MAP psychosis further undergo spontaneous recurrence of their paranoid-hallucinatory states in response to stress. The development of MAP psychosis might therefore be related to persisting brain damage or changes in brain metabolism induced by repeated MAP use, and thus studies of the clinical course and neurological basis of MAP psychosis could provide insights into the pathophysiology of schizophrenia. Accordingly, psychiatrists have studied the clinical characteristics of MAP psychosis and examined the neurobiological basis of MAP-induced behavioral sensitization, using animals. MAP-induced behavioral sensitization might well be related to dopamine supersensitivity; however, the contribution of presynaptic autoreceptors remains controversial, and other hypotheses should be considered. Recently, the process that triggers spontaneous recurrence of MAP psychosis (flashbacks) and corresponding peripheral neurotransmitter functions has been studied. Stress sensitization associated with noradrenergic hyperactivity, involving increased dopamine release, appears to be crucial in the development of flashbacks. Overall, MAP-induced susceptibility to paranoid-hallucinatory states and to abnormal behavior (e.g., stereotyped behavior) in animals is examined as a model for predicting relapses of paranoid schizophrenia. Further extensive studies on the neurobiological and molecular mechanisms of this susceptibility are required.

Amphetamines↗

PubMed1993

The association between psychiatric diagnoses and severe behavior problems in mental retardation.

To investigate the relationship between psychiatric disorders and severe behavior problems in mental retardation, statewide client databases from developmental disabilities services in California (N = 89,419) and New York (N = 45,683) were analyzed and juxtaposed. The study focussed on nine major DSM-III-R psychiatric categories (or their equivalents), and severe forms of aggressive behavior, property destruction, self-injurious behavior, and stereotyped behavior in individuals 45 years old and younger with mental retardation of all levels of severity. In California, 3.9% had at least one psychiatric diagnosis; in New York, 5.4%. The rate of specific psychiatric diagnoses was variable across states, suggesting local preferences in diagnostic practices. Severe behavior problems occurred in 22.1% in California and in 41.4% in New York. This difference in rates can be attributed in part to different recording criteria for behavior problems. With regard to the association between psychiatric diagnoses and problem behaviors the results were consistent across databases: No compelling correlations were found. This means that neither aggression, self-injury, destruction, nor stereotypies determine whether a person receives a psychiatric diagnosis or not.

Adolescent↗

PubMedDate not supplied

[Influence of D1 dopamine receptor activation on extinction of passive avoidance and amnesia in aggressive and submissive mice].

In mice with aggressive and submissive behavioral stereotypes, passive avoidance retrieval in extinction and amnesia was shown to be differently dependent on the activation of D1 dopamine receptors. In extinction, agonist of D1 receptors SKF 38393 injected before training or on 12-th day of testing in a dose of 5 mg/kg impaired the retrieval of a conditioned habit in aggressive mice and improved the retrieval in submissive mice. The opposite effects of D1 receptor activation depending on stereotype were also observed in a procedure of amnesia. In aggressive mice, SKF 38393 essentially reduced the resistance to amnesic effects characteristic of this stereotype. In submissive mice, SKF 38393 attenuated the amnesic effect of a detention in a dangerous compartment and restored the amnesic memory trace. Possible mechanisms of selective involvement of D1 receptors in retention of memory trace of aversive stimuli during extinction and amnesia in mice with different stereotypes of behavior are discussed.

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-ben↗

PubMedDate not supplied

The effect of hand splints on stereotypic hand behavior in Rett's syndrome.

The purpose of this study was to examine the effect of hand splints and one elbow restraint on persistent stereotypic hand movements of four girls with Rett's syndrome. Among the most characteristic features of Rett's syndrome are stereotypic hand wringing and loss of previously acquired functional hand skills. Hand splints and one elbow restraint were used in this study. The subject's stereotypic hand behavior and functional hand use were calculated from five-minute segmental video tape recordings. The study consisted of three phases: baseline, intervention, and withdrawal. All subjects demonstrated a decrease in stereotypic hand behavior after the application of hand splints. Although splints showed a positive effect on hand movements in Rett's syndrome, they could also lead to other, undesirable, movements. Whether splints have a positive effect on the functional use of the hand should be investigated in more subjects.

