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At least 379 records · Page 21Linked to original sources

PubMed1989

Vitamin D-regulated, ATP-dependent calcium transport by intestinal Golgi vesicles during maturation in the rat.

The developmental aspects of calcium uptake by intestinal Golgi vesicles was determined using highly purified Golgi vesicles from enterocytes of suckling (2 wk old), weanling (3 wk old), and adolescent (6 wk old) rats. Calcium uptake by Golgi vesicles at all age groups represented transport into the intravesicular space as evident by temperature dependency and by calcium ionophore A23187-induced calcium efflux studies. Calcium uptake was driven by ATP at all age groups, however, maximal uptake at 15 min was significantly greater in Golgi vesicles of adolescent rats compared to mean values in Golgi vesicles of suckling rats (p less than 0.01). Calcium uptake in the absence of ATP was minimal. The requirement for the adenine base and the hydrolysis of the beta-gamma-phosphodiester was tested by replacement of ATP in the incubation media by CTP and the nonhydrolyzable ATP analogue, adenylyl-(beta-gamma-methylendiphosphonate). Both agents had no stimulatory effect on calcium uptake. Calcium uptake was linear up to 40 s. Kinetic parameters of calcium uptake at free calcium concentrations of 0.04 to 1.0 microM showed a maximal transport capacity of 0.99 +/- 0.05, 0.55 +/- 0.04, and 0.29 +/- 0.03 nmol/mg protein/15 s for adolescent, weanling, and suckling rats, respectively. Km values were 0.16 +/- 0.02, 0.12 +/- 0.03, and 0.07 +/- 0.02 microM for adolescent, weanling and suckling rats, respectively. Km and Vmax values were significantly different between adolescent and suckling rats (p less than 0.01). The calcium regulatory protein calmodulin has no effect on calcium uptake by Golgi vesicles. Vitamin D deficiency in all age groups decreased ATP-dependent calcium uptake. Administration of 1,25-(OH)2 vitamin D3 8 h before death enhanced ATP-dependent calcium uptake in all age groups studied. This enhancement was the result of increase in maximal transport capacity of ATP-dependent calcium uptake. This study demonstrates a vitamin D-regulated ATP-driven calcium uptake by intestinal Golgi vesicles at all age groups including the suckling period. This transport system shows developmental patterns in regard to its kinetic parameters.

Adenosine Triphosphate↗

PubMed1993

Effects of a microgravity environment on the crystallization of biological macromolecules.

Macromolecules crystals are indispensable intermediates in the analysis of macromolecular structure, are essential for the application of x-ray diffraction methods, and are at the same time the greatest obstacle to success. Protein crystals are generally difficult to grow, often of imperfect form or small size, and frequently lack sufficient order. Their growth has become the rate limiting step in x-ray crystallography. Evidence has emerged from protein crystallization experiments carried out in space that suggests macromolecular crystals of improved order and quality can be grown in a microgravity environment. Presumably the absence of density driven convection and sedimentation permits a more deliberate and graceful entry of individual molecules into the crystal lattice. This in turn results in improvements in both morphology and the diffraction patterns of the crystals. The precise mechanisms for these improvements and the means for their optimization are, however, not understood at more than a rudimentary level. I attempt here to review microgravity effects that may play a role in protein crystal growth, sedimentation, convection and surface contact, and suggest their possible mechanisms.

Animals↗

PubMed1998

Control of spatial orientation in a mollusc.

The main function of postural nervous mechanisms in different species, from mollusc to man, is to counteract the force of gravity and stabilize body orientation in space. Here we investigate the basic principles of postural control in a simple animal model, the marine mollusc Clione limacina. When swimming, C. limacina maintains its vertical orientation because of the activity of the postural neuronal network. Driven by gravity-sensing organs (statocysts), the network causes postural corrections by producing tail flexions. To understand how this function occurs, we studied network activity by using a new method. We used an in vitro preparation that consisted of the central nervous system isolated with the statocysts. Output signals from the network (electrical activity of tail motor neurons) controlled an electrical motor which rotated the preparation in space. We analysed the activity of individual neurons involved in postural stabilization under opened or closed feedback loop. When we closed this artificial feedback loop, the network stabilized the vertical orientation of the preparation. This stabilization is based on the tendency of the network to minimize the difference between the activities of the two antagonistic groups of neurons, which are driven by orientation-dependent sensory inputs.

