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PubMed1994

Functional imaging and language: evidence from positron emission tomography.

Positron emission tomography (PET) provides an unprecedented opportunity to study the organization of cognitive functions in the working brain of normal individuals. A number of PET experiments, based on well-established paradigms derived from cognitive psychology, have investigated several aspects of language processing. These studies show that word processing is carried out by a distributed network of cortical areas with functional specificity. Results of this research sometimes confirm--sometimes clearly contradict--classic axioms of language organization. This article illustrates some of the methodological issues in PET research, then provides an overview of the most relevant studies using PET. Integrated with other functional imaging methodologies and with behavioral data from cognitive psychology and lesion studies, PET will certainly continue to represent a precious tool to enhance our knowledge of the functional organization of language.

Animals↗

PubMedDate not supplied

Lessons from a doctoral thesis.

The production of a doctoral thesis is a time-consuming affair that until recently was done in conjunction with professional publishing services. Advances in computer technology have made many sophisticated desktop publishing techniques available to the microcomputer user. We describe the computer method used, the problems encountered, and the solutions improvised in the production of a doctoral thesis by computer. The Apple Macintosh was selected for its ease of use and intrinsic graphics capabilities. A scanner was used to incorporate text from published papers into a word processing program. The body of the text was updated and supplemented with new sections. Scanned graphics from the published papers were less suitable for publication, and the original data were replotted and modified with a graphics-drawing program. Graphics were imported and incorporated in the text. Final hard copy was produced by a laser printer and bound with both conventional and rapid new binding techniques. Microcomputer-based desktop processing methods provide a rapid and cost-effective means of communicating the written word. We anticipate that this evolving technology will have increased use by physicians in both the private and academic sectors.

Academic Dissertations as Topic↗

PubMed2006

Mapping sentence form onto meaning: the syntax-semantic interface.

The understanding of sentences involves not only the retrieval of the meaning of single words, but the identification of the relation between a verb and its arguments. The way the brain manages to process word meaning and syntactic relations during language comprehension on-line still is a matter of debate. Here we review the different views discussed in the literature and report data from crucial experiments investigating the temporal and neurotopological parameters of different information types encoded in verbs, i.e. word category information, the verb's argument structure information, the verb's selectional restriction and the morphosyntactic information encoded in the verb's inflection. The neurophysiological indices of the processes dealing with these different information types suggest an initial independence of the processing of word category information from other information types as the basis of local phrase structure building, and a later processing stage during which different information types interact. The relative ordering of the subprocesses appears to be universal, whereas the absolute timing of when during later phrases interaction takes places varies as a function of when the relevant information becomes available. Moreover, the neurophysiological indices for non-local dependency relations vary as a function of the morphological richness of the language.

Communication↗

PubMed2001

Functional asymmetry in schizophrenic patients during auditory speech processing.

In two experiments, functional laterality and interhemispheric transfer was investigated in schizophrenic patients (n=14) and healthy controls (n=17). In Experiment 1, words and pseudowords were presented either to the left or right ear (monaural condition) or simultaneously to both ears (binaural condition). In Experiment 2, subjects had to discriminate two tones differing in frequency during monaural and binaural stimulation. Healthy controls showed a right ear advantage (REA) for word stimuli, indicating left-hemispheric superiority for word processing. The same lateralization pattern was found in schizophrenic patients, indicating unimpaired functional lateralization of auditory language processing. In both groups, no REA was found for pseudowords resulting in significant WordnessxEar interactions. When presented binaurally, auditory processing of words and pseudowords did not differ significantly from any of the two monaural conditions. Tone discrimination did not lead to any ear asymmetry. The results show normal patterns of functional asymmetry during auditory language processing and tone discrimination in schizophrenic patients.

Adult↗

PubMed1996

Multiple simultaneous stimulus presentation facilitates lexical processing.

Bilateral presentation of two copies of the same word leads to faster lexical decisions compared to unilateral presentation alone (bilateral gain). This has implications for theories of interhemispheric interaction, because it suggests that, under certain conditions, both hemispheres cooperate rather than inhibit each other or act independently. Experiment 1 confirmed that the bilateral gain is word-specific and does not occur for pseudowords. Whereas the bilateral gain proved to be present for words of different word frequencies, results of Experiment 2 suggest that it is slightly stronger for high-frequency words compared to words of lower frequencies. Experiment 3 revealed that higher numbers of stimuli (two versus four copies of the same word/pseudoword) presented at the same time lead to an additional improvement of word processing. These results support a neurobiological model of word representation assuming that words are cortically represented in widely distributed interhemispheric cell assemblies. Summation of activity in such assemblies leads to faster and more reliable ignition of the network.

Adult↗

PubMed2004

Processing of written word and nonword visual information by individuals with prelingual deafness.

