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At least 397 records · Page 22Linked to original sources

Partial failure of a free flap salvaged by using the surviving portion as a "bridge" flap for revascularizing a second free flap.

Partial failure of a free flap can create an unusual dilemma, as guidelines suggesting appropriate further intervention are not well defined. The increased complexity of a second free flap attempt is not necessarily contraindicated, but must be minimized if the same fate as the first is to be avoided. For the unique circumstance where the initial failed flap contained a vascular flow-through, the most distal patent vessels can then secondarily serve in an expeditious manner as the recipient vessels for the second or salvage free flap. The efficacy of this concept has been here validated after limited necrosis occurred in the distal portion of a radial forearm free flap. Following the requisite debridement, the residual flap still maintained a satisfactory arterial and venous flowthrough as a "bridge flap" that supported the attachment of a gracilis muscle free flap, and both flaps in turn preserved a sensate transtarsal amputation stump.

Amputation, Surgical↗

Prospects of regeneration in man.

Reports of fingertip regrowth in children are interpreted in the perspective of epimorphic regeneration in lower forms and in relation to a few other examples in mammals. The latter include cases of antler replacement in deer as well as ingrowth from the margins of holes cut in bat wing membranes and in the external ears of rabbits, pikas, cats, and echolocating bats. It is suggested that the relative inadequacy of regeneration in warm-blooded vertebrates may be attributed to the precocity with which they tend to form dermal scars in healing wounds, scars that are believed to preclude blastema production. Wound healing around the margins of rabbit ear holes is uniquely characterized by the development of prominent epidermal downgrowths adjacent to the severed sheets of dermis in the integument on either side of the ear. If these downgrowths act as epidermal blockades preventing scar formation in favor of allowing blastema cells to accumulate, a logical approach to the experimental induction of regeneration in normally nonregenerating mammalian appendages would involve manipulation of the mechanisms by which epidermis heals amputation stumps.

Amputation, Traumatic↗

Reorganisation in human motor cortex.

Transcranial magnetic stimulation over the motor cortex was used to construct a map of the effective sites on the scalp from which short-latency electromyogram responses could be evoked in muscles proximal to either an amputation stump (two subjects) or an ischemically anesthetized forearm (two subjects). At rest, the maps were larger and the responses bigger when stimulating contralateral to the amputated arm or after anesthesia than they were in the intact arm or before anesthesia. However, this difference disappeared when the maps were constructed during a small tonic voluntary contraction of the target muscle. We conclude that reorganisation of the corticospinal projection to a muscle at rest may no longer be present during activity. If so, this calls into question the possible functional benefits of such reorganisation in the control of movement after peripheral damage.

Amputation Stumps↗

[Medical and surgical outcome of thigh amputation for arteritis].

Results of a minimum 4 year follow up of 87 cases of thigh amputation are discussed. Postoperative mortality was 40% and 40% of patients had survived after one year. Early mortality factors were age (mean 75 years) and the coronary lesion responsible for more than a half of postoperative deaths. Amputation stump complications were noted in 13% of cases, their onset being dependent on 3 factors: loss of femoral pulse, failure of vascular re-establishment and early amputation after this failure. The remaining limb required major amputation in 21% of cases before the end of the second year, the final major level of amputation being a factor of the lack of distal revascularization in 77% of patients.

Age Factors↗

Spinal myoclonus responsive to topiramate.

Spinal segmental myoclonus rarely occurs in peripheral neurological disorders. There are no data about the efficacy of topiramate (TPM) on spinal myoclonus. We describe a patient whose segmental myoclonus in amputation stump was ameliorated markedly by TPM.

Aged↗

Painful neuromas in long below-elbow amputees.

During a five-year period, seven patients were seen who failed to wear their protheses because of neuromas in their amputation stumps. Proximal ligation of the median, radial, and ulnar nerves allowed prosthetic wear and use in every instance. The advantage of this technique used at the time of the original amputation or at an early elective time will aid in the rapid rehabilitation of the patient.

Adult↗

Endoscopic revision of an infected Syme amputation. Case report and review of the literature.

