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PubMed1993

False positive values of PAP and PSA in complicated and non-complicated benign prostatic hypertrophy.

Cancer of the prostate has become the most frequent form of cancer in men. Different tests have been used in cancer of the prostate, including prostate acid phosphatase (PAP) and the prostate specific antigen (PSA). Their value as diagnostic screening is disputed, as it is known that there are false positives for both markers in benign prostate conditions. In order to explain their possible diagnostic value, we studied 112 patients with well-documented benign prostate hyperplasia. The data included in this study were: estimated weight, urinary infection, bladder catheter and histopathological study. By using as cut-off 4 ng/ml for PAP and 10 ng/ml for PSA we found a percentage of false positives of 13% and 14% respectively. These percentages were in relation to the weight of the gland in each cases and in the case of PSA to the patient's clinical situation (infection, catheter).

Acid Phosphatase↗
PubMed1997

[Cerebral vascular complication of hyperhomocysteinemia. Controlling thromboembolic complications with folates].

BACKGROUND: Young patients who experience cardiovascular events may have raised levels of homocysteine. There may be several causes for this hyperhomocysteinemia. CASE REPORT: Cerebrovascular disease occurred in a 40-year-old female smoker with hyperhomocysteinemia. This patient subsequently had several episodes of thromboembolism involving the brain and lower limb arteries. Prothrombin concentration was difficult to control with antivitamin K anticoagulants. Investigations to identify a genetic cause of hyperhomocysteinemia revealed that she was homozygous for the C677T mutation on the methylenetetrahydrofolate reductase gene. There was no G1691A mutation of the factor V gene, a risk factor for familial thrombosis. Supplementation with folic acid successfully halted episodes of thromboembolism (follow-up 2 years) and prothrombin levels stabilized under treatment. DISCUSSION: The C677T mutation, which is common in the general population (15.7%), cannot explain the effect of folate supplementation alone. Other mutations affecting homocysteine metabolism could have a potentializing effect on vascular events.

Adult↗
PubMed2000

Gamma knife radiosurgery as a primary treatment for prolactinomas.

OBJECT: The purpose of this study was to estimate the efficacy of gamma knife radiosurgery (GKS) in controlling tumor growth and endocrinopathy associated with prolactinomas. METHODS: Between 1993 and 1997, 164 of 469 patients with pituitary adenomas treated by GKS harbored prolactinomas. The dose to the tumor margin ranged from 9 to 35 Gy (mean 31.2 Gy), and the visual pathways were exposed to a dose of less than 10 Gy. The mean tumor diameter was 13.4 mm. The mean follow-up time for 128 cases was 33.2 months (range 6-72 months). Tumor control was observed in all but two patients who underwent surgery 18 and 36 months, respectively, after GKS. Clinical cure was achieved in 67 cases. Clinical improvement was noted with a decrease in the hyperprolactinemia after GKS. Nonetheless, in 31 (29%) of 108 patients who were followed for more than 2 years no improvement in serum prolactin levels was demonstrated, although this could be normalized by bromocriptine administration after treatment. Nine infertile women became pregnant 2 to 13 months after GKS and all gave birth to normal children. There was no visual deterioration related to GKS. Five women experienced premature menopause. In these patients there was subtotal disappearance of the tumor and an empty sella developed. CONCLUSIONS: Gamma knife radiosurgery as a primary treatment for prolactinomas can be safe and effective both for controlling tumor growth and for normalization of prolactin hypersecretion. A higher margin dose (> or = 30 Gy) seemed to be associated with a better clinical outcome. Gamma knife radiosurgery may make prolactinomas more sensitive to the bromocriptine.

Humans↗
PubMed2002

Radiosurgery for residual or recurrent nonfunctioning pituitary adenoma.

OBJECT: Nonfunctioning pituitary adenomas comprise approximately 30% of all pituitary tumors. The purpose of this retrospective study is to evaluate the efficacy and role of gamma knife radiosurgery (GKS) in the management of residual or recurrent nonfunctioning pituitary adenomas. METHODS: A review was conducted of the data obtained in 42 patients who underwent adjuvant GKS at the University of Pittsburgh between 1987 and 2001. Prior treatments included transsphenoidal resection, craniotomy and resection, or conventional radiotherapy. Endocrinological, ophthalmological, and radiological responses were evaluated. The duration of follow-up review varied from 6 to 102 months (mean 31.2 months). Fifteen patients were observed for more than 40 months. The mean radiation dose to the tumor margin was 16 Gy. Conformal radiosurgery planning was used to restrict the dose to the optic nerve and chiasm. Tumor control after GKS was achieved in 100% of patients with microadenomas and 97% of patients with macroadenomas. Gamma knife radiosurgery was equally effective in controlling adenomas with cavernous sinus invasion and suprasellar extension. No patient developed a new endocrinological deficiency following GKS. One patient's tumor enlarged with an associated decline in visual function. Another patient experienced a deterioration of visual fields despite a decrease in tumor size. CONCLUSIONS: Gamma knife radiosurgery can achieve tumor control in virtually all residual or recurrent nonfunctioning pituitary adenomas. Dose sparing facilitates tumor management even when the adenoma is close to the optic apparatus or invades the cavernous sinus.

