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PubMed1982

IgE and IgD in human colostrum and plasma.

Using radioimmunoassay techniques, we measured IgE and IgD levels in paired colostrum and plasma samples obtained within 4 days postpartum. In colostrum, IgE was detected in concentrations of 0.5-6 IU/ml in 16 out of 39 samples (41%) and less than 0.5 IU/ml in the remainder, whereas IgD was detected in all samples in concentrations of 2-2000 micrograms/dl. Only a moderate correlation was found between colostral and plasma levels of both IgE (r = +0.60) and IgD (r = +0.74). The correlation coefficient between IgE and IgD in plasma was 0.23, whereas in colostrum it was only 0.05. The colostrum:plasma ratio of IgE varied strikingly from that of IgD; the ratio of IgD was 0.1-22.2 times that of IgE. The findings argue against passive transfer of IgE and IgD from the circulation of milk and suggest possible local mammary production of either or both of these two immunoglobulins.

Adolescent↗

PubMed1985

IgD in human colostrum.

Simultaneous colostrum (C) and plasma samples (P) from 14 women, 1 to 5 days postpartum, were examined. Total IgD and specific IgD antibodies to beta-lactoglobulin, bovine serum albumin, Bermuda grass, and alpha-gliadin were measured by solid phase radioimmunoassay. The geometric mean concentrations of IgD were 35.8 (range 2.2-410) micrograms/dl for colostrum and 591.3 (range 72-4100) micrograms/dl for plasma. Six subjects had a specific IgD antibody C/P ratio more than 10-fold greater than the total IgD C/P ratio, suggesting enhancement of antibody to a specific antigen in the mammary gland. All six had C/P ratios suggestive of local enhancement of IgD antibody to Bermuda grass, and two met this criterion for enhancement of IgD antibodies to beta-lactoglobulin, bovine serum albumin, or alpha-gliadin. Specimens for these studies were obtained during the peak grass pollen season. Seventeen additional subjects were studied to compare total IgD in colostrum and plasma with total IgG and serum albumin. The mean C/P ratio for IgD (0.055 +/- 0.015) exceeded the C/P ratio for total IgG (0.015 +/- 0.003) or total albumin (0.020 +/- 0.002). For 14 of 17 subjects the colostrum/plasma ratio for IgD exceeded the C/P ratio for albumin or IgG. Data were transformed logarithmically and correlation coefficients calculated. For albumin versus IgG in colostrum, there was a strong correlation, r = 0.865, p = 0.001. This was different from albumin versus IgD, r = 0.489, p = 0.046 and from IgD versus IgG, r = 0.556, p = 0.020. These analyses support a different mechanism of entry of IgD into milk compared to IgG or albumin.(ABSTRACT TRUNCATED AT 250 WORDS)

Antibody Formation↗

PubMed1996

Purification and characterization of cell growth factor in bovine colostrum.

Bovine colostrum has growth factor activity for stimulating DNA synthesis in calf kidney epithelial cells (CKT-1), Madincanine kidney epithelial cells (MDCK) and rat L6 myoblasts (L6), of which the DNA stimulation level and the activity change with the time elapsed after the birth of a calf varied with their respective cells. The growth factor activity of colostrum for CKT-1 was stable regardless of the collection time of colostrum, and it was purified about 3,650-fold in an overall yield of 1.2% from colostrum obtained 30 min after the birth of a calf. The purified growth factor had a molecular weight (MW) of 5,000 and an isoelectric point of pH 9.7, and the amino acid composition was: Asx5, Thr2, Ser4, Glx14, Pro2, Gly4, Ala4, Val2, Ile, Leu2, Tyr, Phe, Lys, His and Arg. The stimulated DNA synthesis in CKT-1 and L6 by the addition of purified growth factor at a final concentration of 16ng/ml was as the same extent as calf serum at a final concentration of 1.52 mg/ml, and the relative activity for CKT-1 was even greater than that for L6.

3T3 Cells↗

PubMed1986

Total nitrogen and electrolyte levels in colostrum and transition human milk.

