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PubMed1980

[Immunosupressant activity of direct and indirect acting anticoagulants].

Indirect action anticoagulants, when injected into (CBA--C57BL) F1 mice in doses commensurable with human therapeutic doses, produced different immunotropic effects: acenocoumarin and pelentan had no influence on the formation of immune response, whereas omephin showed a considerable stimulating effect on this process. Large doses of acenocoumarin, pelentan and omephin inhibited the formation of immune response if the antigen was introduced immediately after the injection of the anticoagulant. The immunosuppressing action of pelentan was particularly pronounced. Heparin suppressed the formation of immune responsèe both in imediate and delayed immunization. In immediate immunization the immunosuppresing action of heparin and pelentan injected simultaneously was weaker than the action of heparin alone. Small doses of pelentan haod no influence on the remote effect of heparin, whereas large doses of pelentan abolished the immunosuppressing action of heparin in delayed immunization.

Acenocoumarol↗
PubMed1981

[Allosteric regulation of glucosamine synthetase activity by naphthoquinone derivatives and ethyl ester of di-(4-oxycumarinyl-3)-acetic acid].

The effects of derivatives of naphthoquinone, e.g. 2-methyl-3-phytyl-1,4-naphthoquinone (vitamin K1), 2-methyl-1,4-naphthoquinone (vitamin K3), 3-dihydro-2-methyl-1,4-naphthoquinone-2-sodium sulfonate (vicasol), derivatives of naphthohydroxyquinone, e.g. 2-methyl-1,4-naphthohydroxyquinone 1-monoacetate, 2-methyl-1,4-naphthohydroxyquinone 1,4-diacetate and the oxycumarine derivative di-(4-oxycumarinyl-3)-acetate ethyl ester (pelentan) on the activity of purified glutamine synthetase (EC 5.3.1.19) from rat liver were studied. The enzyme activity was increased under effects of vitamins K1 and K3 and was inhibited by pelentan. The data obtained are indicative of the allosteric effect of these compounds on the enzyme.

Animals↗
PubMed1980

[Role of the liver in producing heat-stable antifactor Xa].

The thermostable antifactor Xa is demonstrable in liver homogenate extracts in an amount exceeding its content in other parenchymatous organs and blood serum. In the course of liver perfusion and incubation of liver sections, the antifactor is demonstrable in the perfused liquid and in the medium used for incubation. Affection of the liver with carbon tetrachloride was attended by the decreased content of the antifactor in serum. The liver seems likely to play an important role in the production of the thermostable antifactor Xa.

Animals↗
PubMed1993

[Breast feeding and oral anticoagulants].

Oral anticoagulants are frequently prescribed during lactation. Because these drugs could affect the hemostasis of the newborn, we did a literature search to find out whether precautions should be taken. It appeared that acenocoumarol and warfarin are not detectable in human milk. Besides the usual daily supplementation of 25 micrograms vitamin K for every breast-fed infant, precautions are not necessary. Phenprocoumon, ethylbiscoumacetate and phenindione are excreted in human milk and could affect neonatal hemostasis.

Acenocoumarol↗
PubMed1976

[Collagen metabolism in the skin with different vitamin K regimens].

Secondary vitamin K deficiency in rats caused by pelentan was accompanied by a decrease in the total collagen content and a rise in free oxyproline in the skin. Under these conditions the rate of collagen hydrolysis proved to increase. Vitamin K (vikasol) prevented development of the mentioned shifts in collagen metabolism.

Animals↗
PubMed1998

[Use of hypoprothrombinemia provocation test for early diagnosis of liver disease caused by harmful environmental agents].

The aim of this work has been to assess the feasibility of using Prothrombin Time (PT) Assay before and after administration of Pelentan (Hypoprothrombinemia Provocation (HPP) Test) for early detection of subclinical toxic hepatic injuries. The proposed modification of PT Assay is based on the observation that people with slight hepatic injury receiving small doses of Pelentan (diethylcoumarol) display remarkably longer PT than healthy people receiving similar doses of the chemical. The test group comprised 37 people occupationally exposed to hepatotoxic agents, 85 males permanently abusing alcohol, while 24 clinically healthy people, not exposed occupationally to the toxic agents served as the control. In addition, 26 hepatitis B and/or C virus carriers were also examined. The results show that: 1. HPP test enables assessment of hepatic function in patients with suspected hepatic injury and in people permanently abusing alcohol; 2. low value of serum prothrombin index 24 h and 48 h after the administration of Pelentan is indicative of the positive result of the test; 3. HPP test provides more information on the functional condition of liver than single PT determination by the Quick assay.

Adult↗