Arthroscopic revision of intra-articular infection is more and more accepted. To our knowledge, there is no description of endoscopic management of an infected amputation stump. This paper presents the case of a 54-year-old man after a Syme amputation of his left leg because of diabetic gangrene of the foot. A local infection of the stump was treated successfully with two endoscopic debridements and lavage. Additionally, the patient received local antibiotics by the application of antibiotic collagenous fleece and chains. This therapeutic management combined with early weight-bearing produced a stable stump.

Amputation Stumps↗

Prosthetic fitting problems of the quasi-Syme amputation.

Unless the original Syme amputation technique has been precisely followed, an amputation stump capable of tolerating little or no end-bearing will frequently result. Such a stump must be fitted with a below knee type of prosthesis as if the patient were a below-knee amputee. Even though it is not designed for other than a below-knee amputation, the socket can be modified to provide a satisfactory prosthesis for a Quasi-Syme stump.

Amputation, Surgical↗

The use of Methenamine as an antiperspirant for amputees.

The socket of a prosthesis is a tightly closed container. Sweating inside the socket is annoying and may also irritate the skin over the stump or lead to local infection such as folliculitis. The most effective method of preventing sweating is by the use of astringent agents. Formaldehyde is a very strong astringent but is not pleasant to use and may cause skin irritation and systemic reactions. Methenamine, in water or when applied to the skin, decomposes to generate formaldehyde in small quantities which do not cause side effects. Methenamine was used on the stump of sixteen amputees. The trial was conducted as a double blind study using two different solutions market as solution A and as solution B. The effectiveness of the solutions as an antiperspirant was evaluated clinically by the subjects and the physician. Solution A containing Methenamine, was found significantly effective, both by the subjects and physician when compared with the solution B the blank one. The use of Methenamine as an antiperspirant is recommended in amputation stumps.

Administration, Topical↗

A clinical trial of a combination of amoxycillin and flucloxacillin in amputations for septic ischaemic lower limb lesions.

The incidence of sepsis after amputation with or without a proximal arterial reconstructive procedure in 24 patients presenting with septic ischaemic lower limb lesions and who received a parenteral combination of amoxycillin and flucloxacillin (Suprapen; Bencard) is compared with that in a similar control group of 22 patients who received antibiotics only if postoperative sepsis developed. There was no significant difference in the incidence of sepsis in the arterial reconstruction wounds. Amputation stump sepsis occurred in 33.3% of patients receiving prophylactic antibiotics compared with 72.7% of the control group. The difference is statistically significant. A similar significant difference was found among 32 patients submitted to primary amputation without an arterial reconstructive procedure. Bacteriological data are discussed.

Adult↗

Idiopathic calciphylaxis.

A 68-year-old woman presented with a painful necrotic ulcer on her right calf and necrotic breakdown of a left below-knee amputation stump as a result of calciphylaxis. No cause could be identified and corrected. Treatment comprised wound care, substituting low molecular weight heparin for warfarin, hyperbaric oxygenation and etidronate disodium, none of which were helpful and major limb amputations were considered the best option for this patient.

Aged↗

Carcinoma arising in burn scar.

A 60-year-old man had under gone a left below-knee amputation 30 years ago owing to trauma and burn suffered in a dynamite explosion. He has been wearing an artificial leg since then. He developed a squamous cell carcinoma on the amputation stump 30 years later. The possible relationship of the burn scar and chronic irritation by the artificial leg to the cancer is discussed.

Amputation, Surgical↗

Management of phantom pain with a textile, electromagnetically-acting stump liner: a randomized, double-blind, crossover study.