The objective of this research was to study the composition of human milk in terms of protein levels and levels of the electrolytes sodium, potassium, calcium, magnesium, phosphorus and chloride in colostrum 48-72 hours post-partum, and in the transition milk (96 +/- 9 hours, 120 +/- 9 hours and 144 +/- 9 hours post-partum) of mothers who had fullterm and pre-term deliveries. The mothers were kept in the hospital with the objective to control a few important lactation parameters such as exercising or resting conditions, sleep, nutrition and suckling stimulation. Only low socioeconomic level mothers took part in the study. The initial period of lactation was studied because this is the time when secretion suffers rapid changes, going from colostrum to transition milk, and then to mature milk. The results observed for the different times and for the two groups were compared both within and between groups. No significant differences were obtained for any of the comparisons, except for transitory oscillations in potassium, calcium, chloride and phosphorus levels observed within groups. In general, it can be said that there was no variation between colostrum and transition milk for the mothers who delivered at full term or pre-term. No differences were found either when the groups were compared at the different times post-partum. This means that, under the conditions used in this study, milk did not vary as its type naturally changed (from colostrum to transition milk) for the two groups and that the levels of the constituents studied also remained unchanged when studied as a function of full-term or pre-term delivery.(ABSTRACT TRUNCATED AT 250 WORDS)

Colostrum↗

PubMed1990

Stimulation by colostrum or mature milk of gastrointestinal tissue development in newborn pigs.

Porcine colostrum and milk were orally administered to newborn pigs to evaluate their gastrointestinal growth-promoting activity. Five piglets per treatment group were gavage-fed 5% lactose (L), defatted colostrum (C) or defatted mature milk (d 16 of lactation) (M) at 3-h intervals over a 24-h period. Colostrum and milk were administered on equivalent dry matter basis and all piglets received 1 mCi of [3H]thymidine per kg BW at the onset of feeding. Small intestines of C- and M-fed pigs were 1.6-and 1.3-fold, respectively, the weight of small intestines of those fed L (P less than .01). Total DNA content of intact small intestines were not different among groups; however, cpm [3H]thymidine/mg intestinal DNA of C and M piglets exceeded (P less than .05) that for L piglets. DNA content and cpm [3H]thymidine of intestinal mucosa did not differ among groups. Total protein in the intestines and intestinal mucosa of C pigs exceeded (P less than .01) that for L and M pigs. Total RNA in the small intestine and intestinal mucosa were similar for C and M groups but less (P less than .01) for L piglets. Stomach and pancreas weights among all pigs were similar, although C and M pigs exceeded L pigs in stomach (P less than .01) and pancreas (P less than .01) RNA content. In contrast, no differences in stomach DNA, protein and cpm [3H]thymidine or in pancreatic DNA, protein and cpm [3H]thymidine were detected. SDS-polyacrylamide gel electrophoresis was used to identify qualitative and quantitative differences in the protein compositions of porcine colostrum and mature milk.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed1986

Importance of diet of dam and colostrum to the biological antioxidant status and parenteral iron tolerance of the pig.

Fifteen second-parity sows were used to determine the importance of vitamin E (E) and selenium (Se) supplementation of the sow's diet and colostrum consumption by the neonatal pig on tolerance to parenteral iron. Selenium (.1 ppm) and E (50 IU/kg) supplementation of the diet of the sow increased plasma tocopherol and Se concentrations, but did not increase plasma glutathione peroxidase (GSH-Px) activity. Colostrum had greater concentrations of E (primarily alpha-tocopherol) and Se than milk. Plasma biological antioxidant status (tocopherol level and GSH-Px activity) of pigs at birth was very low, but by 2 d of age had increased, especially in alpha-tocopherol (nearly a 20-fold increase). Liveability and body weight gain of pigs were not affected by the pre-colostrum iron injection (200 mg Fe as gleptoferron); however, plasma tocopherol concentrations of Fe-injected pigs were lower and plasma Se concentration and GSH-Px activities were higher at 2 d of age than values of pigs not receiving parenteral Fe. Supplementation of the dam's diet with E and Se maintained high tocopherol and Se levels in her colostrum and milk and a high biological antioxidant status in her pigs throughout the nursing period.

Animals↗

PubMed1988

Genetic and environmental factors affecting immunoglobulin G1 concentrations in ewe colostrum and lamb serum.