Animals↗

PubMed2002

Is motor perseveration in unilateral neglect 'driven' by the presence of neglected left-sided stimuli?

Unilateral spatial neglect refers to a difficulty in detecting or acting on information in a particular region of space. When asked to cross out stimuli distributed across a page, patients with neglect may miss many targets on the left. In addition, they have a tendency to return to, and re-mark, right-sided targets that they have already cancelled. A recent retrospective study has shown this effect to be specific to unilateral neglect rather than a consequence of right hemisphere damage in general. Here, a consecutive group of seven right-hemisphere neglect patients performed five versions of a standard cancellation task, each version differing in the quantity of left-sided information presented. All of the participants showed perseveration on right-sided targets in the basic task. A highly significant and linear reduction in perseverative behaviour was observed as left-sided information was removed. In a second study, left-sided targets were again progressively removed but, in this case, were replaced with an additional distractor item, keeping the total quantity of stimuli presented in each condition constant. Again, a significant reduction in right-sided perseveration was observed, indicating a high degree of selectivity to the effect. The results show that a difficulty in perceiving existing cancellation marks, or a non-spatially specific motoric perseveration, are unlikely to fully account for this behaviour. As the patients omitted almost all targets on the left side of the basic cancellation task, the results suggest a striking influence on apparently intentional behaviour from un-cancelled information within the neglected field.

Aged↗

PubMed2002

Immune function during space flight.

It is very likely that the human immune system will be altered in astronauts exposed to the conditions of long-term space flight: isolation, containment, microgravity, radiation, microbial contamination, sleep disruption, and insufficient nutrition. In human and animal subjects flown in space, there is evidence of immune compromise, reactivation of latent virus infection, and possible development of a premalignant or malignant condition. Moreover, in ground-based space flight model investigations, there is evidence of immune compromise and reactivation of latent virus infection. All of these observations in space flight itself or in ground-based models of space flight have a strong resonance in a wealth of human pathologic conditions involving the immune system where reactivated virus infections and cancer appear as natural consequences. The clinical conditions of Epstein-Barr-driven lymphomas in transplant patients and Kaposi's sarcoma in patients with autoimmune deficiency virus come easily to mind in trying to identify these conditions. With these thoughts in mind, it is highly appropriate, indeed imperative, that careful investigations of human immunity, infection, and cancer be made by space flight researchers.

Aerospace Medicine↗

PubMed2006

Preferential reaching across regions of hemispace in adults and children.

The purpose of the current study was to examine hand selection during reaching in children utilizing a developmental version of the preferential reaching paradigm (Bryden, Pryde, & Roy, 2000). A cross-sectional sample of eighty right-handed participants (ranging in age from 3 to 20 years) were asked to reach to objects located in different regions of hemispace. Each participant was asked to carry out two different actions, varying in degree of complexity, on the objects while the experimenter observed, which hand was used to perform each of the tasks. A repeated-measures ANOVA revealed that reaching towards the midline and ipsilateral positions in hemispace resulted in significantly more preferred hand reaches than reaching towards contralateral hemispace, regardless of age and task. With respect to age group effects, it was found that the 6 and 7 year olds and the 9 and 10 year olds relied heavily on their preferred hand to perform the task, indicating that hand selection in these children was driven primarily by motor dominance. In comparison, the youngest children and adults used their nonpreferred hand more frequently in contralateral space, indicating that object proximity cues or a hemispheric bias was driving hand selection. The implications of these findings for understanding hand preference and skill were discussed in terms of motor dominance versus spatial reasoning theory of hand selection in unimanual reaching.

Adolescent↗

PubMed1999

EEG evidence of stimulus-directed response dynamics in human somatosensory cortex.

