PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “NEOPLASMS, MULTIPLE PRIMARY”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 397 records · Page 22Linked to original sources
PubMed2002

p53 mutation analysis for definite diagnosis of multiple primary lung carcinoma.

BACKGROUND: The detection of a second tumor in patients with lung carcinoma raises the question whether this lesion is a metastasis or a second primary lung carcinoma. Patients cannot always be categorized satisfactorily according the criteria of multiple lung carcinoma proposed by Martini and Melamed. This may result in an inadequate treatment schedule in individual patients. Because p53 mutations can be used as clonal marker, the authors investigated whether p53 mutation analysis can differentiate between primary lung carcinomas and metastatic disease. METHODS: Sixty-four tumors in 31 patients with synchronous and metachronous lung tumors were investigated by p53 mutation analysis. RESULTS: In 21 patients, the tumors showed different p53 mutations, and therefore a definite diagnosis of multiple primary lung carcinoma was made. One of these patients did not meet the criteria of Martini and Melamed. In two other patients not matching these criteria, identical mutations were demonstrated in both tumors, indicating the presence of metastatic disease. In eight patients, analysis was not conclusive or possible. CONCLUSIONS: p53 mutation analysis can be a useful tool to confirm or rule out multiple primary lung carcinoma, and the results confirm the criteria of Martini and Melamed. However, in patients not meeting these criteria, the diagnosis of multiple lung carcinoma still has to be considered, and metastatic disease has to be ruled out. P53 mutation analysis can be helpful for this purpose.

Adenocarcinoma↗
PubMed1993

Application of the p53 gene mutation pattern for differential diagnosis of primary versus metastatic lung carcinomas.

The p53 gene mutation pattern was used as a diagnostic marker of multiple and second primary lung carcinomas. Nine cases of multiple carcinoma, which were suspected clinicopathologically to be double or triple primary carcinomas, were examined for p53 protein expression by immunohistochemistry and for genetic abnormality of the p53 gene by polymerase chain reaction (PCR)-single-strand conformation polymorphism (SSCP) analysis. Nine tumors from four cases gave a positive result upon both immunostaining for the p53 protein and PCR-SSCP analysis of the p53 gene. These nine tumors showed different mobility shifts between exons 5 and 8. The four cases were diagnosed genetically as multiple primary carcinomas. To confirm the results of PCR-SSCP analysis, five tumors from two cases that showed different mobility shifts were further analyzed for their nucleotide sequences, and it was found that all of them had point mutations at different codons in exons 5 and 8. These findings suggest that the p53 gene mutation pattern is an effective marker for diagnosis of tumor multiplicity.

Base Sequence↗
PubMed2002

Morphological types of breast cancer in family members and multiple primary tumours: is morphology genetically determined?

BACKGROUND: We conducted the present study to determine whether breast cancer morphology is genetically determined. METHODS: Using the nationwide Swedish Family Cancer Database, which includes data on 10.2 million individuals and over 25,000 morphology-specific breast cancers, we followed morphological types in familial cancers between mothers and daughters and between sisters. Additionally, we recorded morphological data in women who presented with two primary breast cancers and in those who presented with an invasive and in situ breast cancer. We used kappa statistics to examine the association between genetics and morphology. A kappa value of 0 indicates that the process is random and a value of 1 indicates that it is completely determined (i.e. genetic); values between 0.40 and 0.60 are considered to indicate a moderately determined process. RESULTS: The study sample included a total of 25,730 first and 3394 second invasive breast cancers, and 2990 in situ breast cancers. Ductal, lobular, tubuloductal and comedo were the most common invasive types. We identified 164 mother-daughter pairs with breast cancer of a defined morphology, yielding a low kappa value of 0.08. Among 100 sister pairs the kappa value was 0.002. In individuals with two primary breast cancers the kappa values were 0.22 and 0.01 for two invasive and in situ-invasive pairs, respectively. However, for a tumour with a subsequent tumour detected in the contralateral breast less than 1 year later the kappa value was 0.47. CONCLUSION: The data suggest that breast cancer morphology is not genetically determined. However, because of mixed morphologies and the overwhelming prevalence of ductal morphology, the results for rare morphologies should be interpreted with caution.

Adenocarcinoma, Mucinous↗
PubMed1985

Second cancer following cancer of the breast in Connecticut, 1935-82.

