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PubMed1994

[Mite workshop].

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Adult↗
PubMedDate not supplied

[Immunotherapy in allergy].

This report includes a partial interpretation of the possible mechanisms of action related with the efficacy of specific immunotherapy with allergens. This cannot be explained by only one mechanism which regulates the immune reaction, which is why there is the relief that there is a large field in immunology which has yet to be explore.

Allergens↗
PubMed1982

Effect of cyclophosphamide on immunological control mechanisms.

Cyclophosphamide (CY) given before immunization causes greatly increased delayed hypersensitivity skin reactions. Increased cell-mediated immunity is associated with depletion of B-lymphocytes from lymphoid tissue and a depression of those lymphocytes whose precursors turn over more rapidly. In the guinea pig, replacement studies showed that the depleted cells were not T-lymphocytes and had immunoglobulin adherent to their surface, a characteristic of B-lymphocytes. Delayed hypersensitivity reactions increased by CY include chemical contact sensitivity, the tuberculin reaction, delayed hypersensitivity to tularemia vaccine and the Jones-Mote reaction to soluble protein antigens. Pretreatment with CY can also increase the antibody response to some antigens, but depress the response to others. In addition, CY has been found to reverse immunological tolerance where this form of unresponsiveness is due to suppressor cells. CY can also enhance the immune response following depression by antigenic competition or desensitization. Other drugs with a similar, but lesser, effect include melphalan, azathioprine and methotrexate.

Animals↗
PubMed1988

Immunotherapy for nasal allergy.

Controlled studies establish the effectiveness of immunotherapy for allergic rhinitis related to grasses, ragweed, mountain cedar, and birch pollens. Clinical improvement appears to be specific, to require adequate dosage, and to relapse once booster injections are discontinued. Specific immunologic responses increase blocking IgG antibodies in serum and secretions, blunt IgE responses, and reduce lymphocyte reactions. Immediate mediator release is reduced both in basophils challenged in vitro and in nasal secretions after local challenge in vivo. Effects on late-phase inflammatory reactions are still under investigation. Standardization of allergenic extracts by immunologic methods should make useful therapeutic responses more frequent.

Antigen-Antibody Reactions↗
PubMed1982

Failure of hyposensitisation in treatment of children with grass-pollen asthma.

Twenty asthmatic children with laboratory proved bronchial reactivity to rye-grass pollen were studied over two consecutive grass-pollen seasons. In the first year 11 patients received preseasonal hyposensitisation treatment with an aqueous rye extract and nine received placebo injections. No treatment was given in the second year. Patients in both the active-treatment and placebo groups showed a pronounced clinical deterioration in their asthma during both pollen seasons. Serum concentrations of IgG-specific antibodies to the rye allergen before treatment were similar in both groups, but after immunotherapy and before the pollen season in the first year these antibody concentrations were raised significantly in the treated group (p less than 0.005): by the middle of the pollen seasons the difference was no longer significant. IgE-specific antibodies showed a similar but nonsignificant pattern of response. We found no evidence that limited hyposensitisation with a pollen extract is of any clinical benefit in seasonal asthma despite evidence of an immunological response.

Adolescent↗
PubMed1989

A preliminary study of circulating immune complexes during allergen immunotherapy in Thai patients.

Circulating immune complexes are suspected as a potentially serious adverse effect after prolonged allergen immunotherapy. This study was undertaken to determine whether there were any significant immunological differences between 32 subjects with allergic rhinitis/asthma treated with immunotherapy of various durations and 13 subjects with similar diagnosis who had never been treated by immunotherapy. All patients were carefully examined for symptoms and signs of immune-complex diseases with negative results. The presence of circulating immune complexes was evaluated by the modified 125I-C1q binding test, the solid phase conglutinin (K) binding test and determination of C3, C4 and C3d levels. In addition, urinalysis, and quantitative determination of serum IgG, IgA, IgM and IgE were also performed. The overall results suggested that prolonged allergen immunotherapy did not result in an increase of circulating immune complexes or other adverse immunological consequences.

Adult↗
PubMed1997

[Gynecologic allergy to spermatic fluid. A case report].

Seminal fluid allergy is a possible diagnosis in front vulvovaginal inflammations occurring rapidly after coitus. The type I reaction (revealed by the immediate hypersensitivity Prick-test) is most frequently encountered. In case of systemic symptoms, the circulating Ig E specific antibodies can be increased. Treatment is palliative (condoms, antihistamines cream). In case of systemic disease, desensibilisation can be proposed. This infrequent but uncomfortable syndrome is also in question in some cases of immunologic infertility.

Adult↗