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A comparative tolerance study of terfenadine-pseudoephedrine combination tablets and pseudoephedrine tablets in patients with allergic or vasomotor rhinitis.

In this multicentre, double-blind, randomized, parallel group study, 315 patients with allergic or vasomotor rhinitis were treated on a twice daily dosing schedule with either a 60 mg terfenadine-120 mg pseudoephedrine hydrochloride combination or 120 mg pseudoephedrine hydrochloride (extended release) for 2 weeks. No clinically significant differences between the two groups were noted in body weight, temperature, respiration rate or blood pressure following the treatment period. An increase in mean heart rate of approximately 5 beats/min from entry to the final clinic visit was noted in both treatment groups. No clinically significant changes were noted in either treatment group when pre- and post-treatment electrocardiograms were compared. There were also no clinically significant alterations in laboratory values, which included serum chemistry, haematology and urinalysis, within or between either group. The adverse events profiles for both groups were similar. The most frequent adverse event was insomnia, in 40 (25.3%) patients given the terfenadine-pseudoephedrine combination and in 42 (26.8%) of those given pseudoephedrine. No unusual or unexpected adverse events were reported.

Adult↗
PubMedDate not supplied

'Tablet' makes for good medicine. Case study: tablet-style computers can enhance physician satisfaction, revenue stream.

Shawnee Mission (Kan.) Medical Center's affiliated medical practice, Shawnee Mission Physicians Group, is developing an inexpensive, cost-effective solution for electronic patient charge capture. It helps physicians track their inpatient services and billable encounters, integrates with their medical practice information technology scheduling and billing systems, and can incorporate forthcoming hospital-based digital radiology viewing and an electronic medical record. Learn how the system works and how the technology benefits the two organizations.

Diffusion of Innovation↗