Among 41,109 women diagnosed with breast cancer between 1935 and 1982 in Connecticut, 3,984 developed a second cancer, whereas 2,426 were expected [relative risk (RR) = 1.64; 95% CI = 1.6-1.7]. This increased risk persisted for 30 years and was highest in women under 55 years of age at the time of breast cancer diagnosis. Second primary breast cancers (RR = 3.0) accounted for almost one-half of all new neoplasms. However, if subsequent breast cancers were excluded, the risk for all other second cancers was only 1.15 (95% CI = 1.10-1.20), and no excess risk was seen among women over age 55 at initial breast cancer. Significant risks were found for cancers of the ovary (RR = 1.7) and uterine corpus (RR = 1.4), possibly linked with shared reproductive factors such as nulliparity or late age at menopause. Malignant melanoma (RR = 1.5), thyroid cancer (RR = 1.6), and colon cancer (RR = 1.2) were also significantly elevated; possible shared risk factors remain to be elucidated. Significant deficits of multiple myeloma and chronic lymphocytic leukemia were noted. Women who received initial radiotherapy compared with those who did not were at slightly higher risk of developing a second cancer, most notably acute nonlymphocytic leukemia, non-Hodgkin's lymphoma, and cancers of the esophagus, kidney, and connective tissue, although the nature of the associations was not always clear. Some of the soft tissue sarcomas were lymphangiosarcomas of the arm, a consequence of the lymphedema that may complicate radical mastectomy (Stewart-Treves syndrome). Women treated with radiation were at higher risk of developing a second breast neoplasm (RR = 3.9) than nonirradiated women (RR = 2.8). Further investigation should focus on the mechanisms underlying the relationships between breast, genital tract, and colon cancers, and on the effects of treatment modalities on the risk of subsequent neoplasms.

Breast Neoplasms↗
PubMed2002

[Recurrent tumor--pathologic-anatomic findings].

Based on pathological-anatomical findings, early (2 months) and late (2 years) local and distant recurrencies are presented, considering topographic aspects following surgery of primary pulmonary tumours, metastatic pathways and time intervals. Morphological criteria for differentiating two tumours from metastases, systemic recurrencies of the basic disease following early micrometastatic spread, as well as the grading of tumour regression in surgical samples following radio chemotherapy are shown.

Diagnosis, Differential↗
PubMed1998

Breast and pectoralis musculo-aponeurotic fibromatosis: two independent lesions occurring in the same patient. A case report.

We report the first case of primitive breast fibromatosis associated with a synchronous independent musculo-aponeurotic fibromatosis of the omolateral pectoralis major muscle in an otherwise healthy 29-year-old woman without clinical evidence of any genetic syndrome. The primary occurrence of the two lesions was supported by the absence of any macroscopic and microscopic connection. The present case suggests that a pre- or intraoperative frozen section diagnosis of breast fibromatosis should lead the surgeon and pathologist to exclude an independent fibromatosis of the underlying musculo-aponeurotic fascia.

Actins↗
PubMed1999

[Early detection of multiple tumors in primary diagnosis of oral carcinomas using panendoscopy].

Early diagnosis of additional carcinomas in the diagnosis of primary oral squamous epithelial carcinomas is important for prognosis and provides helpful pointers for planning therapy. In a prospective study from 1993 to 1998, 83 patients with histologically confirmed primary squamous epithelial carcinomas of the oral cavity, the oropharynx and the lip underwent panendoscopy staging to check whether early diagnosis of simultaneous, additional carcinomas of the upper aerodigestive tract is possible with this method. Panendoscopy commenced with rigid tracheobronchoscopy followed by rigid esophagoscopy. Afterwards, the nasopharynx, oropharynx and hypopharynx were examined endoscopically. Finally, microlaryngoscopy was performed. Biopsy and microbiological smears were taken from suspect areas. The incidence of simultaneous, additional carcinomas was 8.4%. All tumors were located in the upper aerodigestive tract with the exception of the esophagus, trachea and bronchial system. A simultaneous laryngeal carcinoma was also diagnosed on the vocal cord in a patient with lip carcinoma. Precancerous conditions could also be diagnosed by means of panendoscopy. This study and two retrospective studies from 1988 to 1994 from the Clinic of Oromaxillofacial Surgery and from the Regensburg Tumor Center (1993 to 1997) confirm the high proportion of additional carcinomas in a primary cancer in the "head and neck region." The financial costs and instrumental requirements of the method appear to be justified in view of the high proportion of simultaneous, additional tumors. Expierience so far and the uncomplicated course indicate that this investigation does not entail any additional risk for the patient, which is why panendoscopy can be recommended without reservations for staging in tumors in the head and neck region.

Adult↗
PubMed2000

Fluorodeoxyglucose positron emission tomography, a new technique for increasing the detection rate of coincident thyroid cancer in head and neck oncology.

