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The assessment of proteolysis levels is often achieved by global quantification of the peptides soluble at different TCA concentrations, but little information is available on the features of this precipitation mechanism. Peptic, tryptic and chymotryptic digests of alpha s1, beta, and kappa caseins have been prepared and fractionated by RP-HPLC and each isolated peptide was identified. Each digest was precipitated by adding TCA to different final concentrations (2, 4, 8, and 12%). The soluble fraction was analysed by RP-HPLC. Relationships have been searched between the properties of 75 peptides obtained in this way, and their solubilities in TCA. The best correlation was found with the peptide retention time in RP-HPLC, which can be regarded as the experimental measure of peptide hydrophobicity. We concluded that TCA, by interacting with peptides, induces an increase of the hydrophobicity of peptides which can lead to aggregation through hydrophobic interactions.
Trichloracetic acid for deep and superficial chemical peeling can be effectively utilized by experienced physicians. It is an excellent alternative if phenol chemical peel is contraindicated.
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BACKGROUND AND OBJECTIVES: To evaluate and compare the efficacy and adverse effects of trichloracetic acid and cryotherapy (using liquid nitrogen) in the treatment of external genital warts. STUDY DESIGN: Eighty-six patients were enrolled into a randomized clinical trial in the Genitourinary Medicine Department of the Coventry and Warwickshire Hospital (Coventry) between November 1990 and June 1991. External genital warts were treated with either trichloracetic acid or cryotherapy (using liquid nitrogen) on a once weekly basis. They received up to six treatments of either therapy. RESULTS: Complete clearance of warts in patients who received up to six treatments of cryotherapy were observed in 86% of cases and in 70% of patients who received up to six treatments of trichloracetic acid. Thirty percent of patients who were treated with trichloracetic acid developed ulcerations at the site of its application. CONCLUSION: In this study we found that cryotherapy (using liquid nitrogen) is more effective than that of trichloracetic acid for the treatment of external genital warts. It is also less likely to cause ulceration.
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