Dense multichannel recordings of scalp electroencephalogram (EEG) were obtained in the vicinity of primary somatosensory cortex, time-locked to repetitive vibrotactile stimulation of sites on the right index finger of a single human subject. Frequency-domain analysis of cross-trial averages revealed prominent 'driving' responses in the EEG at the frequency of stimulation, which under specific stimulus conditions displayed pronounced changes in amplitude and topographic organization over brief (4 s) durations of stimulus exposure. The changes were systematic and physiologically coherent, evolving toward driving-response topographies observed in the same subject in conjunction with periodic microstimulation of single mechanoreceptive afferents whose receptive fields occupied corresponding positions on the digit. This dynamic process was orderly and reproducible, and could be controlled by manipulating factors such as the amplitude, frequency, and temporal spacing of the stimuli. The results are tentatively interpreted in light of a previously proposed neurophysiological model of stimulus-driven response plasticity in mammalian somatosensory cortex.

Brain Mapping↗

PubMed2004

Simulation of topological chaos in laminar flows.

In the present study the immersed boundary method is used for numerical simulation of Stokes-flow mixing driven by stirrers moving in a such way that trajectories of the stirrers form a "braid" in the augmented phase space. It is demonstrated that topologically more complex flow can be a more effective blender than its topologically simpler counterpart with the same energy dissipation rate. Positions of elliptic periodic points are detected and it is demonstrated that the total area of unmixed islands is negligible in comparison with the area of the cavity. Matrix representation of a mixing protocol provides a good estimation for the stretching rate.

Centrifugation↗

PubMed1992

Structural dependence of diurnal fluctuations of radon progeny in residential buildings.

Movement of radon progeny inside houses is a complex process that depends both on atmospheric conditions and on building structure. The indoor working level (WL) monitored in four houses of differing structures shows regular diurnal fluctuations related to solar warming of the atmosphere. In the two houses with full basements, radon is removed by indoor/outdoor pressure-driven airflow, and basement WL varies inversely with outdoor temperature. In the two houses with half basements open to crawl spaces, radon is drawn into the basement faster than it is removed, so that basement WL varies directly with outside temperature. Average WL's in basements are about twice as high as first floor WL's and as much as 18 times as high as outdoor WL's. Each house shows an individual pattern of radon progeny movement throughout the building.

Air Pollution, Indoor↗

PubMed2001

Analysis of a parametrically driven pendulum.

We study in this paper the behavior of a periodically driven nonlinear mechanical system. Bifurcation diagrams are found which locate regions of quasiperiodic, periodic, and chaotic behavior within the parameter space of the system. We also conduct a symbolic analysis of the model which demonstrates that the symbolic dynamics of two-dimensional maps can be applied effectively to the study of ordinary differential equations in order to gain global knowledge about them.

Journal Article↗

PubMed2005

Cross-scale nonlinear coupling and plasma energization by Alfvén waves.

We present a new channel for the nonlocal transport of wave energy from the large (MHD) scales to the small (kinetic) scales generated by the resonant decay of MHD Alfvén waves into kinetic Alfvén waves. This process does not impose any restriction on the wave numbers or frequencies of initial MHD waves, which makes it superior compared to the mechanisms of spectral transport studied before. Because of dissipative properties of the nonlinearly driven kinetic Alfvén waves, the decay leads to plasma heating and particle acceleration, which is observed in a variety of space and astrophysical plasmas. Two examples in the solar corona and the terrestrial magnetosphere are briefly discussed.

Journal Article↗

PubMed2006

Dissimilar electro-osmotic flow and ionic current recirculation patterns in porous media detected by NMR mapping experiments.

Random-site percolation clusters were milled into ceramic (polar) and polystyrene (nonpolar) plates as a paradigm for porous media or complex microsystem channel networks. The pore space was filled with electrolyte solutions. Using NMR microscopy techniques, maps of the following quantities were recorded: (i) flow velocity driven by external pressure gradient, (ii) electro-osmotic flow (EOF) velocity, (iii) ionic current density in the presence of EOF, (iv) ionic current density in the absence of EOF. As far as possible, the experiments were supplemented by computational fluid dynamics simulations. It is shown that electro-osmotic flow as well as the electric current density include vortices and recirculation patterns. Remarkably, all transport patterns turned out to be dissimilar, and the occurrence and positions of vortices do not coincide in the different maps.

Journal Article↗

PubMed2006

Resonance-assisted decay of nondispersive wave packets.

