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Candida lusitaniae as an unusual cause of recurrent vaginitis and its successful treatment with intravaginal boric acid.

Increasing use of short-course antifungal therapies in patients with recurrent vulvovaginitis may enable the emergence of less-common, more resistant yeast strains as vaginal pathogens. We report the case of a patient with chronically symptomatic and repeatedly treated vaginal candidiasis whose infection was attributable to Candida lusitaniae, a previously unreported cause of candidal vaginitis.

Administration, Intravaginal↗

Collaborative study of the determination of boric acid in caviar by emission spectroscopy.

Caviar samples were spiked at the 0.1 and 0.2% levels and digested with nitric acid in a closed Teflon-lined digestion vessel to prevent volatility losses. The boron was complexed with 2-ethyl-1,3-hexanediol and extracted into methylisobulty ketone. The emission of the boron oxide band was measured in a nitrous oxidehydrogen flame. The mean recoveries at the 0.1 and 0.2% levels for 6 collaborators were 95.7 and 97.1%, respectively.

Boric Acids↗

Effect of an ointment containing boric acid, zinc oxide, starch and petrolatum on psoriasis.

A randomized double-blind controlled trial was undertaken to study the efficacy of a cow udder ointment versus petroalatum alone. A total of 30 patients participated in the study. Sixteen patients completed the trial with 8 of 9 patients improving in the active group and 6 of 7 patients improving in the placebo group. This difference was not statistically significant. The use of a cow udder ointment for psoriasis cannot be supported, particularly with the potential for side effects.

Administration, Topical↗

[In vitro effectiveness of salicylic, benzoic and boric acid and diiodine thymol solutions on various strains of dermatophytes].

In order to study the in vitro behavior of the drug used according to our formula cultures of Trichophyton mentagrophytes. Trichophyton rubrum, Trichophyton verrucosum, Trichophyton tonsurans, Microsporum canis, Microsporum gallinae, Microsporum audouinii, Microsporum gypseum and Epidermophyton floccosum were prepared in order to prove its efficacy. It was found no growth in cultures to which the drug was added in different concentrations thus proving its efficacy as a fungistatic element. The inocula obtained were re-cultured in the same medium having no drug and no growth was evidenced; this would suggest its efficacy as a fungicide. This efficacy was proved for the different concentrations, that is, from the minimal coinentration (0.1 ml) up to the 1 ml concentration the drug disclosed fungicide power. The untreated controls which were recultured from the original strains grew according to their common development rhythm.

Arthrodermataceae↗

Effect of pretreating samples with boric acid before liquid-chromatographic determination of urinary catecholamines.

Isolation of catecholamines on prepacked gravity-fed ion-exchange columns in conjunction with liquid-chromatographic separation is occasionally subject to disturbances of unknown origin, especially after injection of H3BO3 eluates from the ion-exchange columns onto the chromatography column. Peak spreading, sometimes even peak splitting, has been observed in many laboratories--effects easily confused with those sometimes caused by voided columns or by impurities. To elucidate the origins of these interferences, we performed a combined voltammetric and chromatographic investigation. We show that complexation of the catechol group by borate ions and dissociation of those pH-labile complexes in the course of the chromatographic separation is the cause of those peak distortions. Addition of a small volume of diluted HCI to the borate eluates eliminates such interference and leads to reproducible, easily interpretable chromatographic separations.

Boric Acids↗

Pressure-induced chemical decomposition and structural changes of boric acid.

A combined synchrotron X-ray diffraction, Raman scattering, and infrared spectroscopy study of the pressure-induced changes in H(3)BO(3) to 10 GPa revealed a new high-pressure phase transition between 1 and 2 GPa followed by chemical decomposition into cubic HBO(2), ice-VI, and ice- VII at approximately 2GPa. The layered triclinic structure of H(3)BO(3) exhibits a highly anisotropic compression with maximum compression along the c direction, accompanied by a strong reduction of the interlayer spacing. The large volume variation and structural changes accompanying the decomposition suggest high activation energy. This yields a slow reaction kinetics at room temperature and a phase composition that is highly dependent on the specific pressure-time path followed by the sample. The combined results have been used to propose a mechanism for pressure-induced dehydration of H(3)BO(3) that implies a proton disorder in the system.

Journal Article↗