The treatment of phantom pain is frequently dissatisfying. We wanted to find out whether an electromagnetically shielding stump stocking interwoven with metal (medipro(R)Liner RELAX [medi Bayreuth, Bayreuth, Germany]) could have a positive effect on phantom pain. A double-blind, randomized, crossover trial in a total of 30 leg amputees compared the experimental (=verum) silicon liner (VL) fitted to the amputation stump with a dummy (=placebo) liner (PL). Each liner was worn for two weeks after a two-week baseline period. Daily documentation focused on phantom pain, quality of sleep and improvement of well-being. Twenty-seven of 30 patients completed the 6-week study, and 22 documentations proved valid. On a 0-10 numeric rating scale (NRS), the median pain intensity before treatment was 4, and the median of maximum pain was 6. VL versus PL reduced pain significantly more often (P=0.008), the odds ratio being 5.95. The degree of pain reduction was likewise highly significant (<0.001). Wilcoxon's matched-pairs signed-rank test for the medians of daily maximum pain showed a significant reduction for both PL (P < 0.001) and VL (P <0.001) as compared to baseline, with VL being highly superior again (P < 0.001) versus PL. The experimental device also led to significant amelioration of general well-being (P = 0.037) with an odds ratio of 3.85, and an improvement in the quality of sleep, which was not significantly different than PL (P = 0.223). In this study, the influence of a silicon liner with electromagnetically protecting properties on phantom pain was highly significant. The mechanisms underlying this effect are unclear. Possibilities include reduction of ectopic neuroma activity, shielding from possible electromagnetic weather impulses (sferics), or analgesic effects of changes in the electromagnetic field. PET or fMRI examination with or without a shielding silicon liner might help to elucidate this observation further.

Adult↗

Spinal cord atrophy and reorganization of motoneuron connections following long-standing limb loss in primates.

Primates with long-standing therapeutic amputations of a limb at a young age were used to investigate the possibility that deefferented motor nerves sprout to new muscle targets. Injections of anatomical tracers into the muscles proximal to the amputated stump labeled a larger extent of motoneurons than matched injections on the intact side or in normal animals, including motoneurons that would normally supply only the missing limb muscles. Although the total numbers of distal limb motoneurons remained normal, some distal limb motoneurons on the amputated side were smaller in size and simpler in form. These results suggest that deprived motoneurons survive and retain function by reinnervating new muscle targets. The sprouted motor efferents may account for some of the reorganization of primary motor cortex that follows long-standing amputation.

Amputation, Surgical↗

Increased excitability in the primary motor cortex and supplementary motor area in patients with phantom limb pain after upper limb amputation.

Using functional magnetic resonance imaging and single slice FLASH technique, we investigated reorganization of the hand representation of the primary sensorimotor cortex (SMC) in 16 patients with upper extremity amputation. Patients were asked to perform finger tapping with the intact hand, repetitive eye closing and anteflexion of the amputation stump or intact shoulder. Six normal volunteers served as control. In the normal volunteers activations during shoulder anteflexion, finger tapping and eye closure were located within the central sulcus in a medio-lateral fashion. Patients demonstrated invasion of the face or shoulder representation into the hand representation of the amputated limb. Eight phantom limb pain patients showed significantly greater activation in SMC and supplementary motor area (SMA) in contrast to eight patients without phantom limb pain. We conclude, that different parts of the motor system are affected in patients with phantom limb pain--possibly in the sense of an up-regulation of excitability.

Adolescent↗

[Knee exarticulation: technique for amputation of ischemic extremities].

A knee disarticulation or a trough-knee amputation stump is superior to an above-knee stump. Knee disarticulation does not require that bone be sectioned or muscle cut. The stump allows total end-load capacity. The muscle balance remains undisturbed. Due to the bulbous shape of the stump prosthetic fitting of modern appliances no longer presents problems. An operative technique especially developed for vascular patients is described in detail, including the postoperative treatment and the principles of prosthetic fitting.

Amputation, Surgical↗

Effect of augmentation of nerve supply upon limb regeneration in the chick embryo.

Limb regeneration was induced in 4-day chick embryos by implanting stage 15 neural tube into the amputated stump of the limb. In control animals, amputation alone or amputation with implant of either notochord or somites resulted in development of proximal wing segments only. In experimental animals, more than one-fourth of the animals containing viable neural tube implants developed proximal, middle, and distal limb segments. These regenerated limb segments contained muscle groups, cartilage models, and nervous structures that approximated the normal situations. Since some new parts regenerated in more than one-fourth of the cases, it may be concluded that augmentation of nerve supply is an effective method of inducing regeneration in limbs of chick embryos. Volume measurements of the neural tube implant indicate that a "critical mass" of nerve tissue may be necessary for regeneration to occur.

Animals↗