Presuckle colostral samples and lamb serum samples taken 36 h postpartum were assayed for immunoglobulin G1 (IgG1) concentration (mg/ml) using single radial immunodiffusion. Breeds sampled included Polypay (P), Rambouillet (R), Targhee (T), Columbia (C), Finnish Landrace (F) and Finn crosses (Fx). Sources of variation examined in IgG1 concentration in colostrum (dam trait) included dam's sire breed, dam's sire, age of ewe and number of lambs born. All sources of variation were statistically significant. Least-squares means of IgG1 levels for sire breed were 80, 64, 67, 64, 72 and 69 mg/ml for P, R, T, C, F and Fx breed groups, respectively. A fetal stimulus may exist to increase the mass of IgG1 in colostrum available for multiple births (61, 69 and 77 mg/ml for single, twin and triplet, respectively). Ewe age was a significant source of variation because of a high mean concentration of IgG1 in the yearling's colostrum (100 mg/ml), whereas only slight differences occurred between the other age groups (65 to 67 mg/ml), except for the 7-yr older group (53 mg/ml). Sources of variation examined in IgG1 concentration of lamb serum at 36 h postpartum (lamb trait) included lamb's sire breed, lamb's sire, age of dam, birth type and sex, with dam's colostral IgG1 concentration and day born as covariates. Sire within breed, birth type and the two covariates were significant. Least squares means for sire breed were 36, 32, 33, 32, 31 and 32 mg/ml of serum for P, R, T, C, F and Fx groups, respectively. Lamb serum IgG1 decreased as birth type increased. The heritability of IgG1, estimated by paternal half-sib analyses, was .19 +/- .12 for colostrum and .18 +/- .06 for lamb serum.

Animals↗

PubMed2002

Feed intake patterns, growth performance, and metabolic and endocrine traits in calves fed unlimited amounts of colostrum and milk by automate, starting in the neonatal period.

Feed intake, growth performance, and metabolic and endocrine traits were studied in male calves fed unlimited (GrAL; n = 7) amounts of colostrum for 3 d after birth and mature milk up to d 28 and were compared with calves fed commonly recommended amounts of colostrum and milk (GrRS; n = 7). Calves were fed by automates, and software was available to continuously register the time points and amounts of ingested feed up to 11 d of age. Body weight was measured on d 1, 4, 7, 14, 21, and 28, and blood samples were taken on d 1, 2, 3, 7, 14, 21, and 28 to measure several metabolites and hormones. Feed intake of calves fed GrAL increased from d 1 to 4, then remained stable and was always higher than for calves fed GrRS. Total visits (visits with and without milk intake) were higher for GrRS than GrAL, but visits with milk intake were comparable between groups and meal sizes per visit with milk intake were greater in GrAL than in GrRS. Body weight gain was greater in GrAL than in GrRS in wk 1, but not later. There were significant group differences in plasma concentrations of albumin (GrRS > GrAL), nonesterified fatty acids (GrRS > GrAL), cholesterol (GrRS > GrAL; d 28), insulin (GrAL > GrRS), and cortisol (GrRS > GrAL), but not of immunoglobin G, urea, glucose, triglycerides, growth hormone, and glucagon. In conclusion, calves fed ad libitum were capable of ingesting very large amounts of colostrum and milk, even during wk 1 of life, accompanied by a greater body weight gain in GrAL in the first week, whereas in GrRS, the high number of visits without feed intake indicate that these calves reached no repletion. Compared with calves provided restricted amounts of feed, calves with free access to colostrum and milk were characterized by reduced plasma concentrations of nonesterified fatty acids and by a transiently enhanced insulin and reduced cortisol status.

Animal Nutritional Physiological Phenomena↗

PubMed2003

Health and performance of Holstein calves that suckled or were hand-fed colostrum and were fed one of three physical forms of starter.