The objective of this study was to bring about a better understanding of the abilities of prelingually deafened individuals to process word and nonword visual information. Students with prelingual deafness (n = 18, mean grade = 5.1) and a task-matched hearing control group (n = 28, mean grade = 4.9) judged the identicalness of physically (perceptually) or conventionally identical words or drawings to learn about differences in their processing strategies as the phonological information contained in these stimuli was manipulated. Findings suggested that the information-processing skills of both groups of participants were similar regardless of stimulus material (i.e., words or drawings) and whether such processing required the referencing of conceptual knowledge. Evidence further indicated that both groups relied on similar strategies for processing the stimuli but that neither relied on a phonology-based strategy.

Case-Control Studies↗

PubMed1995

Words interact with colors in a globally aphasic patient: evidence from a Stroop-like task.

Stroop-like manual reaction time tasks were administered to 16 controls and one globally aphasic patient who was unable to match written color words with the corresponding color. Although the patient could not explicitly access the meaning of written color words, he showed a similar pattern of performance in the reaction time tasks as the controls: written words were processed automatically and they interacted with the processing of the color of the letters. Thus, the results of this study suggested that it is possible to process unrecognized words implicitly to a cross-domain semantic level where the processing of words interacts with the processing of colors. The results from this and other studies on implicit language processing indicate that linguistic stimuli can be analysed to relatively high levels without any awareness.

Aphasia↗

PubMed2001

Divided attention and prerecognition processing of spoken words and nonwords.

Three recognition memory experiments examined phonemic similarity and false recognition under conditions of divided attention. The manipulation was presumed to have little effect on automatic, perceptual influences of memory. Prior research demonstrated that false recognition of a test word (e.g., discrepancy) was higher if the study list included a nonword derived from the future test word by changing a phoneme near the end of the item (e.g., discrepan/l/y) relative to an early phoneme change (e.g., /l/iscrepancy). The difference has been attributed to automatic, implicit activation of test words during prerecognition processing of related nonwords. Three experiments demonstrated that the late-change condition also contributed to higher false recognition rates with divided attention at encoding. Dividing attention disrupted recognition memory of studied words in Experiments 1 and 3. Results are discussed in terms of their relevance for an interpretation emphasizing the automatic, implicit activation of candidate words that occurs in the course of identifying spoken words and nonwords.

Attention↗

PubMed1998

[Selected aspects of computer-assisted literature management].

We want to report about our own experiences with a database manager. Bibliography database managers are used to manage information resources: specifically, to maintain a database to references and create bibliographies and reference lists for written works. A database manager allows to enter summary information (record) for articles, book sections, books, dissertations, conference proceedings, and so on. Other features that may be included in a database manager include the ability to import references from different sources, such as MEDLINE. The word processing components allow to generate reference list and bibliographies in a variety of different styles, generates a reference list from a word processor manuscript. The function and the use of the software package EndNote 2 for Windows are described. Its advantages in fulfilling different requirements for the citation style and the sort order of reference lists are emphasized.

Database Management Systems↗

PubMed2000

Semantic handling of medical compound words through sound analysis and generation processes.

Compound words are frequently encountered in the medical domain. Their conciseness complies with the telegraphic style usually adopted by clinicians in daily practice. This amplifies the need for clarifying their semantic interpretation and representation through respectively the analysis and generation processes. While highlighting the peculiarities of medical compound words, this paper shows how model-driven linguistic tools accurately deal with the compositionality of medical language. These statements are illustrated by means of examples, stemming from the handling of surgical procedures as part of the GALEN-IN-USE project.

Linguistics↗

PubMed1997

Process dissociation, cognitive architecture, and response time: comments on Lindsay and Jacoby (1994)

Process dissociation is based on 2 assumptions about the processes being dissociated: invariance of the processes across situations, and stochastic independence of the processes. In a recent application of process dissociation to the Stroop task (D. S. Lindsay & L. L. Jacoby, 1994), both of those assumptions were violated. It is argued that these violations were due to (a) an oversimplification of the processing architecture that ignores common stages such as guessing and response selection, (b) an assumption that the more automatic process (word reading) dominates over the intended process (color naming) in determining responses, and (c) an assumption that switching from the more common speeded response instruction (measuring speed) to a deadline response instruction (measuring accuracy) does not change processing. General implications for applying process dissociation to dynamic tasks are discussed.

Attention↗

PubMed2000

A toolset for medical text processing.

The processing of medical texts is a burden in the absence of a toolset designed for simple operations such as recognizing morphological variants, updating and accessing a word dictionary of the domain and segmenting words with multiple morpho-semantems. The apparent simplicity of these basic operations is an illusion because it soon becomes clear that quality implementation is a long-term task. Coherency between subtasks may be lacking unless strict rules are enforced. In fact, good tools are rarely available or have not been tailored for the medical profession. This paper aims at defining a complete toolset for medical word processing. In addition, it provides relevant examples of the inherent difficulties of this task. It reports on typical results that can be expected from an industry-standard implementation.