Adenoma↗
PubMedDate not supplied

Influence of needle-tip position on the incidence of immediate complications in 2,217 selective lumbar nerve root blocks.

BACKGROUND CONTEXT: Selective lumbar nerve blocks (SLNBs) are a popular, minimally invasive treatment and diagnostic tool for lumbar radiculopathy. It is therefore relevant to determine the complication rate for SLNBs, as well as examine the association between needle-tip position and complication rates in order to improve safety. PURPOSE: The purposes of the present study are to determine the overall rate of immediate, postprocedural complications in a large cohort of patients who received SLNBs and determine if certain needle-tip positions are less likely to cause complications. To our knowledge, this is the first paper to examine the relationship between needle-tip position and complications. STUDY DESIGN: A large retrospective cohort was assembled from patients who had undergone a SLNB. We determined the overall immediate complication rate for all injections. In addition, all patients who received only a single injection were compiled into another cohort, and needle-tip position was determined. The complication rate was determined for each needle-tip position. PATIENT SAMPLE: All adult patients who underwent a SLNB in a single radiology department from April 1, 1997 to May 31, 2002. OUTCOME MEASURES: Patients were observed for 15-30 minutes after their procedure, then interviewed about any self-reported weakness, light-headedness, increase in pain from the preprocedural levels, or development of new pain. Their postprocedural pain was then rated on the Visual Analogue Scale. The radiologic notes from each examination were reviewed for incidence of these, or any other, complications. METHODS: SLNBs were performed as they would be in the normal course of care, using fluoroscopic guidance and methodology established by a single radiologist overseeing the procedures. The radiologist's record of each visit was examined for note of immediate, postprocedural complications. The radiographs from the patients who received a single injection during their visit were examined to determine the position of the needle tip during the procedure. The needle-tip positions from the "Complications" and "No Complications" single injection cohorts were compared to determine if certain needle-tip positions cause less complications than others. RESULTS: Minor complications were encountered in 98 of the 1,777 total patient visits, for an overall complication rate of 5.5%. All complications were transient, and no patient suffered lasting harm. There were 1,232 procedures in which the patient received a single injection, and a minor complication was encountered in 62 of these visits. The complication rate approached 5% for all needle-tip positions, which is not statistically different from the overall complication rate. However, there was an increased likelihood of complications in patients undergoing a multiple injection procedure vs. those who had only one injection. CONCLUSIONS: Our results suggest that SLNBs performed with fluoroscopic guidance have a low incidence of complications. All of our complications were minor. The specific needle-tip position within or adjacent to the lumbar neural foramen does not appear to be associated with the incidence of complications.

Humans↗
PubMed1998

Risk adjustment for complications of hysterectomy: utility of routinely collected administrative data.

Objective: To determine the ability of risk adjustment methods that use routinely collected administrative data to explain variability in complication rates after hysterectomy.Methods: Discharge data on all non-radical hysterectomies performed in North Carolina between January 1988 and September 1994 were obtained from the North Carolina Medical Database Commission. Complications were categorized as 1) surgical (eg, hemorrhage, organ injury) and 2) medical (eg, myocardial infarction, pneumonia). Comorbidities included peritoneal adhesions and chronic medical problems. Hospital charges were adjusted for inflation. Univariate analyses were performed using the Kruskall-Wallis test for skewed continuous variables and chi(2) tests for categorical variables. Multivariate analysis was performed using unconditional logistic regression, with complication rate as the dependent variable.Results: There were 107,648 cases performed at 134 hospitals, with an overall complication rate of 9.5%. When cancer and pregnancy cases were excluded, the surgical complication rate was 5.0%, medical 3.2%. Patients with surgical complications were significantly younger (median age 42 vs 46) and had significantly higher total hospital charges (median $8,127 vs $7,496) than patients with medical complications. Complication rates for individual hospitals varied from 1.5% to 29.3%, with rates highest for academic medical centers (24.3% vs 7.2% for non-teaching hospitals). Significant predictors of complications in univariate analyses included type of hysterectomy, indication, age >/=65 years, insurance status, and teaching hospital status. Coded comorbid conditions were variable in their association with complications. Adjusted odds ratios, controlled for indication and type of procedure, for age >/=65, Medicaid or no insurance, and teaching hospital status were all greater for medical complications than for surgical complications in multivariate analysis (table).The predictive ability of multivariate analysis was better for medical complications than for surgical complications (C-statistic for medical complication model 0.763 vs 0.644 for surgical complications).Conclusions: Surgical complications of hysterectomy are more common, occur in younger women, and are associated with higher hospital charges than medical complications. Complication rates vary widely between hospitals, with teaching hospitals having the highest rates. This difference persists after adjustment for coded comorbidities. Possible explanations for the inability of multivariate analysis to explain the wide range in observed complication rates include 1) shortcomings in the available data or models, such as variability in coding practices between hospitals or variability in surgical difficulty between hospitals that is not captured with ICD-9-CM codes (eg, uterine size, cancer stage) and 2) variability in the quality of care between hospitals. Further research is needed to help determine the role of each of these explanations. Risk adjustment methods that use administrative data based on currently available coding standards are poor predictors of surgical complication rates after hysterectomy and should not be used to reach conclusions about quality of care.