Clinically occult thyroid cancer is not uncommon and may occur in 1% to 10% of the population Since the first studies on the use of fluorodeoxyglucose positron emission tomography (FDG PET) in clinical oncology some reports have appeared on the detection of occult tumors using this imaging modality. According to these results, the number of patients with head and neck cancer and clinically occult coincident primary tumors at initial presentation may be expected to increase. In two of the four patients presented, the coincident tumor was detected with FDG PET. The possible role of this new imaging technique is discussed in correlation with treatment and clinical outcome.

Adult↗
PubMed1987

The hand in metastatic disease.

A review of the world literature shows 163 cases of tumors metastatic to the hand; we report three additional cases. The incidence of primary tumors elsewhere metastasizing to the hand is a little more than 0.1%. In over 16% of cases, a tumor of the hand was the first manifestation of a primary tumor elsewhere. The lung is the chief source, followed by the breast and the kidney. The terminal phalanges are the most frequent site of metastasis, followed by the metacarpals and the proximal phalanges. The mechanism of dissemination remains obscure.

Adenocarcinoma↗
PubMed2004

[Bilateral primary breast cancer: a report of 217 cases].

OBJECTIVE: To report the clinical and pathological characteristics of bilateral primary breast cancer (BPBC) in comparison with unilateral primary breast cancer (UPBC). METHODS: A retrospect database of primary breast cancer patients admitted to the Cancer Hospital from March 1967 through May 2003 was analyzed. RESULTS: A total of 10,470 primary breast cancer patients were treated, among which 271 patients had bilateral primary tumors with an incidence of 2.1%. Most of the BPBC, developed both synchronously (sBPBC, incidence rate: 0.6%) and metachronously (mBPBC, incidence rate: 1.5%), were diagnosed in premenopausal women with an average age of 48. In the latter cases, the median time interval between their occurrences was 57.6 months. The median survival time for patients with sBPBC and mBPBC was 29.6 months and 27.8 months, respectively. There was no statistical difference in survival rate between the 2 groups of patients. Nor was menopausal status related to survival. In mBPBC patients, when the occurrence of the second breast cancer was taken as the beginning of prognostic analysis, the prognosis of BPBC patients was worse than those with unilateral involvement. CONCLUSION: Prognosis of patients with bilateral primary breast cancer is poor. In mBPBC patients whose breast cancers appear one after the other, meticulous follow-up is needed after resection of tumor on one side to early detect development of cancer of the countralateral breast especially within 5 years.

Adult↗
PubMed2004

Clinical features, diagnosis, treatment and prognosis of multiple primary colorectal carcinoma.

AIM: To investigate the clinical features, diagnosis, treatment and prognosis of multiple primary colorectal carcinomas (MPCC). METHODS: A retrospective analysis of 37 patients with MPCC from 1974 to 1998 was carried out. RESULTS: The incidence of MPCC was 2.74%(37/1 348) in patients with primary colorectal carcinomas, 15 cases of them were patients with synchronous carcinomas (SC) and 22 cases were diagnosed as metachronous carcinomas (MC). Most tumors were located in the right colon and rectum. Fifty-five percent (12/22) of MC were diagnosed within 3 years after tumor resection and 41%(9/22) of MC occurred after 8 years. Radical resections were performed in all patients except for 1 case. The 5-year survival rate of SC was 72.7%(8/11) and that of MC after the first cancer and second cancer was 71.4%(15/21) and 38.9%(7/18), respectively. CONCLUSION: The results indicate the importance of complete preoperative examination, careful intraoperative exploration and periodic postoperative surveillance. Early diagnosis and radical resection can increase survival rate of MPCC.

Adult↗
PubMed1993

Previous cancer and radiotherapy as risk factors for lung cancer in lifetime nonsmokers.

A history of previous primary cancer and of radiotherapy were investigated as risk factors for lung cancer in lifetime nonsmokers in a hospital-based case-control study. By design, subjects with a previous tobacco-related primary (of the lung, larynx, oropharynx, esophagus, kidney, bladder, or pancreas) were excluded. Information was available on 30 male and 47 female lung cancer cases and 87 male and 132 female controls, all lifetime nonsmokers, interviewed in hospitals in four United States cities between 1985 and 1990. In males, neither a history of a previous primary nor a history of radiotherapy was associated significantly with lung cancer; however, the numbers of exposed cases were small. In females, after adjustment for age, education, hospital, lifetime environmental tobacco-smoke exposure, and body mass index, both a history of a reproductive primary and a history of radiotherapy were associated significantly with lung cancer (odds ratio [OR] = 4.9, 95 percent confidence interval [CI] = 1.4-17.7, and OR = 4.4, CI = 1.3-15.1, respectively). Due to a high correlation between a history of a reproductive primary and a history of radiotherapy in the cases, it was not possible to estimate the effect of one exposure independent of the other. These results are consistent with the possibility that endocrine factors may play a role in some lung cancers in women.

