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At least 397 records · Page 22Linked to original sources
PubMed1981

Some factors modifying the insulinotropic and cardiovascular effects of isoprenaline in the rat.

The effects of L-isoprenaline on plasma immunoreactive insulin (IRI) and glucose concentrations were examined in pentobarbitone anaesthetized rats. When given by bolus injection hyperinsulinaemia was produced only by very large doses of isoprenaline (100-200 micrograms/kg). Infusion of isoprenaline allowed the demonstration of hyperinsulinaemia at low dose rates (0.07-0.7 microgram kg-1 min-1). Pretreatment with phentolamine or production of a functional sympathectomy by bilateral adrenal demedullation and chronic guanethidine treatment augmented the hyperinsulinaemic effect of isoprenaline. Isoprenaline-induced hyperglycaemia was attenuated by sympathectomy and by phentolamine pretreatment, this attenuation being attributed to the augmented hyperinsulinaemic effect of isoprenaline under these conditions. The increase in heart rate and reduction in blood pressure produced by isoprenaline were also augmented in sympathectomized rats.

Animals↗
PubMed1978

[Significance of modifying factors in the development of peripheral nervous system tumors in rabbits].

The experiments conducted on 170 rabbits have indicated that the development of neurogenic tumors under the exposure to methylnitrosourea procedes more rapidly in immunization with the tissue homogenate from the rabbit sciatic nerve (using a complete Freund's adjuvant) in chronic irritation of the peripheral trunk and in hypothyroidism and estrogenization of the organism of animals under test. Castration and thyroidin administration would reduce the number of experimental tumors of the peripheral nervous system and lengthen the latent period of their development.

Animals↗
PubMed1980

Assays for metabolic alpha-hydroxylation of N'-nitrosonornicotine and N-nitrosopyrrolidine and the influence of modifying factors.

High-pressure liquid chromatographic methods were developed to study microsomal alpha-hydroxylation, which is likely to be an activation mechanism for N-nitrosopyrrolidine (NPYR) and N'-nitrosonornicotine (NNN). The effects of ethanol, phenobarbital and 3-methylcholanthrene pretreatment on the alpha-hydroxylation of NPYR and NNN were determined using F-344 rats and Syrian golden hamsters. In the rat, 3-methylcholanthrene pretreatment decreased the rates of alpha-hydroxylation of NPYR and 5'-hydroxylation of NNN, but increased the rate of 2'-hydroxylation of NNN. Phenobarbital pretreatment of rats did not markedly affect rates of alpha-hydroxylation of NPYR or NNN. In the hamster, 3-methylcholanthrene pretreatment increased the rate of alpha-hydroxylation of NPYR, but did not affect the rates of alpha-hydroxylation of NNN. Phenobarbital or ethanol pretreatment of hamsters resulted in increased rates of alpha-hydroxylation of NPYR and 5'-hydroxylation of NNN. The induction of alpha-hydroxylation of NNN and NPYR by ethanol suggests that these nitrosamines may be more carcinogenic in alcohol-treated animals.

Animals↗
PubMedDate not supplied

[Role of food and other modifying factors in the development of stomach cancer].

The effect of the alimentary, nervous, hormonal and drug factors on gastric secretion and resistance to the action of chemical cancerogenic substances was studied in four experiments. It was established that all these factors affecting gastric secretion for a long time, exert through it an effect on gastric resistance to the action of chemical cancerogenic substances. It was shown as well that gastric resistance to cancerogenic effects correlated directly with the rate of gastric secretion. The higher it was the stronger resistance the stomach exhibited to the action of chemical cancerogenic substances. Decreased gastric secretion is a factor predisposing to cancer of the stomach rather than an obligatory precancerous condition.

Achlorhydria↗
PubMed1995

[Long-term prognosis after coronary angioplasty in relation to the presence of modifiable factors of coronary risk].

Short-term outcome after coronary angioplasty is mainly determined by restenosis, while long-term outcome is determined by new events due to incomplete revascularization, by atherosclerosis progression and by late-restenosis. The aim of this study is to assess if correctly treated coronary risk factors are predictors of poor prognosis after coronary angioplasty. Two-hundred and twenty six patients (209 males, 17 females, mean age 56 +/- 9 years) with successful coronary angioplasty were treated for coronary risk factors. New events (death, myocardial infarction, repeat angioplasty, bypass surgery) were recorded. Ischemia was evaluated by serial exercise tests. The mean follow-up was 31 +/- 12 months. Survival was 99.5% at 1 year and 97.4% after 5 years; "event free survival" was 84.6% at 1 year and 65.9% after 5 years; "ischemia free survival" was 84.6% at 1 year and 44.8% after 5 years. "Ischemia free survival" was higher in patients with single coronary angioplasty and in patients with infarct-related vessel angioplasty. Smoke addiction, diabetes, hypercholesterolemia and hypertension were not significantly correlated with "ischemia free survival". Smokers and diabetics had a trend towards a less favorable 5 year outcome, but without statistical differences. In conclusion, this study shows that correctly treated coronary risk factors do not worsen prognosis after coronary angioplasty.

Aged↗
PubMed1995

[Which factors modify the duration of inpatient psychotherapy?].

The indication for differential duration of inpatient psychotherapy is a difficult question to answer, especially when the possible outcome-success of more severely disturbed patients (e.g. with borderline-personality disorder) is considered. Our own results showed no relevant correlation between the degree of patients' disturbance and treatment duration, neither any relevant correlation between treatment duration and therapists' evaluation of symptomatic or ego-structural improvement. The only marked effect on treatment duration was found for the patients' evaluation of their therapeutic relationship: the better they judged this relationship, the more their therapists tended to elongate inpatient psychotherapy. This finding supports a paradigm, which has been already well confirmed for outpatient psychotherapy: the specific importance of the therapeutic relationship for the therapeutic process even within the scope of inpatient psychotherapy. Another finding of our study indicates that more severely disturbed patients probably need a modified setting of inpatient psychotherapy: favorably a focus oriented interval treatment with short duration periods and alternating focus if necessary.

Adult↗
PubMed1994

[Thrombolysis of acute myocardial infarct: modifying factors of "door-to-needle time"].

Effect of thrombolytic treatment in acute myocardial infarction depends on several factors, most importantly on time to treatment. The door-to-needle time, the interval between admission and thrombolytic therapy initiation, may be one important factor. In a retrospective study, we analysed 151 patients who were admitted to our emergency department with acute myocardial infarction and who received thrombolytic treatment. We analysed door-to-needle time with respect to the factors age, gender, clinical symptoms, presence of prehospital ECG, presence of prehospital complications, day of admission, hour of admission, duration of pain and infarct site. We observed that the door-to-needle time is significantly shorter in those cases with a prehospital ECG (p < 0.001) or no prehospital complications (p < 0.001) as well as inferior infarction (p < 0.02). There was a trend towards a shorter interval in cases with typical chest pain plus autonomic symptoms (p = 0.05). No statistical significance was seen in respect to age, gender, day and hour of admission, and duration of pain. Door-to-needle time with respect to thrombolytic treatment seems to depend on several factors in the preclinical field. Improvement of prehospital diagnosis and prevention of preclinical complications might result in faster thrombolytic treatment of the patient after arrival at the emergency department.

Adult↗