Journal Article↗
PubMed2005

Surgical management of complications associated with percutaneous and/or endoscopic management of pseudocyst of the pancreas.

OBJECTIVE: To study the magnitude of complications associated with the nonoperative management of peripancreatic fluid collections and pseudocysts and to assess the surgical management of these complications. These are compared with complications associated with operative management. SUMMARY BACKGROUND DATA: Pancreatic pseudocysts and peripancreatic fluid collections associated with acute pancreatitis have been managed with success using nonoperative techniques for more than a decade. When successful, these techniques have clear advantages compared with operative management. There has, however, been little focus on the magnitude and outcomes after complications sustained by nonoperative management. Our report focuses on these complications and pseudocysts and on the surgical management. We have been struck by the high percentage of patients who sustain significant and at times life-threatening complications related to the nonoperative management of fluid collections. We further define an association between the main pancreatic ductal anatomy and the likelihood of major complications after nonoperative management. METHODS: Between 1992 and 2003, all patients admitted to our service with peripancreatic fluid collections or pseudocysts were monitored. We evaluated complications patients managed with percutaneous (PD) or endoscopic drainage (E). Data were collected regarding patient characteristics, need for intensive care unit (ICU) stays, hemorrhage, hypotension, renal failure, and ventilator support. We further focused on the duration of fistula drainage from patients who have had a percutaneous drainage, and we assessed the necessity for urgent or emergent operation. By protocol, all patients had pancreatic ductal anatomy evaluated by means of endoscopic retrograde cholangiopancreatography (ERCP) or magnetic resonance cholangiopancreatography (MRCP). Patients with complications of E and PD were compared with 100 consecutive patients who underwent operative management of pseudocyst and fluid collections as their sole mode of intervention. RESULTS: A total of 79 patients with complications of PD, E, or both were studied. There were 41 males and 38 females in the group of patients who sustained complications (mean age 49 years). Sixty-six of the 79 subsequently required operation to manage their peripancreatic fluid collection, 37 urgent or emergent. The mean elapsed time from diagnosis to nonoperative intervention was 18.1 days. This group of 79 patients had mean 3.1 +/- 0.7 hospitalization (range, 1-7) and length-of-stay 42.7 +/- 4.1 days. ICU stays were required in 36 of the 79 (46%). A defined episode of clinical sepsis was identified in 72 of 79 (91%) and was by far the most common complication. Hemorrhage requiring transfusion was identified in 16 of the 79 (20%), clinical shock 51 of the 79 (65%), renal failure 16 of the 79 (20%), ventilator support for longer than 24 hours 19 of the 79 (24%). A persistent pancreatic fistula occurred in 66 of the 79 patients (84%); mean duration was 61.4 +/- 9.6 days. Sixty-three of the 79 patients with complications of E or PD had ductal anatomy (ERCP/MRCP) which predicted failure because of significant disruption or stenosis of the main pancreatic duct. Among the 100 operated patients, 69 complications occurred in 6 of the 100 (6%). Operation was initiated electively a mean interval of 42.7 days after diagnosis of pseudocyst. Hemorrhage, hypotension, renal failure, sepsis, persistent fistula, or urgent operation all were not seen in the complications associated with operated patients. CT imaging obtained at least 6 months after intervention documented complete resolution after surgery alone in 91 and 9 with cystic structures less than 2 cm. In patients with operation after failed nonoperative therapy, 6 patients had persistent cystic lesions less than 2 cm in diameter. CONCLUSION: These data support the premise that a choice between operative and nonoperative management for peripancreatic fluid collections and pseudocysts should be made with careful assessment of the pancreatic ductal anatomy, with a clear recognition of the magnitude of complications which are likely to occur should nonoperative measures be used in patients most likely to sustain complications. It is vital to recognize the magnitude and severity of complications of nonoperative measures as one chooses a modality. Ductal anatomy predicts patients who will have complications or failure of management of their peripancreatic fluid collection.

Adult↗