We present a quantitative semiclassical theory for the decay of nondispersive electronic wave packets in driven, ionizing Rydberg systems. Statistically robust quantities are extracted combining resonance-assisted tunneling with subsequent transport across chaotic phase space and a final ionization step.

Journal Article↗

PubMed2003

Cyclic dynamics in a simple vertebrate predator-prey community.

The collared lemming in the high-Arctic tundra in Greenland is preyed upon by four species of predators that show marked differences in the numbers of lemmings each consumes and in the dependence of their dynamics on lemming density. A predator prey model based on the field-estimated predator responses robustly predicts 4-year periodicity in lemming dynamics, in agreement with long-term empirical data. There is no indication in the field that food or space limits lemming population growth, nor is there need in the model to consider those factors. The cyclic dynamics are driven by a 1-year delay in the numerical response of the stoat and stabilized by strongly density-dependent predation by the arctic fox, the snowy owl, and the long-tailed skua.

Animals↗

PubMed2005

Confinement effects on the thermodynamics of protein folding: Monte Carlo simulations.

The effects of chaperonin-like cage-induced confinement on protein stability have been studied for molecules of varying sizes and topologies. Minimalist models based on Gō-like interactions are employed for the proteins, and density-of-states-based Monte Carlo simulations are performed to accurately characterize the thermodynamic transitions. This method permits efficient sampling of conformational space and yields precise estimates of free energy and entropic changes associated with protein folding. We find that confinement-driven stabilization is not only dependent on protein size and cage radius, but also on the specific topology. The choice of the confining potential is also shown to have an effect on the observed stabilization and the scaling behavior of the stabilization with respect to the cage size.

Computer Simulation↗

PubMed2005

Anemia and erythropoietin in space flights.

Since the very early manned missions in space, a state of anemia associated with reduced erythropoietin levels and reduced plasma volume was disclosed. The reduction in red blood cell mass is driven by a process of selective hemolysis, which has been named neocytolysis. This phenomenon also occurs in people living at a high altitude who descend rapidly to sea level. The origin of the signal leading to destruction of newly produced red blood cells probably is located in central circulation, but the operating mechanism is unknown. The importance of plasma cell volume reduction in the genesis of a lower red cell mass also is supported by the inverse correlation seen at moderate altitude. People arriving at moderate altitude have increased erythropoietin concentration that decreases after a few days and is in inverse correlation with central venous pressure. Studies under simulated microgravity conditions in human beings (bed rest, head-down tilt at -6 degrees , water immersion) and in rats provide further insight in unraveling the mechanism of astronauts' anemia, a problem difficult to study in space because of the limited availability of spaceflights.

Anemia↗

PubMed2006

A dimensionless number analysis of the hybridization process in diffusion- and convection-driven DNA microarray systems.

The present theoretical analysis aims at providing a general understanding of the combined effect the many different process variables have on the hybridization rate in diffusion- and convection-driven DNA microarray systems. It is shown that all process variables can be grouped into only four different dimensionless numbers (the Damkohler number Da, the dimensionless association constant kappa(A), the dimensionless initial concentration C'(0) and a geometrical ratio alpha). These four numbers have a straightforward physical meaning and only contain easily measurable parameters. Reducing the solution space from 7D to 4D, the dimensionless number representation greatly facilitates the insight in the conditions leading to the occurrence of diffusion-limited hybridization rates in both diffusion- and convection-driven DNA microarray systems. This in turn simplifies their design and the interpretation of the experimental results that are obtained with these systems.

Diffusion↗

PubMed2005

Relating coupled map lattices to integro-difference equations: dispersal-driven instabilities in coupled map lattices.

Recently there has been a great deal of interest within the ecological community about the interactions of local populations that are coupled only by dispersal. Models have been developed to consider such scenarios but the theory needed to validate model outcomes has been somewhat lacking. In this paper, we present theory which can be used to understand these types of interaction when population exhibit discrete time dynamics. In particular, we consider a spatial extension to discrete-time models, known as coupled map lattices (CMLs) which are discrete in space. We introduce a general form of the CML and link this to integro-difference equations via a special redistribution kernel. General conditions are then derived for dispersal-driven instabilities. We then apply this theory to two discrete-time models; a predator-prey model and a host-pathogen model.

Animals↗