Intake of colostrum by neonatal calves and early transition to calf starter are two important factors in successful calf programs. Thirty-one Holstein calves were used to determine health and performance of calves that were 1) allowed to remain with their dams for 3 d and suckle (suckled calves) or were removed from their dams and fed colostrum only by bottle (bottle calves); and were 2) fed ground, pelleted, or textured starters, formulated to be isonitrogenous. Bottle calves were removed from their dams at birth, fed 2.84 L of colostrum, placed in individual hutches, and fed 1.89 L of colostrum 12 h after the first feeding. Suckled calves were removed from their dams after 3 d and placed in individual hutches. Once calves were housed in hutches, they were fed 2 L of whole milk twice daily and were provided starters and water beginning on d 3. Calves were weighed at birth and weekly for 6 wk. Blood samples were obtained at birth, 24 h, and weekly for serum protein determination. Starter intake, fecal scores, and electrolyte treatments were recorded daily. Weaning began when calves had consumed 0.68 kg starter for 2 d consecutively. There were no differences in treatment means between suckled and bottle calves for total gain, grain consumption, days with fecal scores >2, or electrolyte treatments per calf. Average days to weaning was greater for bottle calves compared with suckled calves. Mean serum protein concentration at 24 h was greater for bottle (6.0 g/dl) compared with suckled calves (5.8 g/dl) and only 2 of 15 bottle calves had serum protein concentrations <5.0 g/dl compared with 6 of 16 suckled calves. For starter treatments, calves fed textured starter consumed more total grain, were weaned earlier, and weighed more at 6 wk of age than calves fed pelleted starter. Based on 24-h serum protein concentrations, transfer of passive immunity was greater for bottle calves compared with suckled calves.

Animal Nutritional Physiological Phenomena↗

PubMed2005

Size distribution of fat globules in human colostrum, breast milk, and infant formula.

Only a few results are available on the size of human milk fat globules (MFG), despite its significance regarding fat digestion in the infant, and no data are available at <24 h postpartum (PP). We measured the MFG size distribution in colostrum and transitional human milk in comparison with fat globules of mature milk and infant formula. Colostrum and transitional milk samples from 18 mothers were collected regularly during 4 d PP and compared with mature milk samples of 17 different mothers and 4 infant formulas. The size distribution was measured by laser light scattering. For further characterization, the zeta-potential of some mature MFG was measured by laser Doppler electrophoresis. The MFG diameter decreased sigmoidally in the first days. At <12 h PP, the mode diameter was 8.9 +/- 1.0 microm vs 2.8 +/-0.3 microm at 96 h PP. Thus, the surface area of MFG increased from 1.1 +/-0.3 to 5.4 +/-0.7 m2/g between colostrum and transitional milk. In mature milk, the MFG diameter was 4 microm on average and increased with advancing lactation, whereas the droplets in infant formula measured 0.4 microm. The zeta potential of mature MFG was -7.8 +/- 0.1 mV. The fat globules are larger in early colostrum than in transitional and mature human milk and in contrast with the small-sized fat droplets in infant formula. Human MFG also have a low negative surface charge compared with bovine globules. These structural differences can be of nutritional significance for the infant.

Adult↗

PubMed2006

Omitting the dry-off period negatively affects colostrum and milk yield in dairy goats.

Seventeen pregnant multiparous Murciano-Granadina dairy goats, kept in a semi-intensive exploitation system with once daily milking throughout lactation and 1 kidding per year (milk yield, 577 L/300 d), were used to study the effects of dry-off period length on performance during the subsequent lactation. Goats were mated at wk 29 of lactation and were assigned to 2 experimental groups according to dry-off treatment: goats that were dried off 56 d before expected kidding (D56; n = 9) and goats without dry-off (D0; n = 8). After parturition, kids were removed from their mothers and weighed before suckling. Goats were hand milked to obtain colostrum and were machine milked thereafter. Colostrum was sampled for composition and IgG analysis. Milk yield was recorded weekly during the preceding and subsequent lactations. Udders were biopsied in a sample of goats at d -65 (late lactation), d -49 (during dry-off), and d 48 (early lactation) to kidding (d 0). Apoptotic and proliferating cells in mammary tissues were detected immunohistochemically. Five goats (63%) in the D0 group dried off spontaneously at 27 +/- 4 d before kidding and were considered separately (D27). The rest of the D0 goats yielded 0.86 L/d from d -56 to kidding. Goats kidded 2.25 kids/goat, but the D0 kids had smaller birth weights (1.7 kg) than the D27 (2.2 kg) and D56 (2.1 kg) kids. Colostrum of the D0 goats contained less IgG (5.6 mg/mL) than the D27 (32.9 mg/mL) and the D56 (42.4 mg/mL) goats. In the subsequent lactation (210 d), the D0 goats produced less milk (1.78 L/d) than the D27 (2.51 L/d) and D56 (2.24 L/d) goats, with no detectable difference between the D27 and D56 goats. Apoptosis and proliferation indices increased from 0.51 and 2.09%, at d -65, to 1.75 and 7.12% at d -49 (d 7 of dry-off) in D56 goats. Despite differences in daily milk yield during early lactation (d 48) between the D0, D27, and D56 treatments (1.73, 2.68, and 2.53 L/d, respectively), no differences in apoptosis or proliferation indices were detected (D0: 0.65 and 2.48%; D27: 0.68 and 1.37%; and D56: 0.71 and 2.95%), indicating that duration of the dry period did not affect mammary cell turnover during the subsequent lactation. Omitting the dry period between lactations reduced the quality of colostrum and had negative effects on milk yield in dairy goats. Goats dried off spontaneously for 27 d were as productive as goats dried off for 56 d, indicating that less than 2 mo of dry-off may be sufficient in practice.

