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Results for “PALMITIC ACID”

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PubMed1993

Inhibitory action of palmitic acid on the growth of Saccharomyces cerevisiae.

High concentrations of long-chain fatty acids have been found to be harmful to mammalian cells and prokaryotic organisms. This effect was investigated in Saccharomyces cerevisiae. Addition of 3 mmol/L palmitate to a yeast extract-peptone medium caused a significant inhibition of cell growth during the first 2 d of incubation, followed by renewed growth and palmitate utilization. Inhibition was also observed with palmitate concentrations down to 0.1 mmol/L. As inferred from catalase activity determinations, this effect was found to correlate with the absence of peroxisome proliferation. Finally, no inhibition was observed in exponential-phase cultures or in the presence of 0.1 g/L glucose, this suggesting that the physiological state of the cell may determine whether its growth will be inhibited by fatty acids.

Catalase↗
PubMed1980

[Characteristics of palmitic acid transport in muscle membranes: rat skeletal muscles].

1-14C Palmitate uptake by isolated rat plantaris muscle was determined over a 5-min. period following preincubation at 37 degrees C in the presence either of increasing concentrations of palmitate or of other fatty acids, carbohydrates and 2-4 DNP or under anaerobic conditions. Palmitate uptake shows a saturation kinetics and is reduced when the incubation medium contains other fatty acids, carbohydrates, 2-4 DNP on under anaerobic conditions. It is suggested that palmitate uptake could depend on presence of glucose and metabolic energy.

Anaerobiosis↗
PubMed1969

Correlation between percentage of palmitic acid in adipose tissue and serum cholesterol level in patients with multiple sclerosis.

To investigate mechanisms controlling the concentration of serum cholesterol we studied its relationship to the proportions of fatty acids in the lipids of adipose tissue of patients with multiple sclerosis. In 26 men the serum cholesterol concentration had a significant multiple linear regression on the proportion of palmitic, palmitoleic, and grouped longer-chain acids in adipose tissues. In 29 women the serum cholesterol had a significant regression on the proportion of palmitic acid and age. Whether these observations would hold for normal people must be determined in future studies.

Adipose Tissue↗