Artificial Intelligence↗

PubMed2003

Perceptual implicit memory relies on intentional, load-sensitive processing at encoding.

In two experiments, we examined whether the encoding processes leading to perceptual implicit memory satisfied the intentionality and load insensitivity criteria for automaticity. Whether participants intended to process words or digits, in displays containing both, was manipulated in Experiment 1. Results showed an effect of intention on a subsequent perceptual identification task and a recognition task. Load (one, two, and four words) and exposure duration (1,000, 600, and 200 msec) at encoding were manipulated in Experiment 2. Recognition was affected by both variables, but performance on the perceptual identification task was affected only by load. In both experiments, the results showed that controlled (intentional, load-sensitive) processing of words at encoding is essential for later perceptual implicit memory. That is, the encoding processes leading to perceptual implicit memory fail both criteria of automaticity.

Attention↗

PubMed1999

Semantic and phonological information flow in the production lexicon.

When speakers produce words, lexical access proceeds through semantic and phonological levels of processing. If phonological processing begins based on partial semantic information, processing is cascaded; otherwise, it is discrete. In standard models of lexical access, semantically processed words exert phonological effects only if processing is cascaded. In 3 experiments, speakers named pictures of objects with homophone names (ball), while auditory distractor words were heard beginning 150 ms prior to picture onset. Distractors speeded picture naming (compared with controls) only when related to the nondepicted meaning of the picture (e.g., dance), exhibiting an early phonological effect, thereby supporting the cascaded prediction. Distractors slowed picture naming when categorically (e.g., frisbee) related to the depicted picture meaning, but not when associatively (e.g., game) related to it. An interactive activation model is presented.

Humans↗

PubMed1998

Cognitive activity and physiological arousal: processes that mediate mood-congruent memory.

This research proposes that the cognitive activity associated with the experience of an emotional state mediates the occurrence of mood-congruent processing. Two experiments examined the role of cognitive activity in selective processing of words in a mood congruence paradigm. Four induction procedures were used: a depressed-mood induction, a schema induction organized around the theme of writing a paper, an arousal induction, and a control neutral-mood induction. The memory task consisted of recalling a word list composed of negatively associated and thematically organized words. Selective processing was demonstrated in conjunction with the depressed-mood and organizational-schema induction procedures. In contrast, the arousal and neutral induction procedures did not produce selective processing of words from the list. The findings support the thesis that cognitive activity mediates the selective processing typical of mood congruence as distinct from arousal processes per se. The findings are discussed with respect to the resource allocation model and semantic network theory.

Affect↗

PubMed2004

Measurements of auditory-verbal STM span in aphasia: effects of item, task, and lexical impairment.

In the first part of this study, we investigated effects of item and task type on span performance in a group of aphasic individuals with word processing and STM deficits. Group analyses revealed significant effects of item on span performance with span being greater for digits than for words. We also investigated associations between subjects' lexical-semantic and phonological processing abilities and performance on four measures of verbal span (digit and word span, each varied for type of response, verbal vs. pointing) as well as one measure of nonverbal span. We predicted and found that the patterns of association between verbal span tasks and lexical abilities reflected the integrity of language processes and representations deployed in each paradigm used to assess span. Performance on the pointing span task, which engages both lexical-semantic and phonological processes, correlated with measures of both lexical-semantic and phonological abilities. Performance on repetition span, which engages primarily input and output phonological processes, correlated with measures of phonological abilities but not measures of lexical-semantic abilities. However, when partial correlations were performed for two subject groups based on their relative preservation of lexical-semantic ability (less or more than phonological ability), repetition span correlated with lexical-semantic measures only in the subgroup with relatively impaired lexical-semantics. Additionally, performance on the nonverbal span task correlated with measures of phonological abilities, suggesting either a general cognitive deficit affecting verbal and nonverbal STM or possibly, the use of a verbal strategy to perform this task. Our discussion focuses on the interpretation of span measurements in clinical practice and research, as well as the implications of these data for theories of short-term memory and word processing.

Adult↗

PubMed1998

Focus as a contextual priming mechanism in reading.

In two experiments, we found that readers are sensitive to manipulations of syntactically marked focus and that focus is an effective message level contextual priming mechanism. Changes in focus resulted in changes in sentence context effects on subsequent target word processing. This was demonstrated in latency to name the target word (Experiment 1) and in initial looking time on the target in silent reading (Experiment 2). Experiment 2 also revealed direct effects on the focused items, as readers made fewer regressions and spent less total time on a word that was focused than when it was not focused. However, no initial processing time effects were found on the focused word.

Adult↗

PubMedDate not supplied

Preparing for evolving technologies.

It's not always enough to possess basic word processing skills--the medical transcriptionist who can work with various software applications is at an advantage in today's job market.

Computer Graphics↗