Animals↗

PubMed1977

Effect of potassium isobutyrate on absorption of immunoglobulins from colostrum by calves.

Calves received either colostrum with 2.83 meq potassium isobutyrate per gram of gamma-globulin or colostrum with distilled water within 1 h after birth. Blood samples were taken at intervals during the first 72 h for determination of concentrations of gamma-globulin, immunoglobulin IgG and IgM. Calves fed colostrum with distilled water attained higher concentrations in serum of total gamma-globulin, immunolgobulin IgG and IgM. Holstein calves were more efficient than Ayrshire calves in absorbing total gamma-globulin, but differences between breeds were not significant for specific immunoglobulins. Efficiency of gamma-globulin absorption within 24 h was 35.7% for control calves and 24.7% for calves fed colostrum plus potassium isobutyrate. Potassium isobutyrate had a depressing effect on absorption of immunoglobulins by calves.

Animals↗

PubMed1980

Hydrometer test for estimation of immunoglobulin concentration in bovine colostrum.

A practical field method for measuring immunoglobulin concentration in bovine colostrum has been developed from the linear relationship between colostral specific gravity and immunoglobulin concentration. Fourteen colostrums were collected within 24 h postpartum from nursed and unnursed cows and were assayed for specific gravity and major colostral constituents. Additionally, 15 colostrums were collected immediately postpartum prior to suckling and assayed for specific gravity and immunoglobulin concentration. Regression analysis provided an equation to estimate colostral immunoglobulin concentration from the specific gravity of fresh whole colostrum. From this, a colostrometer was developed for practical field use.

Animals↗

PubMed1993

Individual variation in the composition of colostrum and absorption of colostral antibodies by the precolostral buffalo calf.

The total protein and Ig content in the first colostrum was higher in buffalo cows than in dairy crossbred cows. Individual variation in Ig content of first colostrum may be responsible for differences in susceptibility of calves to infections. The decline in Ig content during subsequent milkings was faster in dairy crossbred cows. The major class was IgG in both species. Absorption of colostral proteins and Ig was 14.0 g (68%) and 4.6 g (75.4%), respectively, within 1 h of feeding colostrum to a 7-h-old female buffalo calf. Absorption was decreased to 2.1 and .83 g/h after the first feeding, suggesting that the intestinal absorption of macromolecules declined 1 h after the first feeding. Marginal placental transfer of maternal Ig also was demonstrated in buffalo. An albuminlike protein was predominant in blood plasma of the precolostral buffalo calf. This protein decreased, and IgG in blood plasma increased, after colostrum was fed, indicating that albuminlike protein may be involved in the transfer of maternal nutrients to the fetus.

Absorption↗

PubMed1995

Effects of housing and colostrum feeding on serum immunoglobulins, growth, and fecal scores of Jersey calves.

Ninety-six Jersey calves were used to evaluate the effects of housing and method of colostrum feeding on serum Ig concentrations, incidence and severity of scours, intake, and BW changes from birth to 35 d of age. Calves were separated from the dam and fed 2 L of colostrum in nipple-bottles or allowed to nurse the dam for 3 d. Calves were housed in individual hutches or wooden pens in a barn. Intake of colostrum by calves allowed to nurse the dam was not controlled. Serum IgG and IgM concentrations at 24 h of age were greater for calves that nursed the dam. Scours were less severe when calves were housed in hutches, but number of days scouring was unaffected by treatment. Calves fed colostrum in nipple-bottles and housed in the barn consumed more starter than did other calves from 3 to 5 wk of age. The BW were greater for calves allowed to nurse the dam and housed in hutches. Feed efficiency over the 35-d study was improved when calves nursed the dam. Optimal transfer of passive immunity and housing in hutches appeared to maximize health and growth in this study.