Child↗

PubMed1979

An analysis of overcorrection movements.

Overcorrection procedures were designed for three profoundly retarded adults such that the overcorrection activities were topographically dissimilar to (i.e., did not physically prevent) the stereotyped behavior targeted for treatment. Using reversal designs, we recorded data on both the target behavior and the behavior used as the overcorrection responses. Results showed that overcorrection was effective in reducing the stereotyped behavior for each subject; however, the rates of the overcorrection responses either remained variable or decreased during the treatment phases. These findings suggest that although overcorrection is a valuable technique in reducing behavior, the overcorrection responses (e.g., restitutional acts, positive practice, functional movement training) may not increase in the absence of specific reinforcement contingencies. The importance of utilizing differential reinforcement procedures, especially with mentally retarded persons, in conjunction with ocercorrection was discussed.

Adolescent↗

PubMed2006

Weight stereotypes and behavioral intentions toward thin and fat peers among White and Hispanic adolescents.

PURPOSE: This study examined weight stereotypes among White and Hispanic youth. Specific objectives were to: (a) document stereotyped beliefs about fat vs. thin peers; (b) examine the extent to which stereotyped beliefs contribute to behavioral intentions toward fat vs. thin peers; and (c) explore potential differences in weight stereotypes and behavioral intentions in White and Hispanic youth. METHODS: Participants, 157 Hispanic and 117 White middle school students, completed a demographic and background survey, the Fat Stereotypes Questionnaire (FSQ), Adjective Checklist, and Shared Activities Questionnaire (SAQ). RESULTS: Participants endorsed weight-related stereotypes, which were predictive of their social, academic, and recreation behavioral intentions. Participants indicated greater willingness to engage in social (p < .001), academic (p < .05), and recreational (p < .001) activities with thin vs. fat peers. Few differences were found between White and Hispanic adolescents. CONCLUSIONS: The results of this study highlight the ubiquitous nature of stereotyped beliefs about fat youth. Fat youth are considered unhealthy, lazy, and socially inept by their peers. Such stereotypes influence a variety of behavioral intentions and may contribute to discriminatory behaviors and difficult peer relationships. Additional research focused on weight stereotypes and peer relationships is needed.

Adolescent↗

PubMed1980

Environmental influences on self-stimulatory behavior.

Effects of passive environmental conditions (quiet, radio, and television) and manipulable objects (no toys, toys, toys plus staff interaction) on stereotypic behavior were evaluated. Four institutionalized, mentally retarded residents with high rates of stereotypic behavior were observed in a multipurpose room of their cottage. Results showed statistically significant lower levels of stereotypic behavior under the quiet and music conditions as compared to the television condition. There were no significant differences between the three manipulable-object conditions.

Adult↗

PubMed2003

Correlating brain metabolism with stereotypic and locomotor behavior.

Many studies have shown that developmental cocaine exposure alters brain function and behavior, the present study examined the relationship between brain metabolism and behavioral responses to drug challenge. SKF 82958, a selective D1 dopamine agonist, was administered to preweaning cocaine-exposed (50 mg/kg/day) rats and controls at 60 days of age. Deoxyglucose was administered 30 min later, during the peak behavioral response, to measure brain functional activity. Pearsonproduct-moment correlations of behavior (locomotor activity and stereotypic behavior) with rates of glucose metabolism in components of the nigrostriatal and mesolimbic circuits were analyzed. The analysis revealed that under saline-challenge conditions in control animals, rates of metabolism in mesolimbic regions are positively correlated to rates of locomotor activity, whereas in cocaine-treated rats, these correlations were absent. Following SKF challenge, a different pattern was seen; locomotor activity or stereotypic behavior was not correlated with mesolimbic or nigrostriatal metabolism, respectively, in controls but was positively correlated in cocaine-treated rats. Therefore, cocaine exposure during development enhances the coupling of metabolism in components of the mesolimbic and nigrostriatal dopamine systems with the behavioral output associated with these systems under drug-challenge conditions. This may be due to loss of inhibitory influences within the mesolimbic and nigrostriatal systems. Thus, the correlation of behavior and cerebral glucose metabolism provides a unique way of examining the effect of developmental cocaine exposure.

Animals↗