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PubMed1992

Six-months versus nine-months chemotherapy for tuberculosis of lymph nodes: preliminary results. British Thoracic Society Research Committee.

One-hundred and ninety-nine patients with peripheral lymph node tuberculosis were randomized to treatment with either E2H9R9, Z2H9R9 or Z2H6R6 regimens (E, ethambutol; H, isoniazid; R, rifampicin; Z, pyrazinamide; numbers denote duration of therapy in months). One-hundred and thirty-three patients were diagnosed by aspiration/biopsy leaving residual nodes, 44 were diagnosed after excision of the palpable nodes and 22 were diagnosed on clinical grounds supported by a strongly positive tuberculin test. Treatment was completed as planned by 157 patients. Eight patients required aspirations after commencing chemotherapy, seven on ethambutol and one on pyrazinamide (P = 0.005). There was no statistically significant difference between the regimens in speed of resolution of nodes, or in the percentage with residual nodes at the end of treatment, or in the numbers developing fluctuation or sinuses. Follow-up to 30 months from commencement of treatment continues in order to establish relapse rates for the regimens.

Adolescent↗
PubMed1993

Six months versus nine months chemotherapy for tuberculosis of lymph nodes: final results.

Of 199 patients treated for peripheral lymph node tuberculosis, 157 completed treatment as planned. Fifty received E2H9R9, 56 Z2 H9R9 and 51 Z2H6R6 regimens (E = Ethambutol; H = Isoniazid; R = Rifampicin; Z = pyrazinamide: numbers denote duration of therapy in months). In follow-up from 9 to 30 months, there were no significant differences between the regimens in enlargement of existing nodes, development of new glands or sinuses, in the need for new operative procedures, or in the percentage with measurable nodes at 30 months. Nine patients were felt to have had a clinical relapse (4 E2H9R9; 2 Z2H9R9; 3 Z2H6R6) although this was not confirmed bacteriologically in the five cases where material was sent for culture. These differences were not statistically different. The 6 month Z2H6R6 regimen performs just as well as the 9 month regimens Z2H9R9 and E2H9R9 in patients with fully sensitive organisms, and has the additional benefits of convenience and reduced cost.

Adolescent↗