Animal Nutritional Physiological Phenomena↗

PubMed1996

Effect of a whey protein concentrate used as a colostrum substitute or supplement on calf immunity, weight gain, and health.

The efficacy of a whey protein concentrate was evaluated as a colostrum substitute or supplement in two experiments using four groups of 29 calves. In Experiment 1, calves were fed either 2 L of pooled colostrum (group 1) or 500 g of whey protein concentrate (group 2). A mean total of 123.6 and 17.7 g of Ig was fed to calves in groups 1 and 2, respectively. Mean serum IgG, total protein, and globulin concentrations and Ig antibody activities to Escherichia coli K99 and rotavirus were significantly higher for calves in group 1 at 24 to 36 h and at 3 wk of age. Weight gain from birth to 3 wk of age was significantly lower for calves in group 2. The incidence of diarrhea was high but not different between treatments. The mortality rate (0 to 3 wk) was significantly higher for calves in group 2 (27.6%) than for calves in group 1 (3.4%). In Experiment 2, calves were fed either 2 L of pooled colostrum (group 3) or a solution of 1 L of pooled colostrum plus 500 g of whey protein concentrate (group 4). A mean total of 117.2 and 69.1 g of Ig was fed to calves in groups 3 and 4, respectively. Absorption rate of IgG was significantly lower for calves in group 4. Mean serum IgG, total protein, and globulin concentrations and Ig antibody activities to E. coli K99 and rotavirus were significantly higher for calves in group 3 at 24 to 36 h and at 3 wk of age. Mortality rate, BW gain, and incidence of diarrhea did not differ significantly between groups.

Animal Feed↗

PubMed1999

Antibody titer against bovine respiratory syncytial virus in colostrum-fed dairy calves born in various seasons.

OBJECTIVE: To determine antibody titer against bovine respiratory syncytial virus (BRSV) in dairy calves on farms and to investigate whether passively acquired antibody titers differ in calves born in various seasons. SAMPLE POPULATION: Serum samples from 129 colostrum-fed replacement calves in 8 dairy herds. PROCEDURE: A standard ELISA was used to determine BRSV-specific antibodies in serum samples obtained monthly, and antibody titers for calves born in various seasons were compared. RESULTS: BRSV-specific antibody titer in colostrum-fed dairy calves decreased to undetectable values at 3 to 4 months old. Calves born in winter generally had lower titers, compared with those for calves born in other seasons (P < 0.05). Titers in calves born in seasons other than winter did not differ. CONCLUSIONS AND CLINICAL RELEVANCE: Calves born in winter generally have lower BRSV-specific antibody titers, which may be caused by generally lower antibody titers in colostrum or by factors influencing colostrum intake.

Animals↗

PubMed2002

[Fatty acid composition of colostrum and mature human milk in Hungary].

INTRODUCTION AND AIMS: Because of the lack of up-to-date data on fatty acid composition of human milk in Hungary, the authors analysed fatty acid composition of colostrum (n = 18, one hind milk sample on day 5 after delivery) and mature milk (n = 15, pooled 24 h collections repeated twice with 2 weeks intervals at median duration of lactation of 4 months) samples with high-resolution capillary gas chromatography. RESULTS: Fat content and fatty acid compositions did not differ in 24 h pooled mature human milk samples obtained with 2 weeks intervals. Significantly lower values of linoleic acid [10.98 (4.81) vs. 14.70 (5.32), % w/w, median (range from the 1st to the 3rd quartile), colostrum vs. mature human milk, p < 0.001] and alpha-linolenic acid [0.22 (0.09) vs. 0.68 (0.21), p < 0.0001], and significantly higher values of arachidonic acid [0.70 (0.56) vs. 0.50 (0.12), p < 0.001] and docosahexaenoic acid [0.22 (0.15) vs. 0.18 (0.06), p < 0.05] were found in colostrum than in mature human milk. Significant and positive correlations were seen between linoleic and arachidonic (r = 0.71, p = 0.001) as well as between alpha-linolenic and docosahexaenoic (r = 0.59, p = 0.01) acid values in colostrum, but not in mature human milk. CONCLUSION: While mature human milk linoleic, arachidonic and alpha-linolenic acid values in this study were in the range usually reported in the literature, the contribution of docosahexaenoic acid to the fatty acid composition of human milk was considerably lower in Hungary than in several other populations.

Adult↗