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At least 397 records · Page 22Linked to original sources
PubMed1993

A personal historical perspective of the development of the gastrointestinal endocrine system.

The growth of gastrointestinal endocrinology has become exponential with the introduction of modern molecular biologic techniques. It had its roots in extirpation, as did all of endocrinology, and was the birthplace of the first hormone secretion. Progress was tardy through the 'physiologic secretion' years but gained pace with the advent of radioimmunoassay. With molecular biologic approaches, a plethora of candidate hormones have outstripped ascribable biologic functions. Nonetheless, a semblance of sanity is presented in recognizable clinical syndromes deriving from gut hormone excesses. This and the potential for application of peptide therapy to deficiencies and excesses of gut humor production are exciting prospects for the future.

Digestive System↗
PubMedDate not supplied

[Several parameters of the state of the nervous, immune and endocrine systems in newborn rats exposed to irradiation during the preimplantation period of embryogenesis].

Protracted prenatal irradiation of animals at the preimplantation stage of embryogenesis is shown to produce disturbances in the development of regulation systems, with their consequences persisting up to sexually mature period of postnatal life. Unknown before, these effects of preimplantation irradiation give the experimental confirmation to the main statement of the previously proposed theoretical concept of the "systemic teratogenesis": the ultimate effect of prenatal irradiation is a distortion of the structure of postnatal neuroimmunoendocrine regulation in the direction of overdevelopment of its endocrine component with the following coadaptive underdevelopment of the nervous and immune components.

Abnormalities, Radiation-Induced↗
PubMedDate not supplied

[Changes in the dog endocrine system in the hematopoietic form of radiation sickness].

The endocrine status of the organism estimated by the cortisol, insulin and triiodothyronine content of blood considerably changes during radiation sickness. The most pronounced changes in the endocrine status occur during the primary response and at the height of radiation sickness. The endocrine status test may be used in the individual radiosensitivity prognosis.

Animals↗