Adenocarcinoma↗
PubMed1980

Hodgkin's disease complicated by radiation sarcoma in bone.

Seven patients after treatment of Hodgkin's Disease who developed bone sarcomas in the radiation field were seen at this centre over the past eight years. Radiation-induced sarcoma in bone in patients with Hodgkin's Disease is poorly documented. The large number of cases appeared to be an important new development and led to our review of all the patients with radiation-induced sarcomas (RIS) seen at this centre over the past 40 years. Thirty-seven patients with RIS in previously normal bone were found, and of these, only one patient with underlying Hodgkin's Disease, who was seen here 27 years earlier. Hodgkin's Disease and breast cancer were the most common primary underlying conditions and, as a result, the bones of the shoulder girdle were the commonest site of radiation-induced sarcoma. The clinical histories and radiographic findings of the eight patients with underlying Hodgkin's Disease are discussed in detail.

Adolescent↗
PubMed1989

Exophytic mass of the floor of the mouth.

A tissue mass in the floor of the mouth was found to be an unusual, exophytic squamous cell carcinoma. The patient also had synchronous hepatic metastasis from an occult primary adenocarcinoma. The case is discussed from the standpoint of the differential diagnosis of lesions that may appear as masses of the floor of the mouth. Individuals with one primary cancer are at increased risk for developing second malignancies which may be in either the same anatomic area or in other organ systems. This case report emphasizes the need for the clinician to periodically follow-up any patient with a history of malignancy.

Adenocarcinoma↗
PubMed2003

Double resection for patients with pancreatic cancer and a second primary renal cell cancer.

BACKGROUND: Reports of synchronous or metachronous double kidney-pancreas cancers are very rare. METHODS: We present 2 patients with renal cell carcinoma and synchronous (1 patient) or metachronous (1 patient) primary pancreatic ductal adenocarcinoma. The patients underwent resection for both cancer types with a worthwhile outcome. RESULTS: The appearance of different primaries in an individual may indicate a genetic predisposition to different neoplasms. The study of double primary cancers is important because it might provide understanding of a shared genetic basis of different solid tumors. CONCLUSIONS: The association between these two cancers demands more detailed epidemiological and molecular investigation. From a clinical viewpoint a resectional policy is recommended.

Adenocarcinoma↗
PubMed2003

Body site of cutaneous malignant melanoma--a study on patients with hereditary and multiple sporadic tumours.

Individuals with an increased risk of developing cutaneous malignant melanoma (CMM) include members of kindreds with hereditary cutaneous malignant melanoma (HCMM) and patients who have already been treated for a CMM. Some of these patients develop multiple primary cutaneous malignant melanomas (MCMMs). Ultraviolet radiation is the main instigator of CMM. There are indications that patients in these high-risk groups react differently to sunlight than patients who develop a single sporadic CMM. The objectives of this study were to analyse tumour site in patients with HCMM and sporadic MCMM. Data on 2517 patients with 2608 CMMs from a population-based regional cancer registry were used. The new computer program EssDoll was used for the analyses of primary tumour sites. This software is able to analyse any chosen body area(s) with reference to the number of tumours arising there. When the site of the first and second tumours in patients with sporadic MCMM were analysed in a skin 'field division', there was a significant concordance with respect to site (P < 0.0001). In patients with MCMM, the second primary tumour was significantly thinner than the first (P = 0.001). Primary tumour sites in patients with HCMM were compared with those in patients with a single sporadic CMM. In HCMM we found significantly fewer tumours in the head and neck area and more on the trunk. These differences remained significant in two different body area models, even when stratified for age (P < 0.05). In conclusion, a site-concordance was noted for sporadic MCMM. This may be the result of a 'field effect'. Our results indicate that intermittent ultraviolet exposure may be of relatively greater importance than chronic exposure in HCMM.

Anthropometry↗
PubMed1977

Case report. Tandem lesions: chromophobe adenoma and meningioma.

A number of cases of multiple primary intracranial neoplasms have been reported, including tumors of neuroepithelial and mesenchymal origin. The presence of meniogioma has been reported in association with glioblastoma, oligodendroglioma, astrocytoma, and eosinophilic adenoma. This case represents a unique example of adjacent chromophobe adenoma and meningioma. The usefulness of computed tomography in the diagnosis of concomitant lesions with different density attenuations is discussed.

Adenoma, Chromophobe↗