Contact dermatitis in lens markers due to diallylglycol carbonate.
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Fifty-one patients allergic to IPPD have been reviewed and the clinical features and prognosis discussed. In 38 of the 51 patients, the dermatitis was considered as occupational, the majority being employed in the transport industry.
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This study is a survey of recent literature and my own observations concerning dermatological risks of processing and producing plastics. A plea for understanding and cooperation is directed to manufacturers, jurists, occupational physicians, safety engineers, toxicologists, allergologists, dermatologists, industrial and hobby workers, purchasers, consumers and other people involved in order to reach optimal knowledge about risks of processing, warnings and safety procedures.
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Observations on nine patients with occupational dermatitis from methylisothiocyanate (MITC) lead to the following conclusions: 1. MITC causes primarily a toxic dermatitis, but as a strong sensitizer it induces sensitization as well. 2. Cross reactions between MITC and benzylisothiocyanate, the active agent of Sulbentin antimycotics, were not seen. 3. In patient a MITC acid burn on one foot and leg caused systemic poisoning from absorption with reversible damage to the liver parenchyma.
In the quality control laboratory of a chemical firm, 11 of 16 men developed dermatitis. Of the allergenic substances used, seven men reacted to benzisothiazolone, two to dinitrochlorobenzene, and none to diphenylamine. Two men were negative to all three substances. A poorly ventilated humid working environment was